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| 1 | Antibiotics,gut microbiota,and irritable bowel syndrome:What are the relations?显示文摘Irritable bowel syndrome(IBS)is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits(constipation,diarrhea,or both),and it is often accompanied by symptoms of abdominal bloating and distension.IBS is an important health care issue because it negatively affects the quality of life of patients and places a considerable financial burden on health care systems.Despite extensive research,the etiology and underlying pathophysiology of IBS remain incompletely understood.Proposed mechanisms involved in its pathogenesis include increased intestinal permeability,changes in the immune system,visceral hypersensitivity,impaired gut motility,and emotional disorders.Recently,accumulating evidence has highlighted the important role of the gut microbiota in the development of IBS.Microbial dysbiosis within the gut is thought to contribute to all aspects of its multifactorial pathogenesis.The last few decades have also seen an increasing interest in the impact of antibiotics on the gut microbiota.Moreover,antibiotics have been suggested to play a role in the development of IBS.Extensive research has established that antibacterial therapy induces remarkable shifts in the bacterial community composition that are quite similar to those observed in IBS.This suggestion is further supported by data from cohort and case-control studies,indicating that antibiotic treatment is associated with an increased risk of IBS.This paper summarizes the main findings on this issue and contributes to a deeper understanding of the link between antibiotic use and the development of IBS. | Zarina Mamieva Elena Poluektova Valery Svistushkin Vasily Sobolev Oleg Shifrin Francisco Guarner Vladimir Ivashkin | 2022 | World Journal of Gastroenterology2022，28，12： | 8 |
| 2 | A Global Perspective on Irritable Bowel Syndrome: A Consensus Statement of the World Gastroenterology Organisation Summit Task Force on Irritable Bowel Syndrome显示文摘 | Eamonn M. M. Quigley Hussein Abdel-Hamid Giovanni Barbara Shobna J. Bhatia Guy Boeckxstaens Roberto De Giorgio Michel Delvaux Douglas A. Drossman Amy E. Foxx-Orenstein Francisco Guarner Kok-Ann Gwee Lucinda A. Harris A. Pali S. Hungin Richard H. Hunt John | 2012 | Journal of Clinical Gastroenterology2012，，5： | 4 |
| 3 | Gut flora in health and disease显示文摘 | Francisco Guarner Juan-R Malagelada | 2003 | The Lancet . 2003 (9356)2003，，9356： | 3 |
| 4 | Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced Diarrhea: Results From Multicenter, Randomized, Placebo-Controlled Nutritional Trial显示文摘 | Jordi Giralt José Perez Regadera Ramona Verges Jesus Romero Isabel de la Fuente Albert Biete Jesús Villoria Jose Maria Cobo Francisco Guarner | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，4： | 1 |
| 5 | Gut flora in health and disease显示文摘 | Francisco Guarner Juan-R Malagelada | 2003 | The Lancet2003，，9356： | 1 |
| 6 | Gut flora in health and disease显示文摘 | Francisco Guarner Juan-R Malagelada | | 0，，： | 1 |
| 7 | Gut flora in health and disease显示文摘 | Francisco Guarner Juan-R Malagelada | 2003 | The Lancet2003，，9356： | 1 |
| 8 | Probiotic prophylaxis in predicted severe acute pancreatitis显示文摘 | Gregor Reid Glenn Gibson Mary Ellen Sanders Francisco Guarner James Versalovic | 2008 | The Lancet2008，，9633： | 1 |
| 9 | Gut flora in health and disease显示文摘 | Francisco Guarner Juan-R Malagelada | 2003 | The Lancet2003，，9356： | 1 |
| 10 | Exocrine pancreatic cancer: Symptoms at presentation and their relation to tumour site and stage显示文摘 | Miquel Porta Xavier Fabregat Núria Malats Luisa Guarner Alfredo Carrato Ana Miguel Laura Ruiz Manuel Jariod Sergi Costafreda Susana Coll Juan Alguacil Josep M. Corominas Ricard Solà Antonio Salas Francisco X. Real | 2005 | Clinical and Translational Oncology2005，，5： | 1 |
| 11 | Gut flora in health and disease显示文摘 | Guarner Francisco Malagelada Juan-R | 2003 | The Lancet2003，361，9356： | 1 |
| 12 | World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics October 2011显示文摘 | Francisco Guarner Aamir G. Khan James Garisch Rami Eliakim Alfred Gangl Alan Thomson Justus Krabshuis Ton Lemair Pedro Kaufmann Juan Andres de Paula Richard Fedorak Fergus Shanahan Mary Ellen Sanders Hania Szajewska Balakrishnan Siddartha Ramakrishna Tark | 2012 | Journal of Clinical Gastroenterology2012，，6： | 1 |
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