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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 3 | Water regime-nitrogen fertilizer incorporation interaction:Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China显示文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH_4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N_2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH_4 emissions at low level(75 kg N/ha). But both CH_4 and N_2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields. | Wenjun Dong Jia Guo Lijun Xu Zhifeng Song Jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai | 2018 | Journal of Environmental Sciences2018，30，2： | 12 |
| 4 | Numerical simulation of hydrodynamic and water quality effects of shoreline changes in Bohai Bay显示文摘 | Han JIA 1Yongming SHEN Meirong SU Chunxue YU | 2018 | Frontiers of Earth Science2018，12，3： | 9 |
| 5 | Preparation of Sandwich-like NiCo2O4/rGO/NiO Heterostructure on Nickel Foam for High-Performance Supercapacitor Electrodes显示文摘A kind of sandwich-like NiCo_2O_4/rGO/NiO heterostructure composite has been successfully anchored on nickel foam substrate via a three-step hydrothermal method with successive annealing treatment. The smart combination of NiCo_2O_4, reduced graphene oxide(rGO), and NiO nanostructure in the sandwich-like nano architecture shows a promising synergistic effect for supercapacitors with greatly enhanced electrochemical performance. For serving as supercapacitor electrode, the NiCo_2O_4/rGO/NiO heterostructure materials exhibit remarkable specific capacitance of 2644 mF cm^(-2)at current density of 1 mA cm^(-2),and excellent capacitance retentions of 97.5% after 3000 cycles. It is expected that the present heterostructure will be a promising electrode material for high-performance supercapacitors. | Delong Li Youning Gong Miaosheng Wang Chunxu Pan | 2017 | Nano-Micro Letters2017，9，2： | 8 |
| 6 | Developing More Effective Enhanced Biochar Fertilisers for Improvement of Pepper Yield and Quality显示文摘Utilization of biochar at high application rates can increase soil C and crop yields, decrease greenhouse gas emissions and reduce nutrient run-off from soils. However, the high application rate of 10 t ha-1may not return a profit to the farmer due to the high cost of biochar. In this study biochar was modified through pre-treating the biomass and post-treating with phosphoric acid, minerals and different chemical fertilisers to study the effects of two new enhanced biochar fertilisers on the yield and quality of green pepper in a field experiment with 5 fertilisation treatments and 3 replications. The two new biochar fertilisers significantly(P < 0.05) increased the yield of green pepper(11.33–11.47 t ha-1), compared with the conventional chemical fertiliser(9.72 t ha-1). The biochar fertiliser treatments improved the vitamin C content of green pepper from 236.99 to 278.28 mg kg-1, and also significantly(P < 0.05) reduced the nitrate content from 132.32 to 101.92 mg kg-1, compared with chemical fertiliser. This study indicated that, compared to the use of conventional chemical fertiliser, all of the biochar fertiliser treatments could significantly improve the yield and quality of green pepper. | YAO Chunxue Stephen JOSEPH LI Lianqing PAN Genxing Yun LIN Paul MUNROE Ben PACE Sarasadat TAHERYMOOSAVI Lukas VAN ZWIETEN Torsten THOMAS Shaun NIELSEN Jun YE Scott DONNE | 2015 | Pedosphere2015，25，5： | 8 |
| 7 | Morphologies of Al_4Sr Intermetallic Phase and Its Modification Property upon A356 Alloys显示文摘In general,the modification performance of Al-Sr master alloys is primarily dependent upon the morphologies and sizes of the Al_4Sr intermetallic phase.In this paper,the crystal structure,morphologies,sizes,hardness and elastic modulus of Al_4Sr in Al-Sr master alloys prepared from variant processes were studied by means of optical metallurgical microscope,X-ray diffraction(XRD),scanning electron microscopy(SEM),and nanoindentation system.The results revealed that the microstructures and modification performance of the Al_4Sr phase were related to the preparation processes.That is to say,when a 'direct reaction-hot extrusion' process was used,the Al_4Sr phase exhibited a homogeneous distribution in the Al matrix with small size and roundish shapes,which ensured the Al-Sr master alloy wire advantages involving high recovery,good reproducibility,no delitescence of modification,no corrosion on equipments,and good workability.However,in the case of the traditional 'direct reaction' process,the Al4Sr phase was in large size with shapes of rectangular stripe and plates,which limited the Sr content increasing due to the brittleness of the Al-Sr alloy.It was also found that the morphology and size of the Al_4Sr phases changed during heat treatment at high temperature up to 600 ℃. | Chengwei Liao Jianchun Chun Yang Li Rui Tu Chunxu Pan | 2012 | Journal of Materials Science & Technology2012，28，6： | 7 |
