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| 1 | Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers- Review显示文摘Venous thromboembolism event(VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis(CAT), preferably with low molecular weight heparins(LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers. | Hanno Riess Piet Habbel Anja Jühling Marianne Sinn Uwe Pelzer | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 9 |
| 2 | 确保硫酸的质量显示文摘奥托昆普技术公司Klaus Hasselwander先生论述如何利用现有技术确保硫磺制酸和冶炼烟气制酸装置的产品质量。对硫磺制酸装置,主要是采用可靠的过滤技术,例如带有预涂层的叶式过滤机。对冶炼烟气制酸装置,一是提高净化工序的效率,必要时增设除氟和除汞装置;二是对成品酸进行漂白、除汞、除氧化氮。北德意志冶金公司Hanno Hintze先生介绍该公司在汉堡的冶炼烟气制酸装置为提高硫酸质量所采取的一些措施。 | Klaus Hasselwander Hanno Hintze 王爱群 | 2006 | 硫酸工业2006，，1： | 4 |
| 3 | Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer显示文摘 | Philippe Rougier Hanno Riess Robert Manges Petr Karasek Yves Humblet Carlo Barone Armando Santoro Sylvie Assadourian Laurence Hatteville Philip A. Philip | 2013 | European Journal of Cancer2013，，12： | 4 |
| 4 | Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia显示文摘 | Mitsuro Kanda Hanno Matthaei Jian Wu Seung–Mo Hong Jun Yu Michael Borges Ralph H. Hruban Anirban Maitra Kenneth Kinzler Bert Vogelstein Michael Goggins | 2012 | Gastroenterology2012，，4： | 3 |
| 5 | Perioperative treatment options in resectable pancreatic cancer-how to improve long-term survival显示文摘Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and to determine the most effective perioperative treatment of either chemotherapy and/or radiation therapy. More extensive operations involving extended pancreatectomy, portal vein resection and pancreatic resection in resectable pancreatic cancer with limited liver metastasis, performed in specialized centers seem to be the surgical procedures with a possible impact on survival. After many years of stagnation in pharmacological clinical research on advanced pancreatic ductal adenocarcinomas(PDAC)- since the approval of gemcitabine in 1997- more effective cytotoxic substances(nab-paclitaxel) and combinations(FOLFIRINOX) are now available for perioperative treatment. Additionally, therapies with a broader mechanism of action are emerging(stroma depletion, immunotherapy, antiinflammation), raising hopes for more effective adjuvant and neoadjuvant treatment concepts, especially in the context of 'borderline resectability'. Only multidisciplinary approaches including radiology, surgery, medical and radiation oncology as the backbones of the treatment of potentially resectable PDAC may be able to further improve the rate of cure in the future. | Marianne Sinn Marcus Bahra Timm Denecke Sue Travis Uwe Pelzer Hanno Riess | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 3 |
| 6 | The cellular and molecular basis of hyperthermia显示文摘 | Bert Hildebrandt Peter Wust Olaf Ahlers Annette Dieing Geetha Sreenivasa Thoralf Kerner Roland Felix Hanno Riess | 2002 | Critical Reviews in Oncology and Hematology2002，，： | 3 |
| 7 | Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group显示文摘 | Uwe Pelzer Ingo Schwaner Jens Stieler Mathias Adler J?rg Seraphin Bernd D?rken Hanno Riess Helmut Oettle | 2011 | European Journal of Cancer2011，，11： | 2 |
| 8 | Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas显示文摘 | Marco Dal Molin Hanno Matthaei Jian Wu Amanda Blackford Marija Debeljak Neda Rezaee Christopher L. Wolfgang Giovanni Butturini Roberto Salvia Claudio Bassi Michael G. Goggins Kenneth W. Kinzler Bert Vogelstein James R. Eshleman Ralph H. Hruban Anirban Mai | 2013 | Annals of Surgical Oncology2013，，12： | 2 |
| 9 | miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts显示文摘 | Hanno Matthaei Dennis Wylie Maura B. Lloyd Marco Dal Molin Jon Kemppainen Skye C. Mayo Christopher L. Wolfgang Richard D. Schulick Laura Langfield Bernard F. Andruss Alex T. Adai Ralph H. Hruban Anna E. Szafranska-Schwarzbach Anirban Maitra | 2012 | Clinical Cancer Research2012，，17： | 2 |
