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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Microbial aerosol characteristics in highly polluted and nearpristine environments featuring different climatic conditions显示文摘There is an increasing interest in understanding ambient bioaerosols due to their roles both in health and in climate. Here, we deployed an Ultraviolet Aerodynamic Particle Sizer to monitor viable(fluorescent) bioaerosol concentration levels at city centers(highly polluted) and their corresponding suburbs(near pristine)(total 40 locations) in 11 provinces featuring different climate zones in China between July 16 and 28, 2013. The concentration levels of viable bioaerosol particles(Bio PM) of [0.5 lm were measured, and corresponding percentages of Bio PM%(biological fraction of total PM) and Bio PM2.5%(biological fraction of PM2.5) in particulate matter(PM)and Bio PM, respectively, were determined. For some key cities, indoor viable bioaerosol levels were also obtained.In addition, bacterial structures of the air samples collected across these monitoring locations were studied using pyrosequencing. Bio PM concentration levels ranged from2.1 9 104 to 2.4 9 105/m3 for city centers [Bio PM% =6.4 %(±6.3 %)] and 0.5 9 104 to 4.7 9 105/m3 for suburbs [Bio PM% = 10 %(±8.7 %)]. Distinctive bioaerosol size distribution patterns were observed for different climate zones, e.g., some had fluorescence peaks at 3 lm, while the majority had peaks at 1 lm. Ambient bacterial aerosol community structures were also found different for different geophysical locations. Results suggest that there was a poor overall relationship between PM and Bio PM across 40 monitoring locations(R2= 0.081, two-tailed P value =0.07435). Generally, city centers had higher PM concentrations than suburbs, but not Bio PM and Bio PM%. Indoor bioaerosol levels were found at least tenfold higher than those corresponding outdoors. Bacillus was observed to dominate the bacterial aerosol community in the air sample. | Kai Wei Yunhao Zheng Jing Li Fangxia Shen Zhuanglei Zou Hanqing Fan Xinyue Li Chang-yu Wu Maosheng Yao | 2015 | Science Bulletin2015，60，16： | 10 |
| 3 | Biocompatibility of nano-hydroxyapatite/Mg-Zn-Ca alloy composite scaffolds to human umbilical cord mesenchymal stem cells from Wharton's jelly in vitro显示文摘Seeding cells and scaffolds play pivotal roles in bone tissue engineering and regenerative medicine.Wharton’s jelly-derived mesenchymal stem cells(WJCs)from human umbilical cord represent attractive and promising seeding cells in tissue regeneration and engineering for treatment applications.This study was carried out to explore the biocompatibility of scaffolds to seeding cells in vitro.Rod-like nano-hydroxyapatite(RN-HA)and flake-like micro-hydroxyapatite(FM-HA)coatings were prepared on Mg-Zn-Ca alloy substrates using micro-arc oxidation and electrochemical deposition.WJCs were utilized to investigate the cellular biocompatibility of Mg-Zn-Ca alloys after different surface modifications by observing the cell adhesion,morphology,proliferation,and osteoblastic differentiation.The in vitro results indicated that the RN-HA coating group was more suitable for cell proliferation and cell osteoblastic differentiation than the FM-HA group,demonstrating better biocompatibility.Our results suggested that the RN-HA coating on Mg-Zn-Ca alloy substrates might be of great potential in bone tissue engineering. | GUAN FangXia MA ShanShan SHI XinYi MA Xun CHI LianKai LIANG Shuo CUI YuanBo WANG ZhiBin YAO Ning GUAN ShaoKang YANG Bo | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 4 | Neuronal-like differentiation of single versus multiple treatments with human amnion-derived mesenchymal stem cells induced by basic fibroblast growth factor显示文摘<正>BACKGROUND:Cultures from multiple portions of umbilical cord blood mesenchymal stem cells have been shown to undergo more rapid proliferation and attachment than single portions. OBJECTIVE:To observe growth of basic fibroblast growth factor(bFGF)-induced cultures of human amnion-derived mesenchymal stem cells(AMSCs) and differentiation into neuronal-like cells. DESIGN,TIME AND SETTING:Comparative observation.The study was performed at the Laboratory of Microbiology and Immunology,Basic Medical School of Zhengzhou University from January to May 2008. METHODS:Amnia from full-term,uterine-incision delivery were donated by 12 healthy