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| 1 | Output feedback control of hypersonic vehicles based on neural network and high gain observer显示文摘In this paper,the output feedback control problem for a genetic hypersonic vehicle is considered under the restriction that only the vehicle's velocity and altitude are measurable. High gain observers (HGO) are utilized to provide estimation signals for unmeasurable derivatives of the vehicle's velocity and altitude. Neural network based feedforward function is designed to compensate for model uncertainties. The proposed control design require less knowledge of the hypersonic vehicle's dynamic model. A comprehensive stability analysis of the closed loop system under the output feedback control is carried to prove that the proposed control law yields semiglobal uniformly ultimately bounded tracking while keeping all the closed loop signals bounded. Numerical simulation results are presented to validate the proposed control design. | LI XinDong KIAN Bin DIAO Chen YU YanPing YANG KaiYan ZHANG Yao | 2011 | Science China(Information Sciences)2011，54，3： | 20 |
| 2 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 3 | Influence of Ren and Du meridian electro-acupuncture on neural stem cell proliferation and extracellular signal-regulated kinase pathway in a rat model of focal cerebral ischemia injury显示文摘BACKGROUND:Studies have shown that electro-acupuncture at the Ren meridian could improve proliferation of subventricular zone neural stem cells in cerebral-ischemic rats. However,there are few reports on the influence of electro-acupuncture at the Du meridian on neural stem cell proliferation. OBJECTIVE:To observe the influence of electro-acupuncture at Ren and Du meridians on neural stem cell proliferation in the subventricular zone and altered signal transduction in cerebral ischemia rats. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of Human Anatomy,Medical College of Sun Yat-sen University from May 2006 to February 2008. MATERIALS:Mouse anti-rat bromodeoxyuridine (BrdU) monoclonal antibody was provided by Sigma,USA; mouse anti-rat nestin monoclonal antibody and extracellular signal-regulated protein kinase (ERK) specific inhibitor PD98059 were provided by Calbiochem,Germany; acupuncture needle was provided by Suzhou Acupuncture Supplies,China. METHODS:A total of 126 rats were randomly assigned to four groups:model (n = 36),Du meridian (n = 36),Ren/Du meridian (n = 36),and Ren/Du meridian + PD98059 (n = 18). Rats in the Ren /Du meridian + PD98059 group were observed on days 7 (n = 6) and 14 (n = 12) after cerebral ischemia injury. Rats in the model,Du meridian,and Ren/Du meridian groups were observed on days 7,14,and 28 after cerebral ischemia injury,with 12 rats per group at each time point. Thread occlusion was used to establish middle cerebral artery occlusion models. Electro-acupuncture was performed at Renzhong (DU 26) and Baihui (DU 20) acupoints in the Du meridian group,as well as Chengjiang (RN 24),Guanyuan (RN 4),Renzhong,and Baihui acupoints in the Ren/Du meridian and Ren/Du meridian + PD98059 groups 2 days after model establishment. In addition,electro-acupuncture stimulation with disperse-dense waves was performed,with 30 Hz disperse wave,100 Hz dense wave,and 5 V intensity for 20 minutes. Rats in the Ren/Du meridian + PD98059 group were treated with 0.2 μg PD98059 injection into the subventricular zone,2 μL per rat. Rats in the model group were not treated with electro-acupuncture. MAIN OUTCOME MEASURES:BrdU/nestin immunofluorescent staining was used to detect proliferating neural stem cells in the subventricular zone of cerebral ischemia rats; Western blot was used to determine phosphorylated ERK1 and 2 (pERK1/2) expression in the subventricular zone. RESULTS:On days 14 and 28 after cerebral ischemia,there were significantly more BrdU-positive and BrdU/nestin-positive cells in the Ren /Du meridian group compared with the Du meridian group (P < 0.05). PD98059 decreased the number of BrdU-positive and BrdU/nestin-positive cells induced by electro-acupuncture at the Ren and Du meridians (P < 0.05). On days 7,14,and 28 after treatment,pERK1/2 expression was significantly greater in the Du meridian and Ren/Du meridian groups compared with the model group (P < 0.05). The promoting effect of electro-acupuncture at Ren and Du meridians on ERK1/2 phosphorylation was superior to electro-acupuncture at the Du meridian alone on day 14 after model induction (P < 0.05). However,PD98059 completely abolished the promoting effect of electro-acupuncture at Ren/Du meridians on pERK1/2 expression (P < 0.05). CONCLUSION:Electro-acupuncture at Ren and Du meridians increased proliferation of subventricular zone neural stem cells,which was related to activation of the ERK pathway in a rat model of cerebral ischemia injury. | Wenshu Luo Haibo Yu Zhuoxin Yang Min Pi Lihong Diao Xiaodan Rao | 2010 | Neural Regeneration Research2010，5，6： | 14 |
