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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | A deep seismic sounding profile across the Tianshan Mountains显示文摘The deep seismic sounding profile across the Tianshan Mountains revealed a two-layer crustal structure in the Tianshan region, namely the lower and upper crusts. Lateral variations of layer velocity and thickness are evidently shown. Low-velocity layers spread discontinuously at the bottom of the upper crust. The Mono depth is 47 km in the Kuytun area and 50 km in the Xayar area. In the Tianshan Mountains, the Moho becomes deeper with the maximum depth of 62 km around the boundary between the southern and northern Tianshan Mountains. The average velocity ranges from 6.1 to 6.3 km/s in the crust and 8.15 km/s at the top of the upper mantle. Two groups of reliable reflective seismic phases of the Moho (Pm1 and Pm2) are recognized on the shot record section of the Kuytun area. A staked and offset region, 20-30 km long, is displayed within a shot-geophone distance of 190-210 km in Pm1 and Pm2. Calculation shows that the Moho is offset by 10 km in the northern Tianshan region, 62 km deep in the south while | LU Deyuan LI Qiusheng GAO Rui LI Yingkang LI Dexing LIU Wen ZHANG Zhiying | 2000 | Chinese Science Bulletin2000，45，22： | 9 |
| 3 | The vernalization-induced long non-coding RNA VAS functions with the transcription factor TaRF2b to promote TaVRN1 expression for flowering in hexaploid wheat显示文摘Vernalization is a physiological process in which prolonged cold exposure establishes flowering competence in winter plants. In hexaploid wheat, TaVRN1 is a cold-induced key regulator that accelerates floral transition. However, the molecular mechanism underlying the gradual activation of TaVRN1 during the vernalization process remains unknown. In this study, we identified the novel transcript VAS (TaVRN1 alternative splicing) as a non-coding RNA derived from the sense strand of the TaVRN1 gene only in winter wheat, which regulates TaVRN1 transcription for flowering. VAS was induced during the early period of vernalization, and its overexpression promoted TaVRN1 expression to accelerate flowering in winter wheat. VAS physically associates with TaRF2b and facilitates docking of the TaRF2b-TaRF2a complex at the TaVRN1 promoter during the middle period of vernalization. TaRF2b recognizes the Sp1 motif within the TaVRN1 proximal promoter region, which is gradually exposed along with the disruption of a loop structure at the TaVRN1 locus during vernalization, to activate the transcription of TaVRN1. The tarf2b mutants exhibited delayed flowering, whereas transgenic wheat lines overexpressing TaRF2b showed earlier flowering. Taken together, our data reveal a distinct regulatory mechanism by which a long non-coding RNA facilitates the transcription factor targeting to regulate wheat flowering, providing novel insights into the vernalization process and a potential target for wheat genetic improvement. | Shujuan Xu Qi Dong Min Deng Dexing Lin Jun Xiao Peilei Cheng Lijing Xing Yuda Niu Caixia Gao Wenhao Zhang Yunyuan Xu Kang Chong | 2021 | Molecular Plant2021，14，9： | 7 |
| 4 | Genome editing in plants with MAD7 nuclease显示文摘MAD7 is an engineered nuclease of the Class 2 type V-A CRISPR-Cas(Cas12 a/Cpf1)family with a low level of homology to canonical Cas12 a nucleases.It has been publicly released as a royalty-free nuclease for both academic and commercial use.Here,we demonstrate that the CRISPR-MAD7 system can be used for genome editing and recognizes T-rich PAM sequences(YTTN)in plants.Its editing efficiency in rice and wheat is comparable to that of the widely used CRISPR-Lb Cas12 a system.We develop two variants,MAD7-RR and MAD7-RVR that increase the target range of MAD7,as well as an M-AFID(a MAD7-APOBEC fusion-induced deletion)system that creates predictable deletions from 50-deaminated Cs to the MAD7-cleavage site.Moreover,we show that MAD7 can be used for multiplex gene editing and that it is effective in generating indels when combined with other CRISPR RNA orthologs.Using the CRISPR-MAD7 system,we have obtained regenerated mutant rice and wheat plants with up to 65.6%efficiency. | Qiupeng Lin Zixu Zhu Guanwen Liu Chao Sun Dexing Lin Chenxiao Xue Shengnan Li Dandan Zhang Caixia Gao Yanpeng Wang Jin-Long Qiu | 2021 | Journal of Genetics and Genomics2021，48，6： | 4 |
