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| 1 | Spatial and temporal variation of particulate matter and gaseous pollutants in 26 cities in China显示文摘O3and PM2.5were introduced into the newly revised air quality standard system in February 2012, representing a milestone in the history of air pollution control, and China's urban air quality will be evaluated using six factors(SO2, NO2, O3, CO, PM2.5and PM10) from the beginning of 2013. To achieve the new air quality standard, it is extremely important to have a primary understanding of the current pollution status in various cities. The spatial and temporal variations of the air pollutants were investigated in 26 pilot cities in China from August 2011 to February 2012, just before the new standard was executed. Hourly averaged SO2, NO2and PM10were observed in 26 cities, and the pollutants O3, CO and PM2.5were measured in 15 of the 26 cities. The concentrations of SO2and CO were much higher in the cities in north China than those in the south. As for O3and NO2, however, there was no significant diference between northern and southern cities. Fine particles were found to account for a large proportion of airborne particles, with the ratio of PM2.5to PM10ranging from 55% to 77%. The concentrations of PM2.5(57.5 μg/m3) and PM10(91.2 μg/m3) were much higher than the values(PM2.5: 11.2 μg/m3; PM10 : 35.6 μg/m3) recommended by the World Health Organization. The attainment of the new urban air quality standard in the investigated cities is decreased by 20% in comparison with the older standard without considering O3, CO and PM2.5, suggesting a great challenge in urban air quality improvement, and more eforts will to be taken to control air pollution in China. | Fahe Chai Jian Gao Zhenxing Chen Shulan Wang Yuechong Zhang Jingqiao Zhang Hefeng Zhang Yaru Yun Chun Ren | 2014 | Journal of Environmental Sciences2014，26，1： | 36 |
| 2 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 3 | Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors显示文摘 | Sun Tieying Sun Li Wang Rongmei Ren Xiaoping Sui Dong-jiang Pu Chun Ren Yajuan Liu Ying Yang Zhuo Li Fengzhi | 2014 | Chinese Medical Journal2014，，7： | 34 |
| 4 | Impact of emission control on regional air quality: An observational study of air pollutants before, during and after the Beijing Olympic Games显示文摘An observational study on trace gases and PM2.5was conducted at three sites in and around Beijing, during the Olympic season from 2007 to 2009. Air quality improved significantly during the Olympic Games due to the special emission control measures. However, concentrations of the primary pollutants and PM were found to have risen significantly after the Games. Although the major O3precursors(NOx and VOCs) were well controlled during the Olympic season, O3was still found to be the highest in 2008, based on the data of ground-based observation. All this information suggests that while control of regional emissions for the Beijing Olympic Games did improved the air quality in Beijing, more eforts will be needed for the continuous improvement of regional air quality, especially for significant reductions of O3and fine particulate pollution, and not only in Beijing, but also in the Beijing-Tianjin-Hebei region. | Shulan Wang Jian Gao Yuechong Zhang Jingqiao Zhang Fahe Cha Tao Wang Chun Ren Wenxing Wang | 2014 | Journal of Environmental Sciences2014，26，1： | 20 |
| 5 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 6 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 7 | Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming显示文摘 | Jiangtao Ren Yongjun Pak Lixiazi He Lei Qian Yijun Gu Hui Li Lingjun Rao Jing Liao Chun Cui Xun Xu Jinqiu Zhou Hakchol Ri Lei Xiao | 2011 | Cell Research2011，21，5： | 10 |