| 8 | Effects of chemical modification on physicochemical properties and adsorption behavior of sludge-based activated carbon显示文摘This study aimed to explore the adsorption performance of sludge-based activated carbon(SBC)towards dissolved organic matters(DOMs)removal from sewage,and investigated the modification effect of different types of chemicals on the structure of synthesized SBC.Waste activated sludge(WAS)was used as a carbon source,and HCl,HNO 3,and Na OH were used as different types of chemicals to modify the SBC.With the aid of chemical activation,the modified SBC showed higher adsorption performances on DOMs removal with maximum adsorption of 29.05 mg/g and second-order constant(k)of 0.1367(L/mol/sec)due to the surface elution of ash and minerals by chemicals.The surface elemental composition of MSBC suggested that the content of C-C and C-O functional groups on the surface of modified sludge-based activated carbon(MSBC)played an important role on the adsorption capacities of MSBC towards DOMs removal in sewage.Additionally,the residual molecular weight of DOMs in sewage was investigated using a 3-dimension fluorescence excitationemission matrix(3 D-EEM)and high-performance size exclusion chromatography(HP-SEC).Results showed that the chemical modification significantly improved the adsorption capacity of MSBC on humic acids(HA)and aromatic proteins(APN),and both of Na OH-MSBC and HCl-MSBC were effective for a wide range of different AMW DOMs removal from sewage,while the HNO 3-MSBC exhibited poorly on AMW organics of 2,617 Da and 409 Da due to the reducing content of macropore.In brief,this study provides reference values for the impact of the chemicals of the activation stage before the SBCs application. | Chunxu Wu Lanfeng Li Hao Zhou Jing Ai Hongtao Zhang Jialin Tao Dongsheng Wang Weijun Zhang | 2021 | Journal of Environmental Sciences2021，33，2： | 7 |
| 9 | Modification performance on 4032 Al alloy by using Al–10Sr master alloys manufactured from different processes显示文摘The microstructures and modification performance on 4032 aluminum alloy of the Al–10Sr master alloy wire prepared from 'direct reaction-hot extrusion' and the trapezoidal block from 'direct reaction' were systemically studied by using optical metallurgical microscope, XRD and SEM. It was found that the preparation processes exhibited a significant effect on the microstructures of the Al–10Sr, which thereby influenced its modification performance. It has been found that when the Al–10Sr alloy wire was used, a desirable modification was obtained after 2 min and reached to the best performance at 60 min, and the optimum Sr addition amount was 0.04–0.06 wt%, and the good modification performance was kept even after 300 min. However, when the Al–10Sr alloy trapezoidal block was used, a desirable modification was started after 30 min and reached to the best performance as long as 120 min, and the optimum Sr addition amount was 0.06–0.08 wt%, and the effective modification period was only180 min. Therefore, comparing with the Al–10Sr alloy trapezoidal block, the Al–10Sr alloy wire had better modification efficiency, which not only reduced the Sr addition amount of about 30%, but also greatly decreased the incubation time and improved the ability of anti-fading. | Chengwei Liao Jianchun Chen Yunlong Li Huan Chen Chunxu Pan | 2014 | Progress in Natural Science:Materials International2014，24，2： | 6 |
| 10 | Fabrication and characterization of electrospun TiO_2/CuS micro-nano-scaled composite fibers | Delong Li,Chunxu Pan School of Physics and Technology,Center for Electron Microscopy and MOE Key Laboratory of Artificial Micro-and Nano-structures,Wuhan University,Wuhan 430072,China | 2012 | Progress in Natural Science:Materials International2012，22，1： | 6 |
| 11 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 12 | Abiogenic hydrocarbons in commercial gases from the Songliao Basin,China显示文摘This paper discusses the kinetic fractionation, composition and distribution characteristics of carbon and hydrogen isotopes for various alkane gases formed in different environments, by different mecha- nisms and from different sources in nature. It is demonstrated that the biodegradation or thermode- gradation of complex high-molecule sedimentary organic material can form microbial gas or thermogenic gas. The δ 13C1 value ranges from -110‰ to -50‰ for microbial gases but from -50‰ to -35‰ (even heavier) for thermogenic gases. Controlled by the kinetic isotope fractionation, both microbial and thermogenic gases have δ 13C and δ D values characterized by normal distribution, i.e. δ 13C1< δ 13C2< δ 13C3< δ 13C4 and δ DCH4< δ DC2H6< δ DC3H8<δ DC4H10, and by a positive correlation between the δ 13C and δ D values. Simple carbonbearing molecules (CH4, CO and CO2) can form abiogenic alkane gases via polymerization in the abiological chemical process in nature, with δ 13C1 heavier than -30‰. Moreover, controlled by the kinetic isotope fractionation, abiogenic alkane gases are characterized by a