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| 1 | Cloning and soluble expression of mature α-luffin from Luffa cylindrica and its antitumor activities in vitro显示文摘Luffin -- 一,一种单个链的类型我使核糖体失去活性的蛋白质,它被知道是最 luffin 家庭并且显然有毒拥有 antitumor 活动,从 Luffa cylindrica 种子被孤立。在现在的学习,成熟 -luffin 从 L 被克隆。cylindrica 和它被发现那成熟 -luffin 分享有 luffin 的 96% 氨基酸类似 -- 一。recombinant 成熟 -luffin 成功地在表示条件的优化以后在 Escherichia coli 在一种部分可溶的形式被表示。细菌的生长上的 recombinant 蛋白质的效果并且它的在里面 vitro 蛋白质合成抑制活动被测试。然后,它对不同人的癌症房间线的 antitumor 活动被 CCK-8 试金和流动 cytometry 评估。结果显示 recombinant -luffin 对 E 稍微有毒。coli。它能在兔子网状细胞 lysate 系统禁止蛋白质合成。同时,它在一个剂量依赖者和时间依赖者举止禁止了肿瘤细胞线的生长。另外, recombinant -luffin 能由 apoptosis 导致房间死亡。向肿瘤房间的 -luffin 的 cytotoxicity 使它成为一个潜在的 antitumor 代理人。 | Liling Liu Rupeng Wang Wei He Fengtian He Gang Huang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 6 |
| 2 | Modeling and Analysis of a Micromotor with an Electrostatically Levitated Rotor显示文摘The modeling and evaluation of a prototype rotary micromotor where the annular rotor is supported electrostatically in five degrees of freedom is presented in order to study the behavior of this levitated micromotor and further optimize the device geometry.The analytical torque model is obtained based on the principle of a planar variable-capacitance electrostatic motor while the viscous damping caused by air film between the stator and rotor is derived using laminar Couette flow model.Simulation results of the closed-loop drive motor, based on the developed dynamic model after eliminating mechanical friction torque via electrostatic suspension, are presented.The effects of the high-voltage drive, required for rotation of the rotor, on overload capacity and suspension stiffness of the electrostatic bearing system are also analytically evaluated in an effort to determine allowable drive voltage and attainable rotor speed in operation.The analytical results show that maximum speed of the micromotor is limited mainly by viscous drag torque and stiffness of the bearing system.Therefore, it is expected to operate the device in vacuum so as to increase the rotor speed significantly, especially for those electrostatically levitated micromotors to be used as an angular rate micro-gyroscope. | HAN Fengtian WU Qiuping ZHANG Rong | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 5 |
| 3 | A fault diagnosis method of reciprocating compressor based on sensitive feature evaluation and artificial neural network显示文摘A method combining information entropy and radial basis function network is proposed for fault automatic diagnosis of reciprocating compressors.Aiming at the current situation that the accuracy rate of reciprocating compressor fault diagnosis which depends on manual work in engineering is very low,we apply information entropy evaluation to select the sensitive features and make clear the corresponding relationship of characteristic parameters and failures.This method could reduce the feature dimension.Then,a complete fault diagnosis architecture has been built combining with radial basis function network which has the fast and efficient characteristics.According to the test results using experimental and engineering data,it is observed that the proposed fault diagnosis method improves the accuracy of fault automatic diagnosis effectively and it could improve the practicability of the monitoring system. | 兴成宏 Xu Fengtian Yao Ziyun Li Haifeng Zhang Jinjie | 2015 | High Technology Letters2015，21，4： | 3 |
| 4 | Automorphisms of Maps with a Given Underlying Graph and Their Application to Enumeration显示文摘A graph is called a semi-regular graph if its automorphism group action on its ordered pair of adjacent vertices is semi-regular. In this paper, a necessary and sufficient condition for an automorphism of the graph F to be an automorphism of a map with the underlying graph F is obtained. Using this result, all orientation-preserving automorphisms of maps on surfaces (orientable and non-orientable) or just orientable surfaces with a given underlying semi-regular graph F are determined. Formulas for the numbers of non-equivalent embeddings of this kind of graphs on surfaces (orientable, non-orientable or both) are established, and especially, the non-equivalent embeddings of circulant graphs of a prime order on orientable, non-orientable and general surfaces are enumerated. | LinFanMAO YanPeiLIU FengTIAN | 2005 | Acta Mathematica Sinica,English Series2005，21，2： | 2 |
| 5 | Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics显示文摘Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment. | Lijuan Wen Yu Peng Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu | 2022 | Nano Research2022，15，2： | 2 |
