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| 1 | Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome: one year follow-up results显示文摘·AIM: To investigate the retinal nerve fiber layer(RNFL)thickness changes in patients with obstructive sleep apnea syndrome(OSAS) for one year follow-up. To discuss the possibility of detecting tendency of glaucoma in this population by using spectral domain optical coherence tomography(3D-OCT-2000 Spectral domain).·METHODS: After polysomnographic study, all subjects(64 OSAS patients and 40 controls) underwent detailed ophthalmological examination. After these examinations,patients with glaucoma and patients who had ophthalmological and/or systemic disease were excluded from the study.Totally, 20 patients in OSAS group and five patients in controls were excluded from the study in the first examination and follow-up period. The RNFL thickness was assessed with OCT. Forty-four OSAS patients and 35 control subjects were followed up for12 mo. RNFL thickness change and OSAS patients were evaluated for severity of disease by Apnea-Hypopnea Index(AHI).·RESULTS: Forty-four OSAS patients and 35 controls were enrolled in the study. Statistically significance was found between OSAS patients and controls at the 12 thmo.Average RNFL thickness was found to be significantly lower in last measurements in OSAS patients when compared with first measurements and control subjects(P <0.001, 0.002, respectively). There was a statistically significant correlation among AHI, and RNFL thickness(P <0.05).·CONCLUSION: The results suggest that the patients with OSAS were related with a proportional decrease in the RNFL thickness. These patients should be followed up regularly for glaucomatous changes. Detecting more RNFL thinning in severe OSAS was important. | Mehmet Ozgur Zengin Ibrahim Tuncer Eyyup Karahan | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 9 |
| 2 | Effects of glutamine and curcumin on bacterial translocation in jaundiced rats显示文摘AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice. | Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 3 | Evaluation of systemic risk factors in different optical coherence tomographic patterns of diabetic macular edema显示文摘● AIM: To elucidate the relationship between systemic risk factors and different patterns of diabetic macular edema(DME) determined with optical coherence tomography(OCT).● METHODS: In this cross-sectional study, DME was classified by OCT as diffuse retinal thickness(DRT), cystoid macular edema(CME) and serous retinal detachment(SRD) and the relationship between the systemic risk factors and DME patterns was evaluated.● RESULTS: Of the 57 patients with DME, 21(36.8%) had DRT, 24(42.1%) had CME and 12(21.0%) had SRD. Microor macro-albuminuria was significantly higher in the DRT pattern(61.9%) compared with the SRD(50.0%) and CME patterns(25.0%; P=0.040). Hemoglobin A1 c(Hb A1 c) level was significantly higher and patients were younger in the DRT pattern group(P=0.034, P=0.032). Best corrected visual acuity was the worst and central macular thickness was the thickest in the CME pattern group.● CONCLUSION: Micro-or macro-albuminuria may be more frequent and Hb A1 c level may be higher in patients with DRT. These patients are also seen to be younger than patients with non-DRT. | Durgul Acan Eyyup Karahan Nilufer Kocak Suleyman Kaynak | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 5 |
| 4 | Early rehabilitation improves neurofunctional outcome after surgery in children with spinal tumors显示文摘To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in children with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients(1–17 years old) who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4(range, 2–7) days after surgery for 10(range, 7–23) days. Results from the Modified McCormick Scale, Functional Independence Measure for Children, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pediatric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients' s clinical symptoms have no influences on neurofunctional outcomes. | Nezire Kose Ozge Muezzinoglu Sevil Bilgin Sevilay Karahan Ilkay Is kay Burcak Bilginer | 2014 | Neural Regeneration Research2014，9，2： | 4 |
| 5 | Comparison of the Retinomax hand-held autorefractor versus table-top autorefractor and retinoscopy显示文摘AIM:To compare noncycloplegic and cycloplegic results of Retinomax measurements with findings achieved after cycloplegia using table-top autorefractor and retinoscopy.METHODS:The study included 127 patients(mean age96.7mo,range 21 to 221).Retinomax(Rmax)(Nikon Inc.,Japan)was used to obtain noncycloplegic refraction.Under cycloplegia,refraction was measured with Rmax,table-top autorefractor(TTR)(Nikon NRK 8000,Inc.,Japan)and retinoscopy.The values of sphere,spherical equivalent,cylinder and axis of cylinder were recorded for Rmax,TTR and retinoscopy in each eye.All results were analyzed statistically.RESULTS:The mean spheric values(SV),spherical equivalent values(SEV)and cylindrical values(CV)of the noncycloplegic Rmax(SV:0.64 D,SEV:0.65 D and CV:0.03 D,respectively)were found to be significantly lower than cycloplegic TTR(1.43 D,1.38 D and 0.3 D;P=0.012,P=0.011 and P=0.04,respectively)and retinoscopy(1.34 D,1.45 D and 0.23 D;P=0.04,P=0.002 and P=0.045,respectively).Mean cycloplegic SV,SEV,CV were not significantly different between Rmax and TTR,Rmax and retinoscopy,TTR and retinoscopy.Cycloplegic or noncycloplegic axis values were not different between any method.CONCLUSION:Rmax may be used successfully as a screening tool but may not be accurate enough for actual spectacle prescription.Cycloplegic Rmax measurements may be able to identify refractive error in children because of approximate results to retinoscopy. | Ibrahim Tuncer Mehmet Ozgur Zengin Eyyup Karahan | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 3 |
