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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | A finite element model for predicting the biomechanical behaviour of the human lumbar spine显示文摘 | Pitzen T Geisler F Matthis D | 2002 | Control Eng Pract2002，10，1： | 1 |
| 3 | Image quality assessment based on a degradation model显示文摘 | DAMERA-VENKATA N KITE T D GEISLER W S | | 0，，04： | 1 |
| 4 | Image Quality Assessment Based on a Degradation Model显示文摘 | Damera-Venkata N Kite T D Geisler W S | 2000 | IEEE Trans on Image Processing2000，4，4： | 1 |
| 5 | Motion of threaded cages in posterior lumbar interbody fusion 显示文摘 | Pitzen T Geisler FH Matthis D | 2000 | Eur Spine J2000，9，6： | 1 |
| 6 | Illusions, Perception and Bayes 显示文摘 | Geisler W S Kersten D | 2002 | Nature Neuroscience2002，5，6： | 1 |
| 7 | Identification of genes encoding N-glycan processing beta-Nacetylglucosaminidases in Trichoplusia ni and Bombyx mori: Implications for glycoengineering of baculovirus expression systems显示文摘 | GEISLER C JARVIS D L | 2010 | Biotechnol Prog2010，26，1： | 1 |
| 8 | Demonstration of Spectral Defragmentation in Flexible Bandwidth Optical Networking by FWM显示文摘 | GEISLER D YIN Yawei WEN Ke | 2011 | IEEE Photonics Technology Letters2011，23，24： | 1 |
| 9 | Image quality assessment based on a degradation model 显示文摘 | Damera Venkata N Kite T D Geisler W S | 2000 | Im- age Processing IEEE Transactions on2000，9，4： | 1 |
| 10 | Laparoscopic exp loration for the clinically undetected hernia in infancy and childhood显示文摘 | Geisler D P Jegathesan S Parmley M C | 2001 | Am J Surg2001，182，6： | 1 |
| 11 | Peptide adsorp- tion on a hydrophobic surface results from an interplay of sol- ration, surface, and intrapeptide forces显示文摘 | HORINEK D SERR A GEISLER M | 2008 | Proc Natl Acad Sci U S A2008，105，8： | 1 |
| 12 | Goal orientation,evaluative fear,and perceived coach behavior among competitive youth swimmers in Germany and Japan显示文摘 | Alfermann D Geisler G Okade Y | 2013 | Psychology of sport and exercise2013，14，3： | 1 |
| 13 | Aqueous corrosion of borosilicate glass under acidic conditions: A new corrosion mechanism 显示文摘 | GEISLER T JANSSEN A SCHEITER D | 2010 | Journal of Non-Crystalline Solids2010，356，： | 1 |
| 14 | Risk of clinical leak after lapa- roscopic versus open bowel anastomosis 显示文摘 | E1-Gazzaz G Geisler D Hull T | 2010 | Surg Endosc2010，24，8： | 1 |
| 15 | Image quality assessment based on a degradation model显示文摘 | VENKATA N D KITE T D GEISLER W S | 2000 | IEEE2000，9，6： | 1 |
| 16 | Image quality assessment based on a degradation model显示文摘 | Damera-Venkata N Kite T D Geisler W S | 2000 | IEEE Transactions on Image Processing2000，9，4： | 1 |
| 17 | Hyperglycemia impairs proteasome function by methylglyoxal显示文摘 | Queisser MA Yao D Geisler S | 2010 | Diabetes2010，59，3： | 1 |
| 18 | Laparoseopic eolostomy is safe and leads to a significantly shorter hospital stay for octoge- narians显示文摘 | Lian L Kaiady M Geisler D | 2010 | Surg Endosc2010，24，8： | 1 |
| 19 | A finite element mod-el for predicting the biomechanical behavior of the humanlumbar spine显示文摘 | Pitzen T Geisler F Matthis D | 2002 | Control Eng Pract2002，0，1： | 1 |
| 20 | Image quality assessment based on a degradation model显示文摘 | Damera-Venkata N Kite T D Geisler W S | 2000 | IEEE Transactions on linage Prcocessing2000，9，4： | 1 |
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