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| 1 | Effect of Altering Linoleic Acid and Linolenic Acid Dietary Ratios on the Performance and Tissue Fatty Acid Profiles of Prawn, Macrobrachium rosenbergii (de Man 1879) Post Larvae显示文摘 | A. M. A. S. Goda M. M. Habashy M. A. Hanafy R. A. Mohamed H. A. Mabrouk T. M. El-Afifi S. A.Nada K. A. Mohamed | 2011 | Journal of Agricultural Science and Technology(B)2011，1，7： | 11 |
| 2 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 3 | Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors显示文摘BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation.These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized yet.AIM To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case series.METHODS This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after ER.RESULTS In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 mm.The pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR cases and all cases were treated endoscopically. No patient died due to tumor recurrence.CONCLUSION Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. | Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 4 | Diagnostic utility of narrow-band imaging endoscopy for pharyngeal superfi cial carcinoma显示文摘AIM: To investigate the endoscopic features of pharyngeal superfi cial carcinoma and evaluate the utility of narrow-band imaging (NBI) for this disease. METHODS: In the present prospective study, 335 patients underwent conventional white light (CWL) en-doscopy and non-magnifi ed/magnifi ed NBI endoscopy, followed by an endoscopic biopsy, for 445 superfi cial lesions in the oropharynx and hypopharynx. The macroscopic appearance of superfi cial lesions was categorized as either elevated (< 5 mm in height), flat, or depressed (not ulcerous). Superficial carcinoma (SC) was defi ned as a superfi cial lesion showing high-grade dysplasia or squamous cell carcinoma on histology. The color, delineation, and macroscopic appearances of the lesions were evaluated by CWL endoscopy. The ratio of the brownish area/intervascular brownish epithelium (IBE), as well as microvascular proliferation, dilation, and irregularities, was determined by non-magnifi ed/ magnifi ed NBI endoscopy. An experienced pathologist who was unaware of the endoscopic fi ndings made the histological diagnoses. By comparing endoscopic fi ndings with histology, we determined the endoscopic features of SC and evaluated the diagnostic utility of NBI. RESULTS: The 445 lesions were divided histologically into two groups: a non-SC group, including non-neoplasia and low-grade dysplasia cases, and an SC group. Of the 445 lesions examined, 333 were classified as non-SC and 112 were classif ied as SC. There were no significant differences in age, gender, or the location of the lesions between the patients in the two groups. The mean diameter of the SC lesions was signif icantly greater than that of non-SC lesions (11.0 ± 7.6 mm vs 4.6 ± 3.6 mm, respectively, P < 0.001). Comparisons of CWL endoscopy fi ndings for SC and non-SC lesions by univariate analysis revealed that the incidence of redness (72% vs 41%, respectively, P < 0.001) and a flat or depressed type of lesion (58% vs 44%, respectively, P = 0.013) was significantly higher in the SC group. Using non-magnifi ed NBI endoscopy, the incidence of a brownish area was signifi cantly higher for SC lesions (79% vs 57%, respectively, P < 0.001). On magnifi ed NBI endoscopy, the incidence of IBE (68% vs 33%, P < 0.001) and microvascular proliferation (82% vs 51%, P < 0.001), dilation (90% vs 76%, P =0.002), and irregularity (82% vs 31%, P < 0.001) was also signifi cantly higher for the SC compared with the non-SC lesions. Multivariate analysis revealed that the incidence of redness (P = 0.022) on CWL endoscopy and IBE (P < 0.001) and microvascular irregularities (P < 0.001) on magnif ied NBI endoscopy was signif icantly higher in SC than non-SC