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| 1 | 基于水声学探测的香溪河鱼类资源时空分布特征评估显示文摘为了掌握三峡水库香溪河鱼类资源时空分布特征,2013年5月和11月运用Simrad EY60型分裂波束回声探测仪在香溪河进行了水声学探测,辅以常规渔获物分析方法。渔获物调查共发现鱼类7科41种,其中似鳊、贝氏、、银和蛇等小型鱼类在数量上占据优势地位。水声学探测结果表明,香溪河春季鱼类密度显著高于秋季,采用加权平均法求得2013年5月和11月探测的鱼类密度分别为53.4和15.4 ind./1000 m3。鱼类资源在空间上不均匀分布,从高岚河至香溪河口鱼类密度逐渐降低;在垂直方向上,春季和秋季水声学探测的鱼类密度显示出相同的趋势,即表层>中层>底层。在运用鱼类生物操纵改善水质途径方面,建议通过壮大肉食性鱼类种群来控制小型鱼类资源量,同时通过增殖放流鲢、鳙以加强对浮游植物的滤食作用。 | 连玉喜 黄耿 Malgorzata Godlewska 李翀 赵修江 叶少文 李钟杰 | 2015 | 水生生物学报2015，39，5： | 23 |
| 2 | Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease显示文摘AIM:To assess the mucosa-associated bacterial microflora and mucus layer in adolescents with inflammatory bowel disease(IBD) .METHODS:Sixty-one adolescents(mean age 15 years,SD ± 4.13) were included in the study.Intestinal biopsies from inflamed and non-inflamed mucosa of IBD patients and from controls with functional abdominal pain were cultured under aerobic and anaerobic conditions.The number of microbes belonging to the same group was calculated per weight of collected tissue.The mucus thickness in frozen samples was measured under a fluorescent microscope.RESULTS:The ratios of different bacterial groups in inflamed and non-inflamed mucosa of IBD patients and controls were specific for particular diseases.Streptococcus spp.were predominant in the inflamed mucosa of Crohn's disease(CD) patients(80% of all bacteria) ,and Lactobacillus spp.were predominant in ulcerative colitis patients(90%) .The differences were statistically significant(P = 0.01-0.001) .Lower number of bifidobacteria was observed in the whole IBD group.A relation was also found between clinical and endoscopic severity and decreased numbers of Lactobacillus and,to a lesser extent,of Streptococcus in biopsies from CD patients.The mucus layer in the inflamed sites was significantly thinner as compared to controls(P = 0.0033) and to non-inflamed areas in IBD patients(P = 0.031) .CONCLUSION:The significantly thinner mucosa of IBD patients showed a predominance of some aerobes specific for particular diseases,their numbers decreased in relation to higher clinical and endoscopic activity of the disease. | Krzysztof Fyderek Magdalena Strus Kinga Kowalska-Duplaga Tomasz Gosiewski Andrzej Wedrychowicz Urszula Jedynak-Wasowicz Malgorzata Sladek Stanislaw Pieczarkowski Pawel Adamski Piotr Kochan Piotr B Heczko | 2009 | World Journal of Gastroenterology2009，15，42： | 14 |
| 3 | 油菜茎基溃疡病菌在中国定殖的可能性评估显示文摘为明确油菜茎基溃疡病菌Leptosphaeria maculans在我国定殖的可能性,并制订针对性的检疫措施,本研究基于该病菌在英国、法国、德国、波兰、加拿大、澳大利亚的分布数据,选取与病害发生有关的温度、降水量等15个变量,利用Max Ent和GARP两种生态位模型预测其在其它地区的潜在分布,并利用受试者工作特征曲线(ROC)来评价模型模拟精度。结果显示,2种模型均能够较好地预测L.maculans的分布区域,与已记载的分布区域高度吻合,且全球范围内存在着许多高度适合L.maculans定殖的地区;2种模型也能预测L.maculans在我国的潜在分布区域,并且预测结果一致;GARP结果显示L.maculans在我国的中高度适生区包括内蒙古、吉林、陕西、宁夏、甘肃、新疆、西藏等地。鉴于L.maculans在我国的潜在分布研究结果,建议完善疫情监测体系,采取措施控制病菌的'进入风险',降低病菌'进入'后定殖的可能性。 | 孙颖 周国梁 Malgorzata Jedryczka 陈艳 易建平 | 2015 | 植物保护学报2015，42，4： | 11 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis显示文摘瞄准:尖锐胰腺炎(AP ) 是最普通、经常严重的复杂并发症内视镜后退 cholangiopancreatography (ERCP ) 。在尖锐胰腺炎的致病的早步可能是毛状的内皮损害由导出氧的自由基调停了。N-acetylcysteine - 自由基 scavenger 可能在阻止尖锐胰腺炎和它是的 post-ERCP 是潜在地有效的也知道那个 N-acetylcysteine (ACC ) 罐头在 AP 的试验性的模型减少疾病的严厉。方法:106 个病人随机被分配到二个组。55 个病人被给 N-acetylcysteine (口头上地,在 ERCP 和 600 mg 前的 24 和 12 h 被给 iv 的二 600 mg 剂量,两次为在 ERCP 以后的二天的一天) 。控制组由被给 iv 的 51 个病人组成了。等渗盐两次为在 ERCP 以后的二天的一天。浆液和尿淀粉酶活动在过程以后在 ERCP 和 8 和 24 h 前被测量。主要结果参数是尖锐胰腺炎和第二等的结果参数是的 post-ERCP 在浆液和尿淀粉酶活动的组之间的差别。结果:处于在二个组之间的 post-ERCP 胰腺炎的率没有有效差量(10 病人外套, 4 在 ACC 组织, 6 在控制组织) 。也在在 ACC 组和控制组之间的基线和 post-ERCP 浆液和尿淀粉酶活动没有有效差量。结论:N-acetylcysteine 没能在 post-ERCP 胰腺炎上,以及在浆液和尿淀粉酶活动上表明任何重要预防效果。 | Janusz Milewski Grazyna Rydzewska Malgorzata Degowska Maciej Kierzkiewicz Andrzej Rydzewski | 2006 | World Journal of Gastroenterology2006，12，23： | 10 |
