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| 1 | Effects of early oral feeding after radical total gastrectomy in gastric cancer patients显示文摘BACKGROUND Gastric cancer(GC)is a heavy burden in China.Nutritional support for GC patients is closely related to postoperative rehabilitation.However,the role of early oral feeding after laparoscopic radical total gastrectomy in GC patients is unclear and high-quality research evidence is scarce.AIM To prospectively explore the safety,feasibility and short-term clinical outcomes of early oral feeding after laparoscopic radical total gastrectomy for GC patients.METHODS This study was a prospective cohort study conducted between January 2018 and December 2019 based in a high-volume tertiary hospital in China.A total of 206 patients who underwent laparoscopic radical total gastrectomy for GC were enrolled.Of which,105 patients were given early oral feeding(EOF group)after surgery,and the other 101 patients were given the traditional feeding strategy(control group)after surgery.Perioperative clinical data were recorded and analyzed.The primary endpoints were gastrointestinal function recovery time and postoperative complications,and the secondary endpoints were postoperative nutritional status,length of hospital stay and expenses,etc.RESULTS Compared with the control group,patients in the EOF group had a significantly shorter postoperative first exhaust time(2.48±1.17 d vs 3.37±1.42 d,P=0.001)and first defecation time(3.83±2.41 d vs 5.32±2.70 d,P=0.004).In addition,the EOF group had a significant shorter postoperative hospitalization duration(5.85±1.53 d vs 7.71±1.56 d,P<0.001)and lower postoperative hospitalization expenses(16.60±5.10 K¥vs 21.00±7.50 K¥,P=0.014).On the 5th day after surgery,serum prealbumin level(214.52±22.47 mg/L vs 204.17±20.62 mg/L,P=0.018),serum gastrin level(246.30±57.10 ng/L vs 223.60±55.70 ng/L,P=0.001)and serum motilin level(424.60±68.30 ng/L vs 409.30±61.70 ng/L,P=0.002)were higher in the EOF group.However,there was no significant difference in the incidence of total postoperative complications between the two groups(P=0.507).CONCLUSION Early oral feeding after laparoscopic radical total gastrectomy can promote the recovery of gastrointestinal function,improve postoperative nutritional status,reduce length of hospital stay and expenses while not increasing the incidence of related complications,which indicates its safety,feasibility and potential benefits for gastric cancer patients. | Yi-Xun Lu Yan-Jun Wang Tian-Yu Xie Shuo Li Di Wu Xiong-Guang Li Qi-Ying Song Li-Peng Wang Da Guan Xin-Xin Wang | 2020 | World Journal of Gastroenterology2020，26，36： | 9 |
| 2 | Role of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer显示文摘BACKGROUND Gastric cancer is the second most common malignant tumor in China,ranking third among all malignant tumor mortality rates.Hyperthermic intraperitoneal chemotherapy(HIPEC)has been shown to increase significantly the effectiveness of intraperitoneal chemotherapeutic drugs,prolong the action time of these drugs on intraperitoneal tumor cells,and enhance their diffusion in tumor tissues.HIPEC may be one of the best choices for the eradication of residual cancer cells in the abdominal cavity.AIM The aim of this study was to study the role of preventive HIPEC after radical gastrectomy.METHODS A prospective analysis was performed with patients with c T4 N0-3 M0 gastric cancer to compare the effects of postoperative prophylactic HIPEC plus intravenous chemotherapy with those of routine adjuvant chemotherapy.Patients’medical records were analyzed,and differences in the peritoneal recurrence rate,diseasefree survival time,and total survival time between groups were examined.RESULTS The first site of tumor recurrence was the peritoneum in 11 cases in the conventional adjuvant chemotherapy group and in 2 cases in the HIPEC group(P=0.020).The 1-year and 3-year disease-free survival rates were 91.9%and 60.4%,respectively,in the conventional adjuvant chemotherapy group and 92.1%and 63.0%,respectively,in the HIPEC group.The 1-year and 3-year overall survival rates were 95.2%and 66.3%,respectively,in the conventional adjuvant chemotherapy group and 96.1%and 68.6%,respectively,in the HIPEC group.No significant difference in postoperative or chemotherapy complications was observed between groups.CONCLUSION In patients with c T4 N0-3 M0 gastric cancer,prophylactic HIPEC after radical tumor surgery is beneficial to reduce peritoneal tumor recurrence and prolong survival. | Tian-Yu Xie Di Wu Shuo Li Zhao-Yan Qiu Qi-Ying Song Da Guan Li-Peng Wang Xiong-Guang Li Feng Duan Xin-Xin Wang | 2020 | World Journal of Gastrointestinal Oncology2020，12，7： | 7 |