lesions. Redness alone exhibited signifi cantly higher sensitivity and signifi cantly lower specifi city for the diagnosis of SC compared with redness plus IBE and microvascular irregularities (72% vs 52%, P = 0.002; and 59% vs 92%, P < 0.001, respectively). The accuracy of redness plus IBE and irregularities for the diagnosis of SC was signifi cantly greater than using redness alone (82% vs 62%, respectively, P < 0.001). CONCLUSION: Redness, IBE, and microvascular irregularities appear to be closely related to SC lesions. Magnifi ed NBI endoscopy may increase the diagnostic accuracy of CWL endoscopy for SC. | Noboru Yoshimura Kenichi Goda Hisao Tajiri Yukinaga Yoshida Takakuni Kato Yoichi Seino Masahiro Ikegami Mitsuyoshi Urashima | 2011 | World Journal of Gastroenterology2011，17，45： | 7 |
| 5 | Partially or Totally Replacing Fish Meal with Frozen Artemia as a Dietary Protein Source for Early Stage Giant Freshwater Prawn, Macrobrachium rosenbergii Post Larvae Reared under Controlled Conditions显示文摘 | A. O. Eglal A. M. A. S. Goda A. M. Nour M. E. Nagy H. A. Mabrouk S. M. A. Hebalah | 2011 | Journal of Agricultural Science and Technology(B)2011，1，6： | 5 |
| 6 | Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report显示文摘We report a case of remitting seronegative symmetrical synovitis with pitting edema(RS3 PE) syndrome in a 71-year-old woman. She referred to our hospital with finger stiffness, edema of both hands and feet, pain of bilateral shoulder, wrist, metacarpophalangeal, proximal interphalangeal, and ankle joints. Rheumatoid factor was negative, human leukocyte antigen-B7 antigen was positive. Moreover, matrix metalloproteinase 3(MMP-3) was high. She was diagnosed with RS3 PE syndrome, and treatment with prednisolone(15 mg/d) was started. One week after prednisolone treatment initiation, CRP decreased to negative, and joint pain was almost completely resolved. However, hand stiffness persisted, and MMP-3 level was still high. Thus, prednisolone dose was increased to 20 mg/d, and the stiffness resolved. Twenty days after treatment initiation, MMP-3 was normalized. MMP-3 was more indicative of RS3 PE syndrome symptoms than CRP. Thus, MMP-3 seems to be more sensitive to RS3 PE syndrome symptoms. | Tsuneaki Kenzaka Ken Goda | 2018 | World Journal of Clinical Cases2018，6，5： | 4 |
| 7 | Erythropoietin gene transfer into rat testes by in vivo electropo-ration may reduce the risk of germ cell loss caused by cryptorchidism显示文摘瞄准:由借助于在活体内 electroporation 把老鼠 Epo 基因变成地窟兰花睾丸在精子发生上调查老鼠红细胞生成素(Epo ) 的效果。方法:有通过手术导致的单方的隐睾病的 Sprague-Dawley 老鼠被划分成三个组:第一个组被给 pCAGGS-Epo (pCAGGS-Epo 组) 的睾丸内注射,第二个组被给 pCAGGS (pCAGGS 组) 的睾丸内注射,并且第三个组是给定的睾丸内注射缓冲磷酸盐 saline (PBS 组) 。同时, 30 V 的方形的电的脉搏与 100 ms 的一个时间常数被使用六次。在注射以后的一或二个星期,每个睾丸被称,总数的比率生殖细胞数到 Sertoli 房间(G/S 比率) 的被计算评估精子发生的缺陷。从每三个组拿的十个睾丸被检验在每次指。结果:在 pCAGGS-Epo 或 pCAGGS 控制原生质标志的注射以后的阴囊的重量是(0.85+/-0.08 ) g 并且(0.83+/-0.03 ) g,分别地在星期 1 点(P = 0.788 ) 并且(0.62+/-0.06 ) g 并且(0.52+/-0.02 ) g,分别地在星期 2 点(P = 0.047 ) 。在星期 1 点, spermatids 和精子比在控制睾丸的那些更充满有 pCAGGS-Epo 的睾丸。在星期 2 点, spermatids 和精子几乎没在任何一个组被检测。G/S 比率在星期 1 点是 23.27 +/-6.80 对 18.63+/-5.30 (P = 0.0078 ) 并且在星期 2 点的 7.16+/-3.06 对 6.05+/-1.58 (P = 0.1471 ) 分别地。结论:到由在活体内 electroporation 的老鼠睾丸的 Epo 的转移可以减少隐睾病引起的细菌房间损失的风险。 | Masaki Dobashi Kazumasa Goda Hiroki Maruyama Masato Fujisawa | 2005 | Asian Journal of Andrology2005，7，4： | 3 |
| 8 | ESTIMATION OF CHAIN REACTION BANKRUPTCY STRUCTURE BY CHANCE DISCOVERY METHO—WITH TIME ORDER METHOD AND DIRECTED KEYGRAPH显示文摘Chain reaction bankruptcy is regarded as common phenomenon and its effect is to be taken into account when credit risk portfolio is analyzed.But consideration and modeling of its effect leave much room for improvement.That is mainly because method for grasping relations among companies with limited data is underdeveloped.In this article,chance discovery method is applied to estimate industrial relations that are to include companies' relations that transmit