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| 1 | Antioxidant Machinery Related to Decreased MDA Generation by Thymus Algeriensis Essential Oil-induced Liver and Kidney Regeneration显示文摘Objective This study was conducted to determine the histopathological and biochemical effects of Thymus algeriensis essential oil(TEO) on hydrogen peroxide(H_2O_2)-induced oxidative stress in liver and kidney tissues of rats. Methods Rats were treated in six groups and were exposed for 2 weeks to low(LD; 100 μmol/L) and high doses(HD;1 mmol/L) of H_2O_2 in the presence or absence of TEO(180 mg/kg). Liver and kidney atrophy was measured by using biochemical and histopathological assays. Results Our study demonstrated that H_2O_2 induced liver and kidney atrophy, as evidenced by the significant elevation of serum aminotransferase, urea, and creatinine levels compared with those in the control rats. Urea levels were estimated by evaluating the activity of serum urease that hydrolyzes urea into CO_2 and ammonia. However, TEO treatment significantly alleviated oxidative stress in the H_2O_2-induced liver and kidney toxicity model by reducing the levels of malondialdehyde concomitantly with marked elevations in superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase, as well as decrease in glutathione activity. Conclusion Our data demonstrated that TEO protected against H_2O_2 toxicity by decreasing oxidant levels and DNA damage, as well as increasing antioxidant levels, indicating that TEO has a spectrum of antioxidant and DNA-protective properties. | Guesmi Fatma Amit K Tyagi Bellamine Houda Landoulsi Ahmed | 2016 | Biomedical and Environmental Sciences2016，29，9： | 3 |
| 2 | Precontoured buttress plate vs reconstruction plate for acetabulum posterior wall fractures: A biomechanical study显示文摘BACKGROUND The purpose of open reduction and internal fixation of acetabulum posterior wall fractures is to restore anatomical structure and stability of the hip joint, in order to start weight bearing as soon as possible and prevent hip arthrosis; restoration of the anatomy should preserve function of the joint as well. Although 'special shaped precontoured plates' have been developed in recent years for surgical treatment of this region, studies comparing the traditional plates with the newly designed precontoured plates are lacking.AIM To evaluate the biomechanical properties of precontoured anatomic buttress and conventional curved reconstruction plates(CCRPs) for posterior wall acetabulum fracture treatment.METHODS Twelve pelvis models were created for testing plate treatment of fracture in the posterior wall of the acetabulum. These 12 pelvis models were used to create 24 hemipelvis models(experimental) by cutting from the sagittal plane and passing over the center of gravity, after which the posterior wall acetabular fractures(of similar type and size) were created. In these experimental models, the right acetabulum was fixed with a 5-hole CCRP, while the left was fixed with a precontoured anatomic buttress plate(PABP). Samples were placed through thetest device and were subjected to static load testing, with a constant testing velocity of 2 mm/min until the load reached 2.3 kN or the acetabular fixation failed. Dynamic tests were also performed with sinusoidal wave load, with a maximal load of 2.3 kN and a load ratio of 0.1.RESULTS The average stiffness values were 460.83 ± 95.47 N/mm for the PABP and 291.99± 118.58 N/mm for the 5-hole CCRP. The precontoured anatomic acetabulum buttress plates had significantly higher rigidity than the CCRPs(P = 0.022). There was a statistically significant difference between the unloaded and 2.3 kN-loaded values of AL(posterosuperior fracture line vertical to the ground surface) and CL(posteroinferior fracture line vertical to the ground surface) parameters for both the PABPs and the 5-hole CCRPs(P = 0.036 and P = 0.045, respectively).According to the static tests, the amount of total displacement was significantly less in the PABPs than in the CCRPs. Comparative analysis of the displacement in the BL(posterior wall fracture line horizontal to the ground) parameter yielded no statistically significant differences between the PABP and the 5-hole CCRPs(P= 0.261).CONCLUSION PABP provides more stable fixation in acetabulum posterior wall fractures than5-hole CCRP, allowing for proximal or distal fracture line screw application without reshaping. | Güray Altun Gürsel Saka Teyfik Demir Fatma Kübra Erbay Elibol Mehmet Or?un Polat | 2019 | World Journal of Orthopedics2019，10，5： | 3 |
