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| 1 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 2 | CBF/CBV maps in normal volunteers studied with ^(15)O PET:a possible index of cerebral perfusion pressure显示文摘Local cerebral perfusion pressure(CPP) is a primary factor controlling cerebral circulation and previous studies have indicated that the ratio of cerebral blood flow(CBF) to cerebral blood volume(CBV) can be used as an index of the local CPP. In this study,we investigated whether the CBF/CBV ratio differs among different brain structures under physiological conditions, by means of O positron emission tomography. Nine healthy volunteers(5 men and 4women, mean age,47.0 ±1.2 years) were studied by H2 O bolus injection for CBF measurement and by C O inhalation for CBV measurement. The CBF/CBV ratio maps were created by dividing the CBF images by the CBV images after anatomical normalization.Regions of interest were placed on the CBF/CBV maps and comparing the regions. The mean CBF/CBV ratio was highest in the cerebellum(19.3 ± 5.2/min)' followed by the putamen(18.2 士 3.9), pons(16_4 土 4.6)' thalamus(14.5 土 3.3), cerebral cortices(13.2 土 2.4), and centrum semiovale(11.5 土 2.1).The cerebellum and putamen showed significantly higher CBF/CBV ratios than the cerebral cortices and centrum semiovale. We created maps of the CBF/CBV ratio in normal volunteers and demonstrated higher CBF/CBV ratios in the cerebellum and putamen than in the cerebral cortices and deep cerebral white matter. The CBF/CBV may reflect the local CPP and should be studied in hemodynamically compromised patients and in patients with risk factors for small-artery diseases of the brain. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 2 |
| 3 | Recent advances in the study of epigenetic effects induced by the phycotoxin okadaic acid显示文摘 | Edmond Ekué Creppy Adama Traoré Isabelle Baudrimont Marta Cascante Maria-Rosaria Carratú | 2002 | Toxicology2002，，： | 1 |
| 4 | Role of positron emission tomography with 2-deoxy-2-[ 18 F]fluoro-d-glucose in evaluating the effects of arterial infusion chemotherapy and radiotherapy on pancreatic cancer显示文摘 | Masato Yoshioka Tsutomu Sato Tomoki Furuya Satoshi Shibata Hideaki Andoh Yoshihiro Asanuma Jun Hatazawa Eku Shimosegawa Kenji Koyama Yuzo Yamamoto | 2004 | Journal of Gastroenterology2004，，1： | 1 |
| 5 | A reciprocation prosthesis for a patient with sacral agenesis 显示文摘 | Ekus L Kruger L Ferguson N | 1984 | Inter-Clinic Information Bulletin1984，19，4： | 1 |
| 6 | A reciprocation prosthe- sis for a patient with sacral agenesis 显示文摘 | Ekus L Kruger L Ferguson N | 1984 | Inter-Clin Info Bull1984，19，4： | 1 |
| 7 | Distribution of the [3H]-label from low doses of radioactive ochratoxin a ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys显示文摘 | Amadou Kane Edmond Ekué Creppy Angelika Roth Robert R?schenthaler Guy Dirheimer | 1986 | Archives of Toxicology1986，，4： | 1 |
| 8 | Diagnostic performance of fluorodeoxyglucose positron emission tomography/magnetic resonance imaging fusion images of gynecological malignant tumors: comparison with positron emission tomography/computed tomography显示文摘 | Kazuya Nakajo Mitsuaki Tatsumi Atsuo Inoue Kayako Isohashi Ichiro Higuchi Hiroki Kato Masao Imaizumi Takayuki Enomoto Eku Shimosegawa Tadashi Kimura Jun Hatazawa | 2010 | Japanese Journal of Radiology2010，，2： | 1 |
| 9 | SSJD14101300036876显示文摘 | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，，： | 1 |
| 10 | A reciprocation prosthesis for a patient with sacral agenesis 显示文摘 | Ekus L Kruger L Ferguson N | 1984 | Inter Clinic Inform Bull1984，19，4： | 1 |
| 11 | A double blind comparative clinical trial of mefloquine and chloroquine in symptomatic falcipamm malaria显示文摘 | Ekue JMK Ulrch AM Atenyl JAW | 1983 | Bull WHO1983，61，： | 1 |
| 12 | ^15O-PET定量显像评价默认模式神经网络:脑血流与氧代谢的比较研究显示文摘目的静息态功能磁共振成像(rs-fMRI)通过基于血氧水平依赖(BOLD)信号的自发振荡发现了默认模式神经网络(DMN)的存在。BOLD信号反映了脱氧血红蛋白的浓度,而该浓度依赖于局部脑血流(CBF)和脑氧代谢率(CMRO2)的关系。但是,这两者在rs-fMRI时无法区分。研究者尝试通过15O标记气体和水的定量PET显像分析DMN的功能相关区域,并比较CBF和CMRO2在发现DMN功能相关区域中的作用。方法9名正常志愿者[男5名,女4名,年龄(47.0±1.2)岁]行^15O-O2、^15O-CO气体和^15O-H2O的PET显像。通过自动显影法并转换成蒙特利尔神经病学研究所(MNI)标准化脑模板获得定量CBF和CMRO2图像。根据已完成的rs-fMRI图像于标化PET图像上设置感兴趣区(ROI)。在DMN功能相关区域分析中,对脑内所有成对的区域计算其Pearson相关系数(r),同时获得CBF和CMRO2各自发现的功能相关区域的分布图。本研究定义r>0.7为显著正相关,比较CBF和CMRO2各自的功能相关区域的分布图。结果CBF显像时在24对局部脑区域中发现显著正相关(r>0.7),而CMRO2显像时发现22对,两者间有12对神经网络区域是重复的。 | 唐军(译) Jo Aoe Tadashi Watabe Eku Shimosegawa Hiroki Kato Yasukazu Kanai Sadahiro Naka Keiko Matsunaga Kayako Isohashi Mitsuaki Tatsumi Jun Hatazawa | 2018 | 中华核医学与分子影像杂志2018，38，12： | 0 |
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