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| 1 | Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI显示文摘瞄准:与已知的额外的肝的原发性瘤对包括 CT, MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法:它是一国际多集中学习,并且有 12 个中心和 125 个病人(64 男性, 61 女性,变老 59+/-11 年) 包含,与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色,在 27% 的胸,在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra, Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用;为至少五分钟的连续扫描。结果:有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人,更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的,三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人,后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论:CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。 | Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse Robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert Hahn Christian Greis | 2006 | World Journal of Gastroenterology2006,12,11: | 39 |
| 2 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019,16,1: | 7 |
| 3 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020,17,1: | 5 |
| 4 | Multislice CT angiography in the selection of patients with ruptured intracranial aneurysms suitable for clipping or coiling显示文摘 | H. E. Westerlaan J. Gravendeel D. Fiore J. D. M. Metzemaekers R. J. M. Groen J. J. A. Mooij M. Oudkerk | 2007 | Neuroradiology2007,,12: | 2 |
| 5 | Coronary angiography with multi-slice computed tomography显示文摘 | Nieman K Oudkerk M Rensing BJ | 2001 | Lancet2001,357,9256: | 1 |
| 6 | Prevalence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study显示文摘 | Sarah E. Vermeer Peter J. Koudstaal Matthijs Oudkerk Albert Hofman Monique M.B. Breteler | 2002 | Stroke: Journal of the American Heart Association2002,,1: | 1 |
| 7 | Angiography with multi-slice computed tomography显示文摘 | Nieman K Oudkerk M Rensing BJ | 2001 | Lancet2001,357,9256: | 1 |
| 8 | Cavernous transformation of the portal vein secondary to tumor thrombosis of hepatocellular car- cinoma : spiral CT visualization of the collateral vessels显示文摘 | Song B Min P Oudkerk M | 2000 | Abdom Imaging2000,25,4: | 1 |
| 9 | Hypertension and cerebral white matter lesion in a prospective cohort study显示文摘 | De Leeuw FE de Groot JC Oudkerk M | 2002 | Brain2002,125,4: | 1 |
| 10 | Coronary anglo- raphy with multi-slice computed tomography 显示文摘 | Nieman K Oudkerk M Rensing BJ | 2001 | Lancet2001,357,9256: | 1 |
| 11 | Coronary calcification improves cardiovascular risk prediction in the elderly显示文摘 | Oudkerk M Hofman A | 2005 | Circulation2005,112,4: | 1 |
| 12 | Coronary fly-through or virtual angioscopy using dual-source MDCT data 显示文摘 | van Ooijen P M A de Jonge G Oudkerk M | 2007 | European Journal of Radiology2007,17,11: | 1 |
| 13 | 1H chemical shift imaging charac- terization of human brain tumor and edema 显示文摘 | Sijens PE Oudkerk M | 2002 | Eur Radiol2002,12,: | 1 |
| 14 | Perfusion MR imaging for differentiation of benign and malignant meningiomas显示文摘 | Hao Zhang Lars A. R?diger Tianzhen Shen Jingtao Miao Matthijs Oudkerk | 2008 | Neuroradiology2008,,6: | 1 |
| 15 | Hypertension and cerebral white matter lesions in a prospective cohort study显示文摘 | de Leeuw FE de Groot JC Oudkerk M | | 0,,: | 1 |
| 16 | Prospects for population screening and diagnosis of lung cancer显示文摘 | Field JK Oudkerk M Pedersen JH | 2013 | Lancet2013,382,6: | 1 |
| 17 | Comparison of con- trast enhanced magnetic resonance angiography embolism:a pro- spective study显示文摘 | Oudkerk M van BEJ Widlopolski P | 2002 | Lancet2002,359,9318: | 1 |
| 18 | Prevalence and risk factors of silent brain infarcts in the Population-Based Rotterdam Scan Study显示文摘 | Vermeer SE Koudstaal PJ Oudkerk M | 2002 | Stroke2002,33,1: | 1 |
| 19 | Atrial fibrillation and the risk of cerebral white matter lesions 显示文摘 | de Leeuw FE de Groot JC Oudkerk M | 2000 | Neurology2000,54,9: | 1 |
| 20 | Cerebral white matter lesions and cognitive function:the rotterdam scan study显示文摘 | De Groot J C de L eeuw F E Oudkerk M | 2000 | Ann Neurol2000,47,2: | 1 |