| 6 | Developmental Toxicity in Mice Following Paternal Exposure to Di-N-Butyl-Phthalate (DBP)显示文摘Objective The aim of the present study was to investigate the effects of paternal Di‐N‐butyl‐phthalate (DBP) exposure pre‐ and postnatally on F1 generation offspring,and prenatally on F2 generation offspring.Methods Male mice were exposed to either 500 mg/kg or 2 000 mg/kg of DBP for 8 weeks,and mated with non‐exposed females.Three‐quarters of the females were sacrificed a day prior to parturition,and examined for the number of living and dead implantations,and incidence of gross malformations.Pups from the remaining females were assessed for developmental markers,growth parameters,as well as sperm quantity and quality.Results There were no changes in the fertility of parents and in intrauterine development of the offspring.Pups of DBP‐exposed males demonstrated growth‐retardation.Following paternal exposure to 500 mg/kg bw of DBP,there were almost twice the number of males than females born in the F1 generation.F1 generation females had a 2.5‐day delay in vaginal opening.Paternal exposure to 2 000 mg/kg bw of DBP increased the incidence of sperm head malformations in F1 generation males;however,there were no changes in the fertility and viability of foetuses in the F2 generation.Conclusion Paternal DBP exposure may disturb the sex ratio of the offspring,delay female sexual maturation,and deteriorate the sperm quality of F1 generation males. | Malgorzata M.DOBRZY SKA Ewa J.TYRKIEL Krzysztof A.PACHOCKI | 2011 | Biomedical and Environmental Sciences2011，24，5： | 9 |
| 7 | Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis显示文摘AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker.METHODS Serum IL9 as well as other cytokines(IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease(CD) and 74 with ulcerative colitis(UC) and in 122 apparently healthy controls. The clinical activity of CD and UC was expressed in terms of the Crohn's Disease Activity Index(CDAI) and the Mayo Scoring System(MDAI), respectively, and the severity of bowel inflammation in UC patients was assessed using Mayo endoscopic score. Cytokine concentrations were measured by a flow cytometry-based method using Luminex x MAP? technology. Highsensitive C-reactive protein concentrations(hs CRP) were determined in CD and UC patients using the enhanced immunoturbidimetric method.RESULTS Systemic IL9 was significantly lower in healthy individuals [9 pg/m L(95%CI: 8.2-10)] than in patients with inflammatory bowel disease(IBD): both inactive [14.3 pg/m L(11.9-19.9)] and active [27.6 pg/m L(24.5-32), P < 0.0001]. Cytokine concentrations were significantly higher in active CD [27.4 pg/m L(23.4-32.2)] and in active UC [32.7 pg/m L(27-38.9)] compared to inactive diseases [15.9 pg/m L(10.8-23.4) in CD and 19.4 pg/m L(13.9-27.1) in