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| 1 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 2 | Use of C-Band frequencies for satellite navigation: benefits and drawbacks显示文摘 | Markus Irsigler Günter W. Hein Andreas Schmitz-Peiffer | 2004 | GPS Solutions2004，，3： | 1 |
| 3 | Is There A Universal Need for Positive Self - Regard? 显示文摘 | Heine S J Lehman D R Markus H R & Kitayama S | 1999 | Psychology Review1999，106，： | 1 |
| 4 | Is there a universal need for positive self-regard显示文摘 | Heine S J Lehman D R Markus H R Kitayama S | 1999 | Annual Review of Psychology1999，，106： | 1 |
| 5 | In there a universal need for positive self-regard?显示文摘 | HEINE S J LEHMAN D R MARKUS H R SHINOBU K | 1999 | Psychological Review1999，106，4： | 1 |
| 6 | TGF-β-dependent induction of CD4 + CD25 + Foxp3 + Tregs by liver sinusoidal endothelial cells显示文摘 | Antonella Carambia Barbara Freund Dorothee Schwinge Markus Heine Alena Laschtowitz Samuel Huber David C. Wraith Thomas Korn Christoph Schramm Ansgar W. Lohse Joerg Heeren Johannes Herkel | 2014 | Journal of Hepatology2014，，3： | 1 |
| 7 | In there a universal need for positive self -- regard 显示文摘 | Heine S J Lehman D R Markus H R et at | 1999 | Psychological Review1999，106，4： | 1 |
| 8 | Is there a universal need for positive self-regard显示文摘 | HEINE S J LEHMAN D R MARKUS H R | 1999 | Psychological Review1999，106，4： | 1 |
| 9 | Is There a Universal Need for Posifve Self-regard显示文摘 | HEINE S J LEHMAN D R MARKUS H R KITAYAMA S | 1999 | Psycho- logical Review1999，106，： | 1 |
| 10 | 热轧扁平材断面轮廓与平直度准稳态弹黏塑性离线模拟显示文摘为了预报宽板带在冷、热轧中的金属变形行为,需要借助精确的计算程序,并要考虑轧件变形和辊系变形间的耦合。对于又薄又宽的带材,即大宽厚比轧件,采用商用有限元软件模拟断面形状与平直度,需要耗费大量的计算时间[1,2]。开发了一个专业有限元程序[3-6],用于模拟轧制中轧件的弹黏塑性流动行为[7,8]。该方法基于准稳态理论和全隐式应力更新方法[9-12],考虑了轧件变形和辊系变形间的耦合[13],能够较准确得到轧件断面变化和内部残余应变、应力分布[14-16],据此可进行板带屈曲分析和平直度预报[17],以及轧机的断面形状与平直度调控能力评价[18,19]。所开发的模型基于鲁棒数值算法,计算结果与商用有限元软件模拟结果进行了对比验证,也将与热轧生产数据进行比较。该模型可用于系统深入地研究板形参数,开发冷、热轧带钢的平直度判据。值得一提的是,模型基于弹黏塑性本构关系,并考虑道次间的加工硬化与软化行为,得到了纵向应力、应变和轧制力横向分布。 | Alexander Kainz Markus Widder Erik Parteder Gerald Hein Karl Schrkhuber Klaus Zeman 张国民 | 2012 | 世界钢铁2012，12，6： | 0 |
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