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| 1 | Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA显示文摘Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.Much of the newly-discovered transcriptome appears to represent long non-coding RNA(lncRNA),a heterogeneous group of largely uncharacterised transcripts.Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date.One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA(miRNA) pathways.lnc RNA has been shown to act as both a source and an inhibitory regulator of mi RNA.At the transcriptional level,a model is emerging whereby lnc RNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes.Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping,as well as conferring specificity on histone modifying complexes by directing them to specific loci. | Iain M.Dykes Costanza Emanueli | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 71 |
| 2 | “Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis显示文摘Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations.Plaque psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune responses.In recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis pathogenesis.In this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular psoriasis.We further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis. | Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson | 2021 | Cellular & Molecular Immunology2021，18，2： | 7 |
| 3 | miRNAGE-34 induces cardiac damAGE显示文摘 | Costanza Emanueli Thomas Thum | 2013 | Cell Research2013，23，7： | 2 |
| 4 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 5 | Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs显示文摘 | Emanueli C Salis MB Pinna A | 2002 | Circulation2002，106，17： | 1 |
| 6 | Adenovirus-mediated human tissue kallikrein gene delivery induces angiogenesis in normoperfused skeletal muscle显示文摘 | Emanueli C Zaeheo A Minasi A | 2000 | Arterioscler Thromb Vase Biol2000，20，11： | 1 |
| 7 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases 显示文摘 | Emanueli G Madeddu P | 2004 | Arch Mal Coeur2004，97，6： | 1 |
| 8 | Nitric oxide-releasing aspirin derivative,NCX 4016,promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia显示文摘 | Emanueli C Van Linthout S Salis MB | 2004 | Arterioscler Thromb Vasc Biol2004，24，11： | 1 |
| 9 | Local delivery of human tissue kallikrcin gene accelerates spontaneous angiogenesis in mouse model of hind limb ischemia 显示文摘 | Emanueli C MinasiA Zacheo A | 2001 | Circulation2001，103，1： | 1 |
| 10 | Increasing destructiveness of tropical cyclone over the past 30 years显示文摘 | EMANUAL | 2005 | Nature2005，436，4： | 1 |
| 11 | Cytogenetics of papillary renal cell tumors显示文摘 | Kovacs G Fuzesi L Emanual A | 1991 | Genes Chromosomes Cancer1991，3，4： | 1 |
| 12 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases显示文摘 | Emanueli C Madeddu P | | 0，，06： | 1 |
| 13 | Reversal of angiogenic growth factor up regulation by revascularization of lower limb ischemia显示文摘 | PORCU P EMANUELI C KAPATSORIS M | 2002 | Circulation2002，105，： | 1 |
| 14 | Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia 显示文摘 | Emanueli C | 2001 | Circulation2001，103，： | 1 |
| 15 | Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs显示文摘 | Emanueli C Salis MB Pinna A | 2002 | Circulation2002，1062，257： | 1 |
| 16 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic disease显示文摘 | Emanueli C Madeddu P | 2004 | Arch Mal Coeur2004，97，6： | 1 |
| 17 | Adenovirus- Mediated Human Tissue Kallikrein Gene Delivery Induces Angiogenesis in Normoperfused Skeletal Muscle 显示文摘 | Emanueli C Zacheo A Minasi A | 2000 | Arterioscler Thromb Vase Biol2000，20，： | 1 |
| 18 | Cardiovascular actions of neurotrophins 显示文摘 | Caporali A Emanueli C | 2009 | Physiol Rev2009，89，1： | 1 |
| 19 | Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikreingene transfer显示文摘 | Emanueli C Salis MB van Linthout S | 2004 | Circulation2004，110，： | 1 |
| 20 | Reversal of angiogenic growth factor upregulation by revascularization of lower limb ischemi- a显示文摘 | Porcu P Emanueli C Kapatsoris M | 2002 | Circulation2002，105，1： | 1 |
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