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| 1 | Non-invasive diagnosis of liver fibrosis and cirrhosis显示文摘The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, during the last 20 years, it has become evident that this 'gold-standard' is imperfect; even according to its proponents, it is only 'the best' among available methods. Attempts at uncovering non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and can be repeated essentially as often as required. Most are much less expensive than liver biopsy. Consequently, their use is growing, and in some countries the number of biopsies performed, at least for routine evaluation of hepatitis B and C, has declined sharply. However, the accuracy and diagnostic value of most, if not all, of these methods remains controversial. In this review for the practicing physician, we analyze established and novel biomarkers and physical techniques. We may be witnessing in recent years the beginning of the end of the first phase for the development of non-invasive markers. Early evidence suggests that they might be at least as good as liver biopsy. Novel experimental markers and imaging techniques could produce a dramatic change in diagnosis in the near future. | Yoav Lurie Muriel Webb Ruth Cytter-Kuint Shimon Shteingart Gerardo Z Lederkremer | 2015 | World Journal of Gastroenterology2015，21，41： | 36 |
| 2 | Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis显示文摘AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages. RESULTS: The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedminimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL). CONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential. | Ron Benyair Maria Kondratyev Elena Veselkin Sandra Tol-chinsky Marina Shenkman Yoav Lurie Gerardo Z Lederkremer | 2011 | World Journal of Gastroenterology2011，17，48： | 3 |
| 3 | Liver transplantation in patients with portal vein thrombosis显示文摘 | Gerardo Manzanet Fernando Sanjuán Paco Orbis Rafael López ángel Moya Manuel Juan Juanjo Vila Josep Asensi Pedro Sendra José Ru??z Mart??n Prieto José Mir | 2001 | Liver Transplantation2001，，2： | 1 |
| 4 | Aero- monas hydrophila clinical and environmental ecotypes as revealed by genetic diversity and virulence genes 显示文摘 | MaGuadalupe A A Cesar H R Gerardo Z | 2005 | FEMS Microbiol Lett2005，，10： | 1 |
| 5 | Color Doppler ultrasound in the preoperative assessment of adnexal masses显示文摘 | Gerardo Z Patrizia V Andrea L | 1994 | Acta Obstet Gynecol Scand1994，73，8： | 1 |
| 6 | Survival and reproductive function after treatment of malignant germ cell ovarian tumors 显示文摘 | Gerardo Z Crisfina B Maria GC | 2001 | Clin Oncolo2001，19，2： | 1 |
| 7 | Molecular phylogeny of Cypripedium (Orchidaceae:Cypripedioideae) inferred from multiple nuclear and chloroplast regions显示文摘 | Li J H Liu Z J Gerardo A | 2011 | Molecular Phylogenetics and Evolution2011，61，： | 1 |
| 8 | Survival and reproductive function after treatment of malignant germ cell ovarian tumors显示文摘 | Gerardo Z Cristina B Maria GC | 2006 | Journal of Clinical Oncology2006，19，2： | 1 |
| 9 | Aeromonas hydrophila clinical and environmental ecotypes as revealed by genetic diversity and viru- lence genes显示文摘 | Maga A Cesar H R Gerardo Z | 2005 | FEMS Microbiol Lett2005，242，： | 1 |
| 10 | Aeromonas hydrophila clinical and environmental ecotypes as revealed by genetic diversity and virulence genes显示文摘 | MA G A A CESAR H R GERARDO Z | 2005 | FEMS Microbiol Lett2005，242，： | 1 |
| 11 | Aeromonas hydrophila clinical and environmental ecotypes as revealed by genetic diversity and virulence genes显示文摘 | Ma G A A Cesar H R Gerardo Z | 2005 | FEMS Microbiol Lett2005，242，： | 1 |
| 12 | Survival and reproductive function after treatment of malignant germ cell ovarian tumors显示文摘 | Gerardo Z Cristina B Maria G C | 2001 | Journal of Clinical Oncology2001，19，2： | 1 |
| 13 | Survival and reproductive function after treatment of malignant germ cell ovarian tumors显示文摘 | Gerardo Z Cristina B Maria GC | 2006 | Journal of Clinical Oncology2006，19，2： | 1 |
| 14 | PAHs in American oyster Crassostrea virginica from the Terminos Lagoon,Campeche,Mexico显示文摘 | ELSA N GERARDO G OMAR Z Et al | 1999 | Marine Pollution Bulletin1999，38，8： | 1 |
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