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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Assessment of duodenogastric reflux by combined continuous intragastric pH and bilirubin monitoring显示文摘AIM: To assess the diagnostic value of a combination of continuous intragastric pH and bilirubin monitoring in the detection of duodenogastric reflux (DGR), and the effects of diet on the bilirubin absorbance.METHODS: 30 healthy volunteers were divided into twogroups: standard diet group (Group 1) 18 cases, free diet group (Group 2) 12 cases. Each subjects were subjected to simultaneous 24 hour intragastric pH and spectrophotometric bilirubin concentration monitoring (Bilitec 2000).RESULTS: There was no difference of preprandial phasebilirubin absorbance between two groups. The absorbanceof postprandial phase was significantly increased in group 2than group 1. There was no difference between preprandialphase and postprandial phase absorbance in group 1.Postprandial phase absorbance was significantly higher ingroup 2. In a comparison of bile reflux with intragastric pHduring night time, there were 4 types of reflux:Simultaneous increase in absorbance and pH in only 19.6%, increase in bilirubin with unchanged pH 33. 3 %, pHincrease with unchanged absorbance 36. 3 %, and bothunchanged in 10. 8 %. Linear regression analysis showed nocorrelation between percertage total time of pH < 4 aridpercentage total time of absortance > 0. 14, r=0.068, P<0.05.CONCLUSION: Because of the dietary effect, highabsorbance fluids or foods should be avoided in detection.Intrsgastric pH and bilirubin monitoring separately predictthe presence of duodenal (and/or pancreatic) reflux and bilereflux. They can not substitute for each other. The detectionof DGR is improved if the two parameters are combinedsimultanoously. | Fei Dai Jun Gong Ru Zhang Jin-Yan Luo You-Ling Zhu Xue-Qin Wang,Department of Gastroenterology,Second Hospital of Xi’ an Jiaotong University,Xi’an 710004,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 30 |
| 3 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 4 | Simultaneous oxidation of NO,SO_2 and Hg^0 from flue gas by pulsed corona discharge显示文摘A process capable of simultaneously oxidizing NO,SO2,and Hg0 was proposed,using a high-voltage and short-duration positive pulsed corona discharge.By focusing on NO,SO2,and Hg0 oxidation effciencies,the influences of pulse peak voltage,pulse frequency,initial concentration,electrode number,residence time and water vapor addition were investigated.The results indicate that NO,SO2 and Hg0 oxidation effciencies depend primarily on the radicals(OH,HO2,O) and the active species(O3,H2O2,etc.) produced by the pulsed corona discharge.The NO,SO2 and Hg0 oxidation effciencies could be improved as pulse peak voltage,pulse frequency,electrode number and residence time increased,but they were reduced with increasing initial concentrations.By adding water vapor,the SO2 oxidation effciency was improved remarkably,while the NO oxidation effciency decreased slightly.In our experiments,the simultaneous NO,SO2,and Hg0 oxidation effciencies reached to 40%,98%,and 55% with the initial concentrations 479 mg/m3,1040 mg/m3,and 15.0 μg/m3,respectively. | XU Fei,LUO Zhongyang,CAO Wei,WANG Peng,WEI Bo,GAO Xiang,FANG Mengxiang,CEN Kefa State key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou 310027,China. | 2009 | Journal of Environmental Sciences2009，21，3： | 22 |
| 5 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 6 | Direct adaptive neural control for stabilization of nonlinear time-delay systems显示文摘This paper is concerned with the problem of adaptive neural control for uncertain nonlinear strict-feedback time-delay systems with unknown virtual control coefficients. Radial basis function (RBF) neural networks are employed to directly approximate unknown virtual control signals, and then the adaptive neural control law is constructed by Lyapunov-Krasovskii functionals and backstepping. In order to avoid encountering a large number of adaptive parameters when using RBF neural networks as function approximators, an unknown constant, instead of unknown neural weights themselves, is employed as the estimated parameter. This technique makes only one adaptive parameter tuned online, thus significantly alleviating the burdensome computation. Meanwhile, some continuous functions are introduced to overcome the design difficulty originating from the use of one adaptive parameter. The proposed adaptive control guarantees the boundedness of all the signals in the closed-loop system. Simulation studies are presented to illustrate the effectiveness of the scheme. | WANG Min ZHANG SiYing CHEN Bing LUO Fei | 2010 | Science China(Information Sciences)2010，53，4： | 17 |
