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| 1 | Flower-, wire-, and sheet-like MnO_2-deposited diatomites:Highly efficient absorbents for the removal of Cr(Ⅵ)显示文摘Flower-, wire-, and sheet-like MnO2-deposited diatomites have been prepared using a hydrothermal method with Mn(Ac)2, KMnO4and/or MnSO4 as Mn source and diatomite as support. Physical properties of the materials were characterized by means of numerous analytical techniques, and their behaviors in the adsorption of chromium(VI) were evaluated.It is shown that the MnO2-deposited diatomite samples with different morphologies possessed high surface areas and abundant surface hydroxyl groups(especially the wire-like MnO2/diatomite sample). The wire-like MnO2/diatomite sample showed the best performance in the removal of Cr(VI), giving the maximum Cr(VI) adsorption capacity of 101 mg/g. | Yucheng Du Liping Wang Jinshu Wang Guangwei Zheng Junshu Wu Hongxing Dai | 2015 | Journal of Environmental Sciences2015，27，3： | 17 |
| 2 | Origination and Establishment of a Trigenic Reproductive Isolation System in Rice显示文摘 | Yidan Ouyang Guangwei Li Jiaming Mi Conghao Xu Hongyi Du Chengjun Zhang Weibo Xie Xianghua Li Jinghua Xiao Huazhi Song Qifa Zhang | 2016 | Molecular Plant2016，9，11： | 7 |
| 3 | Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells显示文摘Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始,渗入,和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的自强和区别的分子的机械。这里,我们发现那配对的相关 homeobox 1 (PRRX1 ) ,以前是的一个 homeodomain 抄写因素报导了控制骨胳的开发,在外皮的神经祖先被表示并且为他们的自强和合适的区别被要求。进一步, PRRX1 是在 glioma 样品和标签 GIC 的 overrepresented。Glioma 房间和 GIC 与 PRRX1 弄空不能在 vitro 宣传或在异种皮移植老鼠模型形成肿瘤。PRRX1 调整的 GIC 自强功能被多巴胺 D2 受体(DRD2 ) 调停。PRRX1 直接在 GIC 把它的表示绑在 DRD2 倡导者和 transactivates。发信号的 DRD2 的阻塞妨碍 GIC 自强,而它的 overexpression 恢复宣传和弄空 PRRX1 的 GIC 的 tumorigenic 潜力。最后, PRRX1 加强经由调停 DRD2 的细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 和 AKT 的 GIC 激活。因此,我们的学习建议那治疗学的指向在 GIC 的 PRRX1DRD2ERK/AKT 轴是为对待 GBM 的有希望的策略。 | Yamu Li Wen Wang Fangyu Wang Qiushuang Wu Wei Li Xiaoling Zhong Kuan Tian Tao Zeng Liang Gao Ying Liu Shu Li Xiaobing Jiang Guangwei Du Yan Zhou | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 4 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 5 | Isolation and expression pattern analysis of novel ESTs from human fetal brain显示文摘In order to learn the mechanism of brain development and differentiation, 90 expressed sequence tags (ESTs) were isolated by differential display from the cerebrum and cerebellum of 13-week and 33-week fetal brains. After searching database, 74 of them represented novel genes, some of them were homologous to the brain development related genes. Using total cDNA probes, 79 of the ESTs and their expression differences in fetal brain were further characterized. | Meihui Pan Jiangang Yuan Guangwei Du Yan Zhou Hui Yao Boqin Qiang | 1998 | Chinese Science Bulletin1998，43，21： | 3 |
| 6 | Thermo-Calc based multi-component micro-segregation model and solidification paths calculations显示文摘On the basis of a multi-length scale modeling, a mixture-averaged multi-component /multiphase micro-segregation model was proposed without pre-set function for the micro-scale solute profile. The model explains the effect of morphologies of solidifying phases and solid back diffusion (SBD) on segregation, and covers the two limiting solidification cases of Scheil and Lever-rule models. A commercial Thermo-Calc software package/database was linked to the algorithms via its TQ6-interface for instantaneous determination of the related thermodynamic data of the multi-component alloys. The influences of cooling rate and other parameters on the solidification path and micro-segregation behavior were numerically investigated by sample calculation of the ternary Al-Cu-Mg alloys. A parallel experimental investigation on Al-Cu-Si alloys solidified under different cooling conditions was conducted to validate the theoretical model. Reasonable agreements were gained between the predicted solidification paths and the measured results. | Zhao Guangwei Li XinZhong Xu Daming Guo Jingjie Fu Hengzhi Du Yong He Yuehui | 2012 | China Foundry2012，9，3： | 3 |
