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| 1 | Soil particle size distribution and its relationship with soil water and salt under mulched drip irrigation in Xinjiang of China显示文摘Soil particle size distribution(PSD),one of the most important soil physical attributes,is of great importance to soil water movement,soil erosion and soil solute migration.In this study,the soil PSD of 563 soil samples from the mulched drip irrigated cotton fields in Xinjiang of China were measured by laser diffraction particle size analyzer.The soil PSD characteristics and its relations with soil water and salt were studied by using the combined methods of textural triangle,fractal and multifractal analysis.The results showed very low clay content(about 1.52%) while really high sand content of the studied soil,and a complex shape of bimodal or unimodal of soil PSD.The results also showed that the two indices,i.e.,standard deviation and the peak value of soil particle relative volumes,were good indicators of soil PSD and thus had good relations with fractal and multifractal characteristics.The correlative analysis further indicated that the mulched drip irrigation had a significant impact on the distribution of the soil salt,while this impact withered for the deeper soil layer.The soil texture feature was found to dominate soil water and salt distribution,especially the surface soil salt content and the deep soil water content. | HU HongChang TIAN FuQiang HU HePing | 2011 | Science China(Technological Sciences)2011，54，6： | 33 |
| 2 | Thermodynamic watershed hydrological model: Constitutive relationship显示文摘The representative elementary watershed (REW) approach proposed by Reggiani et al. was the first attempt to develop scale adaptable equations applicable directly at the macro scale. Tian et al. extended the initial definition of REW for simulating the energy related processes, and re-organized the deriving procedure of balance equations so that additional sub-regions and substances could be easily incorpo-rated. The resultant ordinary differential equation set can simulate various hydro-logical processes in a physically reasonable way. However, constitutive and geo-metric relationships have not been developed for Tian et al.'s equation set, which are necessary for the thermodynamic watershed hydrological model to apply in hydrological modeling practice. In this work, the constitutive equations for mass exchange terms and momentum exchange terms were developed as well as geo-metric relationships. The closed ordinary differential equation set with nine equa-tions was finally obtained. | TIAN FuQiang HU HePing LEI ZhiDong | 2008 | Science China(Technological Sciences)2008，51，9： | 6 |
| 3 | Detection and characterization of diverse alpha-and betacoronaviruses from bats in China显示文摘Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses(CoVs) were detected in 50 of 951(positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by pan-coronavirus RT-PCR screening. Based on 400-nt RNA-dependent RNA polymerase(Rd RP) sequence analysis, eight belonged to genus Alphacoronavirus and 42 to Betacoronavirus.Among the 50 positive specimens, thirteen gave rise to CoV full-length Rd RP gene amplification for further sequence comparison, of which three divergent sequences(two from a unreported province) were subjected to full genome sequencing. Two complete genomes of betacoronaviruses(JTMC15 and JPDB144) and one nearly-complete genome of alphacoronavirus(JTAC2) were sequenced and their genomic organization predicted. The present study has identified additional numbers of genetically diverse bat-borne coronaviruses with a wide distribution in China. Two new species of bat CoV, identified through sequence comparison and phylogenetic analysis, are proposed. | Lin Xu Fuqiang Zhang Weihong Yang Tinglei Jiang Guanjun Lu Biao He Xingyu Li Tingsong Hu Gang Chen Yun Feng Yuzhen Zhang Quanshui Fan Jiang Feng Hailin Zhang Changchun Tu | 2016 | Virologica Sinica2016，31，1： | 6 |
| 4 | A two-dimensional numerical model coupled with multiple hillslope hydrodynamic processes and its application to subsurface flow simulation显示文摘A numerical hillslope hydrodynamic model is of great importance in facilitating the understanding of rainfall-runoff mechanism.However,most of the currently existing models do not consider the effect of coupled hydrodynamic processes as runoff,subsurface flow or groundwater flow.In this study,the Tsinghua Hillslope Runoff Model based on multiple hydrodynamic process,THRM model,is developed,which couples with Saint Venant equation for surface runoff and Richards equation for variably saturated soil water movement(including subsurface flow and groundwater flow).A finite difference scheme with improved boundary conditions is adopted in this research.It is revealed from the simulation that the THRM model has a high computational efficiency and stability in simulating subsurface flow of the experimental hillslope,which is valuable in assessing the hillslope runoff generation mechanism.A model based sensitivity analysis is also carried out.The impact of boundary condition,grid size and initial soil moisture on simulation result and model stability are revealed,which provides insightful references to understand the mechanism of subsurface flow. | LAN Min HU HongChang TIAN FuQiang HU HePing | 2013 | Science China(Technological Sciences)2013，56，10： | 6 |