| 6 | Analysis and Prevention for Oscillation Failure of Capacitive Micro-accelerometers显示文摘As actuator of the force-rebalanced servo loop, the electrostatic force generator of the micro-accelerometer shows high nonlinearity while the interpole of the micro-electro-mechanical system(MEMS) sensor is far away from its balance position. The control system cannot rebalance itself with the limited bandwidth after an external long overload, because the characteristics of the force generator differ from normal case. Although for similar problems, solutions with cascading lead-lag blocks, with the anti-windup(AW) technology, or with the sliding-mode control, are widely reported, the problems such as performance loss or difficulty to synthesize a digital controller still remain. Based on existing researches, remedies are developed by analyzing the characteristic of the system not only near the balance position, but also corresponding to the whole moveable range of the interpole, and a new controller is proposed. The solution is compared with the common solutions of cascading lead-lag blocks method, AW methods, and sliding mode methods. Comparison results show that the proposed solution avoid performance loss, compared to cascading lead-lag blocks solution; the proposed solution is easily synthesized and implemented in the analog servo loop of the micro-accelerometer, compared to digital AW methods; at the same time, the proposed solution avoids suffering the chattering effect problem but just utilize it, compared to the sliding-mode control solution. Nevertheless, comparison results show the solution is lack of commonality, since the solution is only more suitable to micro electrostatic force-rebalance system. The SIMULINK models with and without the proposed solution, taking typical micro-accelerometer parameters, have been set up for simulation; corresponding experiments utilizing electrometric method are also conducted after the successful simulations. Simulation and experiment results verify that the micro-accelerometer will reliably return to normal operation after external long overload with the proposed solution. Therefore, it is expected to design the analog servo loop of high performance micro electrostatic force-rebalance system so as to ensure the rebalance after long overload without performance loss. | WAN Caixin DONG Jingxin HAN Fengtian | 2010 | Chinese Journal of Mechanical Engineering2010，23，3： | 2 |
| 7 | Optimum design and experiment of composite leaf spring landing gear for electric aircraft显示文摘The composite leaf spring landing gear of an electric aircraft is optimized.With the strength and workability as constraints and the minimum structural weight as an objective,the two-stage optimization of the leaf spring landing gear with glass fiber unidirectional prepreg is carried out using a genetic algorithm,namely,the optimization of continuous thickness of layup,and the optimization of the layup sequence and discrete thickness.In the optimization process,the ground loads are calculated according to the structural stiffness of each chromosome,thus the stiffness constraints are relaxed,and the optimization results are compared with those using stiffness constraints.The static experiment verification reveals that the numerical simulation and experimental results are consistent,that is,the optimized leaf spring meets the strength requirements.The results show that the leaf spring landing gear based on two-stage optimization method achieves the objective of weight reduction. | Donghui LI Zhenwei FAN Yewei ZHANG Jian ZANG Fengtian YANG | 2020 | Chinese Journal of Aeronautics2020，33，10： | 2 |
| 8 | Capacitive sensor interface for an electrostatically levitated micromotor 显示文摘 | Han Fengtian Wu Qiuping Zhang Rang | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，10： | 1 |
| 9 | Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease显示文摘BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression, and finally lead to dementia. OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people. DESIGN: Case-control, comparative observation. SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College. PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM-Ⅳdiagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed. METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then 'NEST'PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism, following by biomedical statistics analysis based on the clinical total cholesterol level. MAIN OUTCOME MEASURES: Polymorphism of APOE promoter-219 G/T and total cholesterol level. RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [11.8%(13/110), 45.5%(40/88), χ2=8.2, P < 0.01]. The TT allele frequency of the