| 8 | Application of fiber Bragg grating based strain sensor in pipeline vortex-induced vibration measurement显示文摘The vortex-induced vibrations(VIV)is an important topic of study in many different scientific and engineering fields.While VIV can be of benefit in some cases,oftentimes,it is an undesirable phenomenon that can be quite dangerous.In particular for offshore pipelines,VIV can lead to fatiguing of the pipe structure and can cause disastrous consequences if left unchecked.A number of different methods have been applied to the measurement of VIV,especially for the elongated,thin cylindrical structures.The use of fiber optic fiber Bragg gratings(FBGs)in particular has gained popularity over the recent years due to their distinct properties.However,FBGs are also very fragile and are susceptible to failure when placed in harsh environments without protection.In this paper,56 FBGs encapsulated in stainless steel tubes were applied to the measurement of VIV in a28-m model pipeline under controlled and uncontrolled conditions.Tests show that the encapsulated sensors possessed good sensitivity as well as fatigue life(>80000 cycles).The measurements from FBGs were also high enough to allow frequency domain analysis of the pipeline VIV under the two conditions.The authors conclude that the encapsulated FBGs are a viable tool for the study of VIV in pipeline structures. | REN Liang JIA ZiGuang HO Michael Siu Chun YI TingHua LI HongNan | 2014 | Science China(Technological Sciences)2014，57，9： | 9 |
| 9 | Study on Floating Properties and Stability of Air Floated Structures显示文摘In this paper, the buoyancy, kinetic properties and stability of air floated structures have been studied by theoreticaland experimental methods. The equations for calculation of the buoyancy of the air floated buoy are derived according tothe Boyler law and the equilibrium equations of the air floated structure are established. Through simplification of the airfloated structure as a single freedom rigid body and spring system, the natural period of heaving and some kinetic proper-ties are discussed. In the stability analysis, the formulas for calculation of the meta centric height are presented. The the-oretical results are in good agreement with the data observed from the model test and prototype test. The air buoyancy de-crease coefficient presented in this paper has a large influence on the floating state, stability and dynamic properties of theair floated structure. The stability of the air floated structure can also be judged by the parameter of meta centric height,and calculations show that the air floated structure is less stable than the conventional float. | BIE Shean(别社安) JI Chunning(及春宁) REN Zengjin(任增金) LI Zengzhi(李增志) | 2002 | China Ocean Engineering2002，17，2： | 8 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 12 | Laboratory Simulation of Vertical Hydrocarbon Microseepage显示文摘基于烃 microseepage 的一个概念的模型,当模仿的 caprock 和它的 overlying 阶层首先被设置模仿烃 microseepage 和它的近表面的表情的过程,一台宏大小的试验性的设备使用了水泥和石英沙的匹配的混合物。模拟实验的结果建议那模仿的 caprock,它的 overlying 阶层有某个封上的能力;烃 microseepage 被点气体来源的压力统治,并且温度起仅仅一个辅助作用;在烃 microseepage 的路径上,烃集中的分发是扇形的;由模仿的 caprock 和它的 overlying 阶层的链烷的微分吸附导致色析法的效果的出现。在模仿的 caprock 以内的不同移居模式被 i 钢瓶煤气的比率显示出到 n 钢瓶煤气。在表面土壤的烃的集中与点气体来源的压力有好通讯。这些模拟结果是重要的推进在表面地球化学探索恢复的异例的机制的学习。 | WANG Guojian CHENG Tongjin FAN Ming REN Chun CHEN Weijun | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 7 |