| 7 | Three-dimensional Evolutionary Models of the Qiongxi Structures,Southwestern Sichuan Basin,China:Evidence from Seismic Interpretation and Geomorphology显示文摘褶层结束是在有压缩性的差错相关的褶层的学习的特色。如此的结束能由于戳差错上的排水量的损失或 / 并且形成一个侧面或倾斜的斜面。因此,高质量的地震数据将明白地帮助定义哪个机制应该为给定的差错相关的褶层的结束负责。在四川盆的 Qiongxi 和 Qiongxinan 结构,中国是拥有在他们之间的北结束和结构的僵绳的自然差错繁殖褶层的例子。合拢 / 指责几何学和沿着罢工排水量变化被工业 3-D 抑制地震体积。我们解释北结束和结构的僵绳附近的褶层的 plunge 由于排水量的损失罢工。与北结束联系的差错几何学变化从一在 Qiongxinan 结构的冠扁平斜面在排水量最大的地方,到简单地 Qiongxi 结构的北尖端附近的一个斜面,没有形成一个侧面或倾斜的斜面。在这研究,我们也使用排水模式,在沿着一个差错的排水量与推进为 Qiongxinan 的侧面的繁殖建议一个模型的持续时间成正比的 Qiongxinan 结构和假设的冠保存的胚胎的结构和 Qiongxi 结构。明确地,我们建议结构首先在易碎的单位以内作为一个孤立的差错斜面开始了。与弄短增加,差错变得以更弱的页岩单位与更低的分队连接创造 hybridized 差错繁殖褶层。我们的模型为 Qiongxinan 和 Qiongxi 结构的侧面的繁殖历史建议可能的解释,并且也提供一条其他的途径给在迟了的新生代在西南的四川盆证实以前的 Pingluoba 结构的活动。 | JIA Qiupeng JIA Dong LUO Liang CHEN Zhuxin LI Yiquan DENG Fei SUN Shengsi LI Haibin | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 17 |
| 8 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 9 | Detecting soil salinity with arid fraction integrated index and salinity index in feature space using Landsat TM imagery显示文摘Modeling soil salinity in an arid salt-affected ecosystem is a difficult task when using remote sensing data because of the complicated soil context(vegetation cover,moisture,surface roughness,and organic matter)and the weak spectral features of salinized soil.Therefore,an index such as the salinity index(SI)that only uses soil spectra may not detect soil salinity effectively and quantitatively.The use of vegetation reflectance as an indirect indicator can avoid limitations associated with the direct use of soil reflectance.The normalized difference vegetation index(NDVI),as the most common vegetation index,was found to be responsive to salinity but may not be available for retrieving sparse vegetation due to its sensitivity to background soil in arid areas.Therefore,the arid fraction integrated index(AFII)was created as supported by the spectral mixture analysis(SMA),which is more appropriate for analyzing variations in vegetation cover(particularly halophytes)than NDVI in the study area.Using soil and vegetation separately for detecting salinity perhaps is not feasible.Then,we developed a new and operational model,the soil salinity detecting model(SDM)that combines AFII and SI to quantitatively estimate the salt content in the surface soil.SDMs,including SDM1 and SDM2,were constructed through analyzing the spatial characteristics of soils with different salinization degree by integrating AFII and SI using a scatterplot.The SDMs were then compared to the combined spectral response index(COSRI)from field measurements with respect to the soil salt content.The results indicate that the SDM values are highly correlated with soil salinity,in contrast to the performance of COSRI.Strong exponential relationships were observed between soil salinity and SDMs(R2>0.86,RMSE<6.86)compared to COSRI(R2=0.71,RMSE=16.21).These results suggest that the feature space related to biophysical properties combined with AFII and SI can effectively provide information on soil salinity. | Fei WANG Xi CHEN GePing LUO JianLi DING XianFeng CHEN | 2013 | Journal of Arid Land2013，5，3： | 14 |
| 10 | Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1显示文摘Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in the treatment of liver fibrosis remain largely elusive. Here, we discover that celastrol exerts anti-fibrotic effects via promoting the production of reactive oxygen species(ROS) and inducing ferroptosis in activated hepatic stellate cells(HSCs). By using activity-based protein profiling(ABPP) in combination with bio-orthogonal click chemistry reaction and cellular thermal shift assay(CETSA), we show that celastrol directly binds to peroxiredoxins(PRDXs), including PRDX1, PRDX2, PRDX4 and PRDX6,through the active cysteine