| 3 | Quality of life and chemotherapy-related symptoms of turkish cancer chil- dren undergoing chemotherapy显示文摘 | Fatma TA Zumrut B Mehmet K | 2013 | Asian Pacific J Cancer Prey2013，14，20： | 1 |
| 4 | Central composite rotatable design for liquefaction of pine barks 显示文摘 | KORKUT A FATMA K ESEN B | 2005 | Fuel Processing Technology2005，87，1： | 1 |
| 5 | Intravenous dexmedetomidine,but not midazolam,prolongs bupiva-caine spinal anesthesia显示文摘 | Fatma N K Belgin Y Gurkan T | 2010 | Can J Anaesth2010，27，1： | 1 |
| 6 | Central composite rotatable design for liquefaction of pine barks显示文摘 | Korkut A Fatma K Esen B | 2005 | Fuel Processing Technology2005，87，1： | 1 |
| 7 | Effect of temperature on in vitro pollen ger-mination and tube growth in sweet cherries显示文摘 | FATMA K FILIZ G | 2009 | American-Eur-asian Journal Agricuture and Environment Science2009，6，5： | 1 |
| 8 | expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, Bcl-2, Bax, and apoptotic index显示文摘 | NILGUN K FATMA A HAKAN K | 2007 | Pathology-Research and Practice2007，203，： | 1 |
| 9 | Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo显示文摘 | SANJA R SHERWIN Y C FATMA K | 2002 | J Biol Chem2002，277，6： | 1 |
| 10 | Roles of β-amylase and starch breakdown during temperatures stress显示文摘 | FATMA K DONG Y S CHARLES L G | 2006 | Physiologia Plantarum2006，126，1： | 1 |
| 11 | Roles ofβ-amylaseand starch breakdown during temperatures stress显示文摘 | Fatma K Dong Y S Charles L G | 2006 | Physiol plan-tarum2006，126，： | 1 |
| 12 | Synthesis,structural and optical properties of novel borylated Cu(Ⅱ)and Co(Ⅱ)metal complexes of 4-benzylaminobiphenylglyoxime显示文摘 | FATMA K SALIHA I YASEMIN C | 2007 | Journal of Organometallic Chemistry2007，692，12： | 1 |
| 13 | Roles of β-amylase andstarch breakdown during temperatures stress显示文摘 | Fatma K Dong Y S Chariles L G | 2006 | Physiolplantarum2006，126，： | 1 |
| 14 | RNA interference of Arabidopsis beta -amylase 8 prevents maltose accumulation upon cold shock and increase sensitivity of PSII photochemical efficiency to freezing stress 显示文摘 | Fatma K Guy Charles L | 2005 | The Plant Journal2005，，44： | 1 |
| 15 | High prevalence o f OXA-51-type class D -lactamases among cefta zidim eresista nt clinical isolates of A cinetobacterspp: co-existence with OXA-58 in multiplecent res显示文摘 | Haluk V Fatma B Murat K | 2006 | J Antimicrob Chemother2006，58，3： | 1 |
| 16 | Is routine pregnancy test necessary in women of reproductive age admitted to the emergency department?显示文摘BACKGROUND:This study aimed to determine the necessity of pregnancy test in women of reproductive age admitted to emergency department(ED) in routine practice.METHODS:We retrospectively reviewed the records of patients who presented to the ED between January 1,2006 and December 31,2010 and received a pregnancy test.RESULTS:The median age of 1 586 patients enrolled into the study was 27 years.Of these patients,19.55%had a positive result of pregnancy test.The most common complaint at admission was abdominal pain in 60.15%of the patients,and pregnancy test was prescribed.15.83%of the patients with abdominal pain had a positive result of pregnancy test.Of the patients,30.64%had nausea-vomiting at admission,and 11.52%had a positive result of pregnancy test.When other complaints were considered,the most commonly observed complaints were non-specific symptoms such as dizziness,malaise and respiratory problems.Of the patients,70.93%were not remembering the date of last menstruation,and 9.51%showed a positive result of pregnancy test.Urinary tract infection(UTI) was commonly diagnosed with an incidence of 17.65%,which was followed by nonspecific abdominal pain(NSAP)(16.77%) and gastrointestinal disorders such as gastritis and peptic ulcer(6.87%).Of the patients,88.40%were discharged from ED,and 11.60%were hospitalized.CONCLUSION:Pregnancy test should be given to women of reproductive age as a routine practice in ED in developing countries like Turkey. | zlem Kksal Fatma zdemir Erol Armagan Nuran ner Pinar inar Sert Deniz Sigirli | 2013 | World Journal of Emergency Medicine2013，4，3： | 1 |