| 13 | A WRKY transcription factor confers aluminum tolerance via regulation of cell wall modifying genes显示文摘Modification of cell wall properties has been considered as one of the determinants that confer aluminum(Al)tolerance in plants,while how cell wall modifying processes are regulated remains elusive.Here,we present a WRKY transcription factor WRKY47 involved in Al tolerance and root growth.Lack of WRKY47 significantly reduces,while overexpression of it increases Al tolerance.We show that lack of WRKY47 substantially affects subcellular Al distribution in the root,with Al content decreased in apoplast and increased in symplast,which is attributed to the reduced cell wall Al-binding capacity conferred by the decreased content of hemicellulose I in the wrky47-1 mutant.Based on microarray,real time-quantitative polymerase chain reaction and chromatin immunoprecipitation assays,we further show that WRKY47 directly regulates the expression of EXTENSIN-LIKE PROTEIN(ELP)and XYLOGLUCAN ENDOTRANSGLUCOSYLASE-HYDROLASES17(XTH17)responsible for cell wall modification.Increasing the expression of ELP and XTH17 rescued Al tolerance as well as root growth in wrky47-1 mutant.In summary,our results demonstrate that WRKY47 is required for root growth under both normal and Al stress conditions via direct regulation of cell wall modification genes,and that the balance of Al distribution between root apoplast and symplast conferred by WRKY47 is important for Al tolerance. | Chun Xiao Li Jing Ying Yan Jiang Yuan Ren Li Sun Chen Xu Gui Xin Li Zhong Jie Ding Shao Jian Zheng | 2020 | Journal of Integrative Plant Biology2020，62，8： | 7 |
| 14 | Data Analysis of Chang'E-1 Gamma-Ray Spectrometer and Global Distribution of U,K,and Th Elemental Abundances显示文摘Gamma 光线分光计(GRS ) 是 Chang'E-1 (CE-1 ) 上的主要收费载重之一月亮的探查,主要试图在月亮的表面上检测元素的丰富和分布。在 03:58 在 2007 年 11 月 28 日,它执行了月亮的 gamma 光线的第一观察。2008 年 10 月 24 日,有效 gamma 光线系列的 2105 h 被 CE-1 GRS 获得了,它盖住月亮的整个表面。这份报纸主要描述处理由使用导出元素的丰富的过程和 CE-1 GRS 时间系列改正了系列的方法的数据:首先,到进为印射的象素的箱数据;然后,执行累积系列的背景扣除并且获得元素的一个山峰区域;并且最后,当模特儿使用元素的丰富倒置生产元素的丰富。在这些上基于比 EPR 在 5s 处理方法, U 的全球丰富地图, K,和 Th。在在 near-EPR 海底山下面的岩浆结晶化压力和融化的条件之间的关联暗示来源吗? | ZOU Yongliao ZHANG Liyan LIU Jianzhong MU Lingli REN Xin ZHANG Guangliang CHANG Jin YAN Jun ZHANG Nan ZHANG Hongbo LU Chang LIU Jianjun ZUO Wei SU Yan WEN Weibin BIAN Wei WANG Min XU Chun LI Chunlai OUYANG Ziyuan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 6 |
| 15 | Establishment and application of distant hybridization technology in fish显示文摘Hybridization is widely used. However, for a long time, systematic theories and technologies related to hybridization in fish have been lacking. In this study, through long-term systematic research, we investigated and obtained the main rules regarding inheritance and reproduction related to fish distant hybridization. Furthermore, we established one-step and multistep breeding technologies that were suitable for interspecific hybridization and intraspecific hybridization. Simultaneously, we used these two breeding technologies to produce a batch of diploid fish lineages and tetraploid fish lineages and improved fishes. In addition, we widely discuss the methods, technologies and results of hybridization breeding, referring to the domestic and foreign literature on fish hybridization. We hope that this paper will be beneficial for the research and application of fish hybrid breeding. | Shi Wang Chenchen Tang Min Tao Qinbo Qin Chun Zhang Kaikun Luo Rurong Zhao Jing Wang Li Ren Jun Xiao Fangzhou Hu Rong Zhou Wei Duan Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 16 | MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1显示文摘以前的研究证明了 microRNA-1304 (miR-1304 ) 是在癌症的某些类型的 dysregulated,包括非小的房间肺癌症(NSCLC ) ,并且可能涉及肿瘤幸存或生长。在这研究,我们在 vitro 在 NSCLC 调查了 miR-1304 和它的功能的直接目标。人的肺腺癌房间线(A549 和 NCI-H1975 ) 被学习。房间增长和幸存经由房间数, MTT 和殖民地形成试金被调查。