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| 1 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 2 | CBF/CBV maps in normal volunteers studied with ^(15)O PET:a possible index of cerebral perfusion pressure显示文摘Local cerebral perfusion pressure(CPP) is a primary factor controlling cerebral circulation and previous studies have indicated that the ratio of cerebral blood flow(CBF) to cerebral blood volume(CBV) can be used as an index of the local CPP. In this study,we investigated whether the CBF/CBV ratio differs among different brain structures under physiological conditions, by means of O positron emission tomography. Nine healthy volunteers(5 men and 4women, mean age,47.0 ±1.2 years) were studied by H2 O bolus injection for CBF measurement and by C O inhalation for CBV measurement. The CBF/CBV ratio maps were created by dividing the CBF images by the CBV images after anatomical normalization.Regions of interest were placed on the CBF/CBV maps and comparing the regions. The mean CBF/CBV ratio was highest in the cerebellum(19.3 ± 5.2/min)' followed by the putamen(18.2 士 3.9), pons(16_4 土 4.6)' thalamus(14.5 土 3.3), cerebral cortices(13.2 土 2.4), and centrum semiovale(11.5 土 2.1).The cerebellum and putamen showed significantly higher CBF/CBV ratios than the cerebral cortices and centrum semiovale. We created maps of the CBF/CBV ratio in normal volunteers and demonstrated higher CBF/CBV ratios in the cerebellum and putamen than in the cerebral cortices and deep cerebral white matter. The CBF/CBV may reflect the local CPP and should be studied in hemodynamically compromised patients and in patients with risk factors for small-artery diseases of the brain. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 2 |
| 3 | A phase I study of concurrent weekly carboplatin and paclitaxel combined with intensitymodulated pelvic radiotherapy as an adjuvant treatment for earlystage cervical cancer patients with positive pelvic lymph nodes显示文摘 | Mabuchi S Takahashi R Isohashi F | 2013 | Int J Gynecol Cancer2013，23，7： | 1 |
| 4 | Dosevolume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent Nedaplatin-based chemoradiation therapy for early-stage cervical cancer显示文摘 | ISOHASHI F YOSHIOKA Y MABUCHI S | 2013 | International Journal of Radiation Oncology Biology Physics2013，85，3： | 1 |
| 5 | Insulin -like growthfactor stimulation increases radiosensitivity of a pancreaticcancer cell line through endoplasmic reticulum stress un-der hypoxic conditions 显示文摘 | Isohashi F Endo H Mukai M | 2008 | Cancer Sci2008，99，12： | 1 |
| 6 | 18F-FDG PET/MRI fusion in characterizing pancreatic tumors:comparison to PET/CT显示文摘 | Tatsumi M Isohashi K Onishi H | | 0，，04： | 1 |
| 7 | Impact of the addition ofconcurrent chemotherapy to pelvic radiotherapy in surgically treated stage Ⅰ bl-Ⅱ b cervical cancer patients with intermediate-risk or high-risk factors: A 13-year experience 显示文摘 | Okazawa M Mabuchi S Isohashi F | 2013 | Int J Gynecol Cancer2013，23，3： | 1 |
| 8 | Dose-volume his- togram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent Nedaplatin- based chemoradiation therapy for early- stage cervical cancer 显示文摘 | Isohashi F Yoshioka Y Mabuchi S | 2013 | Int J Radiat Oncol Biol Phys2013，85，3： | 1 |
| 9 | Postoperative concurrent nedaplatin-based chemoradiotherapy improves sur- vival in early-stage cervical cancer patients with adverse risk factors显示文摘 | Mabuchi S Morishige K Isohashi F | 2009 | Gynecol Oncol2009，115，3： | 1 |
| 10 | Insulin-like growth factor stim-ulation increases radiosensitivity of a pancreatic cancer cell linethrough endoplasmic reticulum stress under hypoxic conditions显示文摘 | Isohashi F Endo H Mukai M | 2008 | Cancer Sci2008，99，12： | 1 |
| 11 | Radiotherapy targeting cancer stem cells: current views and future perspectives显示文摘 | Ogawa K Yoshioka Y Isohashi F | 2013 | Anticancer Res2013，33，3： | 1 |
| 12 | Concurrent weekly nedaplatin, external beam radiotherapy and high dose- rate brachytherapy in patients with FIGO stage HI b cervical cancer: a comparison with a cohort treated by radiotherapy alone显示文摘 | MABUCHI S UGAKI H ISOHASHI F | 2010 | Gynecologic and Obstetric Investigation2010，69，4： | 1 |
| 13 | Concurrent weeklynedaplatin, external beam radiotherapy and high - dose - ratebrachytherapy in patients with FIGO stage M b cervical cancer : acomparison with a cohort treated by radiotherapy alone显示文摘 | MABUCHI S UGAKI H ISOHASHI F | 2010 | Gyne-col Obstet Invest2010，69，4： | 1 |
| 14 | Postoperative concurrent nedaplatin-based chemoradiotherapy improves survival in early-stage cervical cancer patients with adverse risk factors 显示文摘 | MABUCHI S MORISHIGE K ISOHASHI F | 2009 | Gynecol Oncol2009，115，3： | 1 |
| 15 | Radiotherapy targeting cancer stem cells:current views and future perspectives显示文摘 | Ogawa K Yoshioka Y Isohashi F | | 0，，03： | 1 |
| 16 | Salvage high-dose-rate interstitial brachytherapy for locally recurrent rectal cancer: long-term follow-up results显示文摘 | Morimoto M Isohashi F Yoshioka Y | 2014 | Int J C/in Oncol2014，19，2： | 1 |
| 17 | Concurrent weekly neda-platin,external beam radiotherapy and high-dose - rate brachy-therapy in patients with FIGO stage IIIb cervical cancer:a com-parison with a cohort treated by radiotherapy alone显示文摘 | Mabuchi S Ugaki H Isohashi F | 2010 | Gynecol Obstet Invest2010，69，4： | 1 |
| 18 | Postoperative concurrentnedaplatin-based chemoradiotherapy improves survival in early-stagecervical cancer patients with adverse risk factors 显示文摘 | Mabuchi S Morishige K Isohashi F | 2009 | GynecolOncol2009，115，3： | 1 |
| 19 | Risk factors for pericardial effusion in patients with stage I esophageal cancer treated with chemoradiotherapy 显示文摘 | Tamari K Isohashi F Akino Y | 2014 | Anticancer Res2014，34，12： | 1 |
| 20 | Concurrent weekly nedaplatin, extemal beam radiotherapy and high-dose-rate brachytherapy in pa-tients with FIGO stage Ⅲ b cervical cancer:a comparison with a cohort treated by radiotherapy alone 显示文摘 | Mabuchi S Ugaki H Isohashi F | 2010 | Gynecol Obstet Invest2010，69，4： | 1 |
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