| 17 | Quantitation of aflatoxins in pistachios and groundnuts using HPLC-FLD method显示文摘 | FATMA H OZGUR G BULENT K | 2014 | Food Control2014，38，： | 1 |
| 18 | HLA-DQB1 * 等位基因和基因危险性到类型 1 糖尿病 mellitus显示文摘 AIM: To determine human leukocyte antigen (HLA)DQB1 allele association with susceptibility to type 1 diabetes (T1D) and to clinical and laboratory findings. METHODS: This study was conducted on 85 unrelated Egyptian children with T1D recruited consecutively from the Pediatric Diabetes Endocrinology outpatients Clinic; Mansoura University Children’s Hospital, Egypt. Patient mean follow up period was 2.5 years. Patients were subdivided according to level of HbA1c (optimal/suboptimal control < 8.5% and poor control ≥ 8.5%). Thecontrol group consisted of 113 unrelated ageand sexmatched healthy subjects without T1D or other autoimmune diseases. Genomic DNA extraction was done for all subjects using a DNA isolation kit. HLA-Class Ⅱ-DQB1 allele typing was carried out with a polymerase chain reaction-sequence-specific oligonucleotide probe using a INNO-LiPA HLA-DQB1 update kit. RESULTS: Significant differences were detected between Egyptian patients with T1D and control groups in the frequencies of DQB1*02 [44.4% vs 18.6%, corrected P value (Pc) < 0.001] and DQB1*03 (41.2% vs 24.4%, Pc < 0.001). Significant differences were also observed between control groups and T1D patients in the frequencies of DQB1*05 (14.6% vs 7.2%, P = 0.029) and DQB1*06 (34.1% vs 7.2%, P < 0.001). However, after correction for multiple comparisons, the significance was retained for HLA-DQB1*06 (Pc < 0.001) but lost for HLA-DQB1*05. HLA-DQB1*0201, *0202, *030201 were positively associated with T1D (Pc = 0.014, Pc < 0.001, and Pc < 0.001 respectively), while HLA-DQB1*060101 was negatively associated (Pc < 0.001) with the condition. Although the HLA-DQB1 alleles 030101 and 050101 were significantly higher in controls (P = 0.016, P = 0.025 respectively), both of them lost statistical significance after correction of P value. The frequency of the HLA-DQB1 genotypes 02/02, 02/03, and 03/03 was higher in T1D patients, and the frequency of the genotypes 03/06, 05/06, and 06/06 was higher in controls, these differences being statistically significant before correction. After correction, the genotypes 02/02, 02/03 in T1D, and the genotypes 03/06, 06/06 in controls were still significant (Pc = 0.01, Pc < 0.001, Pc < 0.001, and Pc = 0.04, respectively). Non-significant associations were found between the frequency HLA-DQB1 alleles and genotypes in T1D in relation to the grade of diabetic control, Microalbuminuria, age, gender, age of presentation, weight, height, frequency of diabetic ketoacidosis (P =0.42), serum cholesterol, and fasting and post-prandial level of C-peptide (P = 0.83, P = 0.9, respectively). CONCLUSION: The Current work suggests that HLADQB1 alleles *030201, *0202, *0201, and genotypes 02/03, 02/02 may be susceptibility risk factors for development of T1D in Egyptian children, while the HLADQB1*060101 allele, and 03/06, 06/06 genotypes may be protective factors. HLA-DQB1 alleles and genotypes do not contribute to microalbuminuria or grade of diabetic control. | Youssef M Mosaad Fatma A Auf Shereen S Metwally Ashraf A Elsharkawy Amany K El-Hawary Rasha H Hassan Ziyad E Tawhid Farha A El-Chennawi | 2012 | World Journal of Diabetes2012，3，8： | 1 |
| 19 | Performance status of patients is the major prognostic factor at all stages of pancreatic cancer显示文摘 | Faruk Tas Fatma Sen Hatice Odabas Leyla K?l?c Serkan Kesk?n Ibrah?m Y?ld?z | 2013 | International Journal of Clinical Oncology2013，，5： | 1 |
| 20 | Immunohistochemical expression of PTEN in normal,hyperplastic and malignant endometrium and its correlation with hormone receptors,bcl-2,bax,and apoptotic index显示文摘 | NILGUN K FATMA A HAKAN K | 2007 | Pathol Res Pract2007，203，3： | 1 |
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