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| 1 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 2 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 3 | Heterostructured graphene quantum dot/WSe2/Si photo-detector with suppressed dark current and improved detectivity显示文摘 | Mengxing Sun Qiyi Fang Dan Xie Yilin Sun Liu Qian Jianlong Xu Peng Xiao Changjiu Teng Weiwei Li Tianling Ren Yanfeng Zhang | 2018 | Nano Research2018，11，6： | 5 |
| 4 | Trends and predictors of myocardial infarction or vascular death after ischaemic stroke or TIA in China, 2007-2018: insights from China National Stroke Registries显示文摘Background Although stroke management,primary and secondary preventions have been improved in China last decades,the trends and predictors of major vascular events after ischaemic stroke or transient ischaemic attack(TIA)at national scale are less known.Methods Data were obtained from the three phases of China National Stroke Registry(CNSR),including CNSR-Ⅰ(years 2007-2008),CNSR-Ⅱ(years 2012-2013)and CNSR-III(years 2015-2018).For comparison,patients who were diagnosed as ischaemic stroke or TIA were included.Kaplan-Meier estimates of myocardial infarction(MI)or vascular death were calculated at 1 year.Independent predictors were further assessed with a Cox proportional hazards regression.Results From 2007 to 2018,a total of 50284 patients with ischaemic stroke or TIA were enrolled in this study.A declining trend was found in 1-year MI or vascular death(p for trend<0.001),while recurrent stroke depicted a U-shape curve with a nadir in 2012-2013 cohort.A similar trend was also observed in patients who were admitted to 26 hospitals in all three CNSRs.In 2015-2018 cohort,only 251(1.7%;95%CI 1.5%to 1.9%)MI or vascular death had occurred at 1 year.Older age,previous stroke or TIA,history of coronary artery disease and the National Institutes of Health Stroke Scale>6 were associated with both an increased risk of MI or vascular death and recurrent stroke.While early antiplatelet therapy and lipid-lowering agents at discharge predicted a reduced risk.Conclusion A declining trend and current low incidence of MI or vascular death,rather than recurrent stroke,after ischaemic stroke or TIA were observed in China.Traditional factors were found as independent predictors.These findings suggested there is still much room to improve for stroke management. | Long Li Yuesong Pan Mengxing Wang Jing Jing Xia Meng Yong Jiang Caixia Guo Zening Jin Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 4 |
| 5 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 6 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 7 | Zero Watermarking Algorithm for Medical Image Based on Resnet50-DCT显示文摘Medical images are used as a diagnostic tool, so protecting theirconfidentiality has long been a topic of study. From this, we propose aResnet50-DCT-based zero watermarking algorithm for use with medicalimages. To begin, we use Resnet50, a pre-training network, to draw out thedeep features of medical images. Then the deep features are transformedby DCT transform and the perceptual hash function is used to generatethe feature vector. The original watermark is chaotic scrambled to get theencrypted watermark, and the watermark information is embedded into theoriginal medical image by XOR operation, and the logical key vector isobtained and saved at the same time. Similarly, the same feature extractionmethod is used to extract the deep features of the medical image to be testedand generate the feature vector. Later, the XOR operation is carried outbetween the feature vector and the logical key vector, and the encryptedwatermark is extracted and decrypted to get the restored watermark;thenormalized correlation coefficient (NC) of the original watermark and therestored watermark is calculated to determine the ownership and watermarkinformation of the medical image to be tested. After calculation, most ofthe NC values are greater than 0.50. The experimental results demonstratethe algorithm’s robustness, invisibility, and security, as well as its ability toaccurately extract watermark information. The algorithm also shows goodresistance to conventional attacks and geometric attacks. | Mingshuai Sheng Jingbing Li Uzair Aslam Bhatti Jing Liu Mengxing Huang Yen-Wei Chen | 2023 | Computers, Materials & Continua2023，，4： | 1 |
| 8 | Physiological responses and quality attributes of table grape fruit to chitosan preharvest spray and postharvest coating during storage显示文摘 | MengX Li B Liu J | 2008 | Food Chem2008，106，： | 1 |
