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		题名	作者	年代	出处	被引量
	1	Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression.	Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li	2010	World Journal of Gastroenterology2010，16，33：	10
	2	Tumor necrosis factor-α as a proliferative signal for an IL-2-dependent T cell Line:strict species specificity of action显示文摘	Bombara M Aiyer R	1989	J Immunol1989，142，：	1
	3	Effect of solvents on the synthesis of nano-size zinc oxide and its properties显示文摘	Kanade K G Kale B B Aiyer R C	2006	Materials Research Bulletin2006，41，：	1
	4	Fabrication of sucrose biosensor based on single mode planar optical waveguide using co-immobilized plant invertase and GOD 显示文摘	Dipali S B Anu V Aiyer R C	2007	BiosensBioelectron2007，22，：	1
	5	Humidity sensor using planar optical waveguides with claddings of various oxide materials显示文摘	Ansari Z A Karekar R N Aiyer R C	1997	Thin Solid Films1997，305，：	1
	6	显示文摘	Shashikant Patole Islam M Aiyer R C	2005	J Mater Sci2005，10，：	1
	7	A microwave microstrip ring resonator as a moisture sensor for biomaterials : application to wheat grains显示文摘	Abegaonkar M P Karekar R Aiyer R C	1999	Measurement Science and Technology1999，10，10：	1
	8	Study of microstructure, impedance and de electrical properties of Ru02-spinel based screen printed 'green' NTC thermistor显示文摘	JAGTAP S RANE S AIYER R GOSAVI S AMALNERKAR D	2010	Current Applied Physics2010，10，4：	1
	9	Miniaturized nondestructive microwave sensor for chickpea moisture measurement显示文摘	Abegaonkar M P Karekar R Aiyer R C	1999	Review of Scientific Instruments1999，70，7：	1
	10	Solution structureof eucommia antifungal model distinct w ith a five-di-sulfide motif显示文摘	Shashikant P Islam M Aiyer R C	2005	J Mater Sci2005，10，：	1
	11	Effect of solvents on the synthesis of nano-size zinc oxide and its properties 显示文摘	KANADE K G KALE B B AIYER R C	2006	Mater Res Bull2006，41，：	1
	12	Berries and ellagic acid prevent es- trogen-induced mammary tumorigenesis by modulating en- zymes of estrogen metabolism 显示文摘	Aiyer H S Gupta R C	2010	Cancer Prey Res (Phi- la)2010，3，6：	1
	13	Influence of berry polyphenols on receptor signaling and cell-death pathways:Implications for breast cancer prevention显示文摘	Aiyer H S Warri A M Woode D R	2012	Agricultural and Food Chemistry2012，60，23：	1
	14	显示文摘	Garje A D Aiyer R C	2008	J Mater Sci: Mater Electron2008，19，：	1
	15	Synthesis, characterization, and morphology of p-toluene sulfonicacid-doped polyaniline: A material for humidity sensingapplication 显示文摘	KULKARNI M V VISWANATH A K AIYER R C	2005	J Polym Sci Part B: Polym Phys2005，43，16：	1
	16	Effect of solvents on the synthesis of nano-size zinc oxide and its properties显示文摘	Kanade K G Kale B B Aiyer R C	2006	Materials Research Bulletin2006，41，：	1
	17	显示文摘	Shashikant Patole Islam M Aiyer R C	2005	Journal of Materials Science2005，10，：	1

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