| 5 | Recent advances on electroactive CNT-based membranes for environmental applications:The perfect match of electrochemistry and membrane separation显示文摘Global climate change,growing population,and environmental pollution underscore the need for a greater focus on providing advanced water treatment technologies.Although electrochemical basedprocesses are becoming promising solutions,they still face challenges owing to mass transport and upscaling which hinder the exploitation of this technology.Electrode design and reactor configuration are key factors for achieving operational improvements.The electroactive membrane has proven to be a breakthrough technology integrating electrochemistry and membrane separation with an enhanced mass transport by convection.In this review article,we discuss recent progress in environmental applications of electroactive membranes with particular focus on those composed of carbon nanotubes(CNT)due to their intriguing physicochemical prope rties.Their applications in degradation of refractory contaminants,detoxification and sequestration of toxic heavy metal ions,and membrane fouling alleviations are systematically reviewed.We then discuss the existing limitations and opportunities for future research.The development of advanced electroactive systems depends on interdisciplinary collaborations in the areas of materials,electrochemistry,membrane development,and environmental sciences. | Yanbiao Liu Fuqiang Liu Ning Ding Xuemei Hu Chensi Shen Fang Li Manhong Huang Zhiwei Wang Wolfgang Sand Chong-Chen Wang | 2020 | Chinese Chemical Letters2020，31，10： | 6 |
| 6 | Molecular Characteristics and Phylogenetic Analysis of N Gene of Human Derived Rabies Virus显示文摘Objective To investigate the relationship between the molecular characteristics and phylogenetic evolution of rabies N gene.Methods Saliva samples were collected from rabies cases,and RT-PCR was used to amplify the N gene of rabies virus with the specific primers.The amplifying product of RT-PCR was cloned to pUCm-T vector and transformed into E.coli XL1-Blue and then the blue-white selection,PCR screening and gene sequencing were carried out to identify the positive clones.Finally,ExPASy and other bioinformatics softwares were used to analyze and predict the structure and biological characteristics of the N genome.Results The amplification product of RT-PCR was 1 353 bp,the recombinant plasmid pUCm-T/N was constructed,the whole length of the N gene open reading frame was composed of 1 353 nucleotide residues to code 450 amino acids (20 kinds),the accession number submitted to the Genbank was HM756692,its sequence homology of nucleotides and amino acids compared with the vaccine strain CTN-1-V was 90% and 99% respectively.The evolutionary analysis showed that the isolated strain belonged to genotype I with certain geographic regionality.Conclusion The characteristics investigation and bioinformatics analysis of Hunan0806 N gene will provide fundament data to reveal the significance of the N gene characteristics for rabies epidemiology and its prevention & control. | CAI Liang TAO XiaoYan LIU YunZhi ZHANG Hong GAO LiDong HU ShiXiong LIU FuQiang LI Hao SHEN XinXin LIU JiaHui WANG ShiQing TANG Qing | 2011 | Biomedical and Environmental Sciences2011，24，4： | 4 |
| 7 | Numerical Study of Effect of Compressor Swirling Flow on Combustor Design in a MTE显示文摘An effect of the swirling flow on the combustion performance is studied by the computational fluid dynamics(CFD) in a micro-gas turbine with a centrifugal compressor, dump diffuser and forward-flow combustor. The distributions of air mass and the Temperature Pattern Factor(as: Overall Temperature Distribution Factor-OTDF) in outlet are investigated with two different swirling angles of compressed air as 0° and 15° in three combustors. The results show that the influences of swirling flow on the air distribution and OTDF cannot be neglected. Compared with no-swirling flow, the air through outer liner is more, and the air through the inner liner is less, and the pressure loss is bigger under the swirling condition in the same combustor. The Temperature Pattern Factor changes under the different swirling conditions. | MU Yong WANG Chengdong LIU Cunxi LIU Fuqiang HU Chunyan XU Gang ZHU Junqiang | 2017 | Journal of Thermal Science2017，26，4： | 3 |
