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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Isolation of Lymphocytes and Their Innate Immune Characterizations from Liver,Intestine,Lung and Uterus显示文摘In steady-state conditions, the number and distribution of lymphocyte populations are under homeostatic control.New lymphocytes are continuously produced in primary and secondary lymphoid organs and then achieve immune-competence within different tissues, and they must challenge with resident cells for survival. The first step in the study of tissue lymphoid cells is their isolation in intact and viable form appropriate for establishment of in vitro culture systems. For reasons of simplicity, cell purity, cell yields and various purposes, lymphocytes obtained from different tissues in different labs were subjected to diverse protocols. To fully elucidate the nature of the local immune system as well as to adequately study the innate role of lymphocytes in liver, intestine, lung and uterus, we briefly reviewed the characterization of resident lymphocytes, and additional information on those cells from non-lymphoid tissues by using the recommended operation procedure was also presented. | Jianhong Zhang Zhongjun Dong Rongbin Zhou Deming Luo Haiming Wei Zhigang Tian | 2005 | Cellular & Molecular Immunology2005，2，4： | 8 |
| 3 | Direct load control by distributed imperialist competitive algorithm显示文摘Demand side management techniques have drawn significant attentions along with the development of smart grid.This paper proposes a new direct load control(DLC)model for scheduling interruptible air conditioner loads.The model is coordinated with the unit commitment and economic dispatch to minimize the total operation cost over the whole dispatch horizon.The network constraints are also considered in the model.To ensure the thermal comfort of the occupants,we are among the first to incorporate the advanced two-parameter thermal inertia dynamical model of customer houses into the DLC model to calculate the indoor temperature variation.This paper also proposes a distributed imperialist competitive algorithm to effectively solve the model.The simulation studies prove the efficiency of the proposed methodology. | Fengji LUO Junhua ZHAO Haiming WANG Xiaojiao TONG Yingying CHEN Zhao Yang DONG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，4： | 3 |
| 4 | Enhancement of Fe3O4/Au Composite Nanoparticles Catalyst in Oxidative Degradation of Methyl Orange Based on Synergistic Effect显示文摘Fe 3 O 4/Au nanoparticles (Fe 3 O 4/Au NP ) 催化剂被采用 H 2 O 2 作为氧化剂。评估 Fe 3 O 4/Au nanoparticles,不同降级条件被调查例如催化剂的数量, H 2 O 2 集中和 pH 价值。基于我们的数据,甲基橘子在一短时间完全被降级。提高的催化活动和增加的氧化率常数可以被归功于到 synergistic H 2 O 2 到哦激进,它是强壮的氧化种类之一。而且, Fe 3 O 4/Au nanoparticles 展出了令人满意为潜在的工业申请再循环性能。 | Qin Gao Yan Xing Mingli Peng Yongshuai Liu Zhiyi Luo Yanyan Jin Haiming Fan Kebin Li Chao Chen Yali Cui | 2017 | Chinese Journal of Chemistry2017，35，9： | 2 |
| 5 | In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem显示文摘Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem ^(64) Cu-NOTAQD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellentimaging capability and more reliable diagnostic outcomes.By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform,as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics. | Sixiang Shi Feng Chen Shreya Goel Stephen A.Graves Haiming Luo Charles P.Theuer Jonathan W.Engle Weibo Cai | 2018 | Nano-Micro Letters2018，10，4： | 2 |
| 6 | Multiple-Sized Amphiphilic Janus Gold Nanoparticles by Ligand Exchange at Toluene/Water Interface显示文摘Amphiphilic Janus gold nanoparticles(GNPs) are prospected to encapsulate drug molecules in cancer therapy and to serve as heterogeneous catalysts at oil/water interfaces, where Janus GNPs with different sizes are required. In this work, multiple-sized precursor GNPs were synthesized by seeded growth method protected with tris(hydroxymethyl)phosphine oxide(THPO) ligand molecule, and a ligand exchange reaction with triphenylphosphine(PPh3) at the toluene/water interface was employed to prepare amphiphilic Janus GNPs. UV-vis and transmission electron microscopy(TEM) analyses indicate that the as-prepared GNPs are nanocrystals with average diameters of 2.3 nm, 9.5 nm, 16.1 nm and 18.8 nm, respectively. Contact angle, Raman and X-ray photonic spectroscopy(XPS) analyses reveal that the selfassembled GNP films exhibit hydrophilic on one side and hydrophobic on another, owing to the adsorption of hydrophilic ligands(THPO and THP) and a similar amount of hydrophobic ligands(PPh3 and PPh3O).Angle-resolved XPS analysis further demonstrates that the individual GNPs actually possess hydrophilic and hydrophobic compartments on the surface, which regularly packed by supramolecular interactions at toluene/water interface to form the self-assembled GNP films. | Kun Luo Yongdong Xiang Haiming Wang Li Xiang Zhihong Luo | 2016 | Journal of Materials Science & Technology2016，32，8： | 1 |