| 3 | Inflammation inhibitory effects of sirolimus and paclitaxel-eluting stents on interleukin-1β-induced coronary artery in-stent restenosis in pigs显示文摘背景冠的动脉 in-stent 狭窄(ISR ) 和迟了的 stent 血栓作为 stenting 的重要复杂并发症留下。对 sirolimus 和 paclitaxel-eluting stents 的发炎反应在 interleukin (IL ) 劝诱的一个猪狭窄模特儿被调查 -1.Methods 微型猪(n=12;2-3 月旧、称的 25-30 kg ) 受到 thoracotomy。中间的左前面的下降冠的动脉和左降声调符号的片断(10 公里) 冠的动脉被暴露并且无菌地包了,一个棉花网孔与 IL-1 (5 g ) 浸泡了。在 2 个星期以后,动物是 anesthetized,量的冠的动脉 X 线摄影法(QCA ) 被执行。狭窄地点为 stent 插入被使随机化进三个组:一个 sirolimus-eluting stent (SES ) 组(FirebirdTM, n=7 ) ,一个 paclitaxel-eluting stent (足) 组(TAXUSTM, n=9 ) ,并且一个赤裸金属的 stent (BMS ) 组(YINYITM, Dalian Yinyi Biomaterials 发展有限公司,中国, n=8 ) 。三不同 stents 随机被植入进狭窄片断。单核白血球 chemoattractant protein-1 (MCP-1 ) 的表示,肿瘤坏死 factor-alpha (TNF-) , P-selectin 和脉管的房间粘附 molecule-1 (VCAM-1 ) 被 .Results QCA 显示出的反向的联合抄写的聚合酶链反应(RT-PCR ) 决定在 IL-1 的严重狭窄对待片断。SES 和足组晚显示出更低的 1 月的 angiographic 在 stent 和损害以内的腔损失(LLL ) 与由后续 QCA 的 BMS (P 0.05 ) 相比。SES 在由后续 QCA 在猪减少 1 月的发炎损害比足的显示出更低的 LLL ((0. | ZHOU Xu-chen HUANG Rong-chong ZHANG Bo YIN Da LIANG Bin WANG Shao-peng GUAN Qi-gang SUN Xi-zhuo MIAO Zhi-lin HE Xue-zhi HAN Feng-tong CHENG Ying ZHANG Li ZENG Ding-yin | 2010 | Chinese Medical Journal2010，，17： | 6 |
| 4 | 经自然腔道取标本手术(NOSES)治疗结直肠癌的国际共识显示文摘近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳的心理状态。尽管NOSES的手术创伤显著减轻,然而该技术也存在一些潜在问题。尤其随着这项新技术的兴起,人们对其无菌的把控、肿瘤学结果和病例选择等问题表示出关切。因此,迫切需要一部操作指南来规范NOSES手术在结直肠癌中的开展。经过国际NOSES联盟全体成员的三轮讨论,最终形成了该部共识。这一共识有助于NOSES在全球范围内的长远发展。 | Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES | 2019 | Gastroenterology Report2019，7，1： | 3 |
| 5 | Genetic control of compound leaf development in the mungbean(Vigna radiata L.)显示文摘Many studies suggest that there are distinct regulatory processes controlling compound leaf development in different clades of legumes.Loss of function of the LEAFY(LFY)orthologs results in a reduction of leaf complexity to different degrees in inverted repeat-lacking clade(IRLC)and non-IRLC species.To further understand the role of LFY orthologs and the molecular mechanism in compound leaf development in non-IRLC plants,we studied leaf development in unifoliate leaf(un)mutant,a classical mutant of mungbean(Vigna radiata L.),which showed a complete conversion of compound leaves into simple leaves.Our analysis revealed that UN encoded the mungbean LFY ortholog(VrLFY)and played a significant role in leaf development.In situ RNA hybridization results showed that STM-like KNOXI genes were expressed in compound leaf primordia in mungbean.Furthermore,increased leaflet number in heptafoliate leaflets1(hel1)mutants was demonstrated to depend on the function of VrLFY and KNOXI genes in mungbean.Our results suggested that HEL1 is a key factor coordinating distinct processes in the control of compound leaf development in mungbean and its related non-IRLC legumes. | Keyuan Jiao Xin Li Shihao Su Wuxiu Guo Yafang Guo Yining Guan Zhubing Hu Zhenguo Shen Da Luo | 2019 | Horticulture Research2019，6，1： | 2 |
| 6 | Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart显示文摘Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant challenges.The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic environment.Herein,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction processes.In vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on SpGel.The cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also proven.Furthermore,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and remuscularization.In conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI. | Ge Guan Da Huo Yanzhao Li Xiaolin Zhao Yinghao Li Zhongliang Qin Dayu Sun Guanyuan Yang Mingcan Yang Ju Tan Wen Zeng Chuhong Zhu | 2021 | Bioactive Materials2021，6，12： | 2 |
| 7 | Preparative isolation of triterpenoids from Ganoderma lucidum by counter-current chromatography combined with pH-zone-refining 显示文摘 | Cheng CR Li YF Xu PP Feng RH Yang M Guan SH Guo DA | 2012 | Food Chem2012，130，： | 1 |
| 8 | The contribution of Chinese exports to climate change显示文摘 | Weber Christopher L Peters Glen P Da B Guan | 2008 | Energy Policy2008，，36： | 1 |
