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| 1 | Liver stiffness in the hepatitis B virus carrier:A non-invasive marker of liver disease influenced by the pattern of transaminases显示文摘AIM: To investigate the usefulness of transient elastography by Fibroscan (FS),a rapid non-invasive technique to evaluate liver fibrosis,in the management of chronic hepatitis B virus (HBV) carriers.METHODS: In 297 consecutive HBV carriers,we studied the correlation between liver stiffness (LS),stage of liver disease and other factors potentially influencing FS measurements.In 87 chronic hepatitis B (CHB) patients,we monitored the FS variations according to the spontaneous or treatment-induced variations of biochemical activity during follow-up.RESULTS: FS values were 12.3 ± 3.3 kPa in acute hepatitis,10.3 ± 8.8 kPa in chronic hepatitis,4.3 ± 1.0 kPa in inactive carriers and 4.6 ± 1.2 kPa in blood donors.We identified the cut-offs of 7.5 and 11.8 kPa for the diagnosis of fibrosis ≥ S3 and cirrhosis respectively,showing 93.9% and 86.5% sensitivity,88.5% and 96.3% specificity,76.7% and 86.7% positive predictive value (PPV),97.3% and 96.3% negative predictive value (NPV) and 90.1% and 94.2% diagnostic accuracy.At multivariate analysis in 171 untreated carriers,fibrosis stage (t = 13.187,P < 0.001),active vs inactive HBV infection (t = 6.437,P < 0.001),alanine aminotransferase (ALT) (t = 4.740,P < 0.001) and HBV-DNA levels (t = -2.046,P = 0.042) were independently associated with FS.Necroinflammation score (t = 2.158,> 10/18 vs ≤ 10/18,P = 0.035) and ALT levels (t = 3.566,P = 0.001) were independently associated with LS in 83 untreated patients without cirrhosis and long-term biochemical remission (t = 4.662,P < 0.001) in 80 treated patients.During FS monitoring (mean follow-up 19.9 ± 7.1 mo) FS values paralleled those of ALT in patients with hepatitis exacerbation (with 1.2 to 4.4-fold increases in CHB patients) and showed a progressive decrease during antiviral therapy.CONCLUSION: FS is a non-invasive tool to monitor liver disease in chronic HBV carriers,provided that the pattern of biochemical activity is taken into account.In the inactive carrier,it identifies non-HBV-related causes of liver damage and transient reactivations.In CHB patients,it may warrant a more appropriate timing of control liver biopsies. | Filippo Oliveri Barbara Coco Pietro Ciccorossi Piero Colombatto Veronica Romagnoli Beatrice Cherubini Ferruccio Bonino Maurizia Rossana Brunetto | 2008 | World Journal of Gastroenterology2008，14，40： | 43 |
| 2 | Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis显示文摘Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. | Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David KSimmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong EZhang Mark QMartindale Jiang Liu | 2019 | National Science Review2019，6，5： | 2 |
| 3 | Effects of n -3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease显示文摘 | L. Spadaro O. Magliocco D. Spampinato S. Piro C. Oliveri C. Alagona G. Papa A.M. Rabuazzo F. Purrello | 2007 | Digestive and Liver Disease2007，，3： | 2 |
| 4 | Bayesian compressive sampling for pattern synthesis with maximally sparse non uniform linear arrays显示文摘 | Giacomo Oliveri Andrea Massa | | 0，，02： | 1 |
| 5 | Transarterial (chemo) embolisati- on for unresectable hepatocellular carcinoma显示文摘 | Oliveri RS Wetterslev J Gluud C | 2011 | The Cochrane Da- tabase of Systematic Reviews2011，3，00： | 1 |
| 6 | 'e' antigen defective hepatitis 13 virus and course of chronic infeorion显示文摘 | Brunetto MR Giarin MM Oliveri F | 1991 | Hepatol1991，13，4： | 1 |
| 7 | Bayesian Compressive Sam-pling for Pattern Synthesis with Maximally SparseNon-Uniform Linear Arrays 显示文摘 | OLIVERI G MASSA A | 2011 | IEEE Antennas andPropagation Magazine2011，59，2： | 1 |
| 8 | Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers 显示文摘 | Brunetto MR Oliveri F Colombatto P Moriconi F Ciccorossi P Coco B Romagnoli V Cherubini B Moscato G Maina AM Cavallone D Bonino F | 2010 | Gastroenterology2010，139，2： | 1 |
| 9 | MIMO radar and groundbased SAR imaging systems: equivalent approaches for remotesensing显示文摘 | Tarchi D Oliveri F Sammartino P F | 2013 | IEEE Trans on Geoscience and Remote Sensing2013，51，1： | 1 |
| 10 | Linear ar-ray thinning exploiting almost difference sets 显示文摘 | OLIVERI G DONELLI M MASSA A | 2009 | IEEE Transactions on Antennas and Propagation2009，57，12： | 1 |
| 11 | Left but not right tempo- ral lobe involvement in opaque idiom comprehension:a re- petitive transcranial stimulation study显示文摘 | Oliveri M Papagno C Romero L | 2004 | Journal of Cogni- tive Neuroscience2004，，5： | 1 |
| 12 | ADS-basedguidelines for thinned planar arrays显示文摘 | OLIVERI G MANICA L MASSA A | 2010 | IEEE Trans-actions on Antennas and Propagation2010，58，6： | 1 |
| 13 | Compressive sensing pattern matching techniques for synthesizing planar sparse arrays显示文摘 | Viani F Oliveri G Massa A | 2013 | IEEE Trans Antennas Propag2013，61，9： | 1 |
| 14 | Application of class-modelling techniques to near infrared data for food authentication purposes显示文摘 | P. Oliveri V. Di Egidio T. Woodcock G. Downey | 2010 | Food Chemistry2010，，4： | 1 |
| 15 | Transient elastography : a new surrogate marker of liver fibrosis influenced by major changes of transaminases 显示文摘 | Coco B Oliveri F Maina AM | 2007 | J Viral Hepat2007，14，5： | 1 |
| 16 | Molecular cloning and characterization of mu-rine ICOS and identification of B7h as ICOS ligand显示文摘 | Mages H W Hutloff A Heuck C BiJchner K Himmelbauer H Oliveri F | 2000 | Eur J Immunol2000，30，： | 1 |
| 17 | Inhibition of neutral endopeptidase potentiates bronchoconstriction induced by neurokinin A in asthmatic patients显示文摘 | Crimi N Palermo F Oliveri R | 1994 | Clin Exp Allerg1994，24，2： | 1 |
| 18 | Direction-of-arrival estimation through Bayesian compressive sensing strategies显示文摘 | Carlin M Rocca P Oliveri G ei al | 2013 | IEEE Transactions on Antennas and Propagation2013，61，7： | 1 |
| 19 | Solitary Langerhans cell- histiocytosis orbital lesion:case report and review of the literature 显示文摘 | Ulivieri S Oliveri G Filosomi G | 2008 | Neurocirugia(Astur)2008，19，5： | 1 |
| 20 | Contralateral neglect induced by right posterior parietal rTMS in healthy subjects 显示文摘 | Fierro B Brighina F Oliveri M | 2000 | Neuroreport2000，11，7： | 1 |
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