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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Immunization with an immunodominant self-peptide derived from g|ucose-6- phosphate isomerase induces arthritis in DBA/1 mice显示文摘 | Bruns L Frey O Morawietz L | 2009 | Arthritis Res Ther2009，11，4： | 1 |
| 4 | Measurement of cerebral oxygenation state in anaesthetized children using the INVOS 5100 cerebral oximeter显示文摘 | Dullenkopf A Frey B Baenziger O | 2003 | Paediatric Anaesthesia2003，13，5： | 1 |
| 5 | Plasma membrane voltage changes during nanosecond pulsed electric field exposure 显示文摘 | Frey W White J A Price R O | 2006 | Biophysical Journal2006，90，10： | 1 |
| 6 | Prev-alence of genotypes 1and 2of bovine viral diarrheavirus in Lower Saxony,Germany显示文摘 | TAJIMA M FREY H R YAMATO O | 2001 | Virus Res2001，76，1： | 1 |
| 7 | Protein kinase C signaling mediates a program of cell cycle withdrawl in the intestinal epithelium显示文摘 | Clark JA Leontieva O | 2000 | J-Cell-Biol2000，151，4： | 1 |
| 8 | How to prevent postoperative in- trauterine adhesions显示文摘 | Frey C Chanelles O Poncelet C | 2010 | Gynecol Obstet Fertil2010，38，9： | 1 |
| 9 | Ciinical and experimental effects of mediumchain triglycerides based fat emulsions 显示文摘 | Bach AC Frey A Lutz O | 1989 | Clin Nutr1989，8，： | 1 |
| 10 | Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter - related sepsis显示文摘 | Brotschi B Baenziger O Frey B | 2009 | J Perinat Med2009，37，6： | 1 |
| 11 | Assessment of the influence of flying altitude and scan angle on biophysical vegetation products derived from airborne laser scanning显示文摘 | Morsdorf F Frey O Meier E | 2008 | International Journal of Remote Sensing2008，29，5： | 1 |
| 12 | Bone morphogenetic proteins in clinical applications显示文摘 | Gautschi O P Frey S P Zellweger R | | 0，，08： | 1 |
| 13 | Ameliorated course of glu- cose-6-phosphate isomerase( G6PI)-induced arthritis in IFN-γreceptor knockout mice exposes an arthritis-promoting role of IFN - γ显示文摘 | Frey O Mitera T Kelchtermans H | 2011 | J Autoimmun2011，36，2： | 1 |
| 14 | Block of the brachial plexus branches by the humeral route: A prospective study of 503 ambulatory patients-proposal of a nerve blocing sequence 显示文摘 | Kern O Mahoudeau G Freys G Golfetto T Calon B | 1999 | Acta Anaesthesiol Scand1999，43，： | 1 |
| 15 | Deep surveying of al- ternative splicing complexity in the human transcriptome by high-throughput sequencing 显示文摘 | Pan Q Shai O Lee LJ Frey B J | 2008 | Nature Genetics2008，40，12： | 1 |
| 16 | Atlantoaxial mobility after screw fixation of the odontoid: a computed tomographie study显示文摘 | Jeanneret B Vernet O Frei S | 1991 | J Spinal Disord1991，4，2： | 1 |
| 17 | Use of continuous positive airway pressure during flexible bronchoscopy in young children显示文摘 | TRACHSEL D ERB T O FREI F J | 2005 | Eur Respir J2005，26，5： | 1 |
| 18 | Measure- ment of ionospheric TEC in spaceborne SAR data显示文摘 | JEHLE M FREY O SMALL D | 2010 | IEEE Transactions on Geoscienee and Remote Sens- ing2010，48，6： | 1 |
| 19 | Use of allozymes as genetic markers for predicting performance in maize single cross hybrids显示文摘 | Frei O M Stuber C W Goodman M M | 1986 | Crop Science1986，26，1： | 1 |
| 20 | Microelectrode-array of IrO2 prepared by thermal treatment of pure Ir显示文摘 | Fierro S Kapalka A Frey O | 2010 | Electrochemistry Communications2010，12，4： | 1 |
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