women. AMSCs were obtained by cell separation and culture techniques,and were passaged and induced by bFGF.From the third passage,a total of 1 mLAMSCs,at a density of 1.0×10~4/mL,was separately harvested from six samples,which served as group A.A total of 1 mLAMSCs,at a density of 1.0×10~4/mL,was harvested separately from the remaining six samples,which served as group B.A total of 0.5 mL from the six samples of group A and 0.5 mL from the six samples of group B were combined to form group C. MAIN OUTCOME MEASURES:Differences in cell quantity among the three groups were compared by cell quantification and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) analysis.Expression of a glial cell marker,neuron-specific enolase,and nestin was detected in the three groups by immunocytochemistry. RESULTS:Cell quantification and MTT analysis of live cells,as well as AMSC absorbance,were significantly greater in group C compared with groups A and B at 18 days of culture(P<0.05),and no significant difference was observed between groups A and B.Glial fibrillary acidic protein, neuron-specific enolase,and nestin were expressed in all groups following bFGF induction. CONCLUSION:Mixed AMSC cultures promoted proliferation,and bFGF-induced AMSCs differentiated into neuronal-like cells. | Hongliang Jiao Fangxia Guan Xiang Hu Jianbin Li Hong Shan Wei Li Jun Li Ying Du Bo Yang Yunfan Zhou | 2009 | Neural Regeneration Research2009，4，9： | 3 |
| 5 | Impact of Air Pollution on Summer Surface Winds in Xi’an显示文摘By analysis of observation data, this paper demonstrates that pollution particles could reduce surface wind speed through blocking solar radiation to the ground. The comparation between temperature at the lowland meteorological station Xi’an and that over the nearby highland station Mt. Hua suggests that surface solar radiation at Xi’an is reduced due to the increasing anthropogenic aerosols. The reduced surface energy suppresses the atmospheric instability and convective flows, and thus the downward transfer of faster winds aloft is reduced. Consequently, wind speeds near surface are weakened. This reduction of surface winds is shown by the significant reverse trends of wind speeds over the two stations at different elevations. The aerosols’ effects on winds are also manifested in the trends of radionsonde wind speed. The decreased surface winds in Xi’an have also reduced local pan evaporation. | YANG Xin DONG Wenjie LIU Fangxia | 2011 | Acta meteorologica Sinica2011，25，4： | 2 |
| 6 | 红色文化对大学生个人品德培育的价值探究显示文摘从最一般的层面来看,个人品德的培育实际上是指个体在社会化过程中学习接受社会普遍的道德原则与核心价值观,并将其内化为个体道德品质与行为的过程,而这一过程离不开文化的滋养。红色文化作为中国共产党领导全国各族人民在长期革命、建设、改革进程中创造的以中国化马克思主义为核心的先进文化,具有传承性、时代性、人民性等鲜明的特征。在新时代中国特色社会主义的伟大实践中,充分挖掘红色文化的有益资源,进一步丰富高校思想政治教育的内容,对于大学生个人理想信念的引导、民族精神的培育、品德培育的示范具有重要的意义和价值。 | 汪玉峰 Huo Fangxia | 2018 | 天水师范学院学报2018，38，3： | 2 |
| 7 | Negatively and positively charged bacterial aerosol concentration and diversity in natural environments显示文摘Bioaerosol charge information is of vital importance for their electrostatic collection. Here, electrostatic means and molecular tools were applied to studying bioaerosol charge dynamics. Positively or negatively charged bioaerosols were collected using an electrostatic sampler operated with a field strength of 1.1 kV cm 1 at a flow rate of 3 L min 1 for 40 min. Those with fewer or no charges bypassing the sampler were also collected using a filter at the downstream of the electrostatic sampler in one environment. The experiments were independently conducted three times in three different environments. The collected bacterial aerosols were cultured directly on agar plates at 26°C, and the colony forming units (CFU) were manually counted. In addition, the CFUs were washed off from the agar plates, and further subjected to polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis (DGGE) for culturable diversity analysis. The results revealed remarkable differences in positively and negatively charged culturable bacterial aerosol concentration and diversity among the studied environments. In the office environment, negatively charged culturable bacterial aerosols appeared to dominate (P = 0.0489), while in outdoor and hotel environments both polarities had similar concentration levels (P = 0.078, P = 0.88, respectively). DGGE patterns for positively charged culturable bacterial aerosols were shown strikingly different from those of negatively charged regardless of the sampling environments. In addition, for each of the environments positively charged culturable bacterial aerosols collected were found to have more band pattern similarity with those positively charged for respective regions of agar plates than those negatively charged, and vice versa. The information developed here is useful for developing efficient electrostatic sampling protocols for bioaerosols. | SHEN FangXia KAI Wei YAO MaoSheng | 2013 | Chinese Science Bulletin2013，58，26： | 1 |
