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| 1 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 2 | Thermally assisted semiconductor-like to insulator transition in gold-poly(methyl methacrylate) nanocomposites显示文摘 | Abyaneh M K Pasricha R Gosavi S W | 2006 | Nanotechnology2006，17，16： | 1 |
| 3 | Trends in average living children at the time of terminal contraception: a time series analysis over 27 years using ARIMA ( p, d, q ) nonseasonal model 显示文摘 | Mumbare SS Gosavi S Almale B | 2014 | Indian J Cnmmunity Ned2014，39，4： | 1 |
| 4 | Matching, linear systems, and the ball and beam 显示文摘 | ANDREEV R AUCIDY D GOSAVI S | 2002 | Automatica2002，38，： | 1 |
| 5 | Rapid detection ofEscherichia coli by using antibody-conjugated silver nanoshells 显示文摘 | KALELE S A KUNDU A A GOSAVI S W | 2006 | Small2006，2，3： | 1 |
| 6 | Tympanosclerosisa beginner's worry:a case series and review of literature显示文摘 | ASARKAR A GOSAVI S | 2013 | Otolaryngology2013，3，： | 1 |
| 7 | In-situ citric acid crosslinking of alginate/polyvinyl alcohol electrospun nanofibers显示文摘 | STONE S A GOSAVI P ATHAUDA T J | 2013 | Materials Letters2013，112，12： | 1 |
| 8 | Rapid detection of Escherichia coli by using antibody-conjugated silver nanoshells 显示文摘 | KALELE S A KUNDU A A GOSAVI S W | 2006 | Small2006，2，3： | 1 |
| 9 | 显示文摘 | Kalele S Gosavi S W Urban J | 2006 | Current Science2006，91，8： | 1 |
| 10 | 显示文摘 | Sharma G Gosavi S W Lochab S P | 2012 | Journal of Lumi- nescence2012，10，132： | 1 |
| 11 | Characterization of SnO2-based H2 gas sensors fabricated by different deposition techniques显示文摘 | ANSARI S G GOSAVI S W GANGAL S A | 1997 | J Mater Sci:Mater Electr1997，8，： | 1 |
| 12 | Conformational transi- tions in adenylate kinase allosteric communication reduces misligation 显示文摘 | Whifford P C Gosavi S Onuchic JN | 2008 | Journal of Biological Chemistry2008，283，4： | 1 |
| 13 | Study on I-V characteristics of lead free NTC thick film thermistor for self-heating application显示文摘 | JAGTAP S RANE S GOSAVI S AMALNERKAR D | 2011 | Microelectronic Engineering2011，88，1： | 1 |
| 14 | Modelling, identification, and passivity-based robust control of piezo-actuated flexible beam 显示文摘 | Gosavi S V Kelkar A G | 2004 | Journal of Vibration and Acoustics2004，126，2： | 1 |
| 15 | Controlled synthesis of ZnO from nanospheres to micro-rods and its gas sensing studies显示文摘 | Navale S C Gosavi S W Mulla I S | 2008 | Talanta2008，75，： | 1 |
| 16 | Preparation, characterization and electrical properties of spinel-type environment friendly thick film NTC thermistors显示文摘 | JAGTAP S RANE S GOSAVI S AMALNERKAR D | 2008 | Journal of the European Ceramic Society2008，28，13： | 1 |
| 17 | Low temperature synthesis and characterization of NTC powder and its 'lead free' thick film thermistors显示文摘 | JAGTAP S RANE S GOSAVI S AMALNERKAR D | 2010 | Microelectronic Engineering2010，87，2： | 1 |
| 18 | Study of microstructure, impedance and de electrical properties of Ru02-spinel based screen printed 'green' NTC thermistor显示文摘 | JAGTAP S RANE S AIYER R GOSAVI S AMALNERKAR D | 2010 | Current Applied Physics2010，10，4： | 1 |
| 19 | Matching,linear systems,and the ball and beam显示文摘 | Andreev F Auckly D Gosavi S | 2009 | Automatica2009，45，12： | 1 |
| 20 | Modelling, identification, and passivity-based robust control of piezo-actuated flexible beam 显示文摘 | Gosavi S V Kelkar A G | 2004 | Journal of vibration and acoustics2004，126，2： | 1 |
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