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	题名	作者	年代	出处	被引量
1	Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population.	Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud	2008	World Journal of Gastroenterology2008，14，42：	2
2	Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘	Mégraud F Lehours P	2007	Clin Microbiol Rev2007，20，2：	1
3	Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘	Mégraud F Lehours P	2007	Clin Microbiol Rev2007，20，2：	1
4	Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report显示文摘	Malfertheiner P M é graud F O'Morain C		0，，02：	1
5	Current concepts in the management of Helicobacter pylori infection显示文摘	Malfertheiner P M graud F O'Morain C	2002	Aliment Pharmacol Ther2002，16，：	1
6	Pore-throat charac- terization in highly porous and permeable sandstones 显示文摘	Nabawy B S Graud Y Rochette P	2009	AAPG Bulletin2009，93，6：	1
7	Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘	Mégraud F Lehours P	2007	Clin Microbial Rev2007，20，2：	1
8	Association of serum pepsinogen with atrophic body gastritis in Costa Rica显示文摘	R. Sierra C. Une V. Ramírez Ma. I González J. A. Ramírez A. Mascarel R. Barahona R. Salas-Aguilar R. Páez G. Avenda?o A. ávalos N. Broutet F. Mégraud	2006	Clinical and Experimental Medicine2006，，2：	1
9	Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘	Me' graud F Lehours P	2007	Clinical microbiology reviews2007，20，2：	1
10	Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘	Mégraud F Lehours P	2007	Clin Microbiol Rev2007，20，2：	1
11	Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report显示文摘	Malfertheiner P Mégraud F O'morain C		0，，02：	1
12	The MACH2 study:role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies显示文摘	Lind T Mégraud F Unge P	1999	Gastroenterology1999，116，2：	1
13	Epidemiology and diagnosis of Helicobacter pylori infection显示文摘	Tonkic A Tonkic M Lehours P graud F	2012	Helicobacter2012，，：	1
14	He\|icobacter pylori detection and antimicrobia\| susceptibility testing显示文摘	M 6 graud F Lehours P	2007	Clin Microbiol Rev2007，20，2：	1
15	Current concepts in the management of Helicobacter pylori infectior-the Maastricht 2-2000 consensusreport显示文摘	Malfertheiner P Mégraud F O' Morain C	2002	Aliment Pharmacol Ther2002，16，2：	1
16	Gross tumor volume and clinical targert volume in radiotherapy:lung cancer 显示文摘	Mormex F Loubeyre P Graud P	2001	Cancer Radiother2001，5，5：	1
17	Association of serum pepsinogen with atrophic body gastritis in Costa Rica显示文摘	R. Sierra C. Une V. Ramírez Ma. I González J. A. Ramírez A. Mascarel R. Barahona R. Salas-Aguilar R. Páez G. Avenda?o A. ávalos N. Broutet F. Mégraud	2006	Clinical and Experimental Medicine2006，，2：	1
18	Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘	Mégraud F Lehours P	2007	Clin Microbiol Rev2007，20，2：	1
19	In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics显示文摘	Pinchuk I V Bressollier P Verneuil B Fenet B Sorokulova I B Mégraud F Urdaci M C		0，，11：	1
20	Helicobacter pylori detection and an-timicrobial susceptibility testing显示文摘	Mégraud F Lehours P	2007	Clin Microbiol Rev2007，20，2：	1

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