Alzheimer disease group was significantly higher than that in the control group [76% (42/55), 48% (21/44)], while GT+GG allele frequency was remarkably lower than that in the control group [24%(13/55), 52%(23/44), χ2=8.7, P < 0.01]. ②Total cholesterol level: The level of the TT genotype patients in the Alzheimer group was obviously higher than that in GT+GG genotype patients (t =2.46, P < 0.05); the cholesterol level in the two genotypes of the control group was similar (P > 0.05). CONCLUSION: TT genotype and allele T in the APOE promoter-219 polymorphisms are the sensitive gene, and genotype TT has a relationship with the increase of total cholesterol level. | Fang Liu1,2, Xiao Sun1, Jing Wang1, Yan Kong1, Li Cui1, Xiangdang Shi2 1Department of Neurology, Fengtian Hospital, Shenyang Medical College, Shenyang 110024, Liaoning Province, China 2Medical University of South Carolina, SC, U.S.A | 2006 | Neural Regeneration Research2006，1，9： | 1 |
| 10 | A differentialcapacitance to voltage converter for electrostatic levitationapplications显示文摘 | Han Fengtian Gao Zhongyu Wang Yongliang | 2002 | Sensors and Actuators A2002，99，3： | 1 |
| 11 | FXR ligands protect against hepatocellular inflammation via SOCS3 induction显示文摘 | Zhizhen Xu Gang Huang Wei Gong Peng Zhou Yuanyin Zhao Yan Zhang Yijun Zeng Min Gao Zhisheng Pan Fengtian He | 2012 | Cellular Signalling2012，，8： | 1 |
| 12 | 125I Radioactive Particles Drive Protective Autophagy in Hepatocellular Carcinoma by Upregulating ATG9B显示文摘Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its wide clinical application.Methods:We investigated the cellular responses to 125I radioactive particles treatment and autophagy-related 9B(ATG9B)silencing in HCC cell lines and Hep3B xenografted tumor model using Cell Counting Kit-8 reagent,western blotting,immunofluorescence,flow cytometry,transmission electron microscopy and immunohistochemistry.Results:In this study,we demonstrated that 125I radioactive particles induced cell apoptosis and protective autophagy of HCC in vitro and in vivo.Inhibition of autophagy enhanced the radiosensitivity of HCC to 125I radioactive particles.Moreover,125I radioactive particles induced autophagy by upregulating ATG9B,with increased expression level of LC3B and decreased expression level of p62.Furthermore,ATG9B silencing downregulated LC3B expression and upregulated p62 expression and enhanced radiosensitivity of HCC to 125I radioactive particles in vitro and in vivo.Conclusions:Inhibition of ATG9B enhanced the antitumor effects of 125I particle radiation against HCC in vitro and in vivo.Our findings suggest that 125I particle radiation plus chloroquine or/and the ATG9B inhibitor may be a novel therapeutic strategy for HCC. | Yunhua Xiao Jing Yuan Chongshuang Yang Junru Xiong Liangyu Deng Qinghua Liang Chuang He Liangshan Li Fengtian He Xuequan Huang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 1 |
| 13 | Cationic lipids enhance siRNA-mediated interferon response in mice显示文摘 | Zheng Ma Jiang Li Fengtian He Annette Wilson Bruce Pitt Song Li | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 14 | Development of multisensory integrated navigation system based on distributed multiprocessor显示文摘 | Wu Qiuping Han Fengtian | | 0，，01： | 1 |
| 15 | Copper-Catalyzed Direct Oxyphosphorylation of Enamides with P(O)-H Compounds and Dioxygen显示文摘有 P (O)-H 混合物和 dioxygen 的 enamides 的简单、方便的催化铜的直接 oxyphosphorylation 在温和条件下面被开发了。这方法论能允许一系列珍贵 -ketophosphine oxides/-ketophosphonates 的合成在由使用乐意地可得到的开始的材料简单地与一个宽广底层范围节制到好收益。 | Wu Liang Zhijie Zhang Dong Yi Qiang Fu Suyuan Chen Lu Yang Fengtian Du Jianxin Ji Wei Wei | 2017 | Chinese Journal of Chemistry2017，35，9： | 1 |
| 16 | FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells 显示文摘 | Qiuhong Zhang Fengtian He Ramalinga Kuruba | 2008 | Cardiovasc Res2008，77，2： | 1 |
| 17 | Experimental study of a variable-capacitance micromotor with electrostatic suspension 显示文摘 | Han Fengtian Wu Qiuping Wang Lei | 2010 | Journal of Micromechanics and Microengineer- ing2010，20，11： | 1 |
| 18 | A Differential Capacitance to Voltage Converter for Electrostatic Levitation Applications显示文摘 | Han Fengtian Gao Zhongyu Wang Yongliang | 2002 | Sensors and Actuators A2002，，99： | 1 |
| 19 | Capacitive Sensor Interface for an Electrostatically Levitated Micromotor显示文摘 | Han Fengtian Wu Qiuping | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，10： | 1 |
| 20 | Curcumin Protects Against Collagen-Induced Arthritis via Suppression of BAFF Production显示文摘 | Gang Huang Zhizhen Xu Yan Huang Xiaojun Duan Wei Gong Yan Zhang Jishan Fan Fengtian He | 2013 | Journal of Clinical Immunology2013，，3： | 1 |
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