| 9 | Stateful implication logic based on perpendicular magnetic tunnel junctions显示文摘As the conventional von Neumann architecture meets critical limitations of data transfer bandwidth and energy consumption,perpendicular magnetic anisotropy magnetic tunnel junction based processing-in-memory paradigm attracts extensive attention as a promising substitute thanks to its nonvolatility,low-power switching,fast access and infinite endurance.In this work,we propose and experimentally demonstrate a new spintronic implication logic gate that consists of two parallel perpendicular magnetic anisotropy magnetic tunnel junctions with different diameters.Material implication and furthermore NAND logic functions are implemented by all electrically-controlled operations.The reliability of this structure is verified,especially in sub-20 nm node,which shows great potential for large-density processing-in-memory applications. | Wenlong CAI Mengxing WANG Kaihua CAO Huaiwen YANG Shouzhong PENG Huisong LI Weisheng ZHAO | 2022 | Science China(Information Sciences)2022，65，2： | 1 |
| 10 | Biodiesel production from rub- ber seed oil using poly ( sodium acrylate) supporting NaOH as a water - resistant catalyst 显示文摘 | Ru Yang Mengxing Su Jianchun Zhang Fuqiang Jin Chunhong Zha Min Li Xinmin Hao | 2011 | Bioresource Technology2011，102，： | 1 |
| 11 | Attention Guided Multi Scale Feature Fusion Network for Automatic Prostate Segmentation显示文摘The precise and automatic segmentation of prostate magnetic resonance imaging(MRI)images is vital for assisting doctors in diagnosing prostate diseases.In recent years,many advanced methods have been applied to prostate segmentation,but due to the variability caused by prostate diseases,automatic segmentation of the prostate presents significant challenges.In this paper,we propose an attention-guided multi-scale feature fusion network(AGMSF-Net)to segment prostate MRI images.We propose an attention mechanism for extracting multi-scale features,and introduce a 3D transformer module to enhance global feature representation by adding it during the transition phase from encoder to decoder.In the decoder stage,a feature fusion module is proposed to obtain global context information.We evaluate our model on MRI images of the prostate acquired from a local hospital.The relative volume difference(RVD)and dice similarity coefficient(DSC)between the results of automatic prostate segmentation and ground truth were 1.21%and 93.68%,respectively.To quantitatively evaluate prostate volume on MRI,which is of significant clinical significance,we propose a unique AGMSF-Net.The essential performance evaluation and validation experiments have demonstrated the effectiveness of our method in automatic prostate segmentation. | Yuchun Li Mengxing Huang Yu Zhang Zhiming Bai | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 12 | Low-complexity and high-performance receive beamforming for secure directional modulation networks against an eavesdropping-enabled full-duplex attacker显示文摘Dear editor,Directional modulation(DM),as an advanced physical-layer security(PLS)transmission technique,is suitable for the line-of-sight(LoS)propagation channel.In[1],the authors presented a DM technique that uses the phased arrays to generate modulation and provides security by deliberately distorting the received signals in other directions. | Yin TENG Jiayu LI Mengxing HUANG Lin LIU Guiyang XIA Xiaobo ZHOU Feng SHU Jiangzhou WANG | 2022 | Science China(Information Sciences)2022，65，1： | 0 |
| 13 | Lignin bioconversion into valuable products:fractionation,depolymerization,aromatic compound conversion,and bioproduct formation显示文摘Lignin fractionation and depolymerization generates heterogeneous streams of aromatic compounds and conversion of aromatic compounds into valuable products,but it is not efficient.Many microbes in nature have evolved metabolic path-ways to convert complex lignin polymers into aromatic compounds and transform these aromatic compounds into central intermediates for bioproduct synthesis.The objective of this paper is to review the recent process development of lignin bioconversion into aromatic compounds and bioproducts.Lignin structural and molecular changes during fractionation and depolymerization are presented.Subsequent lignin conversion into aromatic compounds by upper pathways and further converted into central metabolites and bioproducts via lower pathways are emphasized.In particular,enzymes and mediator systems to enhance lignin conversion and key intermediates in lignin catabolic pathways are discussed.Strategies to enhance bioproduct formation through lignin valorization are summarized. | Mengxing Li Mark Wilkins | 2021 | Systems Microbiology and Biomanufacturing2021，1，2： | 0 |
| 14 | Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds显示文摘Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex challenge.Therefore,we present a novel hemostatic strategy based on magnetic field-mediated guidance.The biphasic Janus magnetic particle(MSS@Fe2O3-T)comprised aggregates ofα-Fe2O3 nanoparticles(Fe_(2)O_(3) NPs)as the motion actuator,negatively modified microporous starch(MSS)as the base hemostatic substrate,and thrombin as the loaded hemostatic drug.Before application,the particles were first wrapped using NaHCO_(3) and then doped with protonated tranexamic acid(TXA-NH_(3)^(+)),which ensured their high self-dispersibility in liquids.During application,the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic guidance.In vivo tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds(“V”-shaped femoral artery and“J”-shaped liver bleeding models).The present strategy,for the first time,extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds. | Qing Li Enling Hu Kun Yu Mengxing Lu Ruiqi Xie Fei Lu Bitao Lu Rong Bao Guangqian Lan | 2021 | Bioactive Materials2021，6，12： | 0 |