UC, P = 0.001]. IL9 correlated weakly with CDAI(ρ = 0.32, P = 0.003) and MDAI(ρ = 0.35, P = 0.002) and strongly with endoscopic inflammation in UC(ρ = 0.74, P < 0.0001). As a negative marker of mucosal healing(MH), IL9 had an accuracy superior to hs CRP and IL6 [97%(P < 0.0001), 67%(P = 0.071), and 55%(P = 0.525), respectively]. IL9 was significantly higher in cachectic IBD patients [30.25 pg/m L(24.4-37.5) vs 21.88 pg/m L(18-26.5), P = 0.026] and negatively correlated with hemoglobin concentrations(ρ =-0.27, P < 0.001). Multiple regression showed IL1β and IL13 to be the independent predictors of circulating IL9 in healthy individuals, IFNγ or IL6 in active and inactive UC, respectively, and IL13 and VEGF-A in both active and inactive CD.CONCLUSION The systemic IL9 level is higher in IBD and corresponds with endoscopic inflammation, suggesting its possible application as a negative marker of mucosal healing in UC. | Malgorzata Matusiewicz Katarzyna Neubauer Iwona Bednarz-Misa Sabina Gorska Malgorzata Krzystek-Korpacka | 2017 | World Journal of Gastroenterology2017，23，22： | 9 |
| 8 | Hepatitis C virus infection in children in the era of directacting antiviral显示文摘Hepatitis C virus(HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral(DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C. | Malgorzata Pawlowska Malgorzata Sobolewska-Pilarczyk Krzysztof Domagalski | 2018 | World Journal of Gastroenterology2018，24，24： | 8 |
| 9 | 三峡库区香溪河鱼类资源水声学探测效果的昼夜差异研究显示文摘三峡大坝的建设和运行很大程度上改变了库区的生态环境,如水文特征、水生生物等,势必影响到鱼类群落结构及分布。由于受到空间范围和生境复杂性等因素的制约,传统的鱼类资源调查方法在大型深水水库实施时存在费时费力、误差大等问题,而水声学探测法作为一种新型评估方法具有高效快捷、不损伤调查对象等优点。 | 连玉喜 叶少文 黄耿 Malgorzata Godlewska 王静雅 刘家寿 李钟杰 | 2015 | 水生生物学报2015，39，5： | 8 |
| 10 | Potential of the ellagic acid-derived gut microbiota metabolite–Urolithin A in gastrointestinal protection显示文摘Urolithin A(UA)is a metabolic compound generated during the biotransformation of ellagitannins by the intestinal bacteria.The physiologically relevant micromolar concentrations of UA,achieved in the plasma and gastrointestinal tract(GI)after consumption of its dietary precursors,have been revealed to offer GI protection.The health benefit has been demonstrated to be principally related to anticancer and anti-inflammatory effects.UA has been shown to possess the capability to regulate multiple tumor and inflammatory signaling pathways and to modulate enzyme activity,including those involved in carcinogen biotransformation and antioxidant defense.The purpose of this review is to gather evidence from both in vitro and in vivo studies showing the potential of UA in GI protection alongside suggested mechanisms by which UA can protect against cancer and inflammatory diseases of the digestive tract.The data presented herein,covering both studies on the pure compound and in vivo generated UA form its natural precursor,support the potential of this metabolite in treatment interventions against GI ailments. | Malgorzata Kujawska Jadwiga Jodynis-Liebert | 2020 | World Journal of Gastroenterology2020，26，23： | 8 |
| 11 | Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus显示文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon. | Krzysztof Domagalski Malgorzata Pawlowska Agnieszka Zalesna Malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn | 2016 | World Journal of Gastroenterology2016，22，41： | 7 |
