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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 3 | Recovery of municipa waste incineration bottom ash and water treatmen sludge to water permeable pavement materials 显示文摘 | LIN C F WU C H HO H M | 2006 | Waste Management2006，26，9： | 1 |
| 4 | Excentral cleavage of beta- carotene in vivo in a healthy man显示文摘 | HO C C de MOURA F F KIM S H | 2007 | Clin Nutr2007，85，3： | 1 |
| 5 | Antiviral effect of epigallocatechin gallate on enterovirus 71显示文摘 | Ho H Y Cheng M L Weng S F | | 0，，14： | 1 |
| 6 | Adaptive fuzzy sliding mode control with chattering elimination for nonlinear SISO systems 显示文摘 | Ho H F Wong Y K Rad A B et | 2009 | Simulation Modelling Practice and Theory2009，17，7： | 1 |
| 7 | Integration of nitrogen and potassium signaling显示文摘 | Tsay Y F Ho C H Chen H Y | 2011 | Annual Review of Plant Biology2011，62，4： | 1 |
| 8 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 9 | Detection and tissue tropism of white spot syndrome baculuvirus(WSBV) in captured brooders of Penaeus monodon with a special emphasis on reproductive organs 显示文摘 | Lo C F Ho C H Chen C H | 1997 | Dis Aquat Org1997，30，： | 1 |
| 10 | Poly(cyano-substituted diheteroareneethylene) as electrode material for electrochemical supercapacitors 显示文摘 | Fusalba F Ho H A Breau L | 2000 | Chem Mater2000，12，9： | 1 |
| 11 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
| 12 | Effects of Asian dust e- vents on daily hospital admissions for chronic obstructive pul- monary disease in Taipei, Taiwan显示文摘 | Chiu H F Tiao M M Ho S C | 2008 | Inhalation Toxicology2008，20，： | 1 |
| 13 | Metaplastic breast carcinomas are basal-like tumours 显示文摘 | REIS-F H HO J S MILANEZI F | 2006 | Histopathology2006，49，1： | 1 |
| 14 | Structure and properties of cast binary Ti-Mo alloys 显示文摘 | HO W F JU C P CHERN-LIN J H | 1999 | Biomaterials1999，20，： | 1 |
| 15 | Consequences of expo- sure to Asian dust storm events on daily pneumonia hospital admissions in Taipei, Taiwan显示文摘 | Cheng M F Ho S C Chiu H F | 2008 | Journal of Toxicology and Environmental Health Part A2008，71，19： | 1 |
| 16 | Formation and characteriza- tion of magnetron sputtered Ta-Si-N-O thin films显示文摘 | Yan H Li L Ho F Y | 2009 | Thin Solid Films2009，517，： | 1 |
| 17 | Experience-weighted attraction learning in normal-form games 显示文摘 | Camerer C F Ho T H | 1999 | Econometrica1999，67，4： | 1 |
| 18 | Structure and properties of cast binary Ti-Mo alloys显示文摘 | Ju C P Chern Lin J H | 1999 | Biomaterials1999，20，： | 1 |
| 19 | Inhibition of TGF-β-induced collagen production in rabbitflexor tendons显示文摘 | Zhang AY Pham H Ho F | 2004 | Hand Surg2004，29，2： | 1 |
| 20 | Highly dispersed metal nanoparticles in functionalized SBA-15显示文摘 | Yang C M Liu P H Ho Y F | 2003 | Chem Mater2003，15，1： | 1 |
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