| 5 | New experimental method for inundation effect of film condensation on horizontal tube bundle显示文摘Theory of film condensation heat transfer(FCHT) for vapor condensed on horizontal tube bundle(HTB) is vital to many industry processes.Meanwhile,the inundation effect is the key to model the film condensation heat transfer coefficient(CHTC) on HTB.This paper proposed a new experimental method,homologous method,to obtain the inundation effect precisely.Based on the requirements of the new test method,a new test facility was designed and established.Then,the superiority of homologous method for inundation effect was investigated based on experiment result and theoretic analysis.The results showed that the homogenous method can effectively control the experimental error of inundation effect,which is less than 50% of the error of CHTC,and less than 30% of the error of the inundation effect gained by routine method.The new test facility built for the homogenous method is excellent in obtaining the accurate inundation effect of film condensation on HTB.All the result is a foundation of the theoretical development of the FCHT on HTB. | MA ZhiXian ZHANG JiLi SUN DeXing | 2012 | Science China(Technological Sciences)2012，55，10： | 3 |
| 6 | Characterization and Molecular Mapping of a New Virescent Mutant in Rice显示文摘Plant leaves play a significant role in photosynthesis.Normal chloroplast development is critical for plant growth and yield performance.Defect of the chlorophyll in chloroplasts may cause abnormal leaf colors,such as yellow,white,or stripe.Chloroplasts have their own genomes encoding for about 100 genes that are essential for plastid protein synthesis and photosynthesis(Kanno and Hirai,1993; | Qunyu Zhang Dexing Xue Xiaoyu Li Yunming Long Xianjie Zeng Yaoguang Liu | 2014 | Journal of Genetics and Genomics2014，41，6： | 2 |
| 7 | ON THE BOUNDARY STABILIZATION OF WAVE EQUATION WITH VARIABLE COEFFICIENT显示文摘This paper is concerned with the stabilization problem of wave equation withvariable coefficient under boundary feedback control. It is shown that the energy of thesystem decays exponentially if the feedback parameters are chosen in some domain. | ZHANG Weitao FENG Dexing(Institute of Systems Science, Academia Sinica, Beijing 100080, China) | 1997 | Systems Science and Mathematical Sciences1997，10，3： | 2 |
| 8 | Microstructures and Mechanical Properties of Nb-Ti Bearing Hot-rolled TRIP Steels显示文摘有高粘性和保留的奥氏体的适当体积百分比的 Nb-Ti 热转动的帮助旅行的钢在实验基于好铁酸盐谷物被开发了。测试,结果证明铌趋于与更少的 降水,和铌钛在矩阵处于答案状态存在能被猛抛处于良好的竟技状态( Nb , Ti ) C 或( Nb , Ti )( C , N ),它在增加收益力量起一个重要作用(从 495 MPa 到 610 MPa )。而且,保留的奥氏体在在张力的变丑期间由转变改进粘性进马氏体上有积极效果。 | Yu CHEN Guoyi TANG Haoyang TIAN Feipeng LI Yu ZHANG Lihui WANG Zhaojun DENG Dexing LUO | 2006 | Journal of Materials Science & Technology2006，22，6： | 2 |
| 9 | Light-Induced Photorefractive Waveguides in Iron-Doped Lithium Niobate Crystals显示文摘Waveguides were fabricated in lithium niobate crystals solely by light irradiation using binary optical masks and SLM-prepared optical masks. Arrayed-waveguides were also obtained by once or twice irradiations of an interferogram of two plane waves. | Jianlin Zhao Peng Zhang Dexing Yang Bili Li(Department of Applied Physics, Northwestern Polytechnical University, Xi’an 710072, P. R. China, Tel: 86-29-8495724, Fax: 86-29-8493154, E-mail: jlzhao@nwpu.edu.cn) | 2003 | 光学学报2003，23，S1： | 1 |
| 10 | Nuclear integrations:challenges for mitochondrial DNA markers显示文摘 | ZHANG Dexing HEWITT G M | 1996 | Trends in Ecolo-gy and Evolution1996，11，6： | 1 |
