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| 1 | Molecular and cellular bases of chronic myeloid leukemia显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative disease characterized by the overproduction of granulocytes,which leads to high white blood cell counts and splenomegaly in patients.Based on clinical symptoms and laboratory findings,CML is classified into three clinical phases,often starting with a chronic phase,progressing to an accelerated phase and ultimately ending in a terminal phase called blast crisis.Blast crisis phase of CML is clinically similar to an acute leukemia;in particular,B-cell acute lymphoblastic leukemia(B-ALL)is a severe form of acute leukemia in blast crisis,and there is no effective therapy for it yet.CML is induced by the BCR-ABL oncogene,whose gene product is a BCR-ABL tyrosine kinase.Currently,inhibition of BCR-ABL kinase activity by its kinase inhibitor such as imatinib mesylate(Gleevec)is a major therapeutic strategy for CML.However,the inability of BCR-ABL kinase inhibitors to completely kill leukemia stem cells(LSCs)indicates that these kinase inhibitors are unlikely to cure CML.In addition,drug resistance due to the development of BCRABL mutations occurs before and during treatment of CML with kinase inhibitors.A critical issue to resolve this problem is to fully understand the biology of LSCs,and to identify key genes that play significant roles in survival and self-renewal of LSCs.In this review,we will focus on LSCs in CML by summarizing and discussing available experimental results,including the original studies from our own laboratory. | Yaoyu Chen Cong Peng Dongguang Li Shaoguang Li | 2010 | Protein & Cell2010，1，2： | 10 |
| 2 | Oxygen and Hydrogen Isotopes of Waters in the Ordos Basin,China:Implications for Recharge of Groundwater in the North of Cretaceous Groundwater Basin显示文摘从 1988 年 1 月在 Ordos 盆从气象学的车站收集到 2005 年 12 月的几百件降水样品被用来建立一根本地大气的水线并且计算现代降水的加权的平均同位素的作文。氧和氢同位素,与为 δ
18 分别地, O 和 δD 在春天在冬季和富人被弄空,并且逐渐地在夏天和秋天减少,说明季节的效果是可观的。他们也证明南方部分和 Ordos 盆的北方部分之间的同位素的差别不是明显的,并且在中间的部分的同位素通常被弄空。32 件样品的同位素作文从浅地下水收集了(不到 150 m 的深度) 在到有为 δ
18 O 并且从 85 ‰到有为 δD 的 63 ‰的一般水准的 46 ‰。他们中的大多数与现代降水是相同的。22 中间、深的地下水的同位素作文(比 275 m 的深度大) 为 δ
18 O 并且从 89 ‰到有为 δD 的 76 ‰的一般水准的 63 ‰。一般水准珍视,说明是显著地不到那些现代降水中间、深的地下水在比较地更低的空气温度被再装。14 C 证明中间、深的地下水的 recharge 在迟了的更新世开始了。从八个湖收集的 13 件湖水样品的同位素定义一个本地蒸发趋势,与 3.77 的一个相对扁平的斜坡,并且证明湖水被现代降水和浅地下水主要喂。 | YANG Yuncheng SHEN Zhaoli WENG Dongguang HOU Guangcai ZHAO Zhenhong WANG Dong PANG Zhonghe | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 3 | MicroRNA-125b-5p inhibits proliferation and promotes adipogenic differentiation in 3T3-L1 preadipocytes显示文摘以前的证据显示了 microRNA-125b (miR-125b ) 家庭戏在癌症房间生长,开发,区别,和 apoptosis 的规定的重要角色。然而,他们是否贡献 adipocyte 区别的过程,仍然保持不清楚。在现在的学习,我们表明表示 miR-125b-5p 铺平, miR-125b 家庭的一个成员,在进成熟 adipocyte 的 3T3-L1 preadipocyte 的区别期间是戏剧性地起来调整的。进 3T3-L1 房间的 miR-125b-5p 的补充支持了由增加的类脂化合物微滴和 adipocyte 特定的分子的标记的 mRNA 层次证实了的 adipogenic 区别,包括 peroxisome 激活 proliferators 的受体, CCAAT/enhancer-binding 蛋白质,丰满的酸绑定的蛋白质 4,并且脂蛋白脂肪分解酵素,并且由 triglyceride 累积。CCK-8 试金证明 miR-125b-5p 补充显著地禁止了房间增长。流动 cytometry 分析证明 miR-125b-5p 象 mRNA 和 G1/S-related 基因的蛋白质表示一样损害了 G1/S 阶段转变,例如 Cyclin D2, Cyclin D3,和 CDK4。不过,它没在 apoptosis 上有效果。由目标基因预言,另外,我们证明 smad4 可以是在鼠标 3T3-L1 preadipocytes 的 miR-125b-5p 的一个潜在的目标,为一些 miR-125b-5p 的函数的财务。一起拿,这些数据显示 miR-125b-5p 可以在 adipocyte 区别用作一个重要积极管理者,至少部分通过下面调整的 smad4。 | Dan Ouyang Yaqiong Ye Dongguang Guo Xiaofang Yu Jian Chen Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 9 |