| 7 | Ecological Benefits of Compound Ridge Culture in Hillside Orchard in the Three Gorge Reservoir Area显示文摘Based on contour tillage of wide ridge and furrow covering and agro-forestry, this paper sets up a compound ridge culture mode in hillside orchards and introduces a long-term observation to the mode's effects on ecological benefits of water and soil conservation. A five-year study shows that compound ridge culture in hillside orchards is effective in water and soil conservation, especially in reducing soil erosion. Compared with the traditional management modes of orchards, compound ridge culture has reduced runoff amount by 41.96%-57.96%, soil erosion amount by 55.47%-67.75%. Compound ridge culture also brings an obvious reduction of soil nutrient loss and of non-point source pollution, which is of great importance for keeping and increasing the productivity of hillside orchards in the Three Gorge Reservoir Area. | LIAO Xiaoyong CHEN Zhijian WANG Haiming LUO Chengde LI Tao | 2008 | Wuhan University Journal of Natural Sciences2008，13，3： | 1 |
| 8 | Enhancement of MoTe2 near-infrared absorption with gold hollow nanorods for photodetection显示文摘Infrared(IR)light photodetection based on two dimensional(2D)materials of proper bandgap has attracted increasing attention.However,the weak IR absorption in 2D materials,due to their ultrathin attribute and indirect bandgap in multilayer structures,degrades their performance when used as IR photodetectors.In this work,we utilize the fact that few-layer MoTe2 flake has a near-IR(NIR)bandgap and demonstrate a^60-fold enhancement of NIR response by introducing a gold hollow nanorods on the surface.Such gold hollow nanorods have distinct absorption peak located also at the NIR regime,therefore induces strong resonance,benefitting NIR absorption in MoTe2,resulting in strong near-field enhancement.With the evidence from steady and transient state optical spectra,we confirm that the enhancement of NIR response originates only photon absorption,rather than electron transport at interfaces as observed in other heterostructures,therefore,precluding the requirement of high-quality interfaces for commercial applications. | Jiawen You Ye Yu Kai Cai Dongming Zhou Haiming Zhu Renyan Wang Qingfu Zhang Hongwei Liu Yuting Cai Dong Lu Jang-Kyo Kim Lin Gan Tianyou Zhai Zhengtang Luo | 2020 | Nano Research2020，13，6： | 1 |
| 9 | Chlorine-passivated superatom Al37clusters for nonlinear optics显示文摘Utilizing a facile top-down synthetic procedure, here we report the finding of a chlorine-passivated Al_(37) superatom cluster. It is demonstrated that the presence of electrophilic groups, severing as protecting ligands, alters the valence electron count of the metallic core and stabilize the as-prepared aluminum clusters especially when even-numbered chlorine atoms are located at equilibrium positions. Following the discussion regarding their reasonable stabilities, we illustrate the feasible reaction pathways in forming such chlorine-passivated Al_(37) superatom clusters which bear delocalized superatomic orbitals with five valence 3P^5 electrons shifting to the chlorine ligands indicative of a closed electron shell 2F^(14) of the metal core. The successful synthesis of such chlorine-protected aluminum clusters evidences the compatibility of general theory of cluster chemistry in both gas phase and wet chemistry. Such simple-ligand-protected aluminum clusters exhibit reverse-saturated-absorption(RSA) nonlinear optical property pertaining to electronic transitions within the discrete energy states of cluster materials. | Haiming Wu Zhixun Luo | 2018 | Science China Chemistry2018，61，12： | 1 |