| 4 | Effects of benzoic acid(Vevo Vitall) on the performance and jejunal digestive physiology in young pigs显示文摘Background: As a organic acid, benzoic acid has become one of the most important alternatives for antibiotics,and its beneficial effect on performance in animals has been proven for a decade. However, knowledge of the effects of benzoic acid on jejunal digestive physiology, especially the antioxidant capacity and mucosal glucagon-like peptide2(GLP-2) concentrations is lacking.Methods: A total of 20 barrows [Duroc ×(Yorkshire × Landrace)] with an average body weight(BW) of 18.75 ± 0.2 kg were used in a 14-d trial to determine the potential mechanisms of benzoic acid supplementation on the performance,nutrient digestibility and jejunal digestive physiology in young pigs. All pigs were randomly allotted to 1 of 2 diets supplemented with 0 or 5000 mg/kg benzoic acid.Results: Relative to the control, benzoic acid supplementation increased the average daily feed intake(ADFI), and average daily gain(ADG) in young pigs(P < 0.05), improved the apparent total tract digestibility of dry matter(DM),crude protein(CP), ether extract(EE), gross energy(GE) and crude ash(P < 0.05), and enhanced the activities of trypsin,lipase and amylase in the jejunum(P < 0.05). Similarly, relative to the control, supplementing benzoic acid in the diet resulted in a trend to reduce the p H values of the digesta(P = 0.06), decreased crypt depth and increased the villus height to crypt depth ratio(P < 0.05) in the jejunum of pigs. Finally, benzoic acid supplementation increased the mR NA expression and concentration of glucagon-like peptide 2 and the activities of glutathione peroxidase and superoxide dismutase in the jejunal mucosa of young pigs(P < 0.05).Conclusions: In conclusion, supplementation with 5000 mg/kg benzoic acid improved the performance of young pigs through promoting nutrient digestion, improving jejunal antioxidant capacity, and maintaining the jejunal morphology in young pigs. | Hui Diao Zengbing Gao Bing Yu Ping Zheng Jun He Jie Yu Zhiqing Huang Daiwen Chen Xiangbing Mao | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 10 |
| 5 | Effect of Dermabrasion and ReCell on Large Superficial Facial Scars Caused by Burn, Trauma and Acnes显示文摘ObjectiveTo 探索在灼伤,损伤和 acnes.MethodsNineteen 病人与大表面的面部疤引起的大表面的面部疤上与房间 ? 相结合的磨去皮肤疤痕之手术的效果被一样的外科医生对待,磨去皮肤疤痕之手术与房间 ? 结合了。根据病原学,病人们被分类进 burning 以后组(n=5 ) , traumatic 以后组(n=7 ) 和粉刺以后的组(n=7 ) 。十五个病人完成了后续,在每个组的 5 个病人。愈合的时间,复杂并发症率,外科手术前并且用耐心的满足分数( PSS )的 18-month-post-operative 评价,温哥华疤规模( VSS ),并且病人和每个组的观察员疤评价规模( POSAS )被分析在burning以后组的 outcomes.ResultsThe 愈合时间比较联合治疗的效果( 19.6 湯味敨瀠票楳楣湡?敲潰瑲摥洠湡条浥湥?景???湩琠楨?慭潪?捡摡浥捩栠慥瑬'文?散瑮牥椠?敂橩湩?慷?湩潣獮獩整瑮眠瑩?畣牲湥? | Pan-xi Yu Wen-qi Diao Zuo-liang Qi Jing-long Cai | 2016 | Chinese Medical Sciences Journal2016，31，3： | 8 |
| 6 | Research into magnetic guidance technology for directional drilling in SAGD horizontal wells显示文摘SAGD horizontal wells are used to enhance oil recovery from heavy oil reservoirs.This technology requires precise separation between the production well and the injection well to ensure the efficient drainage of the reservoir.By studying the attitude of the downhole probe tube and the production well trajectory,an algorithm is proposed for eliminating ferromagnetic interference while drilling injection wells.A high accuracy filter circuit has been designed to correct the detected magnetic signals,which are ultra-weak,frequency-instable,and narrow-band.The directional drilling magnetic guidance system(DD-MGS) has been developed by integrating these advanced techniques.It contains a sub-system for the ranging calculation software,a magnetic source,a downhole probe tube and a sub-system for collecting & processing the detected signals.The DD-MGS has succeeded in oilfield applications.It can guide the directional drilling trajectory not only in the horizontal section but also in the build section of horizontal injection wells.This new technology has broad potential applications. | Gao Deli Diao Binbin Wu Zhiyong Zhu Yu | 2013 | Petroleum Science2013，10，4： | 7 |
