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| 1 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 2 | Room temperature preparation of highly stable cesium lead halide perovskite nanocrystals by ligand modification for white lightemitting diodes显示文摘The poor stability of halide perovskite nanocrystals(NCs)has severely hindered future practical application.Herein,we proposed a facile and effective ligand modification route to synthesize stable CsPbBr_(3) nanocrystals by introducing a double-terminal ligand,namely 4,4'-Azobis(4-cyanovalericacid)(CA),to replace the conventional oleic acid(OA)ligand at room temperature.The as-synthesized CsPbBr_(3)-CA not only possesses high photoluminescence quantum yield(72%)related to the reduced trap defects,but also shows significantly improved stability exposure to water,ethanol,light,and/or heat benefiting from the CA ligand anchored to NC surfaces tightly.The photoluminescence intensity of CsPbBr_(3)-CA maintains about 80%and 75%of its initial emission intensity after immersed in water or ethanol for 360 min,respectively,whereas that of the CsPbBr_(3)-OA was quenched completely within a few minutes.Moreover,an all-inorganic white light-emitting diode(LED)covered 126%National Television System Committee(NTSC)standard and 92%Rec.2020 standard was fabricated by combining the green CsPbBr_(3)-CA and commercial red-emitting K2SiF6:Mn4+(KSF)phosphors onto a blue LED chip.Thus,the presented work initiates the development of the room temperature preparation of high quality CsPbBr_(3) and shows prospect for next-generation displays. | Yu Zhang Guishun Li Changkun She Shaohua Liu Fangyu Yue Chengbin Jing Ya Cheng Junhao Chu | 2021 | Nano Research2021，14，8： | 3 |
| 3 | Low-strain TiP_(2)O_(7) withthree-dimensionalionchannelsas long-life and high-rate anode material for Mg-ion batteries显示文摘Rechargeable magnesium batteries are identified as a promising next-generation energy storage system,but their development is hindered by the anode−electrolyte−cathode incompatibilities and passivation of magnesium metal anode.To avoid or alleviate these problems,the exploitation of alternative anode materials is a promising choice.Herein,we present titanium pyrophosphate(TiP_(2)O_(7))as anode materials for magnesium-ion batteries(MIBs)and investigate the effect of the crystal phase on its magnesium storage performance.Compared with the me-tastable layered TiP_(2)O_(7),the thermodynamically stable cubic TiP_(2)O_(7) displays a better rate capability of 72 mAh g^(−1) at 5000 mA g^(−1).Moreover,cubic TiP_(2)O_(7) exhibits excellent cycling stability with the capacity of 60 mAh g^(−1) after 5000 cycles at 1000 mA g^(−1),which are better than pre-viously reported Ti-based anode materials for MIBs.In situ X-ray diffraction technology confirms the single-phase magnesiumion inter-calation/deintercalation reaction mechanism of cubic TiP_(2)O_(7) with a low volume change of 3.2%.In addition,the density functional theory calcu-lation results demonstrate that three-dimensional magnesiumion diffu-sion can be allowed in cubic TiP_(2)O_(7) with a low migration energy barrier of 0.62 eV.Our work demonstrates the promise of TiP_(2)O_(7) as high-rate and long-life anode materials for MIBs and may pave the way for further development of MIBs. | Fangyu Xiong Yalong Jiang Li Cheng Ruohan Yu Shuangshuang Tan Chen Tang Chunli Zuo Qinyou An Yunlong Zhao Jean-Jacques Gaumet Liqiang Mai | 2022 | Interdisciplinary Materials2022，1，1： | 3 |
| 4 | Enhancing single-cell hyaluronic acid biosynthesis by microbial morphology engineering显示文摘Microbial morphology engineering is a novel approach for cell factory to improve the titer of target product in bio-manufacture.Hyaluronic acid(HA),a valuable glycosaminoglycan polymerized by HA synthase(HAS),a membrane protein,is particularly selected as the model product to improve its single-cell HA-producing capacity via morphology engineering.DivIVA and FtsZ,the cell-elongation and cell division related protein,respectively,were both down/up dual regulated in C.glutamicum via weak promoter substitution or plasmid overexpression.Different from the natural short-rod shape,varied morphologies of engineered cells,i.e.small-ellipsoid-like(DivIVA-reduced),bulb-like(DivIVA-enhanced),long-rod(FtsZ-reduced)and dumbbell-like(FtsZ-enhanced),were observed.Applying these morphology-changed cells as hosts for HA production,the reduced expression of both DivIVA and FtsZ seriously inhibited normal cell growth;meanwhile,overexpression of DivIVA didn't show morphology changes,but overexpression of FtsZ surprisingly change the cell-shape into long and thick rod with remarkably enlarged single-cell surface area(more than 5.2-fold-increase).And finally,the single-cell HA-producing capacity of the FtsZ-overexpressed C.glutamicum was immensely improved by 13.5-folds.Flow cytometry analyses verified that the single-cell HAS amount on membrane was enhanced by 2.1 folds.This work is pretty valuable for high titer synthesis of diverse metabolic products with microbial cell factory. | Yukun Zheng Fangyu Cheng Bo Zheng Huimin Yu | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 3 |