| 15 | Multiresolution generative adversarial networks with bidirectional adaptive-stage progressive guided fusion for remote sensing image显示文摘Remote sensing image(RSI)with concurrently high spatial,temporal,and spectral resolutions cannot be produced by a single sensor.Multisource RSI fusion is a convenient technique to realize high spatial resolution multispectral(MS)images(spatial spectral fusion,i.e.SSF)and high temporal and spatial resolution MS images(spatiotemporal fusion,i.e.STF).Currently,deep learning-based fusion models can only implement SSF or STF,lacking models that perform both SSF and STF.Multiresolution generative adversarial networks with bidirectional adaptive-stage progressive guided fusion(BAPGF)for RSI are proposed to implement both SSF and STF,namely BPF-MGAN.A bidirectional adaptive-stage feature extraction architecture infine-scale-to-coarse-scale and coarse-scale-to-fine-scale modes is introduced.The designed BAPGF introduces a previous fusion result-oriented cross-stage-level dual-residual attention fusion strategy to enhance critical information and suppress superfluous information.Adaptive resolution U-shaped discriminators are implemented to feed multiresolution context into the generator.A generalized multitask loss function unlimited by no-reference images is developed to strengthen the model via constraints on the multiscale feature,structural,and content similarities.The BPF-MGAN model is validated on SSF datasets and STF datasets.Compared with the state-of-the-art SSF and STF models,results demonstrate the superior performance of the proposed BPF-MGAN model in both subjective and objective evaluations. | Yuanyuan Wu Yuchun Li Mengxing Huang Siling Feng | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 16 | Mixed Attention Densely Residual Network for Single Image Super-Resolution显示文摘Recent applications of convolutional neural networks(CNNs)in single image super-resolution(SISR)have achieved unprecedented performance.However,existing CNN-based SISR network structure design consider mostly only channel or spatial information,and cannot make full use of both channel and spatial information to improve SISR performance further.The present work addresses this problem by proposing a mixed attention densely residual network architecture that can make full and simultaneous use of both channel and spatial information.Specifically,we propose a residual in dense network structure composed of dense connections between multiple dense residual groups to form a very deep network.This structure allows each dense residual group to apply a local residual skip connection and enables the cascading of multiple residual blocks to reuse previous features.A mixed attention module is inserted into each dense residual group,to enable the algorithm to fuse channel attention with laplacian spatial attention effectively,and thereby more adaptively focus on valuable feature learning.The qualitative and quantitative results of extensive experiments have demonstrate that the proposed method has a comparable performance with other stateof-the-art methods. | Jingjun Zhou Jing Liu Jingbing Li Mengxing Huang Jieren Cheng Yen-Wei Chen Yingying Xu Saqib Ali Nawaz | 2021 | Computer Systems Science & Engineering2021，39，10： | 0 |
| 17 | 利妥昔单抗治疗非亲缘脐血干血细胞移植后并发免疫性血小板减少症1例报道(英文)显示文摘Immune thrombocytopenia (ITP) is a chronic disease resulting from increased platelet destruction and impaired platelet production. Secondary ITP can be a manifestation of chronic graft-versus-host disease (GVHD) and represent a lymphoproliferative disorder. A boy with chronic graft-versus-host disease after cord blood stem cell transplantation who had severe refractory immune-mediated thrombocytopenia received infusion of rituximab weekly, 375 mg/m2, for 4 weeks. Platelets count of the patient was recovered, and rituximab was well tolerated with no severe toxicity observed during treatment. | Mengxing Li Jishi Wang Yan Zhang Zhiqiang Sun Yanju Li Xiaoli Zhou | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，6： | 0 |
| 18 | High-performance heterogeneous complementary inverters based on n-channel MoS2 and p-channel SWCNT transistors显示文摘异构的互补 inverters 双性人层铝二硫化物创作了(瞬间 2) 和围单人赛的 carbon-nanotube (SWCNT ) 联网被设计,并且 n 类型瞬间 2/p-type SWCNT inverters 与 backgated 结构被制作。地效果晶体管(联邦货物税) 分别地为瞬间 2 和 SWCNT 与大开/关比率基于 MoS2 和 SWCNT 网络显示出高电的性能直到 10 6 和 10 5 。MoS2/SWCNT 互补 inverters 展览 V 在 -V 外面 发信号匹配并且与高山峰电压完成优秀表演 15 的获得,一些 nanowatts 的低静态力量的消费,和 0.45VDD 的高噪音边缘,它对未来逻辑电路应用程序合适。inverter 表演被瞬间 2-FETs 和 SWCNT 联邦货物税的隧道 width-to-length 比率(W/L ) 影响。因此, W/L 应该被优化完成在获得和电源消费之间的折衷。 | Zhixin Li Dan Xie Ruixuan Dai Jianlong Xu Yilin Sun Mengxing Sun Cheng Zhang Xian Li | 2017 | Nano Research2017，10，1： | 0 |
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