| 7 | Morphology analysis of tracks in the aerogels impacted by hypervelocity irregular particles显示文摘As an attractive collector medium for hypervelocity particles,combined with outstanding physical properties and suitable compositional characteristics,SiO2 aerogel has been deployed on outer space missions and laser shock-loaded collection experiments.In this paper,impact experiments were conducted to understand the penetration process of irregular grains,irregular Al_(2)O_(3) grains with two different sizes and speeds(~110μm@7 km/s,~251μm@2.3 km/s)at various density silica aerogels.By classifying the shapes of projectile residues and tracks,the morphology of tracks was analyzed.It was observed that there were several kinds of typical tracks in the penetration of irregular grains,accompanied by residues with the shapes of near-sphere,polyhedron,streamlined body wedge,and rotator.The rotational behavior was demonstrated by the final status of one flake projectile as direct evidence.In addition,there was no obvious relationship between the track length and experimental parameters,which may be caused by the uncertain interaction between aerogels and irregular particles.In addition,it confirmed the existence of fragmentation,melting situation by observing the shape of the impact entrance hole.At the same time,optical coherence tomography was used to observe the detail of tracks clearly,which provided a method to characterize the tracks nondestructively. | Ai Du Yi Ma Mingfang Liu Zhihua Zhang Guangwei Cao Hongwei Li Ling Wang Peijian Si Jun Shen Bin Zhou | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 8 | New Thoughts of Comprehensive Development and Utilization of Salt Lake Resources in Qinghai Province显示文摘Qinghai Province has unique salt lake resources in China characterized by multicomponent,big storage,multi types and easy exploitation.These salt lake resources are concentrated in Qaidam Basin. | DU Guangwei | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
| 9 | An Explicit-Implicit Predictor-Corrector Domain Decomposition Method for Time Dependent Multi-Dimensional Convection Diffusion Equations显示文摘The numerical solution of large scale multi-dimensional convection diffusion equations often requires efficient parallel algorithms.In this work,we consider the extension of a recently proposed non-overlapping domain decomposition method for two dimensional time dependent convection diffusion equations with variable coefficients. By combining predictor-corrector technique,modified upwind differences with explicitimplicit coupling,the method under consideration provides intrinsic parallelism while maintaining good stability and accuracy.Moreover,for multi-dimensional problems, the method can be readily implemented on a multi-processor system and does not have the limitation on the choice of subdomains required by some other similar predictor-corrector or stabilized schemes.These properties of the method are demonstrated in this work through both rigorous mathematical analysis and numerical experiments. | Liyong Zhu Guangwei Yuan Qiang Du | 2009 | Numerical Mathematics(Theory,Methods and Applications)2009，2，3： | 1 |
| 10 | Thermodynamic Assessment of the In-Ni-Sb Systemand Predictions for Thermally Stable Contacts to InSb显示文摘 | Zhanmin Cao Wei Xie Kunpeng Wang Guangwei Du Zhiyu Qiao | 2013 | Journal of Electronic Materials2013，，： | 1 |
| 11 | caidamu xunhuan jingji shiyanqu gongye fazhan silu yu kuangjia yanjiu(A Study on Industrial Development Strategy and Framework of the Qaidam Experimental Zone of Circular Economy)显示文摘 | Shi Jinyou Du Guangwei | | 0，，08： | 1 |
| 12 | Cloning of a novel gene encoding human thioredoxin-like protein显示文摘mRNA differential display (DDRT-PCR) has been used to analyze different human fetal brain tissues of different developmental stages (13- and 33-week). According to the sequence of one EST obtained in this assay, a pair of primers have been designed to screen the arrayed human fetal brain cDNA library. A 1 .2-kb cDNA clone has been found. This cDNA con- | Yan Zhou Meihui Pan Jiangang Yuan Guangwei Du Boqin Qiang | 1999 | Chinese Science Bulletin1999，44，18： | 1 |
| 13 | Isolation and cloning of a novel cDNA LDB1 encoding human LIM domain binding protein显示文摘Primers for screening cDNA library have been designed according to EST AA453734 which is corresponding to the mouse LIM domain binding protein Ldb1. Arrayed human fetal brain cDNA library has been screened by PCR and routine hybridization method. A 2398 bp-cD-NA clone has been obtained. The cDNA encodes a 347 amino acids protein highly homologous to the mouse Ldb1, Xenopus Xldb1 and Drosophila Chip. It also contains an LIM binding domain and a nuclear localization signal. It has been named LDB1 (LIM domain binding protein 1), GenBank accession number is AF052389. Northern blot showed a 2.4 kb band, and the expression amounts of LDB1 in heart, brain and lung were considerably higher than those in other tissues. | ZHOU Yan, DU Guangwei, WANG Junhua, CHEN Jianhe, YUAN Jiangang QIANG BoqinState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China | 1999 | Chinese Science Bulletin1999，44，12： | 0 |
