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| 1 | Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs显示文摘蟹状肿是由于皮损害的异常愈合成长的像肿瘤的皮疤,没有有效 treatment.The 分子的机制位于 \O 下面蟹状肿致病仍然大部分未知。在这研究,我们比较了表示在导出蟹状肿的成纤维细胞和正常成纤维细胞之间介绍的 microRNA (miRNA )( 包括胎儿、成年的真皮的成纤维细胞) 由 miRNA microarray 分析。我们发现在导出蟹状肿的成纤维细胞的 miRNA 侧面与在 normalfibroblasts 的那些是不同的。九 miRNAs 是表示其六在蟹状肿成纤维细胞(KF ) 是显著地起来调整的差别,包括 miR-152, miR-23b-3p, miR-31-5p, miR-320c, miR-30a-5p,和 hsv1-miR-H7,并且其三是调整 significantlydown 的包括 miR-4328, miR-145-5p,和 miR-143-3p。差别的功能的注解表示了他们在为疤创伤愈合重要的几条发信号的小径被充实的 miRNA targetsrevealed。在结论,我们 demonstratethat miRNA 表示侧面在 KF 被改变与相比可以为探索蟹状肿的致病在胎儿、成年的真皮的成纤维细胞,和 expressionprofile 提供有用线索。miRNAs 可能部分由影响相关的几条发信号的小径使创伤愈合留下疤痕贡献 etiologyof 蟹状肿。 | Chao Li Yuehong Bai Hua Liu Xuemei Zuo Haichang Yao Yiming Xu Manlin Cao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 15 |
| 2 | Effect of minor Sc addition on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy显示文摘Influence of Sc content on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy have been investigated by optical microscopy, scanning electron microscopy, electron backscatter diffraction, transmission electron microscopy and slow strain rate test. The results indicate that the addition of Sc results in the formation of the quaternary coherent Al_3(Sc, Zr, Ti) dispersoids during homogenization treatment, which will inhibit the dynamic recrystallization behavior. The number density of Al_3(Sc, Zr, Ti) particles increases with the increase of Sc content, and thus the recrystallization fraction of hot-extruded alloy is reduced and the peak strength in two-stage artificial aging sample is enhanced. At the same time, the wide of precipitation free zone is reduced, and the content of Zn and Mg in grain boundary particles and precipitation free zone is increased with the increase of Sc content. In peak-aged state, the 0.06 wt% Sc added alloy shows the better stress corrosion cracking resistance than the Sc-free alloy because of the reduction of recrystallization fraction and the interrupted distribution of grain boundary precipitates along grain boundary. However, the further addition of Sc to 0.11 wt% will result in the deterioration of stress corrosion cracking resistance due to the increase of electrochemical activity of grain boundary particles and precipitation free zone as well as hydrogen embrittlement. | Zhaoming Li Haichang Jiang Yunli Wang Duo Zhang Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，7： | 14 |
| 3 | Angiotensin Ⅱ promotes NO production, inhibits apoptosis and enhances adhesion potential of bone marrow-derived endothelial progenitor cells显示文摘Endothelial 祖先房间(EPC ) 响应织物局部缺血和 endothelial 损害参予出生后的 neovascularization 和 re-endothelialization 的过程。在场的 EPC 的水平被发现了直接与心血管的疾病的结果被联系,并且能被 stimulatory 或禁止的因素调整。给在血管收缩素 II (AngII ) 和心血管的系统之间的靠近的关系,我们在导出的骨头髓(BM ) 的活动调查了 AngII 的效果 EPC。房间被密度坡度 centrifugation 从老鼠的 BM 孤立。AngII 的管理显著地支持了氮的氧化物(没有) 版本,禁止的 EPC apoptosis 和提高的 EPC 粘附潜力。所有被预告的处理与 valsartan 或 L 名字 EPC 上的这些调停 AngII 的效果稀释。而且, LY294002 和 wortmannin 废除了 AngII 的 anti-apoptotic 效果。西方的污点分析显示了没有 synthase (eNOS ) 蛋白质和 phosphorylated Akt 在 EPC 与 AngII 的处理增加了的那 endothelial。因此, AngII 通过 AngII 类型 1 受体(AT1R ) 改进了 EPC 的几项活动,它可以代表与 angiogenesis 连接 AngII 和 AT1R 的可能的机制。另外,导致 AngII 通过在 EPC 的 eNOS 的合成都不调整 apoptosis 和粘附,并且 PI3-kinase/Akt 小径在导致 AngII 的 antiapoptosis 发信号有一个必要角色。 | Tao Yin Xinliang Ma Li Zhao Kang Cheng Haichang Wang | 2008 | Cell Research2008，18，7： | 12 |
| 4 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 5 | Collaborative filtering recommendation algorithm based on interactive data classification显示文摘In the matrix factorization(MF)based collaborative filtering recommendation method,the most critical part is to deal with the interaction between the features of users and items.The mainstream approach is to use the inner product for MF to describe the user-item relationship.However,as a shallow model,MF has its limitations in describing the relationship between data.In addition,when the size of the data is large,the performance of MF is often poor due to data sparsity and noise.This paper presents a model called PIDC,short for potential interaction data clustering based deep learning recommendation.First,it uses classifiers to filter and cluster recommended items to solve the problem of sparse training data.Second,it combines MF and multi-layer perceptron(MLP)to optimize the prediction effect,and the limitation of inner product on the model expression ability is eliminated.The proposed model PIDC is tested on two datasets.The experimental results show that compared with the existing benchmark algorithm,the model improved the recommendation effect. | Ji Yimu Li Ke Liu Shangdong Liu Qiang Yao Haichang Li Kui | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，5： | 4 |
