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| 1 | Micro RNAs and clinical implications in hepatocellular carcinoma显示文摘AIM To assess the role of some circulating miRNAs(miR-23a, miR-203, miR338, miR-34, and miR-16) as tumor markers for diagnosis of hepatocellular carcinoma(HCC).METHODS One hundred and seventy-one subjects were enrolled, 57 patients with HCC, 57 patients with liver cirrhosis(LC) and 57 healthy subjects as control group. Severity of liver disease was assessed by Child Pugh score. Tumor staging was done using Okuda staging system. Quantification of Micro RNA(miR-23a, miR-203, miR338, miR-34, and miR-16) was performed.RESULTS All studied miRNA showed significant difference between HCC and cirrhotic patients in comparison tohealthy control. miR-23a showed statistically significant difference between HCC and cirrhotic patients being higher in HCC group than cirrhotic. miR-23a is significantly higher in HCC patients with focal lesion size equal or more than 5cm, patients with multiple focal lesions and Okuda stage Ⅲ. At cutoff value ≥ 210, miR-23a showed accuracy 79.3% to diagnose HCC patients with sensitivity 89.47% and specificity about 64.91%. At cut off level ≥ 200 ng/mL, serum alpha fetoprotein had 73.68% sensitivity, 52.63% specificity, 43.75% PPV, 80% NPV for diagnosis of HCC.CONCLUSION MicroR NA 23a can be used as a screening test for early detection of HCC. Also, it is related to larger size of tumour, late Okuda staging and multiple hepatic focal lesions, so it might be a prognostic biomarker. | Amal Ahmed Mohamed Zainab A Ali-Eldin Tamer A Elbedewy Magdy El-Serafy Fatma A Ali-Eldin Hossameldin Abdel Aziz | 2017 | World Journal of Hepatology2017，9，23： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 4 | Fixed point theorems for weak contractions in cone metric spaces显示文摘 | Fatma A S | 2010 | Int Journal of Math Analysis2010，7，48： | 1 |
| 5 | Th2 cytokine-induced up- regulation of 1 l beta-hydroxysteroid dehydrogenase-1 facil- itates glucocorticoid suppression of proasthmatic airway smooth muscle function显示文摘 | HU A FATMA S CAO J | 2009 | Am J Physiol Lung Cell Mol Physiol2009，296，5： | 1 |
| 6 | Mechanistic in- vestigation of the anodic oxidation of 3,4,5-trimethoxy- toluene in acetonitrile 显示文摘 | Ayoub H S Fatma M M Christian A | 2002 | J Electroanal Chem2002，537，： | 1 |
| 7 | Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in adult intensive care units from 14 developing countries of four continents: Findings of the International Nosocomial Infection Control Consortium*显示文摘 | Victor D. Rosenthal Camilla Rodrigues Carlos álvarez-Moreno Naoufel Madani Zan Mitrev Guxiang Ye Reinaldo Salomao Fatma Ulger Humberto Guanche-Garcell Souha S. Kanj Luis E. Cuéllar Francisco Higuera Trudell Mapp Rosalía Fernández-Hidalgo | 2012 | Critical Care Medicine2012，，： | 1 |
| 8 | Mechanistic in- vestigation of the anodic oxidation of p-methoxytoluene in dry and wet acetonitrile 显示文摘 | Ayoub H S Fatma M M Christian A | 1999 | J Electroanal Chem1999，464，： | 1 |
| 9 | Central composite rotatable design for liquefaction of pine barks 显示文摘 | KORKUT A FATMA K ESEN B | 2005 | Fuel Processing Technology2005，87，1： | 1 |
| 10 | Occurrence of deoxynivalenol in durum wheat in Tunisia显示文摘 | FATMA B CHIRAZ Z SALWA A | 2010 | Food Control2010，21，3： | 1 |