reverse distribution of δ 13C values and a normal trend of δ D values, namely δ 13C1> δ 13C2> δ 13C3> δ 13C4 and δ DCH4<δ DC2H6< δ DC3H8< δ DC4H10. The δ 13C values and δ D values are negatively correlated. Natural gases from 26 commercial gas wells distributed in the Xujiaweizi and Yingshan-Miaotaizi faulted depressions in the Songliao Basin, China, show δ13C1 values ranging from -30.5‰ to -16.7‰ with a very narrow δ D range between -203‰―-196‰. These gases are characterized by a reverse distribution of δ 13C values but a normal distribution of δ D values, and a negative correlation between their δ 13C and δ D values, indicating an abiological origin. The present study has revealed that abiogenic hydrocarbons not only exist in nature but also can make significant contribution to commercial gas reserviors. It is estimated that the reserve volume of alkane gases with abiogenic characteristics in these 26 gas wells in the Songliao Basin is over 500×108 m3. The prospecting practice in the Songliao Basin has demonstrated that abiogenic alkane gases are of a promising resource, and it provides an example for the investigation of and search for abiogenic commercial natural gases worldwide. | WANG XianBin GUO ZhanQian TUO JinCai GUO HongYan LI ZhenXi ZHUO ShengGuang JIANG HongLiang ZENG LongWei ZHANG MingJie WANG LianSheng LIU ChunXue YAN Hong LI LiWu ZHOU XiaoFeng WANG YongLi YANG Hui WANG Guang | 2009 | Science China Earth Sciences2009，52，2： | 6 |
| 13 | Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma显示文摘 | Huang Wei Jin Yi Yuan Yunfeng Bai Chunxue Wu Ying Zhu Hongguang Lu Shaohua | 2014 | Chinese Medical Journal2014，，2： | 6 |
| 14 | Structural Synthesis of a Class of 2R2T Hybrid Mechanisms显示文摘Conventional overconstrained parallel manipulators have been widely studied both in industry and academia,however the structural synthesis of hybrid mechanisms with additional constraints is seldom studied,especially for the four degrees of freedom(DOF) hybrid mechanisms.In order to develop a manipulator with additional constraints,a class of important spatial mechanisms with coupling chains(CCs) whose motion type is two rotations and two translations(2R2T) is presented.Based on screw theory,the combination of different types of limbs which are used to construct parallel mechanisms and coupling chains is proposed.The basic types of the general parallel mechanisms and geometric conditions of the kinematic chains are given using constraint synthesis method.Moreover,the 2R2T motion pattern hybrid mechanisms which are derived by adding coupling chains between different serial kinematic chains(SKCs) of the corresponding parallel mechanisms are presented.According to the constraint analysis of the mechanisms,the movement relationship of the moving platform and the kinematic chains is derived by disassembling the coupling chains.At last,fourteen novel hybrid mechanisms with two or three serial kinematic chains are presented.The proposed novel hybrid mechanisms and construction method enrich the family of the spatial mechanisms and provide an instruction to design more complex hybrid mechanisms. | TIAN Chunxu FANG Yuefa GUO Sheng | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 5 |
| 15 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 16 | Zooarchaeological perspective on the Broad Spectrum Revolution in the Pleistocene-Holocene transitional period,with evidence from Shuidonggou Locality 12,China显示文摘Based on optimal foraging theory,prey animals from the Shuidonggou Locality 12(SDG12) are divided into three types according to body size and defense traits:high-ranked large game,low-ranked slow small game,and low-ranked fast small game.Application of the Reciprocal of Simpson's Index to the three types of animals from SDG12 yields a relatively high level of evenness,which implies a broader meat diet of the SDG12 hominids.Compared to values of taxonomic evenness from Mediterranean sites,it is suggested that this dietary expansion probably resulted from the occurrence of the Broad Spectrum Revolution rather than from climatic changes in the Shuidonggou area.Comparative studies between the Natufian phases in Hayonim Cave and the SDG12 validate this argument. | ZHANG Yue ZHANG ShuangQuan XU Xin LIU DeCheng WANG ChunXue PEI ShuWen WANG HuiMin GAO Xing | 2013 | Science China Earth Sciences2013，56，9： | 5 |
| 17 | The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial显示文摘Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain. | Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang | 2019 | Science Bulletin2019，64，2： | 5 |
