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| 1 | 步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压显示文摘肺高血压是结缔组织病(connective tissue disease,CTD)的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压(mean pulmonary arterial pressure,mPAP)升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。 | Kusunose K Yamada H Hotchi J Bando M Nishio S Hirata Y Ise T Yamaguchi K Yagi S Soeki T Wakatsuki T Kishi J Sata M 曲浥晨 | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 2 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 3 | Postoperative long-term evaluation of interposition reconstruction compared with Roux-en-Y after total gastrectomy in gastric cancer: prospective randomized controlled trial显示文摘 | Sumiya Ishigami Shoji Natsugoe Shuichi Hokita Teruaki Aoki Hideyuki Kashiwagi Kosei Hirakawa Tetsuji Sawada Yoshitaka Yamamura Seiji Itoh Koichi Hirata Keiichiro Ohta Kenichi Mafune Yasushi Nakane Tatsuo Kanda Hiroshi Furukawa Iwao Sasaki Tetsuro Kubota M | 2011 | The American Journal of Surgery2011，，3： | 2 |
| 4 | Rhabdomyosarcoma in a ferret (Mustela putorius furo) 显示文摘 | Sakai H Maruyama M Hirata A Sakai H | 2004 | J Vet Med Sci2004，66，1： | 1 |
| 5 | Role of angiotensin II type-1 and type-2 receptors on vascular smooth muscle cell growth and glucose metabolism in diabetic rats显示文摘 | Igarashi M Hirata A Nozaki H | 2007 | Diabetes Res Clin Pract2007，75，3： | 1 |
| 6 | Nipple discharge disorders: current diagnostic management and the role of fiher-ductoscopy显示文摘 | Okazaki A Hirata K Okazaki M | 1999 | Eur Radiol1999，9，4： | 1 |
| 7 | Antiviral Sulfated Polysaccharide from Navicula directa, a Diatom Collected from Deep-Sea Water in Toyama Bay 显示文摘 | LEE J B HAYASHI K HIRATA M | 2006 | Biol Pharm Bull2006，29，10： | 1 |
| 8 | P-Selectin glycoprotein ligand 1 ( PSGL-1)is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration显示文摘 | Hirata T Merrill S G Aab M | 2000 | The Journal of Experimental Medicine2000，192，11： | 1 |
| 9 | CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis ininterleukin-1 receptor antagonist-deficient mice显示文摘 | Kotani M Hirata K Ogawa S | 2006 | Arthritis Rheum2006，54，2： | 1 |
| 10 | Evaluation of the effects of peptide antibiotics human 显示文摘 | Niyonsaba F Someya A Hirata M | 2001 | Eur J Immunol2001，31，4： | 1 |
| 11 | A metalloprotease - disinte- grin, ADAM9/MDCg/meltring, and PKC - d are involved in TPA -induced ectodomain shedding of membrane - anchored heparin - binding EGF - like growth factor显示文摘 | Izumi Y Hirata M Hasuwa H | 1998 | EMBO J1998，17，： | 1 |
| 12 | Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from IL-1β,TNF-α,and IL-17A stimulated endometriotic stromal cells显示文摘 | Hirata T Osuga Y Takamura M | 2010 | Endocrinology2010，151，11： | 1 |
| 13 | Antimicrobial and Lipopolysaccharide-Binding Activities of C-Terminal Domain of Human CAP18 Peptides to Genus Leptospira显示文摘 | ISOGAI E HIRATA M ISOGAI H | 2004 | Journal of Ap- plied Research2004，4，1： | 1 |
| 14 | The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelio- ma显示文摘 | Giroux Leprieur E Hirata T Mo M | 2014 | Lung Cancer2014，85，3： | 1 |
| 15 | Anterior capsule relaxing incisions with neodymium: YAG laser for patients at high-risk for anterior capsulecontraction显示文摘 | Hayashi K Yoshida M Hirata A | 2011 | J Cataract Refract Surg2011，37，1： | 1 |
| 16 | Extraskeletal osteosarcoma in the thigh:a case report显示文摘 | Kajihara M Sugawara Y Hirata M | 2005 | Radiat Med2005，23，2： | 1 |
| 17 | Rolling of Th1 cells via Pselectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1显示文摘 | Atarashi K Hirata T Matsumoto M | 2005 | J Immunol2005，174，3： | 1 |
| 18 | Antibacterial action of Bainiku-Ekisu(Japanese apricot fruit extracts),a traditional drug,on vibrio-parahaernolyticus and its organicacid components显示文摘 | Nose M Hirata I Arai T | 1988 | Journal of the Food Hygienic Society of Japan1988，29，6： | 1 |
| 19 | Sensitivity to gefitinib (Iressa, ZD1839 ) in non-sraall cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation 显示文摘 | Ono M Hirata A Kometani T | 2004 | Mol Cancer Ther2004，3，4： | 1 |
| 20 | Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination显示文摘 | Nishimoto Y Odaka M Hirata K | 2004 | J Neuroimmunol2004，148，12： | 1 |
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