chain reaction of bankruptcy. Time order method and directed KeyGraph are newly introduced to distinguish and express the time order among defaults that is essential information for the analysis of chain reaction bankruptcy.The steps for the data analysis are introduced and result of example analysis with default data in Kyushu, Japan,2005 is presented.The structure estimated by the new method is compared with the structure of actual account receivable holders of bankrupted companies for evaluation. | Shinichi GODA Yukio OHSAWA | 2007 | Journal of Systems Science and Systems Engineering2007，16，4： | 3 |
| 9 | Hypoxia and fatty liver显示文摘The liver is a central organ that metabolizes excessive nutrients for storage in the form of glycogen and lipids and supplies energy-producing substrates to the peripheral tissues to maintain their function,even under starved conditions.These processes require a considerable amount of oxygen,which causes a steep oxygen gradient throughout the hepatic lobules.Alcohol consumption and/or excessive food intake can alter the hepatic metabolic balance drastically,which can precipitate fatty liver disease,a major cause of chronic liver diseases worldwide,ranging from simple steatosis,through steatohepatitis and hepatic fibrosis,to liver cirrhosis.Altered hepatic metabolism and tissue remodeling in fatty liver disease further disrupt hepatic oxygen homeostasis,resulting in severe liver hypoxia.As master regulators of adaptive responses to hypoxic stress,hypoxia-inducible factors(HIFs) modulate various cellular and organ functions,including erythropoiesis,angiogenesis,metabolic demand,and cell survival,by activating their target genes during fetal development and also in many disease conditions such as cancer,heart failure,and diabetes.In the past decade,it has become clear that HIFs serve as key factors in the regulation of lipid metabolism and fatty liver formation.This review discusses the molecular mechanisms by which hypoxia and HIFs regulate lipid metabolism in the development and progression of fatty liver disease. | Tomohiro Suzuki Satoko Shinjo Takatomo Arai Mai Kanai Nobuhito Goda | 2014 | World Journal of Gastroenterology2014，20，41： | 3 |
| 10 | Progress on mid-IR graphene photonics and biochemical applications显示文摘中间红外线(中间 -- 红外)(2-20 m ) photonics 有众多的化学、生物学的指纹由于分子的典型震动的转变察觉到应用在中间 -- 红外光谱区域。不幸地,与可见的光和电信乐队相比,波长, photonic 设备和应用程序是困难的发展在中间 -- 红外波长因为常规材料的内在的限制。打破新地面在里面中间 -- 为革命材料的红外科技电话。Graphene,碳的单个原子层安排在一个蜂房格子,因为它的线性分散乐队结构和零个乐队差距特征,有各种各样的有希望的光、电的性质。在这篇评论文章,我们讨论最近的研究开发在上中间 -- 红外 graphene photonics,特别地 ultrafast 激光和光电探测器。Graphene-photonics-based 生物化学的应用程序,察觉到例如 plasmonic 的、光力学的治疗,和开花成像也被考察。 | Zhenzhou CHENG Changyuan QIN Fengqiu WANG Hao HE Keisuke GODA | 2016 | Frontiers of Optoelectronics2016，9，2： | 2 |
| 11 | Direct control of store-operated calcium channels by ultrafast laser显示文摘Ca^(2+) channels are essential to cell birth,life,and death.They can be externally activated by optogenetic tools,but this requires robust introduction of exogenous optogenetic genes for expression of photosensitive proteins in biological systems.Here we present femtoSOC,a method for direct control of Ca^(2+)channels solely by ultrafast laser without the need for optogenetic tools or any other exogenous reagents.Specifically,by focusing and scanning wavelength-tuned low-power femtosecond laser pulses on the plasma membrane for multiphoton excitation,we directly induced Ca^(2+) influx in cultured cells.Mechanistic study reveals that photoexcited flavins covalently bind cysteine residues in Orai1 via thioether bonds,which facilitates Orai1 polymerization to form store-operated calcium channels(SOCs)independently of STIM1,a protein generally participating in SOC formation,enabling all-optical activation of Ca^(2+) influx and downstream signaling pathways.Moreover,we used femtoSOC to demonstrate direct neural activation both in brain slices in vitro and in intact brains of living mice in vivo in a spatiotemporal-specific manner,indicating potential utility of femtoSOC. | Pan Cheng Xiaoying Tian Wanyi Tang Juan Cheng Jin Bao Haipeng Wang Sisi Zheng Youjun Wang Xunbin Wei Tunan Chen Hua Feng Tian Xue Keisuke Goda Hao He | 2021 | Cell Research2021，31，7： | 2 |
