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| 1 | Current concepts in total femoral replacement显示文摘Total femoral replacement(TFR) is a salvage arthroplasty procedure used as an alternative to lower limb amputation. Since its initial description in the mid-20^(th) century, this procedure has been used in a variety of oncologic and non-oncologic indications. The most compelling advantage of TFR is the achievement of immediate fixation which permits early mobilization. It is anticipated that TFR will be increasingly performed as the rate of revision arthroplasty rises worldwide. The existing literature is mainly composed of a rather heterogeneous mix of retrospective case series and a wide assortment of case reports. Numerous TFR prostheses are currently available and the surgeon must understand the unique implications of each implant design. Long-term functional outcomes are dependent on adherence to proper technique and an appropriate physical therapy program for postoperative rehabilitation. Revision TFR is mainly performed for periprosthetic infection and the severe femoral bone loss associated with aseptic revisions. Depending on the likelihood of attaining infection clearance, it may sometimes be advisable to proceed directly to hip disarticulation without attempting salvage of the TFR. Other reported complications of TFR include hip joint instability, limb length discrepancy, device failure, component loosening, patellar maltracking and delayed wound healing. Further research is needed to better characterize the long-term functional outcomes and complications associated with this complex procedure. | Deepak Ramanathan Marcelo BP Siqueira Alison K Klika Carlos A Higuera Wael K Barsoum Michael J Joyce | 2015 | World Journal of Orthopedics2015，6，11： | 6 |
| 2 | Role of negative pressure wound therapy in total hip and knee arthroplasty显示文摘Negative-pressure wound therapy(NPWT) has been a successful modality of wound management which is in widespread use in several surgical fields. The main mechanisms of action thought to play a role in enhancing wound healing and preventing surgical site infection are macrodeformation and microdeformation of the wound bed, fluid removal, and stabilization of the wound environment. Due to the devastating consequences of infection in the setting of joint arthroplasty, there has been some interest in the use of NPWT following total hip arthroplasty and total knee arthroplasty. However, there is still a scarcity of data reporting on the use of NPWT within this field and most studies are limited by small sample sizes, high variability of clinical settings and end-points. There is little evidence to support the use of NPWT as an adjunctive treatment for surgical wound drainage, and for this reason surgical intervention should not be delayed when indicated. The prophylactic use of NPWT after arthroplasty in patients that are at high risk for postoperative wound drainage appears to have the strongest clinical evidence. Several clinical trialsincluding single-use NPWT devices for this purpose are currently in progress and this may soon be incorporated in clinical guidelines as a mean to prevent periprosthetic joint infections. | Marcelo BP Siqueira Deepak Ramanathan Alison K Klika Carlos A Higuera Wael K Barsoum | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 3 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 4 | EUS-guided choledochoduodenostomy with lumen-apposing metal stent after failed rendezvous in synchronous malignant biliary and gastric outlet obstruction显示文摘 | Manuel Perez-Miranda Carlos De la Serna Higuera Paula Gil-Simon Vicente Hernandez Pilar Diez-Redondo Luis Fernandez-Salazar | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 5 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 6 | Management of pancreatic cancer in the elderly显示文摘Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. The aging of the population will result in a rise in the incidence of pancreatic adenocarcinoma within the next years. Thus, the management of pancreatic cancer in the elderly population is gaining increasing relevance. Older cancer patients represent a heterogeneous group with different biological, functional and psychosocial characteristics that can modify the usual management of this disease, including pharmacokinetic and pharmacodynamic changes, polypharmacy, performance status, comorbidities and organ dysfunction. However, the biological age, not the chronological age, of the patient should be the limiting factor in determining the most appropriate treatment for these patients. Unfortunately, despite the increased incidence of this pathology in older patients, there is an underrepresentation of these patients in clinical trials, and the management of older patients is thus determined by extrapolation from the results of studies performed in younger patients. In this review, the special characteristics of the elderly, the multidisciplinary management of localized and advanced ductal adenocarcinoma of the pancreas and the most recent advances in the management of this condition will be discussed, focusing on surgery, chemotherapy, radiation and palliative care. | Oliver Higuera Ismael Ghanem Rula Nasimi Isabel Prieto Laura Koren Jaime Feliu | 2016 | World Journal of Gastroenterology2016，22，2： | 2 |
| 7 | Suprasellar arachnoid cysts in children report of three cases显示文摘 | C. A. González F. J. Villarejo M. G. Blázquez I. P. Castroviejo A. P. Higueras | 1982 | Acta Neurochirurgica (-)1982，，3： | 2 |
| 8 | A randomized,placebo- controlled study of donepezil in poststroke aphasia显示文摘 | Berthier ML Green C Higueras C | 2006 | Neurology2006，67，： | 1 |
| 9 | Penaeid shrimp hemolymph lipoproteins 显示文摘 | Yepiz - Plascencia G Vargas - Mbores F Higuera - Ciapara I | 2000 | Aquaculture2000，191，23： | 1 |
| 10 | 显示文摘 | I. Vizcaíno A. Torregrosa V. Higueras V. Morote A. Cremades V. Torres S. Olmos C. Molins | 2001 | European Radiology2001，，9： | 1 |
| 11 | Influence of the Thermal-spray Procedure on the Properties of a Nickel-Chromium Coating显示文摘 | HIGUERA V BELZUNCE F J CARRILES A | 2002 | Journal of Materials Science2002，37，3： | 1 |
| 12 | Boltzmann Approach to Lattice Gas Simulations 显示文摘 | Higuera F J Jimenez J | 1989 | Europhysics Letters1989，9，： | 1 |
| 13 | Percutaneous verlebro-- plasty, long-term clinic and radiological outcome显示文摘 | Perez-- Higueras A Alvarez L Rossi RE | 2002 | Neuroradiology2002，44，11： | 1 |
| 14 | Spinal dorsal horn calcium channel α2β-1 subunit upregulation contributes to peripheral nerve injury- induced tactile allodynia显示文摘 | CY Song YH Higuera ES | 2004 | J Neurosci2004，24，： | 1 |
| 15 | Nutritive and metabolic utilization of proteins with high glutamic acid content by the rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | MOYANO F J CARDENETE G HIGUERA M D | 1991 | Comparative Biochemistry and Physiology Part A: Physiology1991，100，： | 1 |
| 16 | Hip and knee arthroplasty in the geriatric population显示文摘 | Selvon F St Clair Carlos Higuera e?al | 2006 | Clinics in Greiatic Medicine2006，22，： | 1 |
| 17 | Nutritive value of diets containing high percentage of vegetable proteins for trout (Oncorhynchus mykiss)显示文摘 | Moyano FJ Cardenete G de la Higuera M | 1992 | Aquat Living Resour1992，5，： | 1 |
| 18 | Influence of temperature and dietary-protein supplementation eitherwith free or coated lysine on the fractional protein-turnover rates in thewhite muscle of carp显示文摘 | M. de la Higuera A. Garzón M.C. Hidalgo J. Peragón G. Cardenete J.A. Lupiá?ez | 1998 | Fish Physiology and Biochemistry1998，，1： | 1 |
| 19 | Maternal peripheral blood lymphocyte subpopulations in normal and pathological pregnancies显示文摘 | Makrydimas G Plachouras N Higueras MT | 1994 | Fetal Diagn Ther1994，9，6： | 1 |
| 20 | Development and analysis of multi-layer scaffolds fortissue engineering显示文摘 | PAPENBURG B J LIU Jun HIGUERA G A | 2009 | Biomaterials2009，30，31： | 1 |
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