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| 1 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 2 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020，17，1： | 5 |
| 3 | A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining:cell body to cell size ratio显示文摘Aim:The aim was to validate a newly developed methodology of semi-automatic image analysis to analyze microglial morphology as marker for microglial activation in ionized calcium-binding adaptor protein-1(IBA-1)stained brain sections.Methods:The novel method was compared to currently used analysis methods,visual characterization of activation stage and optical density measurement,in brain sections of young and aged rats that had undergone surgery or remained naïve.Results:The cell body to cell size ratio of microglia was strongly correlated to the visual characterization activation stage.In addition,we observed specific surgery and age-related changes in cell body size,size of the dendritic processes and cell body to cell size ratio.Conclusion:The novel analysis method provides a sensitive marker for microglial activation in the rat brain,which is quick and easy to perform and provides additional information about microglial morphology. | Iris Bertha Hovens Csaba Nyakas Regien Geertruida Schoemaker | 2014 | Neuroimmunology and Neuroinflammation2014，1，1： | 2 |
| 4 | Variation in the kinetics of caspase-3 activation,Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel显示文摘 | Geertruida MK Theresia MH Monique CAD | 2002 | Biochemical Pharmacology2002，63，4： | 1 |
| 5 | Simultaneous integrated boost irradiation after breast-conserving surgery: physician-rated toxicity and cosmetic outcome at 30 months' follow-up显示文摘 | Enja J Comelis L geertruida H | 2012 | Int J Radiat Oncol Biol Phys2012，82，4： | 1 |
| 6 | Systematic screening for urinary incontinence in older women: Who could benefit from it?显示文摘 | Els Visser Geertruida H. de Bock Boudewijn J. Kollen Marije Meijerink Marjolein Y. Berger Janny H. Dekker | 2012 | Scandinavian Journal of Primary Health Care2012，，： | 1 |
| 7 | Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey显示文摘 | Geertruida A. Posthuma-Trumpie Jakob Korf Aart Amerongen | 2009 | Analytical and Bioanalytical Chemistry2009，，2： | 1 |
| 8 | Variation in the kinetics of easpase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel 显示文摘 | Geertruida M Kolfschoten T M | 2002 | Bio Pharm2002，63，4： | 1 |
| 9 | Epidemiology of chronic non-cancer pain in Europe: narrative review of prevalence, pain treatments and pain impact显示文摘 | Kim J. Reid Julie Harker Malgorzata M. Bala Carla Truyers Eliane Kellen Geertruida Elsiena Bekkering Jos Kleijnen | 2011 | Current Medical Research & Opinion2011，，2： | 1 |
| 10 | Uhraslow microdialysis and microfiltration for in-line, on-line and off-line monitoring显示文摘 | Jakob Korf Kirsten D Huinink Geertruida A | 2010 | Trends Biotechnol2010，28，3： | 1 |
| 11 | Systematic screening for urinary incontinence in older women: Who could benefit from it?显示文摘 | Els Visser Geertruida H. de Bock Boudewijn J. Kollen Marije Meijerink Marjolein Y. Berger Janny H. Dekker | 2012 | Scandinavian Journal of Primary Health Care2012，，1： | 1 |
| 12 | A randomized trial of methotrexate versus azathioprine for severe atopic eczema显示文摘 | Mandy Elvira Schram Evelien Roekevisch Mariska Maria Geertruida Leeflang Jan Dositheus Bos Jochen Schmitt Phyllis Ira Spuls | 2011 | The Journal of Allergy and Clinical Immunology2011，，： | 1 |
| 13 | Ultraslow microdialysis and microfiltration for in-line,on-line and off-line monitoring显示文摘 | Korf J Huininka KD Geertruida A | 2010 | Trends in Biotechnology2010，28，3： | 1 |
| 14 | Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey显示文摘 | Geertruida A. Posthuma-Trumpie Jakob Korf Aart Amerongen | 2009 | Analytical and Bioanalytical Chemistry2009，，2： | 1 |
| 15 | Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis显示文摘 | XueQian Xie Pim Jong Matthijs Oudkerk Ying Wang Nick Hacken Jingtao Miao GuiXiang Zhang Geertruida Bock Rozemarijn Vliegenthart | 2012 | European Radiology2012，，10： | 1 |
| 16 | Laparoscopic hyster- ectomy is preferred over laparotomy in early endometrial cancer pa- tients, however not cost effective in the very obese显示文摘 | Claudia BMB Geertruida HB Karin MV | 2011 | European Journal of Cancer2011，47，14： | 1 |
| 17 | Validation of the 4B5 rabbit monoclonal antibody in determining HER-2/neu status in breast cancer显示文摘 | van der Vegtl B de Bock Geertruida H Joost B | 2009 | Mod Pathol2009，22，7： | 1 |
| 18 | Differences and similarities in breast cancer risk assessment models in clinical practice: which model to choose?显示文摘 | Catharina E. Jacobi Geertruida H. Bock Bob Siegerink Christi J. Asperen | 2009 | Breast Cancer Research and Treatment2009，，2： | 1 |
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