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| 1 | Strategies to optimize the use of marginal donors in liver transplantation显示文摘Liver transplantation is the treatment of choice for end stage liver disease, but availability of liver grafts is still the main limitation to its wider use. Extended criteria donors(ECD) are considered not ideal for several reasons but their use has dramatically grown in the last decades in order to augment the donor liver pool. Due to improvement in surgical and medical strategies, results using grafts from these donors have become acceptable in terms of survival and complications; nevertheless a big debate still exists regarding their selection, discharge criteria and allocation policies. Many studies analyzed the use of these grafts from many points of view producing different or contradictory results so that accepted guidelines do not exist and the use of these grafts is still related to non-standardized policies changing from center to center. The aim of this review is to analyze every step of the donationtransplantation process emphasizing all those strategies, both clinical and experimental, that can optimize results using ECD. | Daniele Pezzati Davide Ghinolfi Paolo De Simone Emanuele Balzano Franco Filipponi | 2015 | World Journal of Hepatology2015，7，26： | 8 |
| 2 | Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature显示文摘Lymphoepithelioma-like hepatocellular carcinoma(LELHCC) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. Here,a case of LEL-HCC is described. An 81-year-old woman with a chronic hepatitis C infection was referred to the general surgery department of our hospital in August 2013 with a diagnosis of HCC. A past ultrasound examination had revealed a 60 mm-diameter nodular lesion in the third segment of the liver. After a needle biopsy,the lesion was diagnosed as HCC. The patient underwent surgery with a liver segmentectomy. Two additional nodes on the gastric wall were detected during the surgical operation. The histology of the removed specimen showed a poorly differentiated HCC with significant lymphoid stroma. Immunohistochemical studies revealed that the epithelial component was reactive for CK CAM5.2,CK8,CK18,CEA(polyclonal) and was focally positive for hepar-1 and that the lymphoid infiltrate was positive for CD3,CD4 and CD8. The tumor cells were negative for Epstein-Barr virus. The gastric nodes were ultimately determined to be two small gastrointestinal stromal tumors(GISTs).The synchronous occurrence of HCC and GIST is another very uncommon finding rarely described in the literature. Here,we report the clinicopathological features of our case,along with a review of the few cases present in the literature. | Andrea Cacciato Insilla Pinuccia Faviana Luca Emanuele Pollina Paolo De Simone Laura Coletti Franco Filipponi Daniela Campani | 2015 | World Journal of Gastroenterology2015，21，36： | 5 |
| 3 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 4 | Carbon Dioxide Capture Using Gas Hydrate Technology显示文摘 | Beatrice Castellani Mirko Filipponi Andrea Nicolini Franco Cotana Federico Rossi | 2013 | Journal of Energy and Power Engineering2013，7，5： | 2 |
| 5 | Liver transplantation for HBV-related cirrhosis in Europe: An ELTR study on evolution and outcomes显示文摘 | Patrizia Burra Giacomo Germani Renè Adam Vincent Karam Alfredo Marzano Pietro Lampertico Mauro Salizzoni Franco Filipponi Jurgen L. Klempnauer Denis Castaing Murat Kilic Luciano De Carlis Peter Neuhaus Sezai Yilmaz Andreas Paul Antonio D. Pinna Andrew K. | 2012 | Journal of Hepatology2012，，： | 2 |
| 6 | Modified RECIST to assess tumor response after Transarterial Chemoembolization of Hepatocellular Carcinoma: CT-pathologic correlation in 178 liver explants显示文摘 | Irene Bargellini Elena Bozzi Daniela Campani Paola Carrai Paolo De Simone Luca Pollina Roberto Cioni Franco Filipponi Carlo Bartolozzi | 2012 | European Journal of Radiology2012，，： | 1 |
| 7 | Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers显示文摘 | Carlo Bartolozzi Valentina Battaglia Irene Bargellini Elena Bozzi Daniela Campani Luca Emanuele Pollina Franco Filipponi | 2013 | Abdominal Imaging2013，，2： | 1 |
| 8 | Treatment with 5-Fluorouracil/Folinic Acid, Oxaliplatin, and Irinotecan Enables Surgical Resection of Metastases in Patients With Initially Unresectable Metastatic Colorectal Cancer显示文摘 | Gianluca Masi MD Samanta Cupini MD Lorenzo Marcucci MD Elisa Cerri MD Fotios Loupakis MD Giacomo Allegrini MD Isa Maura Brunetti MD Elisabetta Pfanner MD Maurizio Viti MD Orlando Goletti MD Franco Filipponi MD Alfredo Falcone MD | 2006 | Annals of Surgical Oncology2006，，1： | 1 |
| 9 | Outcome of pregnancy after organ transplantation: a retrospective survey in Italy显示文摘 | Roberto Miniero Irene Tardivo Emilio Sergio Curtoni Fabrizio Bresadola Gilberto Calconi Antonino Cavallari Paolo Centofanti Franco Filipponi Alessandro Franchello Claudio Goggi Ennio Rocca Carmelo Mammana Antonio Nino Francesco Parisi Enrico Regalia Alber | 2005 | Transplant International2005，，11： | 1 |
| 10 | Single-session Percutaneous Ethanol Ablation of Early-stage Hepatocellular Carcinoma with a Multipronged Injection Needle: Results of a Pilot Clinical Study显示文摘 | Riccardo Lencioni Laura Crocetti Dania Cioni Clotilde Della Pina Filippo Oliveri Paolo De Simone Maurizia Brunetto Franco Filipponi | 2010 | Journal of Vascular and Interventional Radiology2010，，10： | 1 |
| 11 | Detection of biliary complications after orthotopic liver transplantation with MR cholangiography显示文摘 | Piero Boraschi Giovanni Braccini Roberto Gigoni Giorgio Sartoni Emanuele Neri Franco Filipponi Franco Mosca Carlo Bartolozzi | 2001 | Magnetic Resonance Imaging2001，，8： | 1 |
| 12 | Expanding Indications for TIPSS: Portal Decompression Before Elective Oncologic Gastric Surgery in Cirrhotic Patients显示文摘 | Gabriele Catalano Lucio Urbani Paolo De Simone Luca Morelli Laura Coletti Roberto Cioni Giancarlo Matocci Franco Mosca Franco Filipponi | 2005 | Journal of Clinical Gastroenterology2005，，10： | 1 |
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