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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Patterns of Guillain-Barre syndrome in children: Results from a Mexican population显示文摘 | Nachamkin I Arzarte Barbosa P Ung H | 2007 | Neurology2007，69，17： | 1 |
| 3 | Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF- 562,271显示文摘 | Roberts WG Ung E Whalen P | 2008 | Cancer Res2008，68，6： | 1 |
| 4 | Experimental study on mass transfer from pyrolysing coal particles显示文摘 | Suuberg E M Unge P E Lilly W D | 1985 | Fuel1985，64，： | 1 |
| 5 | Synthesis and dentifieation of 4-Methyl-N-(4H-1,2,4-triazol-4-yl)- 2-Benzo- thiazo-laminc, an Impurity in the Synthesis of Tricyclazole显示文摘 | Drcikorn B A Unge r P J | 1989 | Helerocyehe Chem1989，26，6： | 1 |
| 6 | Copper stabilization in ACQ-D treated wood:retention,temperature and species effects显示文摘 | Ung Y T and Cooper P A | 2005 | Holz als Rohund Werkstoff2005，63，： | 1 |
| 7 | Omeprazole or ranitidine in long-termt reatment of reflux esophagitis显示文摘 | Unge P Carling L | 1994 | Gastroenterology1994，107，： | 1 |
| 8 | Rate and extent of adsorption of ACQ preservative components in wood显示文摘 | Tascioglu C Cooper P A and Ung Y T | 2005 | Holzforschung2005，59，： | 1 |
| 9 | Correlation ofVascular Endothelial Growth Factor - D Expression and VEG-FR - 3 - Positive Vessel Density with Lymph Node Metastasisin Gastric Carcinoma 显示文摘 | J ung - H C Young ~ H O Yong - Wook P | 2008 | J Korean Med Sci2008，23，4： | 1 |
| 10 | Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF- 562,27显示文摘 | Roberts W G Ung E Whalen P | 2008 | Cancer Res2008，68，6： | 1 |
| 11 | Purification of collagen-binding proteins of Lactobacillus reuteri NCIB 11951 显示文摘 | Alelj ung P Shen W Rozalska B | 1994 | Curr Microbiol1994，28，： | 1 |
| 12 | Laparoscopic abdominal radical trachelectomy显示文摘 | Cibula D Ungár L Pálfalvi L | | 0，，02： | 1 |
| 13 | Few-mode fiber with inverse-parabolic graded-index profile for transmission of OAM-carrying modes显示文摘 | Ung B Vaity P Wang L | 2014 | Optics Express2014，22，18： | 1 |
| 14 | Role of spinal 5-HT2 re ceptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection 显示文摘 | Ung RV Landry E S Rouleau P | 2008 | Eur J Neurosci2008，28，11： | 1 |
| 15 | The MACH2 stud- y: role of omeprazole ill eradication of Helicobocter pylori with 1 week triple therapies 显示文摘 | Lind T Megraud F Unge P | 1999 | Gastro- en- terology1999，116，： | 1 |
| 16 | The MACH2 study:role of ome- prazole in eradication of Helicobacter pylori with 1-week triple therapies 显示文摘 | Lind T Megraud F Unge P | 1999 | Gastroenterology1999，116，2： | 1 |
| 17 | Omeprazole or ranitidine in long term treatment of reflux esophagitis显示文摘 | Hallerback B Unge P Carling L | 1994 | Gastroenterology1994，107，5： | 1 |
| 18 | Controlled method for silica coating of silver colloids: Influence of coating on the rate of chemical reactions 显示文摘 | UNG T LIZ-MARZAN L M MULVANEY P | 1998 | Langmuir1998，14，： | 1 |
| 19 | The MACH2 study:role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies显示文摘 | Lind T Megraud F Unge P | 1999 | Gastroenterlogy1999，116，： | 1 |
| 20 | Fabrication of phospho- lipid bilayer-coated microchannels for on-chip immunoas- says显示文摘 | Y ang T L ung S Y Cremer P S | 2001 | Anal Chem2001，73，： | 1 |
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