| 12 | 波兰、英国油菜种子样本的健康测试及黑胫病病原菌感染分析(英文)显示文摘对来自波兰及英国的2个相同品种的油菜种子样品进行了健康测试,并重点观察了油菜黑胫病病原菌(Letosphaeriamac ulans/Phomalingam)感染的程度及菌系类型.结果表明来自2个国家的种子都一定程度受微生物感染,品种间差异不大,所检测到的较多的菌属为Alternaria,Fusarium及Penicillium.黑胫病病原菌感染的百分率波兰种子样品平均为0.5%,英国种子样品平均为0.6%,菌系鉴定表明,7.1%的波兰株系及12.3%的英国株系为强致病的Tox+类型.此外,还发现健康测试前种子表面消毒可提高黑胫病病原菌的检出率. | 汪国平 胡开林 Malgorzata JEDRYCZKA | 2003 | 华南农业大学学报2003，24，4： | 7 |
| 13 | Arabidopsis Protein Phosphatase 2C ABI1 Interacts with Type I ACC Synthases and Is Involved in the Regulation of Ozone-Induced Ethylene Biosynthesis显示文摘它的生合成严格地是的在各种各样的生物过程并且因此的一个关键角色由 multiplemechanisms 调整了的乙烯戏。Posttranslational 规定,在控制乙烯生合成枢轴,经由特定的因素的复杂相互影响影响 1-aminocyclopropane1-carboxylate synthase (交流) 蛋白质稳定性。这里,我们证明 Arabidopsis thaliana 蛋白质磷酸酶打 2C, ABI1, abscisic 酸发信号的一个否定管理者,在氧化压力条件下面涉及 ethylenebiosynthesis 的规定。我们发现 ABI1 与 ACS6 和 dephosphorylates 交往它的 C-terminalfragment,压力应答的激活 mitogen 的蛋白质 kinase 的一个目标, MPK6。另外, ABI1 控制 MPK6 也 activitydirectly 并且由这个工具影响 ACS6 phosphorylation 水平。一致地与这,在 ABI1 猛烈紧张(abi1td ) 显著地更高的导致臭氧的乙烯 productionwas 比在野类型的植物。重要地,在 abi1td 异种的导致压力的乙烯生产的增加由一个更高的 ascorbate 氧化还原作用状态被补偿并且提高了抗氧化剂活动。总的来说, thisstudy 的结果提供 ABI1 由影响 ACS6 的活动限制乙烯合成的证据。ABI1 贡献 tostress 显型支撑它在在 abscisic 酸(骆驼毛的织物) 和表明 pathways.Key 词的乙烯之间的相互影响的角色: | Agnieszka Ludwikow Agata Ciesla Anna Kasprowicz-Malusk Filip Mitula Malgorzata Tajdel lukasz Gaigarnski Piotr A. Ziolkowski Piotr Kubiak Arleta Malecka Aneta Piechalak Marta Szabat Alicja Gorska Maciej Dabrowskia Izabela Ibragimow Jan Sadowski | 2014 | Molecular Plant2014，7，6： | 6 |
| 14 | Phosphorus mobility in dam reservoir affected by redox oscillations:An experimental study显示文摘The internal sedimentary phosphorus(P) load of aquatic systems is able to support eutrophication, especially in dam–reservoir systems where sedimentary P stock is high and where temporary anaerobic conditions occur. The aim of this study therefore is to examine the response of sedimentary P exposed to redox oscillations. Surface sediments collected in the Champsanglard dam–reservoir(on the Creuse River, France) were subjected to two aerobic phases(10 and 12 days) alternated with two anaerobic periods(21 and 27 days)through batch incubations. The studied sediment contained 77 ± 3 μmol/g DW of P, mainly associated with the ascorbate fraction(amorphous Fe/Mn oxyhydroxides). The used sediment was rich in organic matter(OM)(21% ± 1%) with primarily allochthone signature.Our results showed that redox oscillations enhance dissolved inorganic phosphorus release at sediment/water interface. During the first anaerobic stage, the P release was mainly controlled by the dissolution/precipitation of iron minerals. The more pronounced increase of P release during the second anaerobic stage(44%) was due to various mechanisms related to the change in quality of dissolved organic matter(DOM), namely a higher SUVA254 and humification indices. The release of more refractory DOM(rDOM) served to lower the microbial metabolism activity, possibly favored iron oxyhydroxide aggregation and thus limiting iron reduction. In addition, rDOM is able to compete for mineral P sorption sites,leading to a greater P release. In reservoir with predominant allochthone OM input, the release of more aromatic DOM therefore plays an important role in P mobility. | Anne Rapin Malgorzata