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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | The role of automated urine particle flow cytometry in clinical practice显示文摘 | Joris R Delanghe Timo T Kouri Andreas R Huber Kurt Hannemann-Pohl Walter G Guder Andreas Lun Pranav Sinha Gudrun Stamminger Lothar Beier | 2000 | Clinica Chimica Acta2000，，1： | 1 |
| 3 | Rapamycin - induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer 显示文摘 | Christiane J B Gudrun E K Markud G | 2004 | Clin Caner Res2004，10，6： | 1 |
| 4 | A Primary Tumor Promotes Dormancy of Solitary Tumor Cells before Inhibiting Angiogenesis显示文摘 | Markus G Grigore C Gudrun K | 2001 | Cancer Res2001，7，15： | 1 |
| 5 | Beneficial effect of epilepsy surgery in a case of childhood non-paraneoplastic limbic encephalitis显示文摘 | Angelika M Gudrun G Gerald P | 2010 | Epilepsy Research2010，90，3： | 1 |
| 6 | lntravital micros- copy of tumor angiogenesis and regression in the dorsal skin fold chamber: mechanistic insights and preclinical testing of therapeutic strategies 显示文摘 | Gudrun E K Andreas G Edward K G | 2009 | Clinical & Experi- mental Metastasis2009，26，4： | 1 |
| 7 | Impact of Thrombophilia on Risk of Arterial Ischemic Stroke or Cerebral Sinovenous Thrombosis in Neonates and Children: A Systematic Review and Meta-Analysis of Observational Studies显示文摘 | Gili Kenet Lisa K. Lütkhoff Manuela Albisetti Timothy Bernard Mariana Bonduel Leonardo Brandao Stephane Chabrier Anthony Chan Gabrielle deVeber Barbara Fiedler Heather J. Fullerton Neil A. Goldenberg Eric Grabowski Gudrun Günther Christine Heller Susanne | 2010 | Circulation2010，，16： | 1 |
| 8 | Minimal requirements for exocytosis:a study using PC 12 cells permeabilized with staphylococcal α-toxin 显示文摘 | Gudrun A Ahnert-Hilger G Bhakdi S | 1985 | J Biol Chem1985，260，12： | 1 |
| 9 | Th-romboembolic events in children with acute lymphoblastic leukemia:prednisoe versus dexamethasone administration显示文摘 | ULRIKE N G ELVIRA A GUDRUN F | 2003 | Blood2003，101，： | 1 |
| 10 | Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer 显示文摘 | Markus G Gudrun EK Evelyn N | 2005 | Transplant International2005，18，1： | 1 |
| 11 | Thromboembolic events in children with acute lymphoblastic leukemia:prednisone versus dexamethasone administration显示文摘 | ULRIKE N G ELVIRA A GUDRUN F | 2003 | Blood2003，101，7： | 1 |
| 12 | Beneficial effect of epilepsysurgery in a case of childhood non-paraneoplastic limbic encep-halitis显示文摘 | Angelika M Gudrun G Gerald P | 2010 | Epilepsy Research2010，90，3： | 1 |
| 13 | Beneficial effect of epilepsy surgery in a case of childhood non-paraneoplastic limbic encephalitis显示文摘 | Angelika M Gudrun G Gerald P | 2010 | Epilepsy Research2010，90，3： | 1 |
| 14 | Quantitative imaging biomarkers: A review of statistical methods for technical performance assessment显示文摘 | Raunig David L McShane Lisa M Pennello Gene Gatsonis Constantine Carson Paul L Voyvodic James T Wahl Richard L Kurland Brenda F Schwarz Adam J G?nen Mithat Zahlmann Gudrun Kondratovich Marina V O’Donnell Kevin Petrick Nicholas Cole Patricia | 2015 | Statistical Methods in Medical Research2015，，： | 1 |
| 15 | Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer显示文摘 | Christiane JB Gudrun EK Markud G | 2004 | Clin caner Res2004，10，6： | 1 |
| 16 | Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane an chored TNF显示文摘 | MATTHIAS G GUDRUN Z EVA G | 1999 | EMBOJ1999，18，11： | 1 |
| 17 | Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer显示文摘 | Markus G Gudrun EK Evelun N et a1 | | 0，，01： | 1 |
| 18 | Rapamycin induced endothelial cell death and tumor vessel thrombosis potentiatecy to toxic therapy against pancreatic cancer 显示文摘 | Christiane JB Gudrun EK Markud G | 2004 | Clin Cancer Res2004，10，6： | 1 |
| 19 | Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer显示文摘 | Markus G Gudrun EK Evelun N | 2005 | Transplant Int2005，18，89： | 1 |
| 20 | Fishery biology and biological reference points for management of ocean quahogs (Arctica islandica) off Iceland 显示文摘 | Gudrun G T Larry D J | 2005 | Fisheries Research2005，75，1： | 1 |
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