| 7 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 8 | Synthesis and anticancer activities of porphyrin induced anticancer drugs显示文摘鉴于性质卟啉在肿瘤有选择地是累积, ftorafur 被绑定修改改进它指向的肿瘤并且减少它的副作用的卟啉块。这些新奇卟啉衍生物和金属混合物与令人满意的产量在温和条件下面被综合,并且所有这些新混合物的构造被描绘由紫外,红外, MS, 1H NMR 系列和基本分析。他们的反癌症活动被 MTT 试金评估;结果显示混合物 4a-c 的反癌症活动象 ftorafur 的一样两次高。 | Dong Hong Li Jun Lin Diao Ke Gui Yu Cheng He Zhou | 2007 | Chinese Chemical Letters2007，18，11： | 6 |
| 9 | Post-failure behavior of tunnel heading collapse by MPM simulation显示文摘Tunnel collapse presents a serious threat to the safety of urban construction. The traditional approach adopted to assess this risk is to evaluate the factor of safety against failure. However, this analysis only determines on whether the tunnel will collapse or not, and does not provide information on the magnitude of the post-failure behavior(for example, catastrophic or progressive) if the tunnel collapse occurs. In this study, a meshless method based on the material point method(MPM) was used to investigate the post-failure behavior of tunnel heading collapse in two-dimensional plane-strain conditions. The capability and accuracy of MPM were verified by comparing the elicited results to centrifuge test data and to analytical solutions obtained from limit state methods. MPM simulations were conducted at different soil conditions(clay or sand) and profiles(homogenous or linear increasing strength) as well as at different tunnel geometries(i.e. tunnel depth and unlined length). The differences in the post-failure behavior and mechanisms are examined and reported. | CHENG XueSong ZHENG Gang SOGA K. BANDARA S.S. KUMAR K. DIAO Yu XU Jie | 2015 | Science China(Technological Sciences)2015，58，12： | 5 |
| 10 | Multi-function radar emitter identification based on stochastic syntax-directed translation schema显示文摘To cope with the problem of emitter identification caused by the radar words' uncertainty of measured multi-function radar emitters, this paper proposes a new identification method based on stochastic syntax-directed translation schema(SSDTS). This method, which is deduced from the syntactic modeling of multi-function radars, considers the probabilities of radar phrases appearance in different radar modes as well as the probabilities of radar word errors occurrence in different radar phrases. It concludes that the proposed method can not only correct the defective radar words by using the stochastic translation schema, but also identify the real radar phrases and working modes of measured emitters concurrently. Furthermore, a number of simulations are presented to demonstrate the identification capability and adaptability of the SSDTS algorithm.The results show that even under the condition of the defective radar words distorted by noise,the proposed algorithm can infer the phrases, work modes and types of measured emitters correctly. | Liu Haijun Yu Hongqi Sun Zhaolin Diao Jietao | 2014 | Chinese Journal of Aeronautics2014，27，6： | 4 |
| 11 | Effects of cerium substitution on phase components, microstructures and magnetic properties of Nd-Fe-Ti-B alloy显示文摘(Nd(1-x)Cex)(12)Fe(77)Ti5B6(x=0,0.2,0.3,0.4,0.6,0.8)alloys were prepared by melt-spinning and annealing techniques.The phase constitutions,microstructures and magnetic properties were investigated by powder X-ray diffraction(XRD),a differential scanning calorimeter(DSC),a vibrating sample magnetometer(VSM)and a transmission electron microscope(TEM).It is found that with the increase of Ce content,the coercivity of the(Nd(1-x)Cex)(12)Fe(77)Ti5B6 alloys reaches maximum first and then decreases.The maximum coercivity reaches 18.5 kOe obtained in the sample of 20%Ce substituted which is 34%higher than the Ce-free sample.TEM results reveal that the micro structure refinement effect is responsible for the coercivity improvement.This phenomenon implies that in some cases,Ce and Ti co-doping is more beneficial to improving of the coercivity than Ti single doping in Nd-Fe-B alloys.With further Ce addition,magnetic properties deteriorate due to the formation of CeFe2 and TbCu7-type phases. | Haijun Peng Yang Luo Yakun Dou Xinyuan Bai Wenlong Yan Dunbo Yu Yuanfei Yang Shulin Diao | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 12 | Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects显示文摘AIM: To investigate the effects of our tumor vaccines on reversing immune tolerance and generating therapeutic response.METHODS: Vaccines were synthesized by solid phase using an Fmoc strategy,where a small molecule toll-like receptor-7 agonist(T7) was conjugated to a monoclonal gastric cancer 7 antigen mono-epitope(T7-MG1) or tri-epitope(T7-MG3).Cytokines were measured in both mouse bone marrow dendritic cells and mouse spleen lymphocytes after exposed to the vaccines.BALB/c mice were intraperitoneally immunized with the vaccines every 2 wk for a total of three times,andthen subcutaneously challenged with Ehrlich ascites carcinoma(EAC) cells.Three weeks later,the mice were killed,and the tumors were surgically removed and weighed.Serum samples were collected from the mice,and antibody titers were determined by ELISA using an alkaline phosphate-conjugated detection antibody for total Ig G.Antibody-dependent cell-mediated cytotoxicity was detected by the lactate dehydrogenase method using natural killer cells as effectors and antibody-labeled EAC cells as targets.Cytotoxic T lymphocyte activities were also detected by the lactate dehydrogenase method using lymphocytes as effectors and EAC cells as targets.RESULTS: Vaccines were successfully synthesized and validated by analytical high performance liquid chromatography and electrospray mass spectrometry,including T7,T7-MG1,and T7-MG3.Rapid inductions of tumor necrosis factor-α and interleukin-12 in bone marrow dendritic cells and interferon γ and interleukin-12 in lymphocytes occurred in vitro after T7,T7-MG1,and T7-MG3 treatment.Immunization with T7-MG3 reduced the EAC tumor burden in BALB/c mice to 62.64% ± 5.55% compared with PBS control(P < 0.01).Six or nine weeks after the first immunization,the monoclonal gastric cancer 7 antigen antibody increased significantly in the T7-MG3 group compared with the PBS control(P < 0.01).As for antibody-dependent cell-mediated cytotoxicity,antisera obtained by immunization with T7-MG3 were able to markedly enhance cell lysis compared to PBS control(31.58% ± 2.94% vs 18.02% ± 2.26%; P < 0.01).As for cytotoxic T lymphocytes,T7-MG3 exhibited obviously greater cytotoxicity compared with PBS control(40.92% ± 4.38% vs 16.29% ± 1.90%; P < 0.01).CONCLUSION: A successful method is confirmed for the design of gastric cancer vaccines by chemical conjugation of T7 and multi-repeat-epitope of monoclonal gastric cancer 7 antigen. | Xiao-Dong Wang Ning-Ning Gao Yu-Wen Diao Yu Liu Dong Gao Wang Li Yan-Yan Wan Jing-Jing Zhong Guang-Yi Jin | 2015 | World Journal of Gastroenterology2015，21，26： | 3 |
| 13 | Migraine and Cochlear Symptoms显示文摘Migraine is one of the most common and highest burdens of disease.As a primary cerebral dysfunction illness,migraine might exhibit other system-related symptoms,including vestibular and cochlear symptoms.With the publication of the diagnostic criteria of vestibular migraine,the link between migraine and vestibular symptoms became clear.However,the relationship between migraine and cochlear symptoms is far from straightforward.Therefore,we focus on the correlation between migraine and deafness,sudden sensorineural hearing loss,acute tinnitus,and chronic tinnitus to better understand the relationship between migraine and cochlear symptoms. | Xin MA Yu-jie KE Yuan-yuan JING Tong-xiang DIAO Li-sheng YU | 2021 | Current Medical Science2021，41，4： | 3 |
| 14 | A Robust Real-time Low-frequency Oscillation Detection and Analysis (LFODA) System with Innovative Ensemble Filtering显示文摘Low-frequency oscillations are hazardous to power system operation,and can lead to cascading failures if not detected and mitigated in a timely manner.This paper presents a robust and automated real-time monitoring system for detecting grid oscillations and analyzing their mode shapes using PMU measurements.A novel Extended Kalman Filtering(EKF)based approach is introduced to detect and analyze oscillations.To further improve the accuracy and efficiency of the presented software system,the EKF approach takes advantages of three effective signal processing methods(including Prony’s Method,Hankel Total Least Square(HTLS)Method,EKF)and adopts a novel voting schema to significantly reduce the computation cost.Results from these methods are processed through a timeseries filter to ensure the consistency of detected oscillations and reduce the number of false