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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 3 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 4 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 5 | An integrated vendor-buyer inventory model with quality improvement and lead time reduction 显示文摘 | Ouyang LY Wub K S Ho C H | 2007 | International Journal of Production Economies2007，108，12： | 1 |
| 6 | Regulation of matrix metalloproteinases (MMP 2, 3, -9, and 13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption显示文摘 | Kusano K Miyaura C Inada M Tamura T ho A Nagase H | 1998 | Endocrinology1998，139，： | 1 |
| 7 | Effect of Hydrothermal Treatment on Formation and Structural Characteristics of Slowly Digestible Non-pasted Granular Sweet Potato Starch显示文摘 | Sang S Ho K Hyo H | 2005 | Starch2005，57，： | 1 |
| 8 | Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘 | No H K Young Park N Ho Lee S Meyers S P | 2002 | International Journal of Food Microbiology2002，74，12： | 1 |
| 9 | Causative factors of retinal de- tachment in maeular holes显示文摘 | Morita H Ideta H ho K | 1991 | Retina1991，11，： | 1 |
| 10 | Colorectal neoplasia in Asia: a multicenter colonscopy survey in symptomatic patients显示文摘 | LEUNG W K HO K Y KIM W H | 2006 | Gastrointest Endosc2006，64，： | 1 |
| 11 | Adaptive fuzzy sliding mode control with chattering elimination for nonlinear SISO systems 显示文摘 | Ho H F Wong Y K Rad A B et | 2009 | Simulation Modelling Practice and Theory2009，17，7： | 1 |
| 12 | Crystal morphological investigation in thin films of poly(aryl ether ketone ketone) having a meta-linka_ge显示文摘 | Gardner K H Hsiao B S Ho R M | 1997 | Polymer1997，20，： | 1 |
| 13 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 14 | Theaflavin-3,3'-digallat from black tea blocks the nitric oxide synthase by down-regulating the aetivation of NF- kappaB in macrophages 显示文摘 | Lin Y L Tsai S H Lin-Shiau S Y Ho C T Lin J K | 1999 | Eur J Pharmaeol1999，367，： | 1 |
| 15 | Nonbasal deformation modes of HCP metals and alloys: Role of dislocation source and mobility显示文摘 | Yoo M H Morris J R Ho K M | 2002 | Metall Mater Trans2002，33，： | 1 |
| 16 | Effects of the addition of titania on the thermal characterization of alumina - supported palladium显示文摘 | Wang C B Lin H K Ho C M | 2002 | J Mole Catal A2002，180，： | 1 |
| 17 | The components of the bid-ask spread in a limit-order market: evidence from the Tokyo Stock Exchange显示文摘 | Ahn H J Cai J Hamao Ho R Y K | 2002 | Journal of Empirical Finance2002，9，4： | 1 |
| 18 | Reduced expression of APC and DCC gene protein in breast cancer显示文摘 | Ho K Y Kalle W H Lo T H | 1999 | Histopathology1999，35，3： | 1 |
| 19 | An in situ heater for a phase-change-material-based actuation system 显示文摘 | Sant H J Ho T Gale B K | 2010 | Journal of Mieromeehanics and Mieroengineering2010，20，8： | 1 |
| 20 | Identification of linear time varying systems by Haar wavelet 显示文摘 | Chen S L Lai H C Ho K C | 2006 | Interna tional Journal of System Science2006，37，： | 1 |
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