| 18 | Quasi-3-yr Cycle of Rainy Season Precipitation in Tibet Related to Different Types of ENSO during 1981–2015显示文摘The rainy season precipitation in Tibet(RSPT) is a direct cause for local floods/droughts. It also indirectly affects the thermal conditions of the Tibetan Plateau, which can result in anomalous patterns of atmospheric circulation over East Asia. The interannual variability of the RSPT is often linked with the El Ni?o–Southern Oscillation(ENSO), but the relevant mechanisms are far from being understood, particularly for different types of ENSO events. We investigated the interannual variation of the RSPT in association with different types of ENSO. A quasi-3-yr period of the RSPT(less–more–more precipitation) was significant at the 95% confidence level. A joint multi-taper method with singular value decomposition analysis of the coupled field between the RSPT and the sea surface temperature(SST)revealed that the developing eastern Pacific type El Ni?o was accompanied by a decrease in the RSPT. The shift from the central Pacific type El Ni?o to the eastern Pacific La Ni?a was accompanied by an increase in the RSPT. Weakening of the central Pacific La Ni?a was accompanied by an increase in the RSPT. Analysis of the mechanism of this coupling, using the same analysis method but other climatic factors, indicated that the gradually strengthening eastern Pacific El Ni?o can inhibit the Walker circulation, weakening the South Asian summer monsoon, and resulting in transport of less water vapor from the Bay of Bengal to Tibet. The change from the central Pacific El Ni?o to the eastern Pacific La Ni?a led to continued strengthening of the Walker circulation with westward movement of the ascending area. This enhanced the South Asian summer monsoon over the Arabian Sea and transported more water vapor to Tibet. The decreasing central Pacific La Ni?a accompanied by persistent cooling of SSTs in the equatorial Pacific led to a strong eastern North Pacific summer monsoon, causing an anomaly in the easterly transport of water vapor from the Sea of Japan to Tibet and increased RSPT. | Chunxue WANG Zhenfeng MA | 2018 | Journal of Meteorological Research2018，32，2： | 5 |
| 19 | Advances in Medical Applications of Additive Manufacturing显示文摘In the past few decades,additive manufacturing(AM)has been developed and applied as a cost-effective and versatile technique for the fabrication of geometrically complex objects in the medical industry.In this review,we discuss current advances of AM in medical applications for the generation of pharmaceuticals,medical implants,and medical devices.Oral and transdermal drugs can be fabricated by a variety of AM technologies.Different types of hard and soft clinical implants have also been realized by AM,with the goal of producing tissue-engineered constructs.In addition,medical devices used for diagnostics and treatment of various pathological conditions have been developed.The growing body of research on AM reveals its great potential in medical applications.The goal of this review is to highlight the usefulness and elucidate the current limitations of AM applications in the medical field. | Chunxu Li Dario Pisignano Yu Zhao Jiajia Xue | 2020 | Engineering2020，6，11： | 4 |
| 20 | Impairment of cognition and sleep after acute ischaemic stroke or transient ischaemic attack in Chinese patients: design, rationale and baseline patient characteristics of a nationwide multicentre prospective registry显示文摘background and aim Cognitive impairment and sleep disorder are both common poststroke conditions and are closely related to the prognosis of patients who had a stroke.The Impairment of CognitiON and Sleep after acute ischemic stroke or transient ischemic attack in Chinese patients(ICONS)study is a nationwide multicentre prospective registry to investigate the occurrence and associated factors of cognitive impairment and sleep disorder after acute ischaemic stroke(AIS)or transient ischaemic attack(TIA).Methods Consecutive AIS or TIA in-hospital patients within 7 days after onset were enrolled from 40 participating sites in China.Comprehensive baseline clinical and imaging data were collected prospectively.Blood and urine samples were also collected on admission and follow-up visits.Patients were interviewed face to face for cognition and sleep related outcomes at 2 weeks,3,6 and 12 months after AIS/TIA and followed up for clinical outcomes by telephone annually over 5 years.results Between August 2015 and January 2018,a total of 2625 patients were enrolled.92.65% patients had AIS and 7.35% patients had TIA.Overall,the average age was 61.04 years,and 72.38% patients were male.Median National Institutes of Health Stroke Scale score was 3 in AIS patients.Conclusions The ICONS study is a large-scale nationwide prospective registry to investigate occurrence and the longitudinal changes of cognitive impairment and sleep disorder after AIS or TIA.Data from this registry may also provide opportunity to evaluate associated factors of cognitive impairment or sleep disorder after AIS or TIA and their impact on clinical outcome. | Yongjun Wang Xiaoling Liao Chunxue Wang Ning Zhang Lijun Zuo Yang Yang Yuesong Pan Xianglong Xiang Jing Jing Xia Meng Xingquan Zhao Yilong Wang Jiong Shi Hao Li | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
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