| 8 | Rapid and Sparse Labeling of Neurons Based on the Mutant Virus-Like Particle of Semliki Forest Virus显示文摘Sparse labeling of neurons contributes to uncovering their morphology, and rapid expression of a fluorescent protein reduces the experiment range. To achieve the goal of rapid and sparse labeling of neurons in vivo, we established a rapid method for depicting the fine structure of neurons at 24 h post-infection based on a mutant viruslike particle of Semliki Forest virus. Approximately 0.014 fluorescent focus-forming units of the mutant virus-like particle transferred enhanced green fluorescent protein into neurons in vivo, and its affinity for neurons in vivo was stronger than for neurons in vitro and BHK21(baby hamster kidney) cells. Collectively, the mutant virus-likeparticle provides a robust and convenient way to reveal the fine structure of neurons and is expected to be a helper virus for combining with other tools to determine their connectivity. Our work adds a new tool to the approaches for rapid and sparse labeling of neurons in vivo. | Fan Jia Xutao Zhu Pei Lv Liang Hu Qing Liu Sen Jin Fuqiang Xu | 2019 | Neuroscience Bulletin2019，35，3： | 3 |
| 9 | Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics显示文摘Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment. | Lijuan Wen Yu Peng Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu | 2022 | Nano Research2022，15，2： | 2 |
| 10 | Analysis of the effect of regional lateral inflow on the flood peak of the Three Gorges Reservoir显示文摘The Three Gorges Region(TGR),located at the lower reach of the Upper Yangtze River Basin(UYRB) in China,suffers from heavy rainstorm frequently.The runoff generated from TGR composes an important part of the total flood at the famous Three Gorges Reservoir(TGRe).During the severe flood period in 1954,for example,the water from TGR accounted for up to 13.2% of the 30-days maximum flood volume of the UYRB.Considering the short and steep tributaries with rapid concentration,the regional lateral inflow(RLI) may induce more serious effect on the flood peak of the TGRe than the volume.However,hydrological data of the sparse gauge stations is too insufficient to evaluate the effect of RLI.This paper studied the impact by analyzing 880 flood events during 1956-2000.By comparing the observed hydrograph and simulated hydrograph with HEC-RAS software regarding no RLI,the effect of RLI on flood peak value and timing properties was identified and quantified.The variability of this effect among floods of different magnitudes was also analyzed.To evaluate the analysis uncertainty associated with the parameter of roughness coefficient,four sets of roughness coefficients from different research groups were employed in this study.The results showed that RLI contributes discharge of 3524 m3/s to flood peaks of the TGRe on average,with the contribution ratio of 15.9%.RLI contributes 12000 m3/s to the flood peaks larger than 50000 m3/s on average,with 25000 m3/s as its upper bound,while the contribution ratio can reach up to 50%,with an average of 20%.The variability of this effect is great among different events.Statistical analysis showed that to larger flood peak of the TGRe,RLI contributes more discharge with higher variability,and the contribution ratio and its variability are slightly larger,and events with higher contribution ratio occur more frequently.RLI can reshape the hydrograph,leading to earlier appearance of flood peak.This effect and its variability increase with the contribution ratio.This study has revealed that RLI plays an important role in large flood peak of the TGRe,which calls for more reliable flood forecasting methods to prolong the forecast lead time and improve the accuracy for the safety of the Three Gorges Dam and the protection of its lower reaches during severe flood disaster period. | WANG BaiWei TIAN FuQiang HU HePing | 2011 | Science China(Technological Sciences)2011，54，4： | 2 |
| 11 | A two-dimensional Richards equation solver based on CVODE for variably saturated soil water movement显示文摘A numerical model of two-dimensional soil water movement under surface drip irrigation condition was developed. The physical process of soil water movement is described by 2D Richards equation,and the upper boundary condition is depicted by the improved moving ponded area boundary. The partial differential equation(PDE) is transformed into ordinary differential equations(ODEs) through spatial semi-discretization and numerically solved by an ordinary differential equation solver(CVODE) . The numerical and field experiments indicate the good performance of the model in terms of accuracy and efficiency. The model provides a useful tool for long-term simulation of soil water movement under surface drip irrigation. Also,the model can serve as a general 2D Richards equation solver for variably saturated soil water movement,which is named as TIVS model(Tsinghua Integrated Variably Saturated soil water movement model). | TIAN FuQiang GAO Long HU HePing | 2011 | Science China(Technological Sciences)2011，54，12： | 2 |
