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| 1 | Epidemiology and Diagnosis of H elicobacter pylori Infection显示文摘 | Ante Tonkic Marija Tonkic Philippe Lehours Francis Mégraud | 2012 | Helicobacter2012，，： | 6 |
| 2 | Diagnosis and Epidemiology of H elicobacter pylori Infection显示文摘 | Xavier Calvet María‐José Ramírez Lázaro Philippe Lehours Francis Mégraud | 2013 | Helicobacter2013，，： | 5 |
| 3 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 4 | Comparative Evaluation of 29 Commercial H elicobacter pylori Serological Kits显示文摘 | Christophe Burucoa Jean‐Charles Delchier Anne Courillon‐Mallet Jean‐Dominique Korwin Francis Mégraud Frank Zerbib Josette Raymond Jean‐Louis Fauchère | 2013 | Helicobacter2013，，3： | 3 |
| 5 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 6 | Risk factors for failure of Helicobacter pylori therapy — results of an individual data analysis of 2751 patients显示文摘 | N.Broutet S.Tchamgoué E.Pereira H.Lamouliatte R.Salamon F.Mégraud | 2002 | Alimentary Pharmacology & Therapeutics2002，，1： | 2 |
| 7 | Impact of chronic Helicobacter pylori infection on Alzheimer’s disease: preliminary results显示文摘 | Claire Roubaud-Baudron Pierre Krolak-Salmon Isabelle Quadrio Francis Mégraud Nathalie Salles | 2012 | Neurobiology of Aging2012，，5： | 2 |
| 8 | Review article: the treatment of refractory Helicobacter pylori infection显示文摘 | F.Mégraud H.Lamouliatte | 2003 | Alimentary Pharmacology & Therapeutics2003，，11： | 2 |
| 9 | Helicobacter pylori infection and gastric cancer显示文摘 | Tamara Matysiak-Budnik Francis Mégraud | 2006 | European Journal of Cancer2006，，6： | 1 |
| 10 | Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘 | Mégraud F Lehours P | 2007 | Clin Microbiol Rev2007，20，2： | 1 |
| 11 | Helicobacter pylori detection and antimicrobial susceptibility testing显示文摘 | Mégraud F Lehours P | 2007 | Clin Microbiol Rev2007，20，2： | 1 |
| 12 | Hepatic Lesions Observed in Hepatitis C Virus Transgenic Mice Infected by H elicobacter hepaticus显示文摘 | Emilie Roux‐Goglin Pierre Dubus Corinne Asencio Marthe‐Aline Jutand Jean Rosenbaum Francis Mégraud | 2012 | Helicobacter2012，，1： | 1 |
| 13 | pyloriantibiotic resistance:prevalence,importance,and advances in testing显示文摘 | Mégraud FH | 2004 | Gut2004，53，9： | 1 |
| 14 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 15 | Technological and Organizaitonal Designs to Achieve Economies of Substitution显示文摘 | Graud R Kumaraswamy A | 1995 | Strategic Management Journal1995，，： | 1 |
| 16 | Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial显示文摘 | Peter Malfertheiner Franco Bazzoli Jean-Charles Delchier Krysztof Celi?ski Monique Giguère Marc Rivière Francis Mégraud | 2011 | The Lancet2011，，9769： | 1 |
| 17 | Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report显示文摘 | Malfertheiner P M é graud F O'Morain C | | 0，，02： | 1 |
| 18 | ,et al, European Multcentre Survey of in Vitro Antimicrobial Resistance in Helico bacter pylori显示文摘 | Glupczynski Y graud Me Lopez-Brea I | 2001 | Eur J Clin Microbiol Infect Dis2001，20，： | 1 |
| 19 | A Humble Bacterium Sweeps This Year’s Nobel Prize显示文摘 | Francis Mégraud | 2005 | Cell2005，，6： | 1 |
| 20 | Current concepts in the management of Helicobacter pylori infection显示文摘 | Malfertheiner P M graud F O'Morain C | 2002 | Aliment Pharmacol Ther2002，16，： | 1 |
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