sites, and inhibits their anti-oxidant activities. Celastrol also targets to heme oxygenase 1(HO-1) and upregulates its expression in activated-HSCs. Knockdown of PRDX1, PRDX2,PRDX4, PRDX6 or HO-1 in HSCs, to varying extent, elevated cellular ROS levels and induced ferroptosis. Taken together, our findings reveal the direct protein targets and molecular mechanisms via which celastrol ameliorates hepatic fibrosis, thus supporting the further development of celastrol as a promising therapeutic agent for liver fibrosis. | Piao Luo Dandan Liu Qian Zhang Fan Yang Yin-Kwan Wong Fei Xia Junzhe Zhang Jiayun Chen Ya Tian Chuanbin Yang Lingyun Dai Han-Ming Shen Jigang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 14 |
| 11 | Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes显示文摘OBJECTIVE: To evaluate the antioxidant and immunomodulatory activities of a unique polysaccharide from the medicinal fungus Flammulina velutipes in vitro.METHODS: Using water extraction and alcohol precipitation, crude polysaccharides were obtained. After purification by DEAE-cellulose 52 ion exchange chromatography and Sephacryl S-300 HR gel filtration chromatography, High performance liquid chromatography equipped with evaporative light-scattering detector, Infrared radiation and Nuclear magnetic resonance were used to evaluate the structure of the polysaccharide. Its immunomodulatory activity was measured by examining the production of nitric oxide(NO) and cytokine secretion, and via lymphocyte proliferation experiments. Its effects on the scavenging activities of hydroxyl radical, superoxide anion and reducing power were also measured.RESULTS: A water-soluble polysaccharide, Flammulina velutipes polysaccharide I-A(FVP I-A), was obtained with a molecular mass of 8.14×104Da determined by high performance gel permeation chromatography. An in vitro antioxidant assay indicated that FVP I-A could scavenge hydroxyl radical, superoxide anion and possessed reducing power and could largely promote NO production and augment the interleukin-1β, interleukin-6, and tumor necrosis factor-α secretion by RAW264.7 macrophages(P<0.05). Moreover, FVP I-A could promote lymphocyte proliferation(P<0.05), and synergistically enhance the augmentation of the proliferation of mouse lymphocytes by concanavalin A and lipopolysaccharides(P<0.01, P<0.05).CONCLUSION: The FVP I-A obtained from Flammulina velutipes possessed antioxidant activity and could enhance non-specific and specific immune responses in vitro. | Ming Wu Xia Luo Xiaoyan Xu Wei Wei Mengyao Yu Nan Jiang Liming Ye Zhirong Yang Xiaofan Fei | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 14 |
| 12 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 13 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 14 | Status and distribution changes of the endangered Green Peafowl (Pavo muticus) in China over the past three decades (1990s-2017)显示文摘Background: Understanding the changes in population dynamics, including demographics, distribution and threats, is essential for species status assessing. The endangered Green Peafowl(Pavo muticus) has experienced sharp population declines and distribution range diminishing both in China and Southeast Asia. Field population surveys have not been conducted in China since the 1990 s, which hindered conservation planning and decision-making.Methods: With interview and line transects methods, we figured out the population and distribution changes of Green Peafowl across its historical ranges over the past three decades in China during 2014-2017.Results: The Green Peafowl once habituated in 54 counties in China. Nearly 60% of the distribution counties were lost in the past three decades, with the left 22 counties distributed in central, southern and western Yunnan, SW China. Population decrease detected in all distribution areas except for Shuangbai and Xinping county where more than 60% of the total population is located. Only about 30% of the former bird population were recorded with the same interviewing method as 20 years ago. Three birds, 1 carcass, 6 calls and 12 footprints were detected along the 865 km line transects, indic-ating extremely low encounter rate of Green Peafowl in field. Sharp decreases in flock sizes were also detected, from 820 birds per flock in the 1990 s to 3-5 