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| 1 | 步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压显示文摘肺高血压是结缔组织病(connective tissue disease,CTD)的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压(mean pulmonary arterial pressure,mPAP)升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。 | Kusunose K Yamada H Hotchi J Bando M Nishio S Hirata Y Ise T Yamaguchi K Yagi S Soeki T Wakatsuki T Kishi J Sata M 曲浥晨 | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 2 | Ice formation and heat transfer with water flow around isothermally cooled cylinders arranged in a line显示文摘 | HIRATA T MATSUI H | 1990 | Jounal of Heat Transfer1990，112，3： | 2 |
| 3 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 4 | Binding pathway determines norepinephrine selectivity for the human β_(1)AR over β_(2)AR显示文摘Beta adrenergic receptors(βARs)mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system.While the hormone epinephrine binds β_(1)AR and β_(2)AR with similar affinity,the smaller neurotransmitter norepinephrine is approximately tenfold selective for the β_(1)AR.To understand the structural basis for this physiologically important selectivity,we solved the crystal structures of the human β_(1)AR bound to an antagonist carazolol and different agonists including norepinephrine,epinephrine and BI-167107.Structural comparison revealed that the catecholamine-binding pockets are identical between β_(1)AR and β_(2)AR,but the extracellular vestibules have different shapes and electrostatic properties.Metadynamics simulations and mutagenesis studies revealed that these differences influence the path norepinephrine takes to the orthosteric pocket and contribute to the different association rates and thus different affinities. | Xinyu Xu Jonas Kaindl Mary J.Clark Harald Hübner Kunio Hirata Roger K.Sunahara Peter Gmeiner Brian K.Kobilka Xiangyu Liu | 2021 | Cell Research2021，31，5： | 2 |
| 5 | Rhabdomyosarcoma in a ferret (Mustela putorius furo) 显示文摘 | Sakai H Maruyama M Hirata A Sakai H | 2004 | J Vet Med Sci2004，66，1： | 1 |
| 6 | Role of angiotensin II type-1 and type-2 receptors on vascular smooth muscle cell growth and glucose metabolism in diabetic rats显示文摘 | Igarashi M Hirata A Nozaki H | 2007 | Diabetes Res Clin Pract2007，75，3： | 1 |
| 7 | The significance of nm 23 protein expression in human gastric carcinoma 显示文摘 | Denno R Hirata K | 1996 | Surg Today1996，26，12： | 1 |
| 8 | The role of the basal ganglia and cerebellum in cognitive impairment : a study using event-related potentials 显示文摘 | Hirata K Tanaka H Zeng X H | 2006 | Clin Neurophysiol2006，59，1： | 1 |
| 9 | An evolutionary optimization based on the immune system and its application to the VLSI floor-plan design problem显示文摘 | TAZAWA I KOAKUTSU S HIRATA H | 1997 | Trans of the Institute of Electrical Engineers of Japan Part C1997，117，7： | 1 |
| 10 | Immunohistochemical localization of endothelial cell derived lipase in atherosclerotic human coronary arteries 显示文摘 | Azumi H Hirata K lshida T | 2003 | Cardiovasc Res2003，58，3： | 1 |
| 11 | A metalloprotease - disinte- grin, ADAM9/MDCg/meltring, and PKC - d are involved in TPA -induced ectodomain shedding of membrane - anchored heparin - binding EGF - like growth factor显示文摘 | Izumi Y Hirata M Hasuwa H | 1998 | EMBO J1998，17，： | 1 |
| 12 | Activation of diacylglycerol O-acyl-transferase 1 gene results in increased tumor necrosis factor-alphagene expression in 3T3-L1 adipocytes 显示文摘 | Hirata T Unoki H Bujo H | 2006 | FEBS Lett2006，580，21： | 1 |
| 13 | Theory and Experi- ment of a 94 GHz Gyrotron Traveling Wave Amplifier显示文摘 | Song H H McDermott D B Hirata | 2004 | Phys Plas2004，11，5： | 1 |
| 14 | Evidence for C-type natriuretic peptide production in the rat kidney显示文摘 | Suzuki E Hirata Y Hayakawa H | 1993 | Biochem Biophys Res Conunuu1993，192，2： | 1 |
| 15 | Effective 30-hour preservation of canine lungs with modified ET-Kyoto solution显示文摘 | Wada H Liu C J Hirata T | 1996 | Ann Thorac Surg1996，61，： | 1 |
| 16 | Antimicrobial and Lipopolysaccharide-Binding Activities of C-Terminal Domain of Human CAP18 Peptides to Genus Leptospira显示文摘 | ISOGAI E HIRATA M ISOGAI H | 2004 | Journal of Ap- plied Research2004，4，1： | 1 |
| 17 | The role of the basal ganglia and cerebellum in cognitive impairment:a study using event-related potentials显示文摘 | Hirata K Tanaka H Zeng XH | | 0，，01： | 1 |
| 18 | Possible predisposing factors for in-the-bag and out-of-the-bag intraocular lens dislocation and outcomes of intraocular lens exchange surgery显示文摘 | Hayashi K Hirata A Hayashi H | 2007 | Ophthalmology2007，114，5： | 1 |
| 19 | Progression of diabetic nephropathy enhances the plasma osteopontin level in type 2 diabetic patients显示文摘 | Yamaguchi H Igarashi M Hirata A | 2004 | Endocr J2004，51，5： | 1 |
| 20 | Immediate reconstruc- tion using a modified thoracodorsal adipofascial cutaneous flap after partial mastectomy 显示文摘 | Kijima Y Yoshinaka H Hirata M | 2011 | Breast2011，20，5： | 1 |
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