| 11 | Nuclear DNA analyses in genetic studies of populations:practice,problems and pros-pect显示文摘 | ZHANG Dexing HEWITT G M | 2003 | Molecular Ecology2003，12，： | 1 |
| 12 | New explicit exact solitary wave solutions for a new Hamiltonlan amplitude equation显示文摘 | Kong Dexing Zhang Weiguo | 1994 | Physics Letters A1994，190，： | 1 |
| 13 | Mitochondrial pseudogenes:evolution's misplaced witnesses显示文摘 | BENSASSON D ZHANG Dexing HARTL D L | 2001 | Trends Ecol Evol2001，16，6： | 1 |
| 14 | Experimental study on a duty ratio fuzzy control method for fan-coil units显示文摘 | Zhao Tianyi Zhang Jili Sun Dexing | 2010 | Building and Environment2010，，2： | 1 |
| 15 | Frequent assimilation of mitochondrial DNA by grasshopper nucleargenomes显示文摘 | BENSASSON D ZHANG Dexing HEWITT G M | 2000 | Mol Biol Evol2000，17，3： | 1 |
| 16 | Mechanical design and energy absorption of 3D novel hybrid lattice metamaterials显示文摘In this paper,three-dimensional(3D)novel hybrid lattice structures with exceptional mechanical properties and energy absorbing performances were proposed,and experimental and finite element simulation comparisons were performed to demonstrate their potential in mechanical application.First,different types of basic cubic unit cells were designed for constructing three types of novel hybrid metamaterials,in which stepped circulation of different unit cells was conceived to generate architected metamaterials.Afterwards,quasi-static compression experiments and finite element simulations were performed to study the deformation process and failure mechanisms of as-fabricated hybrid metamaterials.The energy absorption efficiency,specific energy absorption(SEA)indicators,and energy absorption capabilities of different hybrid lattice metamaterials were compared and analyzed.The results show that the deformation mechanisms of novel hybrid lattice were beneficial for generating remarkable elevated densification strain,and the energy absorption efficiency can be tailored by altering the types or sizes of basic unit cells.Strain-hardening and bilinear features were also obtained. | ZHANG Peng Biligetu QI DeXing XUE Rui LIU Kai HUANG ZhiXin WU WenWang LI Ying | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 17 | An Experimental Technique for Spalling of Concrete 显示文摘 | Zhang Lei Hu Shisheng Chen Dexing | 2009 | Experimental Mechanics2009，49，4： | 1 |
| 18 | Quantum mechanical effects of a nondissipative mesoseopic capacitance coupling circuit with source 显示文摘 | Yu Zhaoxian Zhang Dexing Liu Yehou | 1997 | International Journal of Theoretical Physics1997，36，9： | 1 |
| 19 | Highly conserved nuclear copies of the mitochondrial control region in the desert locustSchistocerca gregaria:some implications for population studies显示文摘 | ZHANG Dexing HEWITT G M | 1996 | Mol Ecol1996，5，： | 1 |
| 20 | Genetic analysis and ecological niche modeling delimit species boundary of the Przewalski’s scorpion(Scorpiones: Buthidae) in arid Asian inland显示文摘Reliable delimitation of venomous scorpions is not only consequential to toxicological studies but also instructive to conservation and exploration of these important medical resources.In the present study,we delimited species boundary for the the Przewalski’s scorpion from arid northwest China through a combined approach employing phylogenetic analysis,ecological niche modeling and morphological comparison.Our results indicate that the Przewalski’s scorpion represent an independent taxonomic unit and should be recognized as full species rank,Mesobuthus przewalskii stat.nov.This species and the Chinese scorpion M.martensii represent the eastern members of the M.caucasicus species group which manifests a trans-Central Asia distribution across the Tianshan Mountains range.We also discussed the likely geographic barrier and climatic boundary that demarcate distributional range of the the Przewalski’s scorpion. | Xueshu Zhang Gaoming Liu Yu Feng Dexing Zhang Chengmin Shi | 2020 | Zoological Systematics2020，45，2： | 1 |
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