birds at present. Poaching and habitat conversion are two widespread and long-lasting threats, while poisoning caused mortality in the past and hydropower construction affect regional population's survival. Large flocks of 18–27 birds were discovered in the field, which increases our confidence of population recovery of this endangered pheasant in China.Conclusions: Only interviewed bird number and counts based on line transects were presented in this study, without further population estimation due to limitation of the data sets. Although the actual population of this cryptic bird must be underestimated, dramatic population declines and distribution concentrations of the endangered Green Peafowl occurred over the past 30 years in China undoubtedly. | Dejun Kong Fei Wu Pengfei Shan Jianyun Gao Dao Yan Weixiong Luo Xiaojun Yang | 2018 | Avian Research2018，9，2： | 12 |
| 15 | Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice显示文摘目的: Epigallocatechin-3-gallate (EGCG ) 是在绿茶的主要多酚。在这研究,我们在非酒精的脂肪肝在胰岛素抵抗和胰岛素清理上调查了 EGCG 的效果疾病(NAFLD ) 老鼠。 | Lu GAN Zi-jun MENG Ri-bo XlONG Jin-qiang GUO Xiao-cui LU Zhi-wei ZHENG Yan-ping DENG Bing-de LUO Fei ZOU Hua LI | 2015 | Acta Pharmacologica Sinica2015，36，5： | 12 |
| 16 | Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on p H-monitoring and symptom-scale显示文摘AIM To compare the outcomes between laparoscopic Nissen fundoplication(LNF)and proton pump inhibitors(PPIs)therapy in patients with laryngopharyngeal reflux(LPR)and typeⅠhiatal hernia diagnosed by oropharyngeal p H-monitoring and symptom-scale assessment.METHODS From February 2014 to January 2015,70 patients who were diagnosed with LPR and type I hiatal hernia and referred for symptomatic assessment,oropharyngeal p H-monitoring,manometry,and gastrointestinal endoscopy were enrolled in this study.All of the patients met the inclusion criteria.All of the patients underwent LNF or PPIs administration,and completed a2-year follow-up.Patients’baseline characteristics and primary outcome measures,including comprehensive and single symptoms of LPR,PPIs independence,and satisfaction,and postoperative complications were assessed.The outcomes of LNF and PPIs therapy were analyzed and compared. RESULTS There were 31 patients in the LNF group and 39patients in the PPI group.Fifty-three patients(25 in the LNF group and 28 in the PPI group)completed reviews and follow-up.Oropharyngeal p H-monitoring parameters were all abnormal with high acid exposure,a large amount of reflux,and a high Ryan score,associated reflux symptom index(RSI)score.There was a significant improvement in the RSI and LPR symptom scores after the 2-year follow-up in both groups(P<0.05),as well as typical symptoms of gastroesophageal reflux disease.Improvement in the RSI(P<0.005)and symptom scores of cough(P=0.032),mucus(P=0.011),and throat clearing(P=0.022)was significantly superior in the LNF group to that in the PPI group.After LNF and PPIs therapy,13 and 53 patients achieved independence from PPIs therapy(LNF:44.0%vs PPI:7.14%,P<0.001)during follow-up,respectively.Patients in the LNF group were more satisfied with their quality of life than those in the PPI group(LNF:62.49±28.68 vs PPI:44.36±32.77,P=0.004).Body mass index was significantly lower in the LNF group than in the PPI group(LNF:22.2±3.1kg/m^2 vs PPI:25.1±2.9 kg/m^2,P=0.001).CONCLUSION Diagnosis of LPR should be assessed with oropharyngeal p H-monitoring,manometry,and the symptom-scale.LNF achieves better improvement than PPIs for LPR with type I hiatal hernia. | Chao Zhang Zhi-Wei Hu Chao Yan Qiong Wu Ji-Min Wu Xing Du Dian-Gang Liu Tao Luo Fei Li Zhong-Gao Wang | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 17 | Changes of serum Tau, GFAP, TNF-α and malonaldehyde after blast-related traumatic brain injury显示文摘 | Liu Mengdong Luo Peng Wang Zhanjiang Fei Zhou | 2014 | Chinese Journal of Traumatology2014，17，6： | 12 |
