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| 1 | Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors显示文摘BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation.These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized yet.AIM To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case series.METHODS This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after ER.RESULTS In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 mm.The pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR cases and all cases were treated endoscopically. No patient died due to tumor recurrence.CONCLUSION Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. | Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 2 | A comparison of three methods of decellularization of pig corneas to reduce immunogenicity显示文摘·AIM: To investigate whether decellularization using different techniques can reduce immunogenicity of the cornea, and to explore the decellularized cornea as a scaffold for cultured corneal endothelial cells(CECs).Transplantation of decellularized porcine corneas increases graft transparency and survival for longer periods compared with fresh grafts.·METHODS: Six-month-old wild-type pig corneas were cut into 100-200 μm thickness, and then decellularized by three different methods: 1) 0.1% sodium dodecyl sulfate(SDS); 2) hypoxic nitrogen(N2); and 3) hypertonic NaCl. Thickness and transparency were assessed visually. Fresh and decellularized corneas were stained with hematoxylin/eosin(H&E), and for the presence of galactose-α1,3-galactose(Gal) and N-glycolylneuraminic acid(NeuGc, a nonGal antigen). Also, a human IgM/IgG binding assay was performed. Cultured porcine CECs were seeded on the surface of the decellularized cornea and examined after H&E staining.· RESULTS: All three methods of decellularization reduced the number of keratocytes in the stromal tissue by >80% while the collagen structure remained preserved. No remaining nuclei stained positive for Gal or NeuGc, and expression of these oligosaccharides on collagen was also greatly decreased compared to expression on fresh corneas. Human IgM/IgG binding to decellularized corneal tissue was considerably reduced compared to fresh corneal tissue. The cultured CECs formed a confluent monolayer on the surface of decellularized tissue.· CONCLUSION: Though incomplete, the significant reduction in the cellular component of the decellularized cornea should be associated with a significantly reduced in vivo immune response compared to fresh corneas. | Whayoung Lee Yuko Miyagawa Cassandra Long David K.C.Cooper Hidetaka Hara | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 7 |
| 3 | Urinary 1-hydroxypyrene levels of garbage collectors with low-level exposure to polycyclic aromatic hydrocarbons显示文摘 | Kunio Hara Tomoyuki Hanaoka Yuko Yamano Toru Itani | 1997 | Science of the Total Environment1997，，1： | 1 |
| 4 | Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor显示文摘 | Hoang Anh Vu Yuuichi Beppu Hoang Thanh Chi Kousuke Sasaki Hideaki Yamamoto Phan Thi Xinh Takashi Tanii Yukihiko Hara Toshiki Watanabe Yuko Sato Iwao Ohdomari Gary E. Gallick | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 5 | Distribution of Non-Gal Antigens in Pig Cornea: Relevance to Corneal Xenotransplantation显示文摘 | David Cohen Yuko Miyagawa Ruhina Mehra Whayoung Lee Kumiko Isse Cassandra Long David L. Ayares David K. C. Cooper Hidetaka Hara | 2014 | Cornea2014，，4： | 1 |
| 6 | Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice显示文摘 | Yuko Nonaka Masamitsu Shimazawa Shinichi Yoshimura Toru Iwama Hideaki Hara | 2008 | Neuroscience Letters2008，，2： | 1 |
| 7 | Open-sandwich immunoassay for sensitive and broad-range detection of a shellfish toxin gonyautoxin显示文摘 | Yuko Hara Jinhua Dong Hiroshi Ueda | 2013 | Analytica Chimica Acta2013，，： | 1 |
| 8 | 窄带成像内镜无法发现的食管浅表性鳞状细胞癌的特点显示文摘背景:窄带成像内镜(NBI)对包括高级别上皮内瘤变在内的浅表性食管鳞状细胞癌(SESCC)的检出率明显高于白光内镜。然而,一些SESCC不能被NBI检测到,却可通过卢戈液染色内镜(LCE)检测到;目前这些SESCC的特征尚不清楚。因此,本研究旨在阐明NBI无法检测到的SESCC的特征。方法:本研究纳入患有头颈或食管SCC或者有头颈或食管SCC病史的患者。首先使用NBI进行食管检查,然后使用LCE检查。使用NBI检查过程中对所有可疑的SESCC病灶以及使用LCE检查过程中对不规则形状和大于5 mm和/或粉红色的卢戈液染色不着色的病变(LVL)进行活检。对NBI下无法发现的SESCC进行统计分析。结果:在105例患者中,147个病灶病理诊断为SESCC,其中15例患者中的20个病灶在NBI下无法检测到;这些病灶的形态均为肉眼观察下的扁平型(0-IIb)。NBI无法检测到的和NBI检测到的病灶大小的中值均为15 mm(P=0.47)。多因素分析揭示了NBI下无法检测到的病灶的独立因素,如大量不规则形状LVL(比值比[OR]:4.94,95%置信区间[CI]:1.39–17.5,P<0.05)和病灶位于食管前壁(OR:4.99,95%CI:1.58–15.8,P<0.05)。结论:当病灶形态完全扁平、内镜下观察到许多不规则形状的LVL或者病灶位于食管前壁时,单独使用NBI检测SESCC具有挑战性。 | Shingo Ono Akira Dobashi Hiroto Furuhashi Akio Koizumi Hiroaki Matsui Yuko Hara Kazuki Sumiyama | 2021 | Gastroenterology Report2021，9，5： | 1 |
| 9 | Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum显示文摘 | Mariko Sue Moyuru Hayashi Akira Kawashima Takeshi Akama Kazunari Tanigawa Aya Yoshihara Takeshi Hara Yuko Ishido Tetsuhide Ito Shin-Ichiro Takahashi Norihisa Ishii Koichi Suzuki | 2012 | Biochemical and Biophysical Research Communications2012，，3： | 1 |
| 10 | Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse显示文摘 | Yuko Hara Elizabeth M. Waters Bruce S. McEwen John H. Morrison | 2015 | Physiological Reviews2015，，3： | 1 |
| 11 | Proposal and quantitative analysis of the CHStone benchmark program suite for pratical C-based high-level synthesis 显示文摘 | Yuko Hara Hiroyuki Tomiyama Shinya Honda | 2009 | Journal of Information Processing2009，4，4： | 1 |
| 12 | Activation of the Activin A-ALK-Smad pathway in systemic sclerosis显示文摘 | Kae Takagi Yasushi Kawaguchi Manabu Kawamoto Yuko Ota Akiko Tochimoto Takahisa Gono Yasuhiro Katsumata Masatoshi Takagi Masako Hara Hisashi Yamanaka | 2010 | Journal of Autoimmunity2010，，3： | 1 |
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