| 5 | Novel hollow Ni0.33Co0.67Se nanoprisms for high capacity lithium storage显示文摘In this work,homogeneous Ni0.33Co0.67Se hollow nanoprisms were synthesized successfully in virtue of Kirkendall effect.It is the first time for bimetallic Ni-Co compounds Ni0.33Co0.67Se to be used in lithium-ion batteries (LIBs).Impressively,the Ni0.33Co0.67Se hollow nanoprisms show superior specific capacity (1,575 mAh/g at the current density of 100 mA/g) and outstanding rate performance (850 mAh/g at 2,000 mA/g) as anode material for LIBs.This work proves the potential of bimetallic chalcogenide compounds as high performance anode materials for LIBs. | Shaohua Zhu Cheng Chen Pan He Shuangshuang Tan Fangyu Xiong Ziang Liu Zhuo Peng Qinyou An Liqiang Mai | 2019 | Nano Research2019，12，6： | 3 |
| 6 | Hisingerite in Trachydacite from Tarim:Implications for Voluminous Felsic Rocks in Transitional Large Igneous Province显示文摘Unlike the typical large igneous provinces(LIPs) that are dominated by mafic-ultramafic rocks, the Tarim large igneous province(TLIP) is characterized by a high proportion of felsic rocks, based on which the TLIP is classified as a transitional LIP. In this study, we focus on the trachydacite from the TLIP in which we report the characteristics of hisingerite employing a variety of techniques such as EMPA, LA-ICPMS, CCD single crystal diffraction, and bulk-rock oxygen isotopes. The hisingerite in this rock is associated with plagioclase, amphibole, apatite and ilmenite. These minerals occur as aggregates of fine curled fibers in micron-scale and display heavy rare earth elements(HREE) enriched signature with significant negative Eu anomalies. In the primitive mantle-normalized trace element spider diagrams, they show pronounced Th and U spikes and Nb, Zr, Hf troughs. Petrological observation and mineralogical study reveal a closely genetic relationship between hisingerite and amphibole, indicating that the hisingerite might have been derived from the breakdown of amphibole during the magma ascent. The formation of hisingerite requires excess water from the surrounding melts, suggesting a hydrous parental magma. The hisingerite and amphibole assign a hydrous crustal source for the rock, and extensive crustal melting accounts for the voluminous felsic rocks in the TLIP. | Mingde Lang Zhiguo Cheng Zhaochong Zhang Fangyue Wang Qian Mao M.Santosh | 2020 | Journal of Earth Science2020，31，5： | 2 |
| 7 | Increasing the catalytic activities of iodine doped titanium dioxide by modifying with tin dioxide for the photodegradation of 2-chlorophenol under visible light irradiation显示文摘 | Zhiqiao He Cheng Wang Hongyu Wang Fangyue Hong Xinhua Xu Jianmeng Chen Shuang Song | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 8 | Microarray analysis of microRNA expression in hepatocellular carcinoma and non‐tumorous tissues without viral hepatitis显示文摘 | Yuan‐ShuaiHuang YongDai Xiao‐FangYu Shi‐YunBao Yi‐BingYin MinTang Cheng‐XiaoHu | 2007 | Journal of Gastroenterology and Hepatology2007，，： | 1 |
| 9 | Efficient Coupling of Complex Fluorooligosaccharides to Phenolic Peptide Mediated by Calcium Iodide显示文摘Besides serving as therapeutic agents and building blocks for glycoprotein synthesis,homogeneous synthetic glycopeptides also benefit understanding function of specific glycoform.However,the selectivity coupling of oligosaccharides to a given peptide remains challenging despite the fact that the synthesis of structure-defined complex oligosaccharides has been greatly facilitated by chemo-enzymatic based approaches.Herein,a Ca^(2+)-promoted glycosylation approach was developed to exclusively modify phenolic peptide using a panel of biologically important glycans. | Pei Liu Xing Quan Fangyu Wei Xianjun Deng Jie Shen Jiansong Cheng | 2023 | Chinese Journal of Chemistry2023，41，19： | 0 |
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