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188篇 您的检索式：作者名="Heeren"

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	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Active at night, sleepy all day – Sleep disturbances in patients with hepatitis C virus infection显示文摘	Meike Heeren Faina Sojref Ramona Schuppner Hans Worthmann Henning Pflugrad Anita B. Tryc Thomas Pasedag Karin Weissenborn	2013	Journal of Hepatology2013，，：	2
3	Hepatitis C virus infection and the brain显示文摘	Karin Weissenborn Anita B. Tryc Meike Heeren Hans Worthmann Henning Pflugrad Georg Berding Martin Bokemeyer Hans L. Tillmann Annemarie Goldbecker	2009	Metabolic Brain Disease2009，，1：	2
4	Analysis of fluorescein isothiocyanate derivatized amphetamine and analogs in human urine by capillary electrophoresis in chips-based and fused-silica capillary instrumentation 显示文摘	Von Heeren F Thormann W	1998	Electrophoresis1998，19，：	1
5	Basic principals highly reliable multiterminal capacitor sensors and performance of some laboratory testmodels显示文摘	HEERENS E C	1982	Sensors and Actuators1982，83，13：	1
6	Triose phosphate isomerase deficiency is caused by altered dimerization not catalytic inactivity-of the mutant enzymes 显示文摘	Ralser M Heeren G Breitenbach M	2006	PLoS ONE2006，1，：	1
7	Predictive effect of p53 and p21 alteration on chemotherapy response and survival in locally advanced adenocarcinoma of the esophagus显示文摘	Heeren P A Kloppenberg F W Hollema H	2004	Anticancer Res2004，24，4：	1
8	Direct temperature resolved HRMS of fire-retarded polymers by in-Source PyMS on an external ion source fourier transform ion cyclotron resonance mass spectrometer显示文摘	Heeren R M A De Koster C G Boon J J	1995	Analytical Chemistry1995，67，21：	1
9	Evaluation of Refolding Conditions for a Human Recombinant Fusion Cytokine Protein,Promegapoietin1a显示文摘	BOYLE D M JOHNSON G V HEEREN R A	2008	Biotechnol Appl Biochem2008，49，：	1
10	Temporal pattern of eytotoxie edema in the perihematomal region after in- tracerebral hemorrhage : a serial magnetic resonance imaging study显示文摘	Li N Worthmann H Heeren M	2013	Stroke2013，44，4：	1
11	Absolute strain gauge 显示文摘	HEERENS W C TARASENKO S D	1991	Sensors and Actuators A- Physical1991，27，13：	1
12	Application of capacitance techniques in sensor design显示文摘	Heerens W C	1986	Phys E Sci Instrum1986，，19：	1
13	Aneurysm of the splenic vein显示文摘	Heeren M Op - de - Beeck B Van - den - Brande P	2004	Acta Chir Belg2004，104，3：	1
14	Isolated lung perfusion for pulmonary metastases, a review and work in progress显示文摘	Grootenboers M J Heeren J van Putte BP	2006	Perfusion2006，21，：	1
15	Visceral artery aneurysms显示文摘	Gehlen JM Heeren PA Verhagen PF	2011	Vasc Endovascular Surg2011，45，8：	1
16	The role of respiration,reactive oxygen species and oxidative stress in mother cell-specific ageing of yeast strains defective in the RAS signalling pathway显示文摘	Heeren G Jarolim S Laun P	2004	FEMS Yeast Res2004，5，2：	1
17	250 kV Sub-nanosecond pulse generator with adjustable pulse-width显示文摘	Heeren T Camp J T	2007	IEEE Transactions on Dielectrics and Elec- trical Insulation2007，14，4：	1
18	Analysis of fluorescein isothiocyanate derivatized amphetamine and analogs in human urine by capillary electrophoresis in chip-based and fused-silica capillary instrumentation 显示文摘	Ramseier A Von Heeren F and Thormann W	1998	Electrophoresis1998，19，1617：	1
19	Age of drinking onset and unin- tentional injury involvement after drinking 显示文摘	Ralph W Heeren T Jamamka A	2000	JAMA2000，1284，：	1
20	The lynching of Bill Dembski显示文摘	F Heeren	2000	The American Spectator2000，，11：	1

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