| 10 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 11 | Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis显示文摘 | Johannes Hartl Hanno Ehlken Christina Weiler-Normann Marcial Sebode Benno Kreuels Nadine Pannicke Roman Zenouzi Claudia Glaubke Ansgar W. Lohse Christoph Schramm | 2014 | Journal of Hepatology2014，，： | 2 |
| 12 | Mass Spectrometry-based Quantitative Proteomic Profiling of Human Pancreatic and Hepatic Stellate Cell Lines显示文摘The functions of the liver and the pancreas differ; however, chronic inflammation in both organs is associated with fibrosis. Evidence suggests that fibrosis in both organs is partially regulated by organ-specific stellate cells. We explore the proteome of human hepatic stellate cells (hHSC) and human pancreatic stellate cells (hPaSC) using mass spectrometry (MS)-based quantitative proteomics to investigate pathophysiologic mechanisms. Proteins were isolated from whole cell lysates of immortalized hHSC and hPaSC. These proteins were tryptically digested, labeled with tandem mass tags (TMT), fractionated by OFFGEL, and subjected to MS. Proteins significantly different in abundance (P < 0.05) were classified via gene ontology (GO) analysis. We identified 1223 proteins and among them, 1222 proteins were quantifiable. Statistical analysis determined that 177 proteins were of higher abundance in hHSC, while 157 were of higher abundance in hPaSC. GO classification revealed that proteins of relatively higher abundance in hHSC were associated with protein production, while those of relatively higher abundance in hPaSC were involved in cell structure. Future studies using the methodologies established herein, but with further upstream fractionation and/or use of enhanced MS instrumentation will allow greater proteome coverage, achieving a comprehensive proteomic analysis of hHSC and hPaSC. | Joao A.Paulo Vivek Kadiyala Peter A.Banks Darwin L.Conwell Hanno Steen | 2013 | Genomics, Proteomics & Bioinformatics2013，11，2： | 2 |
| 13 | Brugada Syndrome: Report of the Second Consensus Conference: Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association显示文摘 | Charles Antzelevitch Pedro Brugada Martin Borggrefe Josep Brugada Ramon Brugada Domenico Corrado Ihor Gussak Herve LeMarec Koonlawee Nademanee Andres Ricardo Perez Riera Wataru Shimizu Eric Schulze-Bahr Hanno Tan Arthur Wilde | 2005 | Circulation2005，，5： | 2 |
| 14 | Ageing and Brugada syndrome: considerations and recommendations显示文摘Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patientwithBrugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditionsmay also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities. | Pieter G. Postema Hanno L Tan Arthur AM Wilde | 2013 | Journal of Geriatric Cardiology2013，10，1： | 2 |
| 15 | Retinal artery occlusion following intravitreal anti-VEGF therapy显示文摘 | von Hanno T Kinge B Fossen K | 2010 | Acta Ophthalmol2010，88，2： | 1 |
| 16 | P0tential of low- molecular chitosan as a DNAdelivery system : biocompatility, bo- dydistribution and ability to complex and protect DNA显示文摘 | Simon C W R Hanno V J K Ruth D | 1999 | Inter- national Journal of Pharrnacentics1999，178，： | 1 |
| 17 | AUA guide-line for the diagnosis and treatment of interstitial cystitis/bladderpain syndrome显示文摘 | HANNO P M BURKS D A CLEMENS J Q | 2011 | J Urol2011，185，6： | 1 |
| 18 | AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome显示文摘 | Hanno PM Burks DA Clemens JQ | 2011 | J Urol2011，185，6： | 1 |
| 19 | Cross‐species analysis of nicotine‐induced proteomic alterations in pancreatic cells显示文摘 | Joao A. Paulo Raul Urrutia Vivek Kadiyala Peter Banks Darwin L. Conwell Hanno Steen | 2013 | Proteomics2013，，9： | 1 |
| 20 | RNA interference显示文摘 | Hanno GJ | 2002 | Nature2002，418，6894： | 1 |
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