| 9 | Rough computational methods for information systems显示文摘 | GUAN JW BELL DA | 1998 | Artificial Intelligences1998，105，12： | 1 |
| 10 | The Application of Chaotic Oscillators to Weak Signal De- tection 显示文摘 | GUAN YU WANG DA JUN CHENG JIAN YA LI | 1999 | IEEE Trans on Industrial and Electronics1999，46，2： | 1 |
| 11 | Does the addition of Braun anastomosis to Billroth Ⅱ reconstruction on laparoscopic-assisted distal gastrectomy benefit patients?显示文摘BACKGROUND Operation is the primary therapeutic option for patients with distal gastrectomy.Braun anastomosis is usually performed after Billroth Ⅱ reconstruction,which is wildly applied on distal gastrectomy because it is believed to benefit patients.However,studies are needed to confirm that.AIM To identify whether the addition of Braun anastomosis to Billroth Ⅱ reconstruction on laparoscopy-assisted distal gastrectomy benefits patients.METHODS A total of 143 patients with gastric cancer underwent laparoscopy-assisted distal gastrectomy at Centre 1 of PLA general hospital between January 2015 and December 2019.Clinical data of the patients were collected,and 93 of the 143 patients were followed up.These 93 patients were divided into two groups:Group 1(Billroth Ⅱ reconstruction,33 patients);and Group 2(Billroth Ⅱ reconstruction combined with Braun anastomosis,60 patients).Postoperative complication follow-up data and relevant clinical data were compared between the two groups.RESULTS There were no significant differences between Group 1 and Group 2 in postoperative complications(6.1%vs 6.7%,P=0.679),anal exhaust time or blood loss.The follow-up prevalence of reflux gastritis indicated no significant difference between Group 1 and Group 2(68.2%vs 51.7%,P=0.109).The followup European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 scores revealed no evident difference between Group 1 and Group 2 as well.Group 1 had a shorter operating time than Group 2 on average(234.6 min vs 262.0 min,P=0.017).CONCLUSION Combined with Billroth Ⅱ reconstruction,Braun anastomosis has been applied due to its ability to reduce the prevalence of reflux gastritis.Whereas in this study,the prevalence of reflux gastritis showed no significant difference,leading to a conclusion that under the circumstance of Braun anastomosis costing more time and more money,simple Billroth Ⅱ reconstruction should be widely applied. | Xiong-Guang Li Qi-Ying Song Di Wu Shuo Li Ben-Long Zhang Li-Yu Zhang Da Guan Xin-Xin Wang Lu Liu | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
| 12 | The application of chaotic oscillators to weak signaldetection显示文摘 | CHEN DA JUN LIN JIAN YA etal | 1999 | IEEE Trans on Industrial Electronics1999，46，2： | 1 |
| 13 | The application of chaotic oscillators to weak signal detection显示文摘 | Guan yu Wang Da jun Chen Jian ya Lin Xing Chen | 1999 | IEEE Transactionson Industrial Electronics1999，46，2： | 1 |
| 14 | The Application of Chaotic Oscillators to Weak Signal Detection显示文摘 | Chen Da Jun Lin Jian Ya | 1999 | IEEE Trans on Industrial Electronics1999，46，2： | 1 |
| 15 | Gastrodin inhibits cell proliferation in vascular smooth muscle cellsand attenuates neointima formation in vivo显示文摘 | Lihua Zhu Hongjing Guan Changping Cui Song Tian Da Yang Xinan Wang Shuming Zhang Lang Wang Hong Jiang | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 16 | Rough computational methods for information systems显示文摘 | GUAN JW BELL DA | 1998 | Artificial Intelligence1998，105，： | 1 |
| 17 | Functional analysis of the O antigen glucosylation gene cluster of Shigella flexneri bacteriophage SfX显示文摘 | Guan S Bastin DA Verma NK | 1999 | Microbiology1999，145，5： | 1 |
| 18 | Experimental study on the strength and ductility of steel tubular columns filled with steel-reinforced concrete显示文摘 | WANG QING-XIANG ZHAO DA ZHOU GUAN PING | 2004 | Engineering Structures2004，26，7： | 1 |
| 19 | Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N6)Virus,Guangdong,China显示文摘 | Mok C K Da Guan W Liu X Q Lamers M M Li X B Wang M Zhang T J Zhang Q L Li Z T Huang J C Lin J Y Zhang Y H Zhao P Lee H H Chen L Li Y M Peiris J S Chen R C Zhong N S Yang Z F | 2015 | Emerg Infect Dis2015，21，12： | 1 |
| 20 | Gastrodin inhibits cell proliferation in vascular smooth muscle cellsand attenuates neointima formation in vivo显示文摘 | Lihua Zhu Hongjing Guan Changping Cui Song Tian Da Yang Xinan Wang Shuming Zhang Lang Wang Hong Jiang | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
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