| 8 | Antioxidative activity of water extracts from leaf, male flower, raw cortex and fruit of Eucommia ulmoides Oliv显示文摘 | ZHANG Qiang SU Yinquan YANG Fangxia | 2007 | Forest Prod 12007，57，12： | 1 |
| 9 | Kallikrein Protects a- gainst Isehemie Stroke by Inhibiting Apoptosis and Inflammation and promoting angiogenesis and neurogenesis 显示文摘 | Chun Fangxia Hang Yin YU Yuyao | 2006 | Human Gene Therapy2006，17，： | 1 |
| 10 | Studies on the Preparation of Biodiesel from Zanthoxylum bungeanum Maxim Seed Oil显示文摘 | YANG Fangxia SU Yinquan LI Xiuhong | 2008 | J Agric Food Chem2008，56，17： | 1 |
| 11 | Urban road network evolution to maximize the capacity显示文摘 | Fangxia Zhao Huijun Sun Jianjun Wu | 2014 | Procedia-Social and Behavioral Sciences2014，138，7： | 1 |
| 12 | Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis显示文摘 | Chun Fangxia Hang Yin Cesar V | 2006 | Exp Neurol2006，197，2： | 1 |
| 13 | Bimodal, templated mesoporous carbons for capacitor applications显示文摘 | Dustin Banham Fangxia Feng Jason Burr | 2010 | Carbon2010，48，： | 1 |
| 14 | Structural and mechanical characteristics of porous 316L stainless steel lab ricated by indirect selective laser sintering 显示文摘 | Xie Fangxia He Xinbo Cao Shunli | 2013 | J Mater Process Technol2013，213，6： | 1 |
| 15 | Microstructure, microhardness and wear resistance of VCdFe surface compos- ites fabricated in situ显示文摘 | YE Fangxia Mirabbos H XU Yunhua | 2013 | Applied Surface Science2013，280，： | 1 |
| 16 | Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis显示文摘 | Chun Fangxia Hang Yin Cesar V | 2004 | Hypertension2004，43，： | 1 |
| 17 | Rotation Invariant Analysis and Orientation Estimation Method for Texture Classification Based on Radon Transform and Correlation Analysis显示文摘 | Wang Xuan Guo Fangxia Xiao Bin | 2010 | Journal of Visual Communication and Image Representation2010，21，1： | 1 |
| 18 | Influence of pore characteristics on microstructure, mechanical properties and corrosion resistance of selective laser sintered porous Ti–Mo alloys for biomedical applications显示文摘 | Fangxia Xie Xinbo He Shunli Cao Min Mei Xuanhui Qu | 2013 | Electrochimica Acta2013，，： | 1 |
| 19 | Development of a novel conductance-based technology for environmental bacterial sensing显示文摘In this study, a simple impedance based technology for measuring bacterial concentrations was developed. The measurement system includes the signal amplification, copper probes and a sample loader. During the experiments, the conductance of Bacillus subtilis var niger, Pseudomonas fluorescens, and Escherichia coli were measured using the combination of a pre-amplifier and a lock-in amplifier. The conductance data were modeled verses the bacterial concentrations. Results indicated that the relationship between the conductance of bacterial suspensions and their concentrations follows a generic model: Y=C1+C2×e ( X/C3 ) , where Y is the conductance (S), X is the bacterial concentration (Number/mL: abbreviated to N/mL) for all species tested, and C1 3 are constants. Gram negative P. fluorescens and E. coli assumed similar conductance curves, which were flatter than that of gram positive B. subtilis var niger. For P. fluorescens and E. coli the culturing technique resulted in higher concentration levels (statistically significant) from 2 to 4 times that measured by the impedance based technology. For B. subtilis var niger, both methods resulted in similar concentration levels. These differences might be due to membrane types, initial culturability and the obtained conductance curves. The impedance based technology here was shown to obtain the bacterial concentration instantly, holding broad promise in realtime monitoring biological agents. | SHEN FangXia TAN MiaoMiao XU Hong XU ZhenCheng YAO MaoSheng | 2013 | Chinese Science Bulletin2013，58，4： | 1 |
| 20 | 显示文摘 | ZHANGShan-shan DUChuan-mei FANGXia etal(章姗姗 杜传梅 方霞 等) | 2008 | 原子与分子物理学报2008，25，： | 1 |
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