Grybos Marion Rabiet Brice Mourier Véronique Deluchat | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 15 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 16 | 利用油菜花瓣实验检测油菜菌核病显示文摘为了探索预测油菜菌核病发生情况的快速、简单、有效的方法;此研究采用检测被核盘菌子囊孢子感染的油菜花瓣数量来预测预报菌核病可能发生严重度程度,实验采用添加了两种不同pH指示剂的改良型Steadman's培养基在室温下培养在油菜花期(3月下旬~4月中旬)每天采自2块试验田的新鲜花瓣,如果花瓣被病原菌子囊孢子感染,接种培养后培养基颜色发生改变,统计被感染的花瓣数;结果表明:除1天在一块田没有检测到被子囊孢子感染的花瓣外,油菜整个花期都有被感染的花瓣出现,但初花期被感染的花瓣较少,而盛花期和终花期被感染的花瓣较多,第一块田被感染的花瓣数在两种培养基上出现的百分率分别为32.0%和40.2%,第二块田分别为27.3%和35.7%。第一块田后期油菜菌核病的发病率和病指分别为2.7%和1.8,第二块田分别为1.5%和0.4。子囊孢子感染的花瓣数与后期油菜菌核病的发病率呈显著正相关(r=0.829,r0.05=0.811)。利用油菜花瓣实验可快速、简单、有效的预测后期油菜菌核病可能发生的情况,从而决定最适宜的防治时期。 | 侯树敏 Malgorzata Jedryczka 李强生 胡宝成 费维新 陈凤祥 吴新杰 江莹芬 | 2009 | 中国农学通报2009，25，17： | 6 |
| 17 | Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales显示文摘BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial importance.Despite a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,yet.AIM To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the study.Hematological indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each person.Model for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD patients.Receiver operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and NAFLD.RESULTS MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly lower.MPR and PLR correlated with assessed indirect and direct markers of liver fibrosis.MPR,NLR and PLR correlated with MELD score.NLR level in NAFLD patients was significantly higher in comparison to controls.MPR correlated with indirect markers of liver fibrosis and NAFLD fibrosis score.AUC values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(>2.227),0.675(<70.445)and 0.929(>0.048),respectively.AUC values and proposed cut-offs for NLR,PLR and MPR in NAFLD group were:0.725(>2.034),0.528(>97.101)and 0.547(>0.038),respectively.CONCLUSION Hematological markers are inseparably connected with serological indices of liver fibrosis in ALC and NAFLD patients.MPR and NLR turned out to be the most powerful parameters in ALC patients. | Agata Michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Andrzej Stepulak | 2020 | World Journal of Gastroenterology2020，26，47： | 6 |
| 18 | Global standard names for the Lowermost Cambrian Series and Stage显示文摘 | Ed Landing Shanchi Peng Loren E. Babcock Gerd Geyer Malgorzata Moczydlowska- Vidal | 2007 | Episodes2007，30，4： | 5 |
| 19 | 利用微卫星标记分析核盘菌遗传多样性显示文摘利用微卫星(SSR)标记,分析来自欧洲和中国的30个核盘菌菌株的遗传多样性和群体结构。结果表明,3对微卫星引物共扩增出21条清晰的谱带,平均每对引物扩增7条谱带,片段长度为158bp~358bp。根据SSR分析结果,30个核盘菌分离物具有较高的遗传相似性。物种水平的Nei遗传多样性指数为0.139 3,Shannon多样性指数为0.248 8。不同菌株群体的Nei遗传距离都较小,为0.009 6~0.049 6。其中俄罗斯群体和奥地利及英国群体之间的遗传距离最大。从30个菌株的UPGMA聚类分析结果看,核盘菌群体结构与地理来源没有明显的直接关系。许多地理来源相同的菌株分散在不同的组里。仅第三组组内的菌株地理来源一致,均来自于中国,且遗传距离比其他菌株的远。群体遗传分析显示,总群体的基因流比较高(2.111 6),基因分化系数比较低(0.191 5)。 | 段晓莉 Witold Irzykowski Malgorzata Jedryczka 李强生 江莹芬 范志雄 胡宝成 | 2012 | 中国油料作物学报2012，34，3： | 5 |
| 20 | DISC1 genetics, biology and psychiatric illness显示文摘精神病学的混乱是高度可继承的,并且在许多,个人们多半从基因和环境的联合效果产生。向是影响的基因之一精神分裂症,双极的混乱和消沉冒险的 DISC1 的证据点的实质的身体,和 DISC1 的功能的研究因而有潜力关于导致主要精神病的小径揭示大部分。这里,我们考察 DISC1 在发展和成年大脑在多重批评小径之上通过效果影响疾病风险的证据。 | Pippa A. THOMSON Elise L.V. MALAVASI Ellen GRüNEWALD Dinesh C. SOARES Malgorzata BORKOWSKA J. Kirsty MILLA | 2013 | Frontiers in Biology2013，8，1： | 5 |
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