房间 apoptosis 和房间周期用分别地染色试金的 annexin V-PE/7-AAD 和 PI 被检验。双酶的记者试金被用来由 miR-1304 验证 heme oxygenase-1 (HO-1 ) 的 post-transcriptional 规定。CRISPR/Cas9 被用来弄空内长的 miR-1304。MiR-1304 的 Overexpression 显著地减少了 NSCLC 房间和殖民地形成的数字和生存能力,和导致的房间 apoptosis 和 G 0/G1 阶段房间骑车拘捕。HO-1 被表明是在 NSCLC 房间的 miR-1304 的一个直接目标。由 hemin (20 mol/L ) 的 HO-1 表示的恢复在细胞生长上废除了 miR-1304 的抑制并且在 A549 细胞救了 miR-1304-induced apoptosis。有 anti-1304 的内长的 miR-1304 的抑制显著地增加了 HO-1 表示并且在 A549 房间支持了房间生长和幸存。在 17 件人的 NSCLC 织物样品, miR-1304 表示显著地被减少,当 HO-1 表示显著地作为与正常的肺纸巾相比被增加时。MicroRNA-1304 是肿瘤 suppressor, HO-1 是它在 NSCLC 的直接目标。结果为 NSCLC 作为一个治疗学的目标为 miR-1304 建议潜力。 | Cheng-gang LI Meng-fan PU Chun-zhu LI Man GAO Ming-xia LIU Cun-zhi YU Hong YAN Chun PENG Yang ZHAO Yu LI Ze-long MA Xin-ming QI Yi-zheng WANG Ling-ling MIAO Jin REN | 2017 | Acta Pharmacologica Sinica2017，38，1： | 6 |
| 17 | Protection of gastric mucosa from ethanol induced injury by recombinant epidermal growth factor in rats显示文摘NTRODUCTIONEpidermalgrowthfactor(EGF)isasinglechainpolypeptidethatissecretedbysubmandibularandBrunner′sglandsandisapowerfulm... | XU Chun Di 1, GAN Ren Bao 2, CHEN Shun Nian 1, JIANG Shi Hu 1 and XU Jia Yu 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 6 |
| 18 | Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells显示文摘食道的有鳞的房间癌(ESCC ) 是最普通的恶意之一。识别预言肿瘤前进和治疗学的分子的目标的新 markersfor 是必要的。它被报导了 Aurora-Aand 矩阵 metalloproteinases 的那 overexpressions (MMP-2 ) 2 可以支持肿瘤的恶意的发展。然而,关系 betweenAurora -- 在肿瘤病人的 A 和 MMP-2 表示没被调查。另外, Aurora-Aregulates MMP-2 表示不充分仍然是的内在的机制阐明了。在这研究,我们表明了那曙光 A, MMP-2 与配对的正常邻近的纸巾相比是 overexpressedin ESCC 纸巾(P ? | Xiaoxia Wang Xiaozhong Li Chaohui Li Chun He Benhong Ren Oing Deng Wei Gao Binquan Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 6 |
| 19 | Design,synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety显示文摘A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized.All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line(HL-60),human lung adenocarcinoma epithelial cell line(A549) and human breast cancer cell line(MDA-MB-231) in vitro by standard MTT assay.The pharmacological results indicated that some compounds exhibited promising antitumor activities.Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC values of 0.13 mmol/L,0.7 mmol/L and 0.5 mmol/L,respectively. | Bei Zhang Yan Fang Zhao Xin Zhai Wei Jie Fan Jun Ling Ren Chun Fu Wu Ping Gong | 2012 | Chinese Chemical Letters2012，23，8： | 6 |
| 20 | DNA methylation polymorphism in flue-cured tobacco and candidate markers for tobacco mosaic virus resistance显示文摘DNA methylation plays an important role in the epigenetic regulation of gene expression during plant growth,development,and polyploidization.However,there is still no distinct evidence in tobacco regarding the distribution of the methylation pattern and whether it contributes to qualitative characteristics.We studied the levels and patterns of methylation polymorphism at CCGG sites in 48 accessions of allotetraploid flue-cured tobacco,Nicotiana tabacum,using a methylation-sensitive amplified polymorphism(MSAP) technique.The results showed that methylation existed at a high level among tobacco accessions,among which 49.3% sites were methylated and 69.9% allelic sites were polymorphic.A cluster analysis revealed distinct patterns of geography-specific groups.In addition,three polymorphic sites significantly related to tobacco mosaic virus(TMV) resistance were explored.This suggests that tobacco breeders should pay more attention to epigenetic traits. | Jie-hong ZHAO Ji-shun ZHANG Yi WANG Ren-gang WANG Chun WU Long-jiang FAN Xue-liang REN | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，11： | 5 |
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