| 4 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 5 | Potential and Suitability Evaluation of CO_2 Geological Storage in Major Sedimentary Basins of China,and the Demonstration Project in Ordos Basin显示文摘From 2010 to 2012, the China Geological Survey Center for Hydrogeology and Environmental Geology Survey(CHEGS) carried out the project 'Potential evaluation and demonstration project of CO2 Geological Storage in China'. During this project, we developed an evaluation index system and technical methods for the potential and suitability of CO2 geological storage based on China's geological conditions, and evaluated the potential and suitability of the primary basins for CO2 geological storage, in order to draw a series of regional scale maps(at a scale of 1:5000000) and develop an atlas of the main sedimentary basins in China. By using these tools, we delineated many potential targets for CO2 storage. We also built techniques and methods for site selection and the exploration and assessment of CO2 geological storage in deep saline aquifers. Furthermore, through cooperation with the China Shenhua Coal to Liquid and Chemical Co., Ltd., we successfully constructed the first coal-based demonstration project for CO2 geological storage in deep saline aquifers in the Yijinhuoluo Banner of Ordos in the Inner Mongolia Autonomous Region, which brought about the basic preliminary theories, techniques, and methods of geological CO2 storage in deep saline aquifers under China's geological conditions. | GUO Jianqiang WEN Dongguang ZHANG Senqi XU Tianfu LI Xufeng DIAO Yujie JIA Xiaofeng | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 8 |
| 6 | Near infrared spectral and polarization imaging observation of coronal emission lines during the 2008 total solar eclipse显示文摘During the 2008 total solar eclipse, the coronal emission lines were observed by using optical fibre spectrometric and polarization imaging system in near infrared waveband. The profiles of the coronal emission lines including Fe XIII 10747 , 10798 and He I 10830 were obtained with dispersion of 0.5 /pix. The intensity of Fe XIII 10747 remained unchanged in the two different coronal regions while the intensity of He I 10830 varied considerably in the two coronal locations no matter whether the prominence appeared or not. The coronal polarization images were observed at Fe XI 7892 with a bandpass of 30 in a series of exposure times. | BAO XingMing ZHANG ZhiYong DENG Jian HU KeLiang XUAN WeiJia LIU YangBing ZHANG HongQi DENG YuanYong WANG DongGuang WANG XiaoFan | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 5 |
| 7 | Characterization of volatile compounds of pu-erh tea using solid-phase microextraction and simultaneous distillation–extraction coupled with gas chromatography–mass spectrometry显示文摘 | Liping Du Jianxun Li Wei Li Yunfei Li Tao Li Dongguang Xiao | 2014 | Food Research International2014，，： | 3 |