| 14 | Cloning of human and mouse GRY-RBP cDNA显示文摘After screening human fetal brain cDNA library, a novel human cDNA encoding an RNA-binding protein was cloned and named GRY-RBP. Human GRY-RBP cDNA is 2 932 bp in length, and encodes a protein of 623 amino acids with a deduced molecular mass of 69.6 ku. Human GRY-RBP contains three RNA recognition motifs (RRMs) and a glycine (G), tyrosin (Y)-rich C-terminus. Computer searches with sequence database revealed its moderate homology with RRMs of many RRM RNA-binding proteins. in this study, the full coding region and partial non-coding region of mouse GRY-RBP cDNA were amplified by PCR using mouse brain cDNA library as template. Three transcripts of Gry-rbp are expressed in ali tissues as shown by Northern blot, but the amounts in heart, planceta and skeletal muscle are considerably higher than those in other tissues. | Guangwei Du Meihui Pan Yan Zhou Jianhe Chen Hui Yao Jiangang Yuan Boqin Qiang | 2000 | Chinese Science Bulletin2000，45，4： | 0 |
| 15 | Cloning and expression analysis of MBLL cDNA显示文摘The mbl (musdeblind) gene of Drosophila encodes a nuclear protein which contains two Cys3His motifs. The mutation of mbl gene will disturb the differentiation of ali the Drosophila’s photoreceptors. Primers have been designed according to human EST086139, which is highly homologous to mbl gene. Human fetal brain cDNA library has been screened and a novel cDNA clone has been obtained. The 2595 bp cDNA, designated MBLL (muscleblind-like), contains an open reading frame which encodes 255 amino acids and has 4 Cys3His motifs (GenBank Acc. AF061261). The amino acids seguence shares high homology to Drosophila’s mbl. The Northern blot and RNA dot blot hybridization of 43 human adult tissues and 7 fetal tissues show that MBLL is a widely expressed gene, but the expression amounts differ in these tissues. | Guangwei Du Yan Zhou Jianhe Chen Junhua Wang Bin Yin Jiangang Yuan Boqin Qiang | 2000 | Chinese Science Bulletin2000，45，7： | 0 |
| 16 | Cloning and identification of PHF2 cDNA and its alternatively spliced transcripts显示文摘Genes encoding proteins with PHD (plant homeodomain) finger motif (C4HC3) are highly conserved from Arabidopsis to Homo sapiens. One of the major functions of these genes is regulating the expression of homeotic genes during the stage of embryonic development. They play a role in cell-cycle and cell differentiation and seem to be related with some human malignant diseases, such as leukemia. A human placenta cDNA library has been screened with cDNA probe amplified by PCR. The PGR primers have been designed according to the M96 (a mouse gene encoding a protein with PHD domain) homologous data in dbEST.A 2. 1 kb insert fragment in a positive cDNA clone has been isolated and sequenced. This new full-length cDNA is named PHF2 (GenBank Acc: AF052205). The putative protein composed of 567 aa has two typical PHD fingers at its N-terminus. Meanwhile it is identified that there are several alternatively spliced transcripts of PHF2 in different human tissues through the PCR amplification, Northern blot | Junhua Wang Guangwei Du Yan Zhou Bin Yin Jiangang Yuan Boqin Qiang | 1999 | Chinese Science Bulletin1999，44，15： | 0 |
| 17 | Genome resources for the elite bread wheat cultivar Aikang 58 and mining of elite homeologous haplotypes for accelerating wheat improvement显示文摘Despite recent progress in crop genomics studies,the genomic changes brought about by modern breeding selection are still poorly understood,thus hampering genomics-assisted breeding,especially in polyploid crops with compound genomes such as common wheat(Triticum aestivum).In this work,we constructed genome resources for the modern elite common wheat variety Aikang 58(AK58).Comparative genomics between AK58 and the landrace cultivar Chinese Spring(CS)shed light on genomic changes that occurred through recent varietal improvement.We also explored subgenome diploidization and divergence in common wheat and developed a homoeologous locus-based genome-wide association study(HGWAS)approach,which was more effective than single homoeolog-based GWAS in unraveling agronomic trait-associated loci.A total of 123 major HGWAs loci were detected using a genetic population derived from AK58 and cs.Elite homoeologous haplotypes(HHs),formed by combinations of subgenomic homoeologs of the associated loci,were found in both parents and progeny,and many could substantially improve wheat yield and related traits.We built a website where users can download genome assembly sequence and annotation data for AK58,perform blast analysis,and run JBrowse.Our work enriches genome resources for wheat,provides new insights into genomic changes during modern wheat improve-.ment,and suggests that efficientmining of elite HHs can make a substantial contribuutionto genomics-assisted breeding in common wheat and other polyploid crops. | Jizeng Jia Guangyao Zhao Danping Li Kai Wang Chuizheng Kong Pingchuan Deng Xueqing Yan Xueyong Zhang Zefu Lu Shujuan Xu Yuannian Jiao Kang Chong Xu Liu Dangqun Cui Guangwei Li Yijing Zhang Chunguang Du Liang Wu Tianbao Li Dong Yan Kehui Zhan Feng Chen Zhiyong Wang Lichao Zhang Xiuying Kong Zhengang Ru Daowen Wang Lifeng Gao | 2023 | Molecular Plant2023，16，12： | 0 |
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