| 10 | Small gold clusters catalyzing oxidant-free dehydrogenation of glycerol initiated by methene hydrogen atom transfer显示文摘Developing oxygen-free methodology for the conversion of alcohols to carbonyls is essentially important because it suppresses the over-oxidation of alcohols to carboxylic acids and enables the production of energetic hydrogen.Here we report a finding of feasible oxidant-free dehydrogenation of glycerol over chemically-pure Au clusters synthesized by a green chemistry method named as laser ablation in liquid(LAL).As results,glycerol is dehydrogenated to form glyceraldehyde which undergoes subsequent dehydrogenation to hydroxymethyl glyoxal.For this,reaction dynamics calculations find interesting dehydrogenation reaction pathways with a low-energy barrier of transition state initiated by hydrogen atom transfer from methene,which differs from the general reaction mechanism based on hydroxyl.Furthermore,it is interesting that the presence of additionalààOH group molecules especially H2O can effectively lower the energy barrier in the activation of the OààH and CààH bonds in glycerol.This principle is also applicable to the oxidant-free dehydrogenation of methanol and ethanol,helping to fully understand the catalytic mechanism of alcohols conversion chemistry. | Anthony M.S.Pembere Chaonan Cui Haiming Wu Zhixun Luo | 2019 | Chinese Chemical Letters2019，30，5： | 1 |
| 11 | Docking-based virtual screening of potential human P2Y12 receptor antagonists显示文摘在 hemostasis 和它的 dysregulation 的血小板戏必需品角色能导致动脉的血栓。P2Y12 是重要血小板膜腺苷 diphosphate 受体,并且它的对手广泛地作为反凝结代理人被开发了。在临床的实践可得到的当前的 P2Y12 禁止者有不充分完成的令人满意的 anti-thrombotic 效果,离开为进一步的改进的房间。为了识别,新化学药品加重同样潜在的反凝结禁止者,我们由基于最近报导的 G 蛋白质当模特儿的相同构造了人的 P2Y12 的一个三维的结构模型联合受体 Meleagris gallopavo 1 肾上腺素能的受体。从 ZINC 数据库的对小分子的三个子集的建模的 P2Y12 的虚拟屏蔽,也就是像铅、像碎片、像药,识别了可能有高有约束力的亲密关系到 P2Y12 的很多混合物。顶的详细分析从有最高的分数的每个子集的三混合物显示所有混合恐水病的体积与经由和受体的大部分恐水病的相互作用在 ligand 绑定地点跳了的一些极的原子补充了的胡子这些。这研究不仅为反血小板禁止者的合理设计提供 P2Y12 的一个结构模型,而且为进一步的开发识别一些潜在的化学药品。 | Hua Chen Xianchi Dong Minyun Zhou Haiming Shi Xinping Luo | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 1 |
| 12 | Cerebrospinal fluid and blood biomarkers in the diagnostic assays of Alzheimer's disease显示文摘The anti-amyloid-j(anti-Aβ)fibrils and soluble oligomers antibody aducanumab were approved to effectively slow down the progression of A lzheimer's disease(AD)at higher doses in 2019,reaffirming the therapeutic effects of targeting the core pathology of AD.A timely and accurate diagnosis in the prodromal or pre-dementia stage of AD is essential for patient recruitment,stratifcation,and monitoring of treat ment effects.A D core biomarkers amyloid-B(Aβ1-42),total tau(t-tau),and phosphorylated tau(p-tau)have been clinically validated to reflect AD-type pathological changes through cerebrospinal fuid(CSF)measurement or positron-emission to-mography(PET)and found to have high diagnostic performance for AD identification in the stage of mild cognitive impairment.The development of ultrasensitive immunoassay technology enables AD pathological proteins such as tau and neurofilament light(NFL)to be measured in blood samples.However,combined biomarker detection or targeting multiple biomarkers in immunoassays will increase detection sensitivity and specifcity and improve diagnostic accuracy..This review summarizes and analyzes the performance of current detection methods for early diagnosis of AD,and provides a concept of detection method based on multiple biomarkers instead of a single target,which may become a potential tool for early diagnosis of AD in the future. | Liding Zhang Xiaohan Liang Zhihong Zhang Haiming Luo | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 0 |
| 13 | An Upper Crustal Ophiolite Remnant within the Feather River Ultramafic Belt, California:Tectonomagmatic Origins and Implications for Its Evolution显示文摘The 150-km-long Feather River ultramafic belt(FRB) of the northern Sierra Nevada,California,consists of serpentinized ultramafic rocks,gabbroic rocks,with lesser amounts of amphibolitic rocks. The gabbroic rocks contain metagabbro and dikes within it. Based on the electron microprobe analyses,the metagabbro consists of typical igneous composition for clinopyroxene and early hornblende,indicating that they bear low grade metamorphism. The gabbroic rocks show Nb and Ta depletion in primitive-mantle normalized plots that is similar to typical island arc rocks. We present that the metagabbro within the ultramafic rocks is forming in the suprasubduction zone setting. Tectonic models are presented for the metagabbro and amphibolitic rocks in FRB. The low P burial metamorphism of the upper plate metagabbro and the high grade amphibolitic rocks are typical of relationships of upper plate ophiolites to metamorphic soles. The amphibolitic rocks record as metamorphic sole forming during subduction initiation beneath the ultramafic rocks and metagabbro. The unusual and protracted tectonic history of the FRB is similar to other ophiolite belts of the Cordillera of California but differs in the lack of crustal rocks. | Jun Luo John Wakabayashi Zhiliang He Jinbiao Yun Quanyou Liu Tianyi Li Haiming Song Wenjiao Xiao | 2019 | Journal of Earth Science2019，30，4： | 0 |