| 8 | Distribution of δ^(34)S and δ^(18)O in SO_4^(2-) in Groundwater from the Ordos Cretaceous Groundwater Basin and Geological Implications显示文摘The Ordos Cretaceous Groundwater Basin,located in an arid-semiarid area in northwestern China,is a large-style groundwater basin.SO_4^(2-) is one of the major harmful components in groundwater.Dissolved SO_4^(2-) concentrations,andδ^(34)S-SO_4^(2-) andδ^(18)O-SO_4^(2-) in groundwater from 14 boreholes and in gypsum from aquifer were analyzed.Results show that SO_4^(2-) in shallow groundwaters originates from precipitation,sulfide oxidation,and dissolution of stratum sulphate,with a big range ofδ^(34)S values,from-10.7‰to 9.2‰,and addition of SO_4^(2-) in deep groundwater results from dissolution of stratum sulphate,with biggerδ^(34)S values,from 7.8‰to 18.5‰,compared with those in shallow groundwater.This research also indicates that three types of sulphate are present in the strata,and characterized by highδ^(34)S values and highδ^(18)O values-style,highδ^(34)S values and middleδ^(18)O valuesstyle, middleδ^(34)S values and lowδ^(18)O values-style,respectively.Theδ^(34)S-SO_4^(2-) andδ^(18)O-SO_4^(2-) in groundwater have a good perspective for application in distinguishing different groundwater systems and determining groundwater circulation and evolution in this area. | YANG Yuncheng SHEN Zhaoli WEN Dongguang HOU Guangcai SHE Hongquan ZHAO Zhenhong WANG Dong LI Jingwen | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 3 |
| 9 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘MiR-195 在在肿瘤的不同类型禁止房间增长被含有。它是否贡献 thymic 的过程上皮的房间(侦探) 增长仍然保持不清楚。在这研究,我们发现 miR-195a-5p 在从变老的老鼠孤立的侦探是高度起来调整的。进一步的实验证明 miR-195a-5p 模仿禁止的 transfection 老鼠的增长髓的 thymic 第 1 行上皮的房间(MTEC1 ) ,而在 MTEC1 的 miR-195a-5p 禁止者的 transfection 有相反的效果。另外, miR-195a-5p 没在 MTEC1 apoptosis 上有明显的效果。而且, Smad7,转变生长因素小径的一个否定管理者,被酶试金作为 miR-195a-5p 的一个直接目标证实。一起拿,我们的结果显示 miR-195a-5p 禁止 MTEC1 增长,至少部分地,经由 Smad7 的下面规定。 | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaolong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 3 |
| 10 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria显示文摘 | Ivaylo I. Ivanov Koji Atarashi Nicolas Manel Eoin L. Brodie Tatsuichiro Shima Ulas Karaoz Dongguang Wei Katherine C. Goldfarb Clark A. Santee Susan V. Lynch Takeshi Tanoue Akemi Imaoka Kikuji Itoh Kiyoshi Takeda Yoshinori Umesaki Kenya Honda Dan R. Littma | 2009 | Cell2009，，3： | 3 |
| 11 | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling显示文摘在从不同年龄的老鼠的胸腺纸巾的 miRNAs 的表示侧面在我们的以前的学习被表明了。在 miRNA 表达式侧面的综合分析以后,我们证明 miR-181a-5p 的表达式显著地在 thymic 被减少从 10- 的上皮的房间(侦探) 到 19-month-old 鼠标当与那相比在从 1-month-old 的侦探由量的反向的 transcriptase 聚合酶的鼠标锁住反应时。我们在侦探假设了那 miR-181a-5p 可能通过调整一些基因或发信号的小径与年龄相关的胸腺复杂物被联系。测试这个假设,老鼠髓的 thymic 上皮的房间(MTEC1 ) 被使用。有 miR-181a-5p 的 Transfection 模仿支持了 MTEC1 房间的增长,但是没影响 apoptosis。效果被颠倒 miR-181a-5p 的表示什么时候在 MTEC1 房间被压制。而且,转变生长因素贝它受体(Tgfbr1 ) 我被酶试金作为 miR-181a-5p 的一个直接目标证实。而且,它被发现 miR-181a-5p 的那 overexpression 下面调整 Smad3 的 phosphorylation 并且堵住了发信号的转变生长因素贝它的激活。不过,一相反地,关联在 Tgfbr1 的表示之间被观察,在侦探的 miR-181a-5p 源于不同年龄的老鼠。一起,我们提供 miR-181a-5p 可以是在侦探,和表示的增长的一个重要内长的管理者的证据在侦探的 miR-181a-5p 的层次可以与年龄相关的胸腺复杂物被联系。 | Dongguang Guo Yaqiong Ye Junjie Qi Lihua Zhang Lifeng Xu Xiaotong Tan Xiaofang Yu Qihong Liu Jilong Liu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 12 | The calibration and initial results of the HeI D3 line flash spectrum obtained during the 2008 total solar eclipse显示文摘The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The average integrated intensity is Eave = 8.13×1013 erg·cm-1· s-1·ster-1 at h = 1100 km, which confirms that the HeI D3 emission is negatively correlated with the solar activity. The surface brightness reaches a maximum of F ave = 8.25×105 erg·cm-2·s-1·ster-1 at about h ≈ (1290 ± 75) km and then decreases exponentially with height when h >1800 km with an exponential index β = 1.63×10-8 cm-1. | LI Hui JI HaiSheng NI HouKun ZHANG HaiYing ZHANG YaNan LIU HongRui DENG YuanYong WANG DongGuang DU QiuSheng ZHOU TuanHui LI JingWei SHEN JinHua | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 13 | Supermodulus effect by grain-boundary wetting in nanostructured multilayers显示文摘The effect of thermal treatments on mechanical properties was systematically investigated in Ni/Mo multilayers with a constant modulation period(160 nm)prepared by magnetron sputtering deposition.A supermodulus effect was found in the annealed multilayers as compared to the as-deposited state.A large tensile stress development was observed in the multilayers.The evolution of grain-boundary(GB)wetting was observed at the interfaces of the multilayers,which results in an enhanced modulus based on the mechanism of GB-wetting-induced interfacial stress/strain.The GB wetting phenomenon was further supported by a thermodynamic calculation.The results not only bring clear evidence of the important role of interfacial structures in governing the elastic behavior of metallic multilayers,but also allow designing the multilayers with special properties through atomic diffusion and wetting at the interfaces based on the thermodynamic calculation. | Jing Wang Lu Han Xiaohu Li Dongguang Liu Laima Luo Yuan Huang Yongchang Liu Zumin Wang | 2021 | Journal of Materials Science & Technology2021，，6： | 1 |
| 14 | Ha birefringent filter for SST 显示文摘 | WANG Dongguang | 2002 | Publications of the Beijing Astronomical Observatory2002，38，： | 1 |
| 15 | New Image Acquisition System In Huairou Solar Observing Station 显示文摘 | Deng Yuanyong Zhang Bin Wang Dongguang | 2000 | Astrophysics Reports2000，35，： | 1 |
| 16 | Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug Resistant Cancer Cells显示文摘 | Alex Chen Min Zhang Dongguang Wei Dirk Stueber Oleh Taratula Tamara Minko Huixin He | | 0，，23： | 1 |
| 17 | Age and sex differences in microRNAs expression during the process of thymus aging显示文摘偏导性的胸腺复杂物和 microRNAs 的重要性(miRNAs,米尔) 在 modulating 的表示胸腺发展在许多研究被报导了。然而,男性和女性怎么在胸腺复杂物以那么多方法不同,仍然保持不清楚。探讨这个问题,我们在未经治疗的 3-month-old 和 12-month-old 调查了 miRNA 表达式侧面雌、雄的鼠标胸腺。结果证明 7 和 18 miRNAs 分别地被定义为性特定、年龄特定的 miRNAs。miR-181c-5p, miR-20b-5p, miR-98b-5p, miR-329-3p, miR-341-5p,和 miR-2137 的表示由量的聚合酶链反应在老鼠胸腺显示出重要年龄差别。miR-2137 的高表达式层次在鼠标 thymic 被检测上皮的房间并且逐渐地在胸腺老化的进程期间增加了。偏导女性的 miRNAs 的 MiR-27b-3p 和 miR-378a-3p 在 vivo 在老鼠胸腺作为性应答、雌激素应答的 miRNAs 被证实。他们的潜在的目标基因和小径被联机软件识别。性特定、年龄特定的 miRNA 表示的可能的规定角色在胸腺老化的过程期间被讨论。我们的结果建议这些 miRNAs 可以是为性特定、年龄特定的胸腺老化和复杂物的学习的潜在的 biomarkers。 | Dongguang Guo Yaqiong Ye Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 1 |
| 18 | Preparation of bi-functional NaGdF 4 -based upconversion nanocrystals and fine-tuning of emission colors of the nanocrystals by doping with Mn 2+显示文摘 | Chengcheng Wang Dongguang Yin Kailin Song Juan Ouyang Bing Liu | 2014 | Vacuum2014，，： | 1 |
| 19 | Establishing pairwise keys in distributed sensor networks显示文摘 | LIU DONGGUANG NING PENG | 2005 | ACM Transactions on Information and System Security2005，8，1： | 1 |
| 20 | Study of the effect of high-pulsed electric field treatment on vacuum freeze-drying of apples显示文摘 | Yali Wu Yuming Guo Dongguang Zhang | 2011 | Drying Technology2011，29，14： | 1 |
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