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| 1 | Heterogeneous populations of neural stem cells contribute to myelin repair显示文摘As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis(MS), leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demonstrated the increasing inability of oligodendrocyte precursor cells(OPCs) to replace lost oligodendrocytes(OLs) in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair. | Rainer Akkermann Felix Beyer Patrick Küry | 2017 | Neural Regeneration Research2017，12，4： | 3 |
| 2 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 3 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | Discovering functional gene expression patterns in the metabolic network of Escherichia coli with wavelets transforms 显示文摘 | RAINER K GUNNAR S MARCUS O | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 5 | Topical anesthesia with PH adjusted versus standard indocaine 4% for corneal cataract surgery显示文摘 | Zehetmayer M Rainer G Turnheim K | 1997 | J Cataract Refract Surg1997，23，9： | 1 |
| 6 | Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene显示文摘 | Eberlein Annett Takasuga Akiko Setoguchi Kouji Pfuhl Ralf Flisikowski Krzysztof Fries Ruedi Klopp Norman Fürbass Rainer Weikard Rosemarie Kühn Christa | 2009 | Genetics2009，，3： | 1 |
| 7 | Solar thermal power plants for solar countries-technology, Economics and market potential 显示文摘 | Helnmut K Rainer K Joachimn | 1995 | Applied Energy1995，，52： | 1 |
| 8 | Health Consequences o{ Aircraft Noise显示文摘 | Martin K Christian M Rainer K | 2008 | Dtsch Arztebl Int2008，105，3132： | 1 |
| 9 | Scientists'Transition to Academic Entrepreneurship显示文摘 | MAXIMILIAN G MART1N O RAINER K S | 2012 | Economic and Psychological Determinants2012，，7： | 1 |
| 10 | Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucosi- desurfactants 显示文摘 | Cornelia MK Andjelka K Rainer HM | 2014 | International Journal of Pharmaceutics2014，474，12： | 1 |
| 11 | The influence of individual differences on skill in end-user computing 显示文摘 | HARRISON A W RAINER R K | 1992 | Journal of Management Information Systems1992，9，2： | 1 |
| 12 | A Simple Micro Controller Based Digital Lock-in Amplifier for The Detection of Low Level Optical Signals 显示文摘 | Adria A D Rainer K | 2002 | Proceedings of the First IEEE International Workshop on Electronic Design2002，7，2： | 1 |
| 13 | Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage显示文摘 | Rainer K Dimitre A Arnd D | 2010 | Stroke2010，41，8： | 1 |
| 14 | Differential Evolution - A Simple and Efficient Heuristic for Global Optimization Over Continuous Spaces显示文摘 | S Rainer K Price | 1997 | J of Global Optimization1997，11，4： | 1 |
| 15 | Risk Analysis for Information Technology 显示文摘 | RAINER R K J R SNYDER C A CARR H H | 1991 | Journal of Management Information Systems1991，8，1： | 1 |
| 16 | Executive Information Systems:A Framework for Development and a Survey of Current Practices显示文摘 | Watson H J Rainer R K Koh C E | 1991 | MIS Quarterly1991，15，1： | 1 |
| 17 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 18 | Differential Evolution-A Simple and Efficient Heuristic for Global Optimization over Continuous Spaces 显示文摘 | Rainer S Price K | 1997 | Journal of Global Optimization (S0925-5001 )1997，11，4： | 1 |
| 19 | Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer显示文摘 | Ralf-Dieter Hofheinz Karoline Horisberger Christoph Woernle Frederik Wenz Uta Kraus-Tiefenbacher Georg K?hler Dietmar Dinter Rainer Grobholz Steffen Heeger Stefan Post Andreas Hochhaus Frank Willeke | 2006 | International Journal of Radiation Oncology Biology Physics2006，，5： | 1 |
| 20 | Topical anesthesia with Ph-adjusted versus standard indocaine 4% for clear corneal cataract surgery显示文摘 | Rainer G Turnheim K | 1997 | J Cataract Refract Surg1997，23，： | 1 |
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