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| 1 | Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: The role of inflammatory biomarkers显示文摘Pneumonia and acute respiratory distress syndrome are common and important causes of respiratory failure in the intensive care unit with a significant impact on morbidity, mortality and health care utilization despite early antimicrobial therapy and lung protective mechanical ventilation. Both clinical entities are characterized by acute pulmonary inflammation in response to direct or indirect lung injury. Adjunct anti-inflammatory treatment with corticosteroids is increasingly used, although the evidence for benefit is limited. The treatment decisions are based on radiographic, clinical and physiological variables without regards to inflammatory state. Current evidence suggests a role of biomarkers for the assessment of severity, and distinguishing sub-phenotypes (hyperinflammatory versus hypo-inflammatory) with important prognostic and therapeutic implications. Although many inflammatory biomarkers have been studied the most common and of interest are C-reactive protein, procalcitonin, and pro-inflammatory cytokines including interleukin 6. While extensively studied as prognostic tools (prognostic enrichment), limited data are available for the role of biomarkers in determining appropriate initiation, timing and dosing of adjunct anti-inflammatory treatment (predictive enrichment) | Sarah Chalmers Ali Khawaja Patrick M Wieruszewski Ognjen Gajic Yewande Odeyemi | 2019 | World Journal of Critical Care Medicine2019，8，5： | 12 |
| 2 | Respiratory failure in the hematopoietic stem cell transplant recipient显示文摘The number of patients receiving hematopoietic stem cell transplantation(HSCT) is rapidly rising worldwide. Despite substantial improvements in peri-transplant care, pulmonary complications resulting in respiratory failure remain a major contributor to morbidity and mortality in the post-transplant period, and represent a major barrier to the overall success of HSCT. Infectious complications include pneumonia due to bacteria, viruses, and fungi, and most commonly occur during neutropenia in the early post-transplant period. Non-infectious complications include idiopathic pneumonia syndrome, periengraftment respiratory distress syndrome, diffuse alveolar hemorrhage, pulmonary veno-occlusive disease, delayed pulmonary toxicity syndrome, cryptogenic organizing pneumonia, bronchiolitis obliterans syndrome, and post-transplant lymphoproliferative disorder. These complications have distinct clinical features and risk factors, occur at differing times following transplant, and contribute to morbidity and mortality. | Patrick M Wieruszewski Svetlana Herasevich Ognjen Gajic Hemang Yadav | 2018 | World Journal of Critical Care Medicine2018，7，5： | 3 |
| 3 | APO-8 '-lyeopenal and apo-12' -lycopenal are metabolic products of lycopene in rat liver显示文摘 | GAJIC M ZARIPHEH S SUN Furong | 2006 | Nutr2006，136，6： | 1 |
| 4 | Does oral health counseling effectively improve oral hygiene of orthodontic patients 显示文摘 | Lalic M Aleksic E Gajic M | 2012 | Eur J Pae- diatr Dent2012，13，3： | 1 |
| 5 | The international quality requirements for the conduct of clinical studies and the challenges for study centers to implement them显示文摘 | Gajic A Herrmann R Salzberg M | 2004 | Ann Oncol2004，15，9： | 1 |
| 6 | Does oral health counseling effectively improve oral hygiene of orthodontic patients 显示文摘 | Lalic M Aleksic E Gajic M | 2012 | Eur J Paediatr Dent2012，13，3： | 1 |
| 7 | Dose oral health counselingeffectively improve oral hygiene of orthodontic patients 显示文摘 | LalicM Aleksic E Gajic M | 2012 | Eur J Paediatr Denti2012，13，3： | 1 |
| 8 | Modeling and optimiza- tion of energy - efficient procedures for removing lead (11) and zinc(11) ions from aqueous solutions using the central composite design显示文摘 | Savic I M Stojiljkovic S T Gajic D G | 2014 | Energy2014，77，： | 1 |
| 9 | Red blood cell storage lesion 显示文摘 | KOR D J VAN BUSKIRK C M GAJIC O | 2009 | Bosn J Basic Med Sci2009，9，： | 1 |
| 10 | Porokeratosis of mibelli : involution and resolution with 5% imiquimod cream 显示文摘 | Gajic B Tang K Whiffeld M | 2011 | Australas J Dermato12011，52，4： | 1 |
| 11 | Apo-8'-lycopenal and apo-12'-lycopenal are metabolic products of lycopene in rat liver显示文摘 | Gajic M Zaripheh S Sun F | 2006 | J Nutr2006，136，6： | 1 |
| 12 | Lattice vibrations in spin-Peierls compound NAY2O5 显示文摘 | Popovic Z V Konstantinovic M J Gajic R | 1999 | Solid State Communications1999，110，： | 1 |
| 13 | Porokeratosis of mibelli: involution and resolution with 5% imiquimod cream显示文摘 | Gajic B Tang K Whitfeld M | 2011 | Australas J Dennatol2011，52，4： | 1 |
| 14 | Shortcommunication : Effects of the progesterone receptorvariants on fertility traits in cattle显示文摘 | Driver A M Huang W Gajic S | 2009 | J Dairy Sci2009，92，8： | 1 |
| 15 | Ventilator-induced lung injury:minimizing its impact in patients with or at risk for ARDS显示文摘 | Biehl M Kashiouris MG Gajic O | | 0，，06： | 1 |
| 16 | Complete androgen insensitivity syndrome显示文摘 | Gajic TM Vujovic S Ivovic M | 2015 | Srp Arh Celok Lek2015，143，34： | 1 |
| 17 | Novel mechanism of bacteriocin secretion and immunity carried out by lacto- ecal multidrug resistance proteins显示文摘 | Gajic O Buist G Kojic M | 2003 | J Biol Chem2003，278，34： | 1 |
| 18 | Development of a chronopotentiometric stripping method forthe determination of selenium in mixed diets 显示文摘 | Zvonimir S Jaroslava Svarc Gajic Nikola M Snczana K | 2005 | Food Chemistry2005，92，4： | 1 |
| 19 | Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental factors.Ecological studies previously suggested a link between climatological factors and COVID-19 fatality rates.However,individual-level impact of these factors has not been thoroughly evaluated yet.AIM To study the association of climatological factors related to patient location with unfavorable outcomes in patients.METHODS In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital stay.Adjusting for baseline parameters and admission date,multivariable regression modeling was utilized.Generalized estimating equations were used to fit the models.RESULTS Twenty-two thousand one hundred eight patients from over 20 countries were evaluated.The median age was 62(interquartile range:49-74)years,and 54%of the included patients were males.The median age increased with increasing latitude as well as the frequency of comorbidities.Contrarily,the percentage of comorbidities was lower in elevated altitudes.Mortality within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 d.Despite the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality within 28 d of hospital admission(aOR=0.96(0.62,1.47),1.04(0.92,1.19),0.49(0.22,0.90),and 0.51(0.27,0.98),for the altitude points of 75 MASL,125 MASL,400 MASL,and 600 MASL,in comparison to the reference altitude of 148 m.a.s.l,respectively.P=0.001).We detected an association between latitude and 28-day mortality as well as hospital-free days in this worldwide study.When the baseline features were taken into account,however,this did not stay significant.CONCLUSION Our findings suggest that differences observed in previous epidemiological studies may be due to ecological fallacy rather than implying a causal relationship at the patient level. | Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija Bogojevic Neha Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith F Heavner Margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group | 2022 | World Journal of Critical Care Medicine2022，11，2： | 0 |
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