| 6 | An artificial neural network approach for prediction of long-term strength properties of steel fiber reinforced concrete containing fly ash显示文摘In this study, an artificial neural network (ANN) model for studying the strength properties of steel fiber reinforced concrete (SFRC) containing fly ash was devised. The mixtures were prepared with 0 wt%, 15 wt%, and 30 wt% of fly ash, at 0 vol.%, 0.5 vol.%, 1.0 vol.% and 1.5 vol.% of fiber, respectively. After being cured under the standard conditions for 7, 28, 90 and 365 d, the specimens of each mixture were tested to determine the corresponding compressive and flexural strengths. The pa- rameters such as the amounts of cement, fly ash replacement, sand, gravel, steel fiber, and the age of samples were selected as input variables, while the compressive and flexural strengths of the concrete were chosen as the output variables. The back propagation learning algorithm with three different variants, namely the Levenberg-Marquardt (LM), scaled conjugate gradient (SCG) and Fletcher-Powell conjugate gradient (CGF) algorithms were used in the network so that the best approach can be found. The results obtained from the model and the experiments were compared, and it was found that the suitable algorithm is the LM algorithm. Furthermore, the analysis of variance (ANOVA) method was used to determine how importantly the experimental parameters affect the strength of these mixtures. | Okan KARAHAN Harun TANYILDIZI Cengiz D. ATIS | 2008 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2008，9，11： | 3 |
| 7 | Primary hepatic carcinosarcoma显示文摘BACKGROUND:Primary hepatic carcinosarcoma is a rare malignant tumor containing an intimate mixture of carci- nomatous and sarcomatous elements.Reports on risk factors, epidemiology,and pathogenesis of the tumor as well as the experience in its treatment are limited. METHOD:We present a case of primary carcinosarcoma of the liver in a 69-year-old man who complained of right hypochondrial pain and weight loss for two months. RESULTS:Magnetic resonance imaging revealed a 14×12 cm mass in segments 7-8 and 4 of the liver with vena hepatica invasion.An ultrasonography-guided biopsy showed osteoid tissue without osteoblastic rimming.Vascular structures accompanied the osteoid tissue.The patient underwent surgery after a diagnosis of hemangioma.Intraoperative frozen sections revealed a carcinosarcoma associated with an osteosarcoma and cholangiocellular carcinoma components. CONCLUSIONS:Preoperative diagnosis of this rare primary hepatic malignant tumor may be difficult by biopsy owing to intratumoral heterogeneity.Highly mature areas of the osteosarcomatous component may lead to misdiagnosis of metaplastic bone tissue.Clinicopathologic features of this rare entity are discussed. | Mehmet elikbilek Kemal Deniz Edip Torun Tarιk Artιs Ersin zaslan kkes brahim Karahan Tahir Ercan Patιroglu mer zbakιr | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 2 |
| 8 | Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps显示文摘 | Erdemoglu E Guney M Karahan N | 2008 | Maturitas2008，59，3： | 1 |
| 9 | A neurosurgical view of anatomical evaluation of anterior C1-C2 for safer transoral odontoidectomy 显示文摘 | Tun K Karahan ST | 2008 | Eur Spine J2008，17，： | 1 |
| 10 | Cyclooxygenase-2 expression in primary and recurrent pterygium显示文摘 | Karahan N Baspinar S Ciris M | 2008 | Indian J Ophthalmol2008，56，4： | 1 |
| 11 | Synthesis and evaluations of novel photoinitiators with side-chain benzophenone,derived from alkylα-hydroxymethacrylates显示文摘 | Karahan Balta D K Arsu N | 2014 | J Photochem Photobio A:Chem2014，274，： | 1 |
| 12 | Production of nitric oxide(NO) by lactic acid bacteria isolated h'om fermented products显示文摘 | Gtndogdu A K Karahan A G Cakmakq M L | 2006 | European Food Research and Technology2006，223，1： | 1 |
| 13 | Intensity of business enterprise R&D expenditure and High-tech manufacturing sector 显示文摘 | KARAHAN | 2015 | behavioral sciences2015，195，3： | 1 |
| 14 | Anglo myolipoma with cavoatrial extension显示文摘 | Akcali Y Karahan O I Kahriman G | 2006 | Eur Urol2006，50，： | 1 |
| 15 | The diagnostic and prognostic significance of soluble urokinase plasminogen activator receptor in systemic inflammatory response syndrome显示文摘 | Yilmaz G Koksal 1 Karahan S C | 2011 | Clinical biochemistry2011，44，14： | 1 |
| 16 | Water quality and fish size affect toxicity of endosulfan, an organochlorine pesticide,to rainbow trout显示文摘 | Capkin E Altinok I Karahan S | 2006 | Chemosphere2006，64，1： | 1 |
| 17 | Influence of Zeolite Additive on Propertiesof Autoclaved Aerated Concrete 显示文摘 | Albayrak M Yorukoglu A Karahan S | 2007 | Building and Environment2007，42，9： | 1 |
| 18 | Investigation of relationship between the D-dimer and ischemia- modified albumin levels with the radiological imaging- based pulmonary embolism severity score in acute pulmonary embolism 显示文摘 | Turedi S Karahan SC Mentese A | 2010 | Anadolu Kardiyol Derg2010，10，4： | 1 |
| 19 | Dual effectiveness of freezing - thawing and sulfate attack on high-volume slag-incorporated ECC显示文摘 | Ozbay E Karahan O Lachemi M | 2013 | Composites Part B: Engineering2013，45，1： | 1 |
| 20 | The Effect of Residual Microbial Products on the Experimental Assessment of the Particulate Inert COD in Wastewaters显示文摘 | ORHON D KARAHAN O SOZEN S | 1999 | Wat Sci Tech1999，33，14： | 1 |
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