| 18 | Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function显示文摘BACKGROUND:Triptolide(TPT)is a diterpenoid triepoxide extracted from the Chinese herb Tripterygium wilfordii Hook.F.It exhibits potent immunosuppressive and anti-inflammatory properties.This study was undertaken to investigate its effects on prolongation of islet allograft survival in rodents.Additionally,we investigated whether TPT would be toxic to islet function in vivo.METHODS:We transplanted BALB/c islets to either chemically induced diabetic C57BL/6 mice or spontaneously diabetic nonobese diabetic(NOD)mice.TPT was injected within 2 weeks or continuously,until rejection,in the two combinations.Then, we evaluated the toxicity of TPT on islet function by daily injection to naive BALB/c or diabetic BALB/c that was cured by syngeneic islet transplantation under the kidney capsule.Mice injected with cyclosporine A(CsA)or vehicle served as controls.Intraperitoneal glucose tolerance tests(IPGTTs)performed at 4 and 8 weeks in the na?ve BALB/c group,and at 2,4,6,and 8 weeks in the syngeneic transplanted group.RESULTS:The medium survival time of islets allograft from TPT treated C57BL/6 and NOD recipients were 28.5 days(range 24-30 days,n=10)and 33.0 days(range 15-47 days,n=6), respectively,and they were significantly different from those of the vehicle treated controls,which were 14.0 days(range 13-16 days,n=6)and 5.0 days(range 4-10 days,n=6),respectively(all P<0.0001).The IPGTT demonstrated that there was no difference between the TPT treated and vehicle treated groups, either in the normal or syngeneic transplanted islet BALB/c mice.However,CsA injection impaired islet function in both normal and syngeneic transplanted mice as early as 4 weeks.CONCLUSION:TPT prolonged islets allograft survival in a chemically induced diabetic or an autoimmune diabetic murine model without impairment of islet function. | Xin, Ming-Jun Cui, Shi-Hua Liu, Shuang Sun, Hai-Chen Li, Fei Sun, Jia-Bang Luo, Bin | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 11 |
| 19 | Clinical Value of Whole-body Magnetic Resonance Diffusion Weighted Imaging on Detection of Malignant Metastases显示文摘Objective To evaluate the value of whole-body diffusion weighted imaging(WB-DWI) on detection of malignant metastasis.Methods Forty-six patients with malignant tumors underwent WB-DWI examinations between April 2007 and August 2007 in our hospital.Before WB-DWI examination,the primary cancers of all the patients were confirmed by pathology,and the TNM-stage was assessed with conventional magnetic resonance imaging(MRI) or computed tomography(CT).WB-DWI was performed using short TI inversion recovery echo-planar imaging(STIR-EPI) sequence.Abnormal high signal intensities on WB-DWI were considered as metastases.The results of WB-DWI were compared with other imaging modalities.For the assessment of the diagnostic capability of WB-DWI,WB-DWI were compared with CT for demonstrating mediastinal lymph node metastases and lung metastases,and with conventional MRI for demonstrating metastases in other locations.Results WB-DWI demonstrated 143 focuses,14 of which were diagnosed to be benign lesions in routine imaging.The number of bone metastases depicted on WB-DWI and routine imaging was 85 and 86;lymph node metastases was 17 and 18;liver metastases was 14 and 14;lung metastases was 4 and 8;and brain metastases was 6 and 8,respectively.WB-DWI failed to detect 12 metastatic lesions including 3 osteoplastic bone metastases,4 lung metastases,3 mediastinal lymph node metastases,and 2 brain metastases.Four metastatic lesions including 2 deltopectoral lymph nodes and 2 rib metastases were detected with WB-DWI alone,all of which evolved greatly during clinical follow-up for more than 6 months.WB-DWI had higher detection rates for metastatic lesions in liver,bone,and lymph nodes than those in lung and brain(χ2=30,P<0.001).Conclusions WB-DWI could detect most of metastatic lesions that were diagnosed with conventional MRI and CT.The limitations of WB-DWI might be had high false-positive rate and low efficiency in detecting mediastinal lymph node,brain,and lung metastases. | Cheng Li Zhen-sheng Liu Xian-mao Du Ling He Jian Chen Wei Wang Fei Sun Fang Du Zhi-gang Luo Zhen-long Xue Yi Zhao Chang-wu Zhou | 2009 | Chinese Medical Sciences Journal2009，24，2： | 11 |
| 20 | Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea显示文摘瞄准: 学习是否 epigallocatechin gallate (EGCG ) ,绿导出茶的多酚,在 vitro 并且在 vivo 的施加的反流行性感冒 A 病毒活动。 | Jia-xin LING Fei WEI Ning LI Jin-lin LI Liang-jun CHEN Yuan-yuan LIU Fan LUO Hai-rong XIONG Wei HOU Zhan-qiu YANG | 2012 | Acta Pharmacologica Sinica2012，33，12： | 11 |
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