| 12 | SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction显示文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. | HAN NIU XIN CHEN XUEQI FU JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG | 2021 | BIOCELL2021，45，4： | 2 |
| 13 | Plasmonic coupling-enhanced in situ photothermal nanoreactor with shape selective catalysis for C–C coupling reaction显示文摘Carbon-carbon(C–C)coupling reactions represent one of the most powerful tools for the synthesis of complex natural products,bioactive molecules developed as drugs and agrochemicals.In this work,a multifunctional nanoreactor for C–C coupling reaction was successfully fabricated via encapsulating the core-shell Cu@Ni nanocubes into ZIF-8(Cu@Ni@ZIF-8).In this nanoreactor,Ni shell of the core-shell Cu@Ni nanocubes was the catalytical active center,and Cu core was in situ heating source for the catalyst by absorbing the visible light.Moreover,benefiting from the plasmonic resonance effect between Cu@Ni nanocubes encapsulated in ZIF-8,the absorption range of nanoreactor was widened and the utilization rate of visible light was enhanced.Most importantly,the microporous structure of ZIF-8 provided shape-selective of reactant.This composite was used for the highly shape-selective and stable photocatalysed C–C coupling reaction of boric acid under visible light irradiation.After five cycles,the nanoreactor still remained high catalytical activity.This Cu@Ni@ZIF-8 nanoreactor opens a way for photocatalytic C–C coupling reactions with shape-selectivity. | Zhenxing Li Yixuan Gong Xin Zhang Yangyang Wen Jiasai Yao Mingliang Hu Miao He Jiahao Liu Rui Li Fuqiang Wang Chuanxin Zhang | 2020 | Nano Research2020，13，10： | 2 |
| 14 | Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggre- gated micelles for controlled release of paclitaxel 显示文摘 | HU Fuqiang REN Guofei YUAN Hong | 2006 | Colloids and Surfaces B: biointerfaees2006，50，2： | 1 |
| 15 | Synthesis and antitumor activity of doxorubicin conjugated stea- ricacid-g-chitosan oligosaccharide polymeric micelles显示文摘 | Hu Fuqiang Liu Lina Du Yongzhong | 2009 | Biomaterials2009，30，36： | 1 |
| 16 | Im- provement Schemes for Indoor Mobile Location Es- timation: A Survey 显示文摘 | Shang Jianga Hu Xuke Gu Fuqiang | 2015 | Mathematical Problems in Engineering2015，，： | 1 |
| 17 | Spatial averaging infiltration model for layered soil显示文摘To quantify the influences of soil heterogeneity on infiltration, a spatial averaging infiltration model for layered soil (SAI model) is developed by coupling the spatial averaging approach proposed by Chen et al. and the Generalized Green-Ampt model proposed by Jia et al. In the SAI model, the spatial hetero- geneity along the horizontal direction is described by a probability distribution function, while that along the vertical direction is represented by the layered soils. The SAI model is tested on a typical soil using Monte Carlo simulations as the base model. The results show that the SAI model can directly incorporate the influence of spatial heterogeneity on infiltration on the macro scale. It is also found that the homogeneous assumption of soil hydraulic conductivity along the horizontal direction will overes- timate the infiltration rate, while that along the vertical direction will underestimate the infiltration rate significantly during rainstorm periods. The SAI model is adopted in the spatial averaging hydrological model developed by the authors, and the results prove that it can be applied in the macro-scale hy- drological and land surface process modeling in a promising way. | HePing Hu ZhiYong Yang FuQiang Tian | 2009 | Science China(Technological Sciences)2009，52，4： | 1 |
| 18 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 19 | Ecohydro-logical evolution model on riparian vegetation in hyper-ar-id regions and its validation in the lower reach of TarimRiver显示文摘 | Liu Dengfeng Tian Fuqiang Hu Heping | 2012 | Hydrological Processes2012，26，13： | 1 |
| 20 | Adsorption of naphthalene onto the carbon adsorbent from waste ion exchange resin: Equilibrium and kinetic characteristics显示文摘 | Chao Long JunDong Lu Aimin Li Dabo Hu Fuqiang Liu Quanxing Zhang | 2007 | Journal of Hazardous Materials2007，，3： | 1 |
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