alarms.The Density-based Spatial Clustering of Applications with Noise(DBSCAN)method is used to accurately classify oscillation modes and the PMU measurement channels.The LFODA system has been functioning well in the State Grid Jiangsu Electric Power Company with 176 PMUs and 1000+channels since February 2018,demonstrating outstanding performance in reducing false alarms with much less computational cost. | Desong Bian Zhe Yu Di Shi Senior Ruisheng Diao Zhiwei Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 15 | HBeAg gene expression with baculovirus vector in silk worm cells显示文摘INTRODUCTIONMiyanoharaetal[1]firstobtainedproductswiththeexpresionofHBeAgactivitybyconstructingayeastexpresionsystem;laterres... | DENG Xiao Zhao, DIAO Zhen Yu, HE Liang, QIAO Ren Liang and ZHANG Lin Yuan | 1999 | World Journal of Gastroenterology1999，5，2： | 3 |
| 16 | A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study显示文摘Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is limited.The objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after surgery.Methods:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December 2006.The endpoint of this study was OS.The nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical usefulness.The nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),respectively.Results:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),respectively.Encouragingly,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup analyses.Decision curve analysis indicated that the nomogram was clinically useful and applicable.Conclusions:The study presents a nomogram that incorporates clinicopathological predictors,which can accurately predict the OS of adult ACC patients after surgery.This model and the corresponding risk classification system have the potential to guide therapy decisions after surgery. | Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao Weibin Xie Xiong Chen Chenyi Liao Hao Yu Xinxiang Fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv Haide Qin Jian Huang Tianxin Lin | 2019 | Cancer Communications2019，39，1： | 3 |
| 17 | Analysis of the Prevalence and Situation of Myopia in Adolescents from South China显示文摘Purpose: To conduct dynamic detection of refraction changes in adolescents with myopia and analyze the correlation between different reexamination times and factors that included age of onset, initial refractive power, and rate of myopia progression.Methods: A total of 900 adolescents(aged 6-15 years) with myopia admitted to Zhongshan Ophthalmic Center between2009 and 2013 were randomly selected in this investigation.All participants underwent objective refraction measurement with an autorefractometer(Topcon 8900) or streak retinoscopy and subjective refraction detection with an autorefractor(Nidek).or minus-lens procedures at different time intervals(6months, 1, and 2 years). Accurate refractive power was obtained..All data were analyzed with SPSS 18.0 statistical software.Results:.The mean refractive power was increased by 0.56 ±0.37 diopters(D) after 6 months,.by 0.83±0.45 D after 1 year,.and by 1.50±0.70 D after 2 years..Among the 900 adolescents,.the most rapid increase in refractive power was observed at the age of 8 years at the 6-month reexamination, at the age of8 and 9 years at the 1-year reexamination,.and at the age of 7-9 years at the 2-year reexamination..The increase in index of refraction tended to diminish with aging..The different cycles of reexamination revealed a slowing of the rate of myopia progression along with the increase in the initial index of refraction..The highest rate of myopia progression was noted in low-myopic adolescents with initial refractive power ranging from-0.25 to 2.75 D.Conclusion:.No positive correlation was documented between different cycles of reexamination and the refractive power. The increase in refractive power was associated with factors that included the reexamination cycle, age of onset, and initial refractive power. | Shuiming Yu Hongxing Diao Junwen Zeng | 2015 | Eye Science2015，30，2： | 3 |