| 14 | Pure Metal Clusters with Atomic Precision for Nanomanufacturing显示文摘Advances in cluster science have enabled the preparation of atomically precise metal clusters with one to a hundred atoms under controllable expansion conditions.After introducing typical gas-phase cluster preparation and reaction apparatuses,this work summarized recent progress in preparing pure metal clusters of single-atom resolution,including neutral and ionic ones,with typical examples of Al,V,Nb,Fe,Co,Ni,Rh,Pt,Ag,Cu,and Pb.With the development of soft-landing deposition technology,the size-selective pure metal clusters with strict atomic precision and predictive property will benefit nanomanufacturing down to atomic and near-atomic scales.This work serves as a modest motivation to stimulate the interest of scientists focusing on interdisciplinary subjects. | Haiming Wu Hanyu Zhang Lijun Geng Yuhan Jia Benben Huang Mengzhou Yang Baoqi Yin Xin Lei Zhixun Luo | 2022 | Nanomanufacturing and Metrology2022，5，3： | 0 |
| 15 | Diagnostic assays for COVID-19:a narrative review显示文摘Coronavirus disease 2019(COVID-19)is a newly emerged infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The number of COVID-19 cases is continuously increasing and no effective drugs or vaccines are currently available.Accurate and efficient diagnostic testing methods are desperately needed for the detection of SARS-CoV-2 and antiviral antibodies in infected individuals.Various assay techniques,including nucleic acid tests[eg,polymerase chain reaction(PCR),reverse transcription-PCR,real-time loop-mediated isothermal amplification,and CRISPR-Cas-based detection],serological tests[eg,immunoglobulin(Ig)A,IgM/G],imaging tests(eg,computed tomography and positron-emission tomography),and nanoparticle-based detections have been reported for COVID-19 diagnosis.This review aims to present the current diagnostic tools for SARS-CoV-2 and their performance characteristics to inform the appropriate selection of diagnostic and surveillance technologies at optimal testing times.We also describe the advantages of detection using combined nucleic acid and imaging tests,or serological testing and point-of-care diagnostics.Developing reliable protein biomarkers targeting the conserved proteins of SARS-CoV-2 rather than IgA,IgM,or IgG would be useful to manage SARS-CoV-2. | Liding Zhang Xiaohan Liang Yanqing Li Hua Zheng Wensheng Qu Baofeng Wang Haiming Luo | 2020 | Journal of Bio-X Research2020，3，4： | 0 |
| 16 | Formation of Al^(+)(C_(6)H_(6))_(13):The Origin of Magic Number in Metal-Benzene Clusters Determined by the Nature of the Core显示文摘The identification of highly abundant,“magic”spe-cies in the mass spectra of clusters have proven to be valuable in nanoscience,leading to the discovery of new stable species such as fullerenes and the elec-tronic shell structures of metallic clusters. | Hanyu Zhang Arthur C.Reber Lijun Geng Daniel Rabayda Haiming Wu Zhixun Luo Jiannian Yao Shiv N.Khanna | 2019 | CCS Chemistry2019，1，5： | 0 |
| 17 | The frontier of microplastics and nanoplastics: Soil health and carbon neutrality显示文摘Microplastics and nanoplastics(MNPs)in soil have drawn increasing concerns about their potential threats to soil ecosystems due to their ubiquitous occurrence and persistence.The interactions of MNPs with soil components,microbial community,plants,and fauna determine their impacts on soil biogeochemical processes and food security.However,they are not largely explored.Further research is also needed to develop reliable and standardized techniques and methods to characterize the relevant MNPs interacting with different types of soil ecosystems and to deeply examine their impacts on soil health,food security,and climate changes.In addition,mitigation protocols and regulation guidelines need to be developed.New findings will provide scientific and technological support for the understanding and management of soil health and carbon neutrality as influenced by MNPs. | Zhuanxi LUO Aoze LI Haiming WANG Baoshan XING | 2023 | Pedosphere2023，33，1： | 0 |
