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| 1 | 持久性有机污染物(POPs)的监测:来自瑞典韦特恩湖的例子显示文摘位于瑞典南部的韦特恩湖是一个大的贫营养化湖泊,它具有高的水面与流域面积比率(大约为0.4)和60年的驻水时间。此湖结合了对大气POP污染的敏感性、对POPs影响的普通敏感性和较慢的浓度降低。提出了鱼体内PCBs和DDT从20世纪60年代一直到1996年的时间系列,以及韦特恩湖沉积物中TCDD的数据,并和其它大湖泊进行了比较。有关北极红点鲑(Salvelinus salvelinus)体内POPs的长期数据集显示每年PCBs有大约5%,DDT有13%的减少。这些速度和其它研究相一致。也讨论了营养物质及其生物效应,以及影响具有长驻水时间的贫营养化湖泊命运的因素。我们提出贫营养的干净湖泊是对于监测生物区中POPs的重要生态系统。 | MnsJ.Lindell Gudrun Bremle Ola Broberg Per Larsson 孙学飞 | 2001 | AMBIO-人类环境杂志2001，30，8： | 4 |
| 2 | Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis显示文摘The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor . | Gudrun Scheving Thorsteinsson Maria Magnussson Lena M Hallberg Nils Gunnar Wahlgren Fredrik Lindgren Petter Malmborg Thomas H Casswall | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Beneficial effect of epilepsy surgery in a case of childhood non-paraneoplastic limbic encephalitis显示文摘 | Angelika M Gudrun G Gerald P | 2010 | Epilepsy Research2010，90，3： | 1 |
| 5 | Percutaneous transgastric irrigation drainage in combination with endoscopic necrosectomy in necrotizing pancreatitis (with videos) <ce:link locator='fx1'/>显示文摘 | Susanne Raczynski Niels Teich Gudrun Borte Henning Wittenburg Joachim M?ssner Karel Caca | 2006 | Gastrointestinal Endoscopy2006，，3： | 1 |
| 6 | Bitter gourd (Momordia charantia): A diretary approach to hyperglycemia显示文摘 | Michael B Krawinkel M D Gudrun B K | 2006 | Natrition Reviews2006，，7： | 1 |
| 7 | Structural characterization of amorphous hydrogenated-carbon nitride (αH-CNx) film deposited by CH4/N2 dielectric barrier discharge plasma:13C,1H solid state NMR,FTIR and elemental analysis显示文摘 | ABHIJIT M GUDRUN S RAINER H | 2009 | Surface and Coatings Technology2009，203，14： | 1 |
| 8 | Vertical perithalamic hemispherotomy: A single‐center experience in 40 pediatric patients with epilepsy显示文摘 | Christian Dorfer Thomas Czech Anastasia Dressler Gudrun Gr?ppel Angelika Mühlebner‐Fahrngruber Klaus Novak Andrea Reinprecht Edith Reiter‐Fink Tatjana Traub‐Weidinger Martha Feucht | 2013 | Epilepsia2013，，11： | 1 |
| 9 | Detection of occult tumour cells in lymph nodes of colorectal cancer patients using real‐time quantitative RT‐PCR for CEA and CK20 mRNAS显示文摘 | ?ke N.V.?berg Gudrun E.Lindmark Anne C.E.Israelsson Sten G.Hammarstr?m Marie‐Louise K.C.Hammarstr?m | 2004 | Int J Cancer2004，，1： | 1 |
| 10 | Controlling the angiogenic switch A balance between two distinct TGF-β receptor signaling pathways显示文摘 | Goumans M J Franck L Gudrun V | 2003 | Trands Cardivos Med2003，13，7： | 1 |
| 11 | A Continuous Time In- ventory Model for a Product Recovery System with Multiple Options 显示文摘 | Rainer Kleber Stefan M Gudrun K | 2002 | International Journal of Production Economic2002，79，2： | 1 |
| 12 | Reelin immunoreactivity in dissociated cultures of the postnatal hippocampus显示文摘 | Alessandra L Scotti M Gudrun Herrmann | 2002 | Brain Research2002，924，： | 1 |
| 13 | Diagnostic performance of 64-slice computed tomography in evaluation of coronary artery bypass grafts 显示文摘 | Gudrun M Thomas S Hohannes B et at | 2007 | AIR2007，189，： | 1 |
| 14 | A continuous time inventory model for a product recovery system with multiple options显示文摘 | Rainer K Stefan M Gudrun I | 2002 | Intemational Journal of Production Economics2002，79，2： | 1 |
| 15 | Ap- plication of a6C1 as a dating tool for modern groundwater 显示文摘 | YUKI T NORIO T GUDRUN M | 2007 | Nuel Instrum Methods B2007，259，： | 1 |
| 16 | Mechanisms underlying the frequency dependence of contraction and I transients in mouse ventricular myocytes显示文摘 | Gudrun A Kanigula M Ines N | 2002 | Journal of Physiology2002，543，3： | 1 |
| 17 | Seed-specific transcription factors ABI3 and FUS3: molecular interaction with DNA显示文摘 | Gudrun M?nke Lothar Altschmied Annegret Tewes Wim Reidt Hans-Peter Mock Helmut B?umlein Udo Conrad | 2004 | Planta2004，，1： | 1 |
| 18 | Mucopolysaccharidoses (MPS):Clinical and Neuroradiological Aspects of the Different Types显示文摘 | Wibke Müller-Forell Gudrun Schulze Frenking Yasmina Amraoui | 2007 | Clinical Neuroradiology2007，32，1： | 1 |
| 19 | Tissue-specific Cu bioaccumulation patterns and differences in sensitivity to water- borne Cu in three freshwater fish: rainbow trout ( Oncorhynchus mykiss), common carp (Cyprinus carpio), and gibel carp (Car- assius auratus gibelio) 显示文摘 | GUDRUN D B WOUTER M WIM D C | 2004 | Aquat Toxicol2004，70，3： | 1 |
| 20 | Space-based AIS for Global Maritime Traffic Monitoring 显示文摘 | GUDRUN H TORKILD E BENTEJ M | 2008 | Acta Astronautica2008，，2： | 1 |
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