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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy显示文摘 | Kubilay Ukinc Halil Onder Ersoz Caner Karahan Cihangir Erem Selcuk Eminagaoglu Arif Bayram Hacihasanoglu Mustafa Yilmaz Mustafa Kocak | 2009 | Endocrine2009，，2： | 1 |
| 3 | Central neurocytoma: proton MR spectroscopy and diffusion weighted MR imaging findings显示文摘 | Murat Kocaoglu Fatih Ors Nail Bulakbasi Onder Onguru Cuneyt Ulutin Halil Ibrahim Secer | 2009 | Magnetic Resonance Imaging2009，，3： | 1 |
| 4 | Non-penetrating deep sclerectomy and collagen implant surgery in glaucoma patients with advanced field loss显示文摘 | Halil Ates Kutay Andac Onder Uretmen | 1999 | International Ophthalmology1999，，3： | 1 |
| 5 | A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin显示文摘 | Kubilay Ukinc Selcuk Eminagaoglu Halil Onder Ersoz Cihangir Erem Caner Karahan Arif Bayram Hacihasanoglu Mustafa Kocak | 2009 | Endocrine2009，，3： | 1 |
| 6 | Central pontine and extra-pontine myelinolysis after correction of severe hypoglycemia显示文摘 | Halil Onder Ethem Murat Arsava Rahsan Gocmen | 2013 | Neurol Sci2013，34，12： | 1 |
| 7 | Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women显示文摘 | Mehmet Refik Bayraktar Ibrahim Halil Ozerol Nilay Gucluer Onder Celik | 2009 | International Journal of Infectious Diseases2009，，2： | 1 |
| 8 | The value of admission glycosylated hemoglobin level in patients with acute myocardial infarction显示文摘 | Mahmut Cakmak Nazmiye Cakmak Sebnem Cetemen Halil Tanriverdi Yavuz Enc Onder Teskin I. Dogu Kilic | 2008 | Canadian Journal of Cardiology2008，，5： | 1 |
| 9 | Isolated internuclear ophthalmoplegia from ischemic origin显示文摘A 67-year-old male with a medical history of hypertension,diabetes mellitus,and previous ischemic stroke applied to the neurology outpatient clinic due to acute onset double vision which had abruptly started 2 days ago.On neurological examination,the right eye could not adduct whereas nystagmus occurs on the left eye abduction(Figure 1).Upon history interrogation,it was learned that the patient had applied to the emergency department two days ago and cranial diffusion-weighted imaging(DWI)was performed which resulted in normal ranges(Figure 2). | Halil Onder Erol Erkan | 2021 | Journal of Acute Disease2021，10，3： | 0 |
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