| 18 | Thin Film Assembly of Gold Nanoparticles for Vapor Sensing via Droplet Interfacial Reaction显示文摘A facile approach to prepare a thin film vapor sensor is demonstrated through droplet interfacial reaction on an IDA microelectrode.Scanning electron microscopy,atomic force microscopy and transmission electron microscopy analyses show that the film of the vapor sensor is composed of self-assembled gold nanocrystals in an average diameter of about 4.3 nm.The as-prepared sensor was examined by potential step method and impedance measurement,which exhibited significant A/?//?,responses and excellent cycle performance to the volatile organic compound(VOC) vapors of acetone,methanol,styrene,benzene,toluene and ethanol.The selectivity to the VOCs with benzene ring or organic solvents suggests that the sensor is probably in line with the swelling and dielectric sensing mechanisms. | Kun Luo Tao Huang Yujia Luo Haiming Wang Chao Sang Xiaogang Li | 2013 | Journal of Materials Science & Technology2013，29，5： | 0 |
| 19 | Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies显示文摘Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully understood.This study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical efficacy.Methods:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD19 CAR-T-cell-mediated killing.The in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T cells.In addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular models.Results:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1,and RB1CC1)provided protec-tion of cancer cells from CD19 CAR-T cell-mediated cytotoxicity.These findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of autophagy.Notably,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD19 CAR-T therapy.Bulk RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD19 CAR-T cell ther-apy.Pharmacological inhibition of autophagy and knockout of RB1CC1 could dramatically sensitize tumor cells to CD19 CAR-T cell-mediated killing in mouse models of both B-cell leukemia and lymphoma.Moreover,our study revealed that cancer-intrinsic autophagy mediates evasion of CAR-T cells via the TNF-α-TNFR1 axis-mediated apoptosis and STAT1/IRF1-induced chemokine signaling activation.Conclusions:These findings confirm that autophagy signaling in B-cell malig-nancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy. | Lu Tang Huan Zhang Fen Zhou Qiuzhe Wei Mengyi Du Jianghua Wu Chenggong Li Wenjing Luo Jie Zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei Huang Zhuolin Wu Yuxi Wen Huiwen Jiang Danying Liao Haiming Kou Wei Xiong Heng Mei Yu Hu | 2024 | Cancer Communications2024，44，3： | 0 |
| 20 | Co_(13)O_(8)—metalloxocubes:a new class of perovskite-like neutral clusters with cubic aromaticity显示文摘Exploring stable clusters to understand structural evolution from atoms to macroscopic matter and to construct new materials is interesting yet challenging in chemistry.Utilizing our newly developed deep-ultraviolet laser ionization mass spectrometry technique,here we observe the reactions of neutral cobalt clusters with oxygen and find a very stable cluster species of Co13O8 that dominates the mass distribution in the presence of a large flow rate of oxygen gas.The results of global-minimum structural search reveal a unique cubic structure and distinctive stability of the neutral Co13O8 cluster that forms a new class of metal oxides that we named as‘metalloxocubes’.Thermodynamics and kinetics calculations illustrate the structural evolution from icosahedral Co13 to the metalloxocube Co13O8 with decreased energy,enhanced stability and aromaticity.This class of neutral oxygen-passivated metal clusters may be an ideal candidate for genetic materials because of the cubic nature of the building blocks and the stability due to cubic aromaticity. | Lijun Geng Mouyi Weng Cong-Qiao Xu Hanyu Zhang Chaonan Cui Haiming Wu Xin Chen Mingyu Hu Hai Lin Zhen-Dong Sun Xi Wang Han-Shi Hu Jun Li Jiaxin Zheng Zhixun Luo Feng Pan Jiannian Yao | 2021 | National Science Review2021，8，1： | 0 |
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