| 12 | Multidisciplinary diagnostic dilemma in differentiating Madelung’s disease—the value of superb microvascular imaging technique:A case report显示文摘BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shoulders,upper arms,trunk,hips,and upper thighs.Our case demonstrates the importance of differential diagnosis and the value of a superb microvascular imaging technique for suspecting and confirming Madelung’s disease.Timely diagnosis and alcohol abstinence could prevent the progression of growing fatty masses and prevent surgery.CASE SUMMARY A 62-year-old male was admitted to the Rheumatology center complaining of symmetric subcutaneous tumors in the area of the parotid and submandibular salivary glands,small soft masses in the occiput and upper third of the forearm,rashes on calves.A high titer of rheumatoid factor and low concentrations of serum complements were detected.The high-end ultrasound and magnetic resonance imaging examinations of all affected areas of the soft tissues showed predominantly adipose tissue(lipomas)without suspicion of liposarcoma.The biopsy from the small salivary gland revealed no pathology.After evaluating the patient’s clinical presentation(symmetrical lipomatosis,cirrhosis,gynecomastia,anemia,hyperuricemia),Madelung’s disease,type I,along with the psoriatic rash and psoriatic arthritis and secondary liver cirrhosis were established.CONCLUSION Madelung’s disease consists of many co-occurring disorders imitating and overlapping with other conditions.Ultrasonography is the first choice for suspecting and confirming symmetrical lipomatosis. | Goda Seskute Austeja Dapkute Dominyka Kausaite Sandra Strainiene Andrius Talijunas Irena Butrimiene | 2021 | World Journal of Clinical Cases2021，9，21： | 2 |
| 13 | Dynamic response of upright breakwaters to impulsive breaking wave forces 显示文摘 | Goda Y | 1994 | Coastal Engineering1994，22，： | 2 |
| 14 | Phase I/II study of intraperitoneal docetaxel plus S-1 for the gastric cancer patients with peritoneal carcinomatosis显示文摘 | S. Fushida J. Kinoshita M. Kaji Y. Hirono F. Goda Y. Yagi K. Oyama Y. Sudo Y. Watanabe T. Fujimura | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 2 |
| 15 | Two acylated anthocyanins from purple sweet potato显示文摘 | Yukihiro Goda Takashige Shimizu Yoshiaki Kato Mikio Nakamura Tamio Maitani Takashi Yamada Norihko Terahara Masaatu Yamaguchi | 1996 | Phytochemistry1996，，1： | 2 |
| 16 | Endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors in J apan: M ulticenter case series显示文摘 | Kenichi Goda Daisuke Kikuchi Yorimasa Yamamoto Kengo Takimoto Naomi Kakushima Yoshinori Morita Hisashi Doyama Takuji Gotoda Yuji Maehata Noritsugu Abe | 2014 | Digestive Endoscopy2014，，： | 2 |
| 17 | Increase in colonic diverticulosis and diverticular hemorrhage in an aging society: lessons from a 9-year colonoscopic study of 28,192 patients in Japan显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Toshiyuki Itoh Yoshimasa Goda Ryuichiro Suda Hideaki Yano Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | International Journal of Colorectal Disease2014，，3： | 2 |
| 18 | Hypoxia-inducible factor-1 alpha is essential for cell cycle arrest during hypoxia 显示文摘 | Goda N Ryan H E Khadivi B | 2003 | Mol Cell Biol2003，23，1： | 1 |
| 19 | The actin cytoskeleton: integrating form and function at the synapse 显示文摘 | DILLON C GODA Y | 2005 | Annual review of neuroscience2005，28，： | 1 |
| 20 | The RRASK motif in xenopus cyclin B2 is required for the substrate recognition of Cdc25C by the cyclin B-Cdc2 complex 显示文摘 | Goda T Ishii T Nakajo N | 2003 | J Biol Chem2003，278，19： | 1 |
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