| 6 | Immobilization of insulin-like growth factor-1 onto thermosensitive hydrogels to enhance cardiac progenitor cell survival and differentiation under ischemic conditions显示文摘Stem cell therapy is a promising approach to treat myocardial infarction. However, direct delivery of stem cells into hearts experiences poor cell engraftment and differentiation, due to ischemic conditions(low nutrient and oxygen) in the infarct hearts. Development of suitable cell carriers capable of supporting cell survival and differentiation under these harsh conditions is critical for improving the efficacy of current stem cell therapy. In this work, we created a family of novel cell carriers based on thermosensitive hydrogels and insulin-like growth factor 1(IGF-1), and investigated if these cell carriers can improve cell survival and differentiation under ischemic conditions. The thermosensitive hydrogels were synthesized from N-isopropylacryla- mide, acrylic acid, acrylic acid N-hydroxysuccinicimide ester, and 2-hydroxyethyl methacrylate-oligo(hydroxybutyrate). The hydrogel solutions can be readily injected through 26G needles, and can quickly solidify at 37 oC to form highly flexible hydrogels. IGF-1 was immobilized into the hydrogels in order to support long-term cell survival and differentiation. Different amount of IGF-1 was immobilized by using hydrogels with different content of N-hydroxysuccinicimide ester groups. Cardiosphere derived cells were encapsulated in the hydrogels and cultured under ischemic conditions. The results demonstrated that a significant improvement of cell survival and differentiation was achieved after IGF-1 immobilization. These IGF-1 immobilized hydrogels have the potential to improve cell survival and differentiation in infarct hearts. | LI ZhenQing XU YanYi LI HaiChang GUAN JianJun | 2014 | Science China Chemistry2014，57，4： | 3 |
| 7 | Wind turbine blade health monitoring with piezoceramic-based wireless sensor network显示文摘In this paper,a piezoceramic-based wireless sensor network(WSN)was developed for health monitoring of wind turbine blades with active sensing approach.The WSN system has an access point that coordinates the network and connects to a PC to control the wireless nodes.One wireless node functions as an actuator to excite an embedded piezoceramic patch with desired guided waves.The remaining wireless nodes function as sensors to detect and transmit the wave responses at distributed locations.The damage status inside the blade was evaluated through the analysis of the sensor signals.Based on wavelet packet analysis results,a damage index and a damage matrix were developed to evaluate the damage status at different locations.To verify the effectiveness of the proposed approach,a static loading test and a wind tunnel test were performed in the Laboratory of Joint Wind Tunnel and Wave Flume at Harbin Institute of Technology(HIT),China.Experimental results show that damage in wind turbine blades can be detected and evaluated by the proposed approach. | Gangbing Song Hui Li Bosko Gajic Wensong Zhou Peng Chen Haichang Gu | 2013 | International Journal of Smart and Nano Materials2013，4，3： | 3 |
| 8 | A Novel TiNi/AlSi Composite with High Strength and High Damping Capacity显示文摘A novel TiNi/AlSi composite with high compressive strength and high damping capacity was obtained by infiltrating Al-12%Si alloy into porous TiNi alloy.It had been found that the high compressive strength (440 MPa) of TiNi/AlSi composite is due to the increase of effective carrying area after infiltrating Al-12%Si alloy,while the high damping capacity is contributed to TiNi carcass,Al-12%Si filling material and micro- slipping at the interface. | Shuwei LIU Xiuyan LI Desheng YAN Haichang JIANG Lijian RONG | 2008 | Journal of Materials Science & Technology2008，24，6： | 3 |
| 9 | Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development显示文摘MG53 is an essential component of the cell membrane repair machinery,participating in the healing of dermal wounds.Here we develop a novel delivery system using recombinant human MG53(rhMG53)protein and a reactive oxygen species(ROS)-scavenging gel to treat diabetic wounds.Mice with ablation of MG53 display defective hair follicle structure,and topical application of rhMG53 can promote hair growth in the mg53/mice.Cell lineage tracing studies reveal a physiological function of MG53 in modulating the proliferation of hair follicle stem cells(HFSCs).We find that rhMG53 protects HFSCs from oxidative stress-induced apoptosis and stimulates differentiation of HSFCs into keratinocytes.The cytoprotective function of MG53 is mediated by STATs and MAPK signaling in HFSCs.The thermosensitive ROS-scavenging gel encapsulated with rhMG53 allows for sustained release of rhMG53 and promotes healing of chronic cutaneous wounds and hair follicle development in the db/db mice.These findings support the potential therapeutic value of using rhMG53 in combination with ROS-scavenging gel to treat diabetic wounds. | Hong Niu Haichang Li Ya Guan Xin Zhou Zhongguang Li Serana Li Zhao Peng Chen Tao Tan Hua Zhu Valerie Bergdall Xuehong Xu Jianjie Ma Jianjun Guan | 2022 | Bioactive Materials2022，7，12： | 2 |