| 11 | Novel benzimidazole-pyrimidine conjugates as potent antitumor agents显示文摘 | Beba T A ti Fatma A F R Mostafa ti R | 2010 | Eur J tied Chem2010，45，： | 1 |
| 12 | Central composite rotatable design for liquefaction of pine barks显示文摘 | Korkut A Fatma K Esen B | 2005 | Fuel Processing Technology2005，87，1： | 1 |
| 13 | Tumor anti-initiating activity of some novel 3, 4-dihydropyrimidinones显示文摘 | Hanaa A T Fatma B Amira M G | 2009 | Pharmacological Reports2009，61，： | 1 |
| 14 | Effect of CeO2 on the Crystallization Behavior and Magnetic Properties of Zn-ferrite Glass Ceramics显示文摘 | Salwa A M Abdel-Hameed Fatma H Margha Mona A Ouis | 2013 | Journal of Alloys and Compounds2013，554，： | 1 |
| 15 | Quality improvement and shelf-life extension of refrigerated Nile tilapia (Oreochromis niloticus) fillets using natural herbs显示文摘 | Fathy A Khalafalla Fatma H M Ali Abdel-Rahim H A Hassan | 2015 | Beni-Suef University Journal of Basic and Applied Sciences2015，4，1： | 1 |
| 16 | expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, Bcl-2, Bax, and apoptotic index显示文摘 | NILGUN K FATMA A HAKAN K | 2007 | Pathology-Research and Practice2007，203，： | 1 |
| 17 | Expression of an aspergillus niger xylanase in yeast:Application in breadmaking and in vitro digestion显示文摘 | Fatma Elgharbi A?da Hmida-Sayari Youssef Zaafouri | 2015 | International Journal of Biological Macromolecules2015，79，： | 1 |
| 18 | Fuzzy portfolio selection using fuzzy analytic hierarchy process显示文摘 | FATMA T BEYZA A | 2009 | Information Sciences2009，179，12： | 1 |
| 19 | Preparation, Crystallization Behavior and Magnetic Properties of Nanoparticles Magnetic Glass- ceramics in the Systems Fe2 03 -CoO-MnO2 , Fe2 03 -NiO-MoO3 and Fe2 03 -CoO-Vz 05 显示文摘 | Salwa A M Abdel-Hameed Fatma H Margha | 2012 | Journal of Non-Crystalline Solids2012，358，： | 1 |
| 20 | Assessment of hepatic fibrosis in pediatric cases with hepatitis C virus in Egypt显示文摘AIM: To assess hepatic fibrosis and factors associated with its progression in children with HCV infection. METHODS: At the Hepatology Unit,Cairo University Children's Hospital,a single liver biopsy was performed to 43 children with HCV infection after an informed consent between 1998-2004. Their mean age at liver biopsy was 8.67 ± 4.3 years. RESULTS: Among the 43 patients' biopsies,12 (27.9%) were having no fibrosis,20 (46.5%) mild fibrosis and 11 (25.6%) moderate to severe fibrosis. The median time for development of fibrosis was estimated to be 5.5 years. Developing fibrosis was significantly associated with shorter duration from first detected ALT elevation to biopsy (12 mo vs 1.2 mo,P = 0.015) and having higher levels of direct serum bilirubin (0.3 mg/dL vs 0.5 mg/dL,P = 0.048). No association was found between fibrosis stage and the presence of co-morbid conditions (P = 0.33). CONCLUSION: Hepatic fibrosis was present in 72.1% of children with HCV infection. The development of fibrosis was associated with higher levels of direct serum bilirubin. There was no significant association between fibrosis and age,duration of infection,risk factors,co-morbid conditions and most biochemical parameters. | Manal A El-Hawary Mona S El-Raziky Gamal Esmat Hanan Soliman Amr Abouzied Maissa El-Raziky Wafaa El-Akel Rokaya El-Sayed Fatma Shebl Abdel Aziz Shaheen Hanaa El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，20： | 1 |
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