| 18 | Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer显示文摘Background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(BC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of BC with muscular invasion.Here,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with BC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive BC(MIBC)from non-muscle-invasive BC(NMIBC)is also proposed.Methods:All eligible BC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and BC muscular invasion was evaluated using the Chi-square tests.In the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion prediction.Then,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation set.Moreover,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the nomogram.Results:Muscular invasion was more prevalent in BC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],P<0.001;3.406[1.912 to 6.068],P<0.001 and 2.483[1.436 to 4.292],P=0.001,respectively).Radiologydetermined tumor size,radiology-determined clinical tumor stage and CSP7 status were identified as independent risk factors of BC muscular invasion by the multivariate regression analysis in the training set.Then,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed to have satisfactory discrimination in the training(AUC 0.784;95%CI:0.715 to 0.853)and validation(AUC 0.743;95%CI:0.635 to 0.850)set.The decision curve analysis(DCA)indicated the clinical usefulness of our nomogram.In models comparison,using the receiver operator characteristic(ROC)analyses,the nomogram showed higher discriminatory accuracy than any variables incorporated in the nomogram alone and the DCAs also identified the nomogram as possessing the highest net benefits at wide range of threshold probabilities.Conclusion:CSP7 status was identified as an independent factor for predicting muscular invasion in BC patients and was successfully incorporated in a clinical nomogram combining the results of the FISH assay with clinical risk factors. | Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang Weibin Xie Xiong Chen Chengran Huang Lifang Huang Haide Qin Jian Huang Tianxin Lin | 2020 | Cancer Communications2020，40，4： | 3 |
| 19 | The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non-small cell lung cancer patients with epidermal growth factor receptor mutation显示文摘Over the past few years,immune checkpoint inhibitors(ICIs)have greatly improved the survival for patients with non-small cell lung cancer(NSCLC)without driver mutations.Compared with wild-type tumors,tumors with epidermal growth factor receptor(EGFR)mutations show more heterogeneity in the expression level of programmed cell death-ligand 1(PD-L1),tumor mutational burden(TMB),and other immune microenvironment characteristics.Whether ICIs are suitable for NSCLC patients with EGFR mutations is still worth exploring.In previous studies,no significantly improved benefits were observed with immunotherapy monotherapy in NSCLC patients with EGFR mutation.Here,we summarized and analyzed data from the clinical trials of ICIs or combined therapy in NSCLC patients with EGFR mutations.We also focused on the mechanisms affecting the efficacy of ICIs in NSCLC patients with EGFR mutations,the characteristics of potential responders,and provided insights into areas worth further investigations in future studies. | Lin Ma Bowen Diao Zhaoqin Huang Bin Wang Jinming Yu Xiangjiao Meng | 2021 | Cancer Communications2021，41，12： | 3 |
| 20 | Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats显示文摘BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic rats.Previous studies have indicated that berberine could be successfully used to manage T2DM.We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.AIM To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.METHODS GK rats were acclimatized for 1 wk.The GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were measured.Pancreatic tissue was observed for pathological changes.Additionally,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.RESULTS Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(P<0.01)and GLP-1(P<0.05).A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three groups.Compared to the Mo group,the Me and Be groups showed a shift in the structure of the gut microbiota.Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bacteroidetes/Firmicutes ratio(P<0.01).Furthermore,Muribaculaceae(P<0.01;P<0.05)was significantly decreased in the Me and Be groups,and Allobaculum(P<0.01)was significantly increased.CONCLUSION Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats. | Jin-Dong Zhao Yan Li Min Sun Chan-Juan Yu Jia-Yun Li Si-Hai Wang Di Yang Cheng-Lin Guo Xue Du Wen-Jin Zhang Ruo-Dong Cheng Xiao-Chuan Diao Zhao-Hui Fang | 2021 | World Journal of Gastroenterology2021，27，8： | 2 |
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