| 10 | Hydrogen-Bonded Dopant-Free Hole Transport Material Enables Efficient and Stable Inverted Perovskite Solar Cells显示文摘Although many dopant-free hole transport materials(HTMs)for perovskite solar cells(PSCs)have been investigated in the literature,novel and useful molecular designs for high-performance HTMs are still needed.In this work,a hydrogen-bonding association system(NH⋯CO)between amide and carbonyl is introduced into the pure HTM layer. | Rui Li Chongwen Li Maning Liu Paola Vivo Meng Zheng Zhicheng Dai Jingbo Zhan Benlin He Haiyan Li Wenjun Yang Zhongmin Zhou Haichang Zhang | 2022 | CCS Chemistry2022，4，9： | 1 |
| 11 | Plasma and syno- vial fluid trxR levels are correlated with disease risk and severity in patients with lung cancer 显示文摘 | Xie Zhijun Sun Jing Li Haichang | 2015 | Eur J Pharmacol2015，765，2： | 1 |
| 12 | Insulin inhibits leukocyte–endothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion显示文摘 | Jia Li Feng Wu Haifeng Zhang Feng Fu Lele Ji Ling Dong Qiuxia Li Wenchong Liu Yuan Zhang Anlin Lv Haichang Wang Jun Ren Feng Gao | 2009 | Journal of Molecular and Cellular Cardiology2009，，4： | 1 |
| 13 | Insulin inhibits tumor necrosis factor-α induction in myocardial ischemia/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation显示文摘 | Jia Li Haifeng Zhang Feng Wu Ying Nan Heng Ma Wenyi Guo Haichang Wang Jun Ren Undurti N. Das Feng Gao | 2008 | Critical Care Medicine2008，，5： | 1 |
| 14 | Lithiophilic seeds and rigid arrays synergistic induced dendrite-free and stable Li anode towards long-life lithium-oxygen batteries显示文摘High energy density lithium-oxygen battery(LOB) is currently regraded as a promising candidate for next-generation power system.However,the dendrite and instability issues of Li metal anode lead to its poor cyclic stability and low energy density.In this work,lithiophilic Al_(2) O_(3) seeds induced rigid carbon nanotube arrays(CNTA)/three-dimensional graphene(3 DG) is developed as a host material for Li anode,namely Al_(2) O_(3)-CNTA/3 DG.It is demonstrated that the lithiophilic feature of Al_(2) O_(3) seeds and the enhanced rigidity of arrays can synergistically induce the uniform Li flux,inhibit the collapse of arrays,and stabilize electrolyte/electrode interfaces.As a result,the Al_(2) O_(3)-CNTA/3 DG-Li anode delivers a high Coulombic efficiency above 97% after 140 cycles(8 mAh cm^(-2) at 4 mA cm^(-2)).With this anode and the breathable CNTA/3 DG cathode,the full LOB exhibits a significantly increased life-span up to 160 cycles(500 mAh g^(-1) at 100 mA g^(-1)),which is almost 3 times longer than that with pure Li foil as the anodes.This work demonstrates a new approach to highly reversibly long-cycling performance of LOBs towards practical application. | Yue Li Haichang Zhang Rui Zhang Junwei Sha Liying Ma Dongdong Zhao Chunsheng Shi Naiqin Zhao | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 15 | Internal friction peak associated with dislocations in Mg-0.6%Zr alloy显示文摘The internal friction(IF) of Mg-0.6%Zr alloy is measured in the present study and two IF peaks of(P 1(97 C,1 Hz) and P 2(230 C,1Hz) ) are found,respectively.It is shown that the novel P 1 peak is frequency independent and the peak temperature increased with the increase of strain amplitude or heating rate.P 1 peak could be repressed by the reheating-up measurements and represented by heat treatment.The mechanism of P 1 peak is clarified by optical microscope(OM) and transmission electron microscope(TEM) observation,and considered to be caused by the creation and expansion of dislocations during plastic deformation.The P 2 peak is a thermally activated relaxation IF peak,and activation energy is 1.46 eV,which is caused by the relaxation of the grain boundaries in Mg-0.6%Zr alloy. | Shuwei LIU Xiaofeng HU Haichang JIANG Xiuyan LI Lijian RONG | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，5： | 0 |
| 16 | PCL2,a novel tumor suppressor in breast cancer显示文摘Polycomb group(PcG)proteins were originally identified as suppressors of the homeotic genes in Drosophila[1],controlling segment identity during embryonic development.Then PcG proteins were found to participate in the regulation of various biologic processes,including cell cycle,apoptosis and tumor development[2].It is commonly accepted that the PcG proteins form